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The map label for this gene is hemB [H]

Identifier: 159184643

GI number: 159184643

Start: 1155681

End: 1156694

Strand: Reverse

Name: hemB [H]

Synonym: Atu1161

Alternate gene names: 159184643

Gene position: 1156694-1155681 (Counterclockwise)

Preceding gene: 159184649

Following gene: 15888498

Centisome position: 40.71

GC content: 59.76

Gene sequence:

>1014_bases
ATGCAGGACAAAACGCATCTGGTCGACGAGATCACCGGCCATCGCCGCATGCGGCGCAATCGCAAGGCGGATTGGACGCG
CCGTCTGGTTCAGGAAAATCGCCTGACCGTTGATGACCTCATCTGGCCGGTTTTCATCGTGCCTGGCAGCAATATTGTCG
AGCCCATTCCGGCTATGCCCGGTGTCAACCGCATGAGCGTCGACCGGCTGGTGGAAGCGGCGAAGGAAGCCGCCGATCTC
GGCATTCCCGCAATCGCCACCTTTCCCAATATCGAGATGGAGCTGCGCGACGAGACCGGCTCGAATGCGCTCGAAGCCAA
CAATCTCATCAATCAGGCGACGATCGCCGTTAAAAAAGCCGTTCCAAATATCGGCATGATCACCGATGTCGCGCTCGATC
CCTTCACCAGCCATGGGCATGACGGCATTCTGCGGGGCGACGAGATCGTCAATGACGAAACCGTCGAGCAGGTCGTCACG
GCCGCCATCCTGCAGGCGGAAGCCGGTTCGGACATTATCTCCCCCTCGGAGATGATGGATGGCCGTATCGGCGCCATCCG
TCGCGGTCTCGATGCCGCCGGGCACCAGAATGTCGGCATCATGGCCTATGCGACGAAATTCTCCTCCGGCTATTATGGTC
CCTATCGCGAGGCGATCTCCACCGCCGGCCTGCTGAAGGGCGACAAAAACAGCTATTACATCAGCCCCGCCAACGGCATG
GAAGCGATCCGCGATGCGGCGCTTGACGTCGAGGAAGGCGCCGACATGCTGATGGTCAAGCCCGGCCTGCCCTATCTCGA
CATCTGCTGGCGGCTGAAGGAGAATTTCGGCCTGCCCACCTTCGCCTATCAGGTGTCCGGCGAATATACCCAGATCAAGG
CCGCGGCCATGAATGGCTGGATCGACGGCGAGCGCGTGATGATGGAAACGCTTCTCTGTTTCAAGCGTGCGGGTTGCGAC
GGTATTCTCACCTATTTCGCCATCGAGGCAGCACGCAAACTGGCAAAGCACTGA

Upstream 100 bases:

>100_bases
CATCGTCCGTCAGGCAGCCGATGAGGGAAGATTGTCGCATTCGCATGGGCCAATGTTCATGGTATGCAGCTTTCCAAATT
TTATCGAAGGACATTCTGAC

Downstream 100 bases:

>100_bases
GGCCGGCGCTTATTGTATTCGGTCGTTTTCTTCCCATATTGTCTGCTGACACGGCGAATATGCCGCGCTGTCAGACCCTC
TCAGGAGAAAACGACCGATG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MQDKTHLVDEITGHRRMRRNRKADWTRRLVQENRLTVDDLIWPVFIVPGSNIVEPIPAMPGVNRMSVDRLVEAAKEAADL
GIPAIATFPNIEMELRDETGSNALEANNLINQATIAVKKAVPNIGMITDVALDPFTSHGHDGILRGDEIVNDETVEQVVT
AAILQAEAGSDIISPSEMMDGRIGAIRRGLDAAGHQNVGIMAYATKFSSGYYGPYREAISTAGLLKGDKNSYYISPANGM
EAIRDAALDVEEGADMLMVKPGLPYLDICWRLKENFGLPTFAYQVSGEYTQIKAAAMNGWIDGERVMMETLLCFKRAGCD
GILTYFAIEAARKLAKH

Sequences:

>Translated_337_residues
MQDKTHLVDEITGHRRMRRNRKADWTRRLVQENRLTVDDLIWPVFIVPGSNIVEPIPAMPGVNRMSVDRLVEAAKEAADL
GIPAIATFPNIEMELRDETGSNALEANNLINQATIAVKKAVPNIGMITDVALDPFTSHGHDGILRGDEIVNDETVEQVVT
AAILQAEAGSDIISPSEMMDGRIGAIRRGLDAAGHQNVGIMAYATKFSSGYYGPYREAISTAGLLKGDKNSYYISPANGM
EAIRDAALDVEEGADMLMVKPGLPYLDICWRLKENFGLPTFAYQVSGEYTQIKAAAMNGWIDGERVMMETLLCFKRAGCD
GILTYFAIEAARKLAKH
>Mature_337_residues
MQDKTHLVDEITGHRRMRRNRKADWTRRLVQENRLTVDDLIWPVFIVPGSNIVEPIPAMPGVNRMSVDRLVEAAKEAADL
GIPAIATFPNIEMELRDETGSNALEANNLINQATIAVKKAVPNIGMITDVALDPFTSHGHDGILRGDEIVNDETVEQVVT
AAILQAEAGSDIISPSEMMDGRIGAIRRGLDAAGHQNVGIMAYATKFSSGYYGPYREAISTAGLLKGDKNSYYISPANGM
EAIRDAALDVEEGADMLMVKPGLPYLDICWRLKENFGLPTFAYQVSGEYTQIKAAAMNGWIDGERVMMETLLCFKRAGCD
GILTYFAIEAARKLAKH

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. Required for nodule development [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=295, Percent_Identity=37.2881355932203, Blast_Score=199, Evalue=4e-51,
Organism=Escherichia coli, GI87081728, Length=319, Percent_Identity=43.8871473354232, Blast_Score=249, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6321398, Length=308, Percent_Identity=36.3636363636364, Blast_Score=170, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21358291, Length=304, Percent_Identity=37.171052631579, Blast_Score=215, Evalue=3e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36971; Mature: 36971

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDKTHLVDEITGHRRMRRNRKADWTRRLVQENRLTVDDLIWPVFIVPGSNIVEPIPAMP
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHCEEEEEECCCCCCCCCCCCC
GVNRMSVDRLVEAAKEAADLGIPAIATFPNIEMELRDETGSNALEANNLINQATIAVKKA
CCCHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHH
VPNIGMITDVALDPFTSHGHDGILRGDEIVNDETVEQVVTAAILQAEAGSDIISPSEMMD
CCCCCCCHHHHCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHC
GRIGAIRRGLDAAGHQNVGIMAYATKFSSGYYGPYREAISTAGLLKGDKNSYYISPANGM
CHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCHH
EAIRDAALDVEEGADMLMVKPGLPYLDICWRLKENFGLPTFAYQVSGEYTQIKAAAMNGW
HHHHHHHCCHHCCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCHHEEEHHHHCCC
IDGERVMMETLLCFKRAGCDGILTYFAIEAARKLAKH
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQDKTHLVDEITGHRRMRRNRKADWTRRLVQENRLTVDDLIWPVFIVPGSNIVEPIPAMP
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHCEEEEEECCCCCCCCCCCCC
GVNRMSVDRLVEAAKEAADLGIPAIATFPNIEMELRDETGSNALEANNLINQATIAVKKA
CCCHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHH
VPNIGMITDVALDPFTSHGHDGILRGDEIVNDETVEQVVTAAILQAEAGSDIISPSEMMD
CCCCCCCHHHHCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHC
GRIGAIRRGLDAAGHQNVGIMAYATKFSSGYYGPYREAISTAGLLKGDKNSYYISPANGM
CHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCHH
EAIRDAALDVEEGADMLMVKPGLPYLDICWRLKENFGLPTFAYQVSGEYTQIKAAAMNGW
HHHHHHHCCHHCCCCEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCHHEEEHHHHCCC
IDGERVMMETLLCFKRAGCDGILTYFAIEAARKLAKH
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8226669; 12597275 [H]