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The map label for this gene is pbpB [H]

Identifier: 159184602

GI number: 159184602

Start: 1059043

End: 1060803

Strand: Direct

Name: pbpB [H]

Synonym: Atu1067

Alternate gene names: 159184602

Gene position: 1059043-1060803 (Clockwise)

Preceding gene: 159184601

Following gene: 159184605

Centisome position: 37.27

GC content: 61.67

Gene sequence:

>1761_bases
ATGATTGCTTTTGTGATGCGGCTCAGGAGCCGGGCGCATTTTATTATTCAGAGACATCCCGGTAAGACTGGCGATGCCAT
CCTCGGTTCCGCCGCCCGCCGCCGGGTCGATGCGCGGGTGAGGCTCGGTATTGTGATCGCCGTCTTCGCCGCCATCTATG
TCGTCGTGGCAGCACGGCTCGTCCAATATGGCCTCGCCGAACCCGTGGCGACGGCCTGGATCAATACCGGGGCCAATGCC
GTCGCCTCCCGGCCTGATATTGTCGACCGCAACGGCATGCTTCTGGCGACCGATCTCAACATGGTGTCGCTTTATGCGGA
TCCGCGCCGGGTGGTTGATCCCGATGAGGTGGTGGAGAAGCTAGCAAGCGTCATCCCCAATCTCGACTGGCGTGAAACGC
ATCGCCGGTTGCGTTCGGACACCGGCTTCCAGTGGCTGCGGCGCCAGCTGACGCCCCGGCAACAGGCGGATATTCTCAAT
CTCGGCATACCGGGTATCGGTTTCCGGCCGGAAAAACGACGGTTCTATCCGGGCGGTCCGGCCGCTTCGCATATTATCGG
CCACGTCAATGTCGACAATCAGGGTCTTGCCGGCATGGAGCGTTATCTCGACCAGCAGGGGCTGGCTGATCTGCGCGCCG
TCGGCCTTGCCAGCGGCGCACCGCTGGAGCCCGTGAAGCTTTCCATCGATATGCGGGTGCAGAACATCGTCCGCGAGGTC
GTCGTGAAGGCGAAGAGCGCCTATGAGGCGGAAGCTGCGGGCTCGGTCATCCTCGATGTGGAGACCGGCGAGGTGCTGGC
CATGGCCTCGGTGCCGGACTACGACCCCAACGAACCGTCCCGCACCCTTGCCGATGGCAGCATCGACAGGGACTATGAAA
AGGGTTGGTTCAACCGCATGAGCAACGCCACCTTCGAAATGGGGTCCACCTTCAAGAGCTTCACGCTCGCCATGGGGCTG
GATGCCGGGGCGATCACCCTCAATTCGGTGGTGGACGCCTCGCGGCCAATCCGCATGGGCGGCTTCACCATCAAGGATTT
CAAGGGCCGGAACCGCCCGCTATCGATCCCGGAAGTGTTTCAATATTCATCGAATATCGGCACGGCGGCGGTGGCCGACA
AGGTGGGCGTCGAAGGCCACCAGCAGTTCCTGACGAAACTCGGGCTGCTGACGAAAATGGACACGGAGATGCCTGGAGTA
GCGACGCCGACCCAGCCGAGAGTGTGGAAGAAGATCAATTCCGTTACCATCTCCTTCGGCCATGGCGTTGCCACCACGCC
GCTGCAGACGGCGGTGGCGGCCGCAGCCCTCATCAATGGCGGCAACCTGATGTCGCCAACGTTCCTGCCGCGTTCGAAAG
AGGATGCGGCCTCGATTTCACGCAGCGTCATCGAGCAGAAGACGAGCGCGGATATGCGCTACCTGTTCAACTGGAACGGC
ATCAAGGGTTCCGGCCGCGGCGCACAGGTGGAGGGATTTCATGTGGGCGGCAAAACCGGAACGGCCGACAAGGTGATCAA
CGGCCGTTACGCCAAGAATATCAATTTCAACGCCTTCGTCGCCGGTTTTCCCATGCACAAGCCGAAATACGTCGTGCTGA
CGATGATTGACGCCCCGAAGACCGGCGTGAATGGCGGGCGCACGGCGGCTTCCACCGCAGCCCCGATGACGCGGGAGATC
ATCGCGCAGACGGCGGGGCTTCTCGGTGTGAAGCCGCGTTTTGGTTATGACGCGACGCCGCAATTGCTGGTGGATTATTG
A

Upstream 100 bases:

>100_bases
GCTCTTTTCATGGCCCCGCGACTGATCCTGTGCCAGCCTCTCCAGAGGCGTTGGTGGTGCGGAATTTTCTTCTGCAGCCA
TGAAGTGGGCGGCATCAGAC

Downstream 100 bases:

>100_bases
GCCCTGACTTGGTGAGGGAGGCGGCAATACGCCCGCCTACCGCTTGAGCCGCATCAGGCTGGAGCCGGTATAGATCGCCA
GCGCCACCCAGATCATCGCA

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 586; Mature: 586

Protein sequence:

>586_residues
MIAFVMRLRSRAHFIIQRHPGKTGDAILGSAARRRVDARVRLGIVIAVFAAIYVVVAARLVQYGLAEPVATAWINTGANA
VASRPDIVDRNGMLLATDLNMVSLYADPRRVVDPDEVVEKLASVIPNLDWRETHRRLRSDTGFQWLRRQLTPRQQADILN
LGIPGIGFRPEKRRFYPGGPAASHIIGHVNVDNQGLAGMERYLDQQGLADLRAVGLASGAPLEPVKLSIDMRVQNIVREV
VVKAKSAYEAEAAGSVILDVETGEVLAMASVPDYDPNEPSRTLADGSIDRDYEKGWFNRMSNATFEMGSTFKSFTLAMGL
DAGAITLNSVVDASRPIRMGGFTIKDFKGRNRPLSIPEVFQYSSNIGTAAVADKVGVEGHQQFLTKLGLLTKMDTEMPGV
ATPTQPRVWKKINSVTISFGHGVATTPLQTAVAAAALINGGNLMSPTFLPRSKEDAASISRSVIEQKTSADMRYLFNWNG
IKGSGRGAQVEGFHVGGKTGTADKVINGRYAKNINFNAFVAGFPMHKPKYVVLTMIDAPKTGVNGGRTAASTAAPMTREI
IAQTAGLLGVKPRFGYDATPQLLVDY

Sequences:

>Translated_586_residues
MIAFVMRLRSRAHFIIQRHPGKTGDAILGSAARRRVDARVRLGIVIAVFAAIYVVVAARLVQYGLAEPVATAWINTGANA
VASRPDIVDRNGMLLATDLNMVSLYADPRRVVDPDEVVEKLASVIPNLDWRETHRRLRSDTGFQWLRRQLTPRQQADILN
LGIPGIGFRPEKRRFYPGGPAASHIIGHVNVDNQGLAGMERYLDQQGLADLRAVGLASGAPLEPVKLSIDMRVQNIVREV
VVKAKSAYEAEAAGSVILDVETGEVLAMASVPDYDPNEPSRTLADGSIDRDYEKGWFNRMSNATFEMGSTFKSFTLAMGL
DAGAITLNSVVDASRPIRMGGFTIKDFKGRNRPLSIPEVFQYSSNIGTAAVADKVGVEGHQQFLTKLGLLTKMDTEMPGV
ATPTQPRVWKKINSVTISFGHGVATTPLQTAVAAAALINGGNLMSPTFLPRSKEDAASISRSVIEQKTSADMRYLFNWNG
IKGSGRGAQVEGFHVGGKTGTADKVINGRYAKNINFNAFVAGFPMHKPKYVVLTMIDAPKTGVNGGRTAASTAAPMTREI
IAQTAGLLGVKPRFGYDATPQLLVDY
>Mature_586_residues
MIAFVMRLRSRAHFIIQRHPGKTGDAILGSAARRRVDARVRLGIVIAVFAAIYVVVAARLVQYGLAEPVATAWINTGANA
VASRPDIVDRNGMLLATDLNMVSLYADPRRVVDPDEVVEKLASVIPNLDWRETHRRLRSDTGFQWLRRQLTPRQQADILN
LGIPGIGFRPEKRRFYPGGPAASHIIGHVNVDNQGLAGMERYLDQQGLADLRAVGLASGAPLEPVKLSIDMRVQNIVREV
VVKAKSAYEAEAAGSVILDVETGEVLAMASVPDYDPNEPSRTLADGSIDRDYEKGWFNRMSNATFEMGSTFKSFTLAMGL
DAGAITLNSVVDASRPIRMGGFTIKDFKGRNRPLSIPEVFQYSSNIGTAAVADKVGVEGHQQFLTKLGLLTKMDTEMPGV
ATPTQPRVWKKINSVTISFGHGVATTPLQTAVAAAALINGGNLMSPTFLPRSKEDAASISRSVIEQKTSADMRYLFNWNG
IKGSGRGAQVEGFHVGGKTGTADKVINGRYAKNINFNAFVAGFPMHKPKYVVLTMIDAPKTGVNGGRTAASTAAPMTREI
IAQTAGLLGVKPRFGYDATPQLLVDY

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=528, Percent_Identity=30.4924242424242, Blast_Score=180, Evalue=3e-46,
Organism=Escherichia coli, GI1786854, Length=441, Percent_Identity=24.9433106575964, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 63415; Mature: 63415

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAFVMRLRSRAHFIIQRHPGKTGDAILGSAARRRVDARVRLGIVIAVFAAIYVVVAARL
CHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQYGLAEPVATAWINTGANAVASRPDIVDRNGMLLATDLNMVSLYADPRRVVDPDEVVEK
HHHCCCCHHHHHHHHCCCHHHCCCCCEECCCCEEEEECCCEEEEECCCCCCCCHHHHHHH
LASVIPNLDWRETHRRLRSDTGFQWLRRQLTPRQQADILNLGIPGIGFRPEKRRFYPGGP
HHHHCCCCCHHHHHHHHHCCCCHHHHHHHCCCCHHCCEEECCCCCCCCCCCCCCCCCCCC
AASHIIGHVNVDNQGLAGMERYLDQQGLADLRAVGLASGAPLEPVKLSIDMRVQNIVREV
CHHHEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHH
VVKAKSAYEAEAAGSVILDVETGEVLAMASVPDYDPNEPSRTLADGSIDRDYEKGWFNRM
HHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
SNATFEMGSTFKSFTLAMGLDAGAITLNSVVDASRPIRMGGFTIKDFKGRNRPLSIPEVF
CCCCCHHCCCHHHHHHEECCCCCCEEHHHHHCCCCCEEECCEEEECCCCCCCCCCCHHHH
QYSSNIGTAAVADKVGVEGHQQFLTKLGLLTKMDTEMPGVATPTQPRVWKKINSVTISFG
HHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCEEEEEC
HGVATTPLQTAVAAAALINGGNLMSPTFLPRSKEDAASISRSVIEQKTSADMRYLFNWNG
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECC
IKGSGRGAQVEGFHVGGKTGTADKVINGRYAKNINFNAFVAGFPMHKPKYVVLTMIDAPK
CCCCCCCCEEEEEEECCCCCCHHHHHCCCEECCCCCEEEEECCCCCCCCEEEEEEECCCC
TGVNGGRTAASTAAPMTREIIAQTAGLLGVKPRFGYDATPQLLVDY
CCCCCCCCCHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCEEECC
>Mature Secondary Structure
MIAFVMRLRSRAHFIIQRHPGKTGDAILGSAARRRVDARVRLGIVIAVFAAIYVVVAARL
CHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQYGLAEPVATAWINTGANAVASRPDIVDRNGMLLATDLNMVSLYADPRRVVDPDEVVEK
HHHCCCCHHHHHHHHCCCHHHCCCCCEECCCCEEEEECCCEEEEECCCCCCCCHHHHHHH
LASVIPNLDWRETHRRLRSDTGFQWLRRQLTPRQQADILNLGIPGIGFRPEKRRFYPGGP
HHHHCCCCCHHHHHHHHHCCCCHHHHHHHCCCCHHCCEEECCCCCCCCCCCCCCCCCCCC
AASHIIGHVNVDNQGLAGMERYLDQQGLADLRAVGLASGAPLEPVKLSIDMRVQNIVREV
CHHHEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHH
VVKAKSAYEAEAAGSVILDVETGEVLAMASVPDYDPNEPSRTLADGSIDRDYEKGWFNRM
HHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
SNATFEMGSTFKSFTLAMGLDAGAITLNSVVDASRPIRMGGFTIKDFKGRNRPLSIPEVF
CCCCCHHCCCHHHHHHEECCCCCCEEHHHHHCCCCCEEECCEEEECCCCCCCCCCCHHHH
QYSSNIGTAAVADKVGVEGHQQFLTKLGLLTKMDTEMPGVATPTQPRVWKKINSVTISFG
HHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCEEEEEC
HGVATTPLQTAVAAAALINGGNLMSPTFLPRSKEDAASISRSVIEQKTSADMRYLFNWNG
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECC
IKGSGRGAQVEGFHVGGKTGTADKVINGRYAKNINFNAFVAGFPMHKPKYVVLTMIDAPK
CCCCCCCCEEEEEEECCCCCCHHHHHCCCEECCCCCEEEEECCCCCCCCEEEEEEECCCC
TGVNGGRTAASTAAPMTREIIAQTAGLLGVKPRFGYDATPQLLVDY
CCCCCCCCCHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]