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The map label for this gene is zitB [H]

Identifier: 159184519

GI number: 159184519

Start: 881927

End: 882934

Strand: Direct

Name: zitB [H]

Synonym: Atu0891

Alternate gene names: 159184519

Gene position: 881927-882934 (Clockwise)

Preceding gene: 159184518

Following gene: 15888237

Centisome position: 31.04

GC content: 61.31

Gene sequence:

>1008_bases
ATGACGACGACTTCCGAACCTTTCGCCGCGGCGGAGCATCACCATATTTATCTCGGCCAGAATCATGAGCGCAATGAAAG
GCGTGTCTGGATGGTCATTGCATTGACCACCGTCATGATGGTGGCAGAGATCGTCGCCGGCCACTGGTTCGGCTCCATGG
CGCTGACGGCTGACGGATGGCACATGTCCACCCATGCGGGCGCGATGCTGATTTCGGCGCTCGCCTATCTCTATGCAAGG
CGCGAGGCGCGCAATCCCCGCTTCAGCTTCGGCACCGGCAAGTTCGGTGATCTCGCCGGTTTTGCCAGTGCCGTCGTGCT
TGCCGTGGTGGCGCTGCTCATTGCGGTAGAAAGTGGCTTGCGCCTCGTCAGCCCCGTCCAGATCGATTTCAACCAGGCTA
TTCTCGTTGCAGTCATCGGCCTTGTCGTCAATCTCGTCAGCGCCGTGCTGCTGAAGGATGACCATCACCACGACCGTGGC
CACGGCCACGGCCATGGTCACGCTTCGCATGCCCATCACGGCCACGGCAGCCATGCCCACCACGATCACGGTTCGCATGC
ACAGCACGGCGCAAAGGGCGGGCGGGACAATAATCTGCGCGCCGCCTATCTGCATGTGCTGGCGGATGCGCTGACCTCGG
TCCTTGCCATCGTCGCGTTGCTGCTCGGCAAGTGGAACGGCTGGAACTTTCTCGACCCGTTGATGGGCATCGTCGGCGGT
CTGGTCATCGCCCGCTGGTCATGGGGGCTCATTCGCTCCACGGCAACGACGCTGGTCGATGCGGTGCCGCTGACGGACGA
CCTGCCGCAGGAAATCCGTGATACGGTGGAAACGGAAGAAGATCGCATCACCGATCTGCATGTCTGGCAGGTTGGCCCCG
GCCACCATGCGGCCATCGTCGCGATCCATTCGCAGGCGCCGAAAGCGCCGGCCTTTTATAAACAGAAACTTGCCGCCATA
CATGAACTGTCGCATGTGACAGTGGAAGTCAGCCCGGCAAGTGCCTAA

Upstream 100 bases:

>100_bases
GCTGAAGACCTACATCCGGTAGGTCAATGCAGGCCAGCAGAATGGAAAGAAGCCCGCAGAGTTGAGAAGGGCCGGTAAAT
TCGAGAGAGGATTGAGCGAC

Downstream 100 bases:

>100_bases
TGGGACTCGCCTATTCGGTATATTCCGAATAGGCGCCACGCACCCATTCTGCCTGTGCTTCCGCCTTGTCTTCGGCGGAG
GCGGCCGGCGTATCCTGATA

Product: cation efflux system protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTTTSEPFAAAEHHHIYLGQNHERNERRVWMVIALTTVMMVAEIVAGHWFGSMALTADGWHMSTHAGAMLISALAYLYAR
REARNPRFSFGTGKFGDLAGFASAVVLAVVALLIAVESGLRLVSPVQIDFNQAILVAVIGLVVNLVSAVLLKDDHHHDRG
HGHGHGHASHAHHGHGSHAHHDHGSHAQHGAKGGRDNNLRAAYLHVLADALTSVLAIVALLLGKWNGWNFLDPLMGIVGG
LVIARWSWGLIRSTATTLVDAVPLTDDLPQEIRDTVETEEDRITDLHVWQVGPGHHAAIVAIHSQAPKAPAFYKQKLAAI
HELSHVTVEVSPASA

Sequences:

>Translated_335_residues
MTTTSEPFAAAEHHHIYLGQNHERNERRVWMVIALTTVMMVAEIVAGHWFGSMALTADGWHMSTHAGAMLISALAYLYAR
REARNPRFSFGTGKFGDLAGFASAVVLAVVALLIAVESGLRLVSPVQIDFNQAILVAVIGLVVNLVSAVLLKDDHHHDRG
HGHGHGHASHAHHGHGSHAHHDHGSHAQHGAKGGRDNNLRAAYLHVLADALTSVLAIVALLLGKWNGWNFLDPLMGIVGG
LVIARWSWGLIRSTATTLVDAVPLTDDLPQEIRDTVETEEDRITDLHVWQVGPGHHAAIVAIHSQAPKAPAFYKQKLAAI
HELSHVTVEVSPASA
>Mature_334_residues
TTTSEPFAAAEHHHIYLGQNHERNERRVWMVIALTTVMMVAEIVAGHWFGSMALTADGWHMSTHAGAMLISALAYLYARR
EARNPRFSFGTGKFGDLAGFASAVVLAVVALLIAVESGLRLVSPVQIDFNQAILVAVIGLVVNLVSAVLLKDDHHHDRGH
GHGHGHASHAHHGHGSHAHHDHGSHAQHGAKGGRDNNLRAAYLHVLADALTSVLAIVALLLGKWNGWNFLDPLMGIVGGL
VIARWSWGLIRSTATTLVDAVPLTDDLPQEIRDTVETEEDRITDLHVWQVGPGHHAAIVAIHSQAPKAPAFYKQKLAAIH
ELSHVTVEVSPASA

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=292, Percent_Identity=32.1917808219178, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI222080086, Length=277, Percent_Identity=26.3537906137184, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI40255009, Length=277, Percent_Identity=26.3537906137184, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI21359890, Length=287, Percent_Identity=23.3449477351916, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI52352805, Length=273, Percent_Identity=23.4432234432234, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI52351208, Length=137, Percent_Identity=30.6569343065693, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786966, Length=285, Percent_Identity=30.8771929824561, Blast_Score=93, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32564488, Length=298, Percent_Identity=28.8590604026846, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17555794, Length=300, Percent_Identity=26, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17555796, Length=289, Percent_Identity=25.9515570934256, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193210990, Length=324, Percent_Identity=24.3827160493827, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323899, Length=360, Percent_Identity=25.5555555555556, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320411, Length=224, Percent_Identity=24.1071428571429, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24645863, Length=273, Percent_Identity=28.2051282051282, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24656728, Length=289, Percent_Identity=25.2595155709343, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24656724, Length=289, Percent_Identity=25.2595155709343, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24656720, Length=289, Percent_Identity=25.2595155709343, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24656715, Length=289, Percent_Identity=25.2595155709343, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357035, Length=289, Percent_Identity=25.2595155709343, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583858, Length=262, Percent_Identity=24.0458015267176, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24585900, Length=290, Percent_Identity=22.4137931034483, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24585898, Length=290, Percent_Identity=22.4137931034483, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24585896, Length=290, Percent_Identity=22.4137931034483, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921672, Length=290, Percent_Identity=22.4137931034483, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 36158; Mature: 36026

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTSEPFAAAEHHHIYLGQNHERNERRVWMVIALTTVMMVAEIVAGHWFGSMALTADGW
CCCCCCCCCCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
HMSTHAGAMLISALAYLYARREARNPRFSFGTGKFGDLAGFASAVVLAVVALLIAVESGL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
RLVSPVQIDFNQAILVAVIGLVVNLVSAVLLKDDHHHDRGHGHGHGHASHAHHGHGSHAH
EEECCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HDHGSHAQHGAKGGRDNNLRAAYLHVLADALTSVLAIVALLLGKWNGWNFLDPLMGIVGG
CCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LVIARWSWGLIRSTATTLVDAVPLTDDLPQEIRDTVETEEDRITDLHVWQVGPGHHAAIV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEE
AIHSQAPKAPAFYKQKLAAIHELSHVTVEVSPASA
EEECCCCCCHHHHHHHHHHHHHHHEEEEEECCCCC
>Mature Secondary Structure 
TTTSEPFAAAEHHHIYLGQNHERNERRVWMVIALTTVMMVAEIVAGHWFGSMALTADGW
CCCCCCCCCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
HMSTHAGAMLISALAYLYARREARNPRFSFGTGKFGDLAGFASAVVLAVVALLIAVESGL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
RLVSPVQIDFNQAILVAVIGLVVNLVSAVLLKDDHHHDRGHGHGHGHASHAHHGHGSHAH
EEECCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HDHGSHAQHGAKGGRDNNLRAAYLHVLADALTSVLAIVALLLGKWNGWNFLDPLMGIVGG
CCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LVIARWSWGLIRSTATTLVDAVPLTDDLPQEIRDTVETEEDRITDLHVWQVGPGHHAAIV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEE
AIHSQAPKAPAFYKQKLAAIHELSHVTVEVSPASA
EEECCCCCCHHHHHHHHHHHHHHHEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]