Click here to switch to the map view.

The map label for this gene is coxA [H]

Identifier: 159184458

GI number: 159184458

Start: 763517

End: 765226

Strand: Direct

Name: coxA [H]

Synonym: Atu0768

Alternate gene names: 159184458

Gene position: 763517-765226 (Clockwise)

Preceding gene: 159184457

Following gene: 15888112

Centisome position: 26.87

GC content: 59.65

Gene sequence:

>1710_bases
ATGGCTGGACCTTCCGCACACGACGATCATCACTCGCATGGTCAATCCGCACATGACGCGCATGCGCATGACGATCATTC
GCATGATCATTCCCATAAGCCGGGCTTTTTCGCCCGCTGGTTCCTGTCCACCAACCACAAGGACATCGGCACGCTGTACC
TGATCTTCGCCATCATGGCGGGTATCATCGGCGGCGGGCTTTCGGTCGTCATGCGTATGGAGCTGCAGGAGCCGGGCATC
CAGATCTTCCACGGTCTGGCTTCCATGGTCTACGGCTTCGAGGGCGATGCCGCCATCGACGGCGGTAAGCACATGTTCAA
CGTGTTCACGACAGCGCACGCGCTGATCATGATCTTCTTCATGGTCATGCCGGCGATGATCGGCGGTTTTGCCAACTGGA
TGATCCCGATCATGATCGGCGCGCCTGACATGGCTTTCCCGCGCCTCAACAATATTTCCTTCTGGCTCATCGTTCCGGCC
TTCATCCTGCTGCTCCTGTCGCTCTTCGTCGAAGGTCCGGCGGGTGCTTATGGCGTGGGTGGCGGCTGGACCATGTATCC
GCCTCTGTCGACCAGTGGCATGCCCGGGCCGGCGGTGGATCTTGCGATCTTCTCGCTGCACGTCGCCGGTGCATCCTCGA
TCCTCGGCGCCATCAACTTCATCACCACCATCCTGAACATGCGCGCGCCGGGCATGACGCTGCACAAGATGCCGCTGTTT
GCCTGGTCGGTTCTGGTCACCGCATTCCTGCTCCTGCTTTCGCTTCCGGTTTTGGCAGGTGGCATCACCATGCTTCTGAC
CGACCGTAACTTCGGCACGGCGTTCTTCTCGCCGGAGGGCGGCGGTGATCCGATCCTCTACCAGCATCTGTTCTGGTTCT
TCGGTCACCCGGAAGTGTACATTCTGATCCTGCCCGGTTTCGGCATCATCAGCCACATCGTGTCCACCTTCTCCAAGAAG
CCGGTCTTCGGTTATCTCGGCATGGCTTACGCCATGGTCGCCATCGGTGCGGTCGGCTTCATCGTCTGGGCCCACCACAT
GTACACGGTCGGCCTGTCGCTCGAGGCACAGCGCTACTTCGTTTTCGCCACCATGGTCATCGCGGTGCCGACGGGGATCA
AGATCTTCTCGTGGATCGCGACGATGTGGGGCGGTTCGCTGACCTTCTCGACCCCGATGGTCTGGGCAATCGGCTTTATC
TTCCTGTTCACGGTCGGTGGTGTCACCGGTGTGCAGCTCGCCAATGCCGGTCTCGACCGTTCGCTGCACGACACCTATTA
CGTCGTGGCTCACTTCCACTACGTGCTGTCGCTCGGCGCCGTCTTTGCGATCTTCGCCGGCTGGTATTACTGGTTCCCGA
AGATCACCGGCTACATGTACAACGAGTTCATCGGCAAGCTGCATTTCTGGGTCATGTTCATCGGCGTGAACCTGATCTTC
TTCCCGCAGCACTTCCTTGGTCTCGCCGGCATGCCGCGCCGCTACATCGATTATCCCGATGCTTACGCCGGCTGGAACAT
GGTATCGTCCTACGGTTCCTATATCTCGGCCGTTGCCGTTGGCATCTTCCTCTTCGGCGTCTGGGAAGCCTTCGCCAAGA
AGCGCATCGCCGGTAACAATCCCTGGGGTGAAGGTGCGACGACGCTTGAATGGCAGCTGTCTTCGCCGCCGCCTTACCAC
CAGTGGGAACAGCTTCCGCGCATCCGCTGA

Upstream 100 bases:

>100_bases
TGAACGGCGCGAACCGGGCGTTGATGGCCTCCGTCGATGGCGCTCCGCGCACGGTCGACGTTGCCGCCAACGAAACCAAC
TGAGACCTGGAGTGACGACA

Downstream 100 bases:

>100_bases
TGCGCGGGCCGGACGGCGCAGGCTCGGCTTGCGCATTCCGGCTGCTGAAAAAGAGGGACGGCGCGGTTGGGTCCGTGCCG
TTTCCCGAACGGGCAGCTTC

Product: cytochrome-c oxidase chain I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 569; Mature: 568

Protein sequence:

>569_residues
MAGPSAHDDHHSHGQSAHDAHAHDDHSHDHSHKPGFFARWFLSTNHKDIGTLYLIFAIMAGIIGGGLSVVMRMELQEPGI
QIFHGLASMVYGFEGDAAIDGGKHMFNVFTTAHALIMIFFMVMPAMIGGFANWMIPIMIGAPDMAFPRLNNISFWLIVPA
FILLLLSLFVEGPAGAYGVGGGWTMYPPLSTSGMPGPAVDLAIFSLHVAGASSILGAINFITTILNMRAPGMTLHKMPLF
AWSVLVTAFLLLLSLPVLAGGITMLLTDRNFGTAFFSPEGGGDPILYQHLFWFFGHPEVYILILPGFGIISHIVSTFSKK
PVFGYLGMAYAMVAIGAVGFIVWAHHMYTVGLSLEAQRYFVFATMVIAVPTGIKIFSWIATMWGGSLTFSTPMVWAIGFI
FLFTVGGVTGVQLANAGLDRSLHDTYYVVAHFHYVLSLGAVFAIFAGWYYWFPKITGYMYNEFIGKLHFWVMFIGVNLIF
FPQHFLGLAGMPRRYIDYPDAYAGWNMVSSYGSYISAVAVGIFLFGVWEAFAKKRIAGNNPWGEGATTLEWQLSSPPPYH
QWEQLPRIR

Sequences:

>Translated_569_residues
MAGPSAHDDHHSHGQSAHDAHAHDDHSHDHSHKPGFFARWFLSTNHKDIGTLYLIFAIMAGIIGGGLSVVMRMELQEPGI
QIFHGLASMVYGFEGDAAIDGGKHMFNVFTTAHALIMIFFMVMPAMIGGFANWMIPIMIGAPDMAFPRLNNISFWLIVPA
FILLLLSLFVEGPAGAYGVGGGWTMYPPLSTSGMPGPAVDLAIFSLHVAGASSILGAINFITTILNMRAPGMTLHKMPLF
AWSVLVTAFLLLLSLPVLAGGITMLLTDRNFGTAFFSPEGGGDPILYQHLFWFFGHPEVYILILPGFGIISHIVSTFSKK
PVFGYLGMAYAMVAIGAVGFIVWAHHMYTVGLSLEAQRYFVFATMVIAVPTGIKIFSWIATMWGGSLTFSTPMVWAIGFI
FLFTVGGVTGVQLANAGLDRSLHDTYYVVAHFHYVLSLGAVFAIFAGWYYWFPKITGYMYNEFIGKLHFWVMFIGVNLIF
FPQHFLGLAGMPRRYIDYPDAYAGWNMVSSYGSYISAVAVGIFLFGVWEAFAKKRIAGNNPWGEGATTLEWQLSSPPPYH
QWEQLPRIR
>Mature_568_residues
AGPSAHDDHHSHGQSAHDAHAHDDHSHDHSHKPGFFARWFLSTNHKDIGTLYLIFAIMAGIIGGGLSVVMRMELQEPGIQ
IFHGLASMVYGFEGDAAIDGGKHMFNVFTTAHALIMIFFMVMPAMIGGFANWMIPIMIGAPDMAFPRLNNISFWLIVPAF
ILLLLSLFVEGPAGAYGVGGGWTMYPPLSTSGMPGPAVDLAIFSLHVAGASSILGAINFITTILNMRAPGMTLHKMPLFA
WSVLVTAFLLLLSLPVLAGGITMLLTDRNFGTAFFSPEGGGDPILYQHLFWFFGHPEVYILILPGFGIISHIVSTFSKKP
VFGYLGMAYAMVAIGAVGFIVWAHHMYTVGLSLEAQRYFVFATMVIAVPTGIKIFSWIATMWGGSLTFSTPMVWAIGFIF
LFTVGGVTGVQLANAGLDRSLHDTYYVVAHFHYVLSLGAVFAIFAGWYYWFPKITGYMYNEFIGKLHFWVMFIGVNLIFF
PQHFLGLAGMPRRYIDYPDAYAGWNMVSSYGSYISAVAVGIFLFGVWEAFAKKRIAGNNPWGEGATTLEWQLSSPPPYHQ
WEQLPRIR

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=531, Percent_Identity=61.7702448210923, Blast_Score=612, Evalue=1e-175,
Organism=Escherichia coli, GI1786634, Length=536, Percent_Identity=41.4179104477612, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6226519, Length=547, Percent_Identity=55.0274223034735, Blast_Score=592, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6226524, Length=343, Percent_Identity=59.1836734693878, Blast_Score=400, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6226523, Length=268, Percent_Identity=52.2388059701493, Blast_Score=258, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 62690; Mature: 62559

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGPSAHDDHHSHGQSAHDAHAHDDHSHDHSHKPGFFARWFLSTNHKDIGTLYLIFAIMA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
GIIGGGLSVVMRMELQEPGIQIFHGLASMVYGFEGDAAIDGGKHMFNVFTTAHALIMIFF
HHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MVMPAMIGGFANWMIPIMIGAPDMAFPRLNNISFWLIVPAFILLLLSLFVEGPAGAYGVG
HHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
GGWTMYPPLSTSGMPGPAVDLAIFSLHVAGASSILGAINFITTILNMRAPGMTLHKMPLF
CCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AWSVLVTAFLLLLSLPVLAGGITMLLTDRNFGTAFFSPEGGGDPILYQHLFWFFGHPEVY
HHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEECCCCCCCCHHHHHHHHHCCCCCEE
ILILPGFGIISHIVSTFSKKPVFGYLGMAYAMVAIGAVGFIVWAHHMYTVGLSLEAQRYF
EEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHH
VFATMVIAVPTGIKIFSWIATMWGGSLTFSTPMVWAIGFIFLFTVGGVTGVQLANAGLDR
HHHHHHHHHCCCHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCHHHHHHCCCCCC
SLHDTYYVVAHFHYVLSLGAVFAIFAGWYYWFPKITGYMYNEFIGKLHFWVMFIGVNLIF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPQHFLGLAGMPRRYIDYPDAYAGWNMVSSYGSYISAVAVGIFLFGVWEAFAKKRIAGNN
HHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PWGEGATTLEWQLSSPPPYHQWEQLPRIR
CCCCCCCEEEEEECCCCCCHHHHHCCCCC
>Mature Secondary Structure 
AGPSAHDDHHSHGQSAHDAHAHDDHSHDHSHKPGFFARWFLSTNHKDIGTLYLIFAIMA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
GIIGGGLSVVMRMELQEPGIQIFHGLASMVYGFEGDAAIDGGKHMFNVFTTAHALIMIFF
HHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MVMPAMIGGFANWMIPIMIGAPDMAFPRLNNISFWLIVPAFILLLLSLFVEGPAGAYGVG
HHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
GGWTMYPPLSTSGMPGPAVDLAIFSLHVAGASSILGAINFITTILNMRAPGMTLHKMPLF
CCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AWSVLVTAFLLLLSLPVLAGGITMLLTDRNFGTAFFSPEGGGDPILYQHLFWFFGHPEVY
HHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEECCCCCCCCHHHHHHHHHCCCCCEE
ILILPGFGIISHIVSTFSKKPVFGYLGMAYAMVAIGAVGFIVWAHHMYTVGLSLEAQRYF
EEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHH
VFATMVIAVPTGIKIFSWIATMWGGSLTFSTPMVWAIGFIFLFTVGGVTGVQLANAGLDR
HHHHHHHHHCCCHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCHHHHHHCCCCCC
SLHDTYYVVAHFHYVLSLGAVFAIFAGWYYWFPKITGYMYNEFIGKLHFWVMFIGVNLIF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPQHFLGLAGMPRRYIDYPDAYAGWNMVSSYGSYISAVAVGIFLFGVWEAFAKKRIAGNN
HHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PWGEGATTLEWQLSSPPPYHQWEQLPRIR
CCCCCCCEEEEEECCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2172930; 1965217; 12597275 [H]