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The map label for this gene is ctaB

Identifier: 15888112

GI number: 15888112

Start: 765616

End: 766569

Strand: Direct

Name: ctaB

Synonym: Atu0769

Alternate gene names: 15888112

Gene position: 765616-766569 (Clockwise)

Preceding gene: 159184458

Following gene: 159185407

Centisome position: 26.94

GC content: 61.32

Gene sequence:

>954_bases
ATGACCGTTATCGACGATCGCGACATGATGGGCGCAGAAAGCTCCGAACTTTCGGAAGCCGGCGCACGCGATTATTTCGA
GTTGCTGAAGCCGCGCGTCATGTCGCTCGTCGTCTTCACGGCCTTTGCCGGCCTCGTGCTGGCGCCGGGTGAAATCAACC
CTATTCTTGGGCTCATTGCCATTCTCTGTATCGCGGTCGGCGCCGGCGCGTCCGGTGCGCTCAACATGTGGTACGATGCC
GATATCGATGCCGTGATGACCCGCACCGCCAAGCGGCCGATCCCGTCGGGCCGCATCGCGCCGCGCGAAGCTCTTGCCTT
CGGCCTGACACTGTCGGCCTTCTCGGTCGTCATCCTCGGCCTTGCGGTCAACTGGTTCTCCGCCGGCCTGCTTGCCTTCA
CCATCTTCTTTTATGCCGTCGTTTATACGATGTGGCTGAAGCGCTCGACGCCGCAGAACATCGTCATCGGCGGTGCTGCC
GGCGCTTTCCCGCCCATGCTCGGCTGGGCCTGCGTCACCGGCGGCGTTTCGCTTGATAGCGTCATCCTGTTCCTGATCAT
CTTCCTGTGGACGCCGGCGCATTTCTGGGCGCTGGCGCTGTTCAAGATGCGTGATTACGGCGCGGTCGGCATTCCGATGA
TGCCAAATGTAGCGGGCGAGCGCTCCACCAAGAACCAGATGATCGTTTATGCGGTGCTGACCGCGGCGGCCGCCGTTGCG
CCCTTTTTCACGGGTCTGGCGAGCGCCGGTTACGGCATTTTCGCCGCCGTGCTGAGCGCGATCTTCGTCTACTGTTCGTT
CGATGTCCGGCGCATGCCTGAAGGCGACGAGAAGATGTTGCCCGCCAAGAAGATGTTCGCCTATTCGGTGCTTTATCTCT
TCGCGATTTTCTCCGGCCTTCTGGCCGATCATTTCGCGCCGGCCCTGAAGGCCGTGATTTCGGGAGTCCTGTAA

Upstream 100 bases:

>100_bases
CATGAATTGACGCATCGCGCATGCCAGAAATCCGTTTCGTTTTTCGGGCCGGTGCAAGGGGTGTCGCGGCAGGCGGCATC
TGAAGGAAACAGGACAGGAA

Downstream 100 bases:

>100_bases
TGGAAACGGTGGAACTGAGCGCGGCGCAGAAAAAATCGAGACGTGGGCGCAATATTGCACTCGGCGTCCTGCTCGCCGGT
CTGGTGGTGCTGTTCTACGT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MTVIDDRDMMGAESSELSEAGARDYFELLKPRVMSLVVFTAFAGLVLAPGEINPILGLIAILCIAVGAGASGALNMWYDA
DIDAVMTRTAKRPIPSGRIAPREALAFGLTLSAFSVVILGLAVNWFSAGLLAFTIFFYAVVYTMWLKRSTPQNIVIGGAA
GAFPPMLGWACVTGGVSLDSVILFLIIFLWTPAHFWALALFKMRDYGAVGIPMMPNVAGERSTKNQMIVYAVLTAAAAVA
PFFTGLASAGYGIFAAVLSAIFVYCSFDVRRMPEGDEKMLPAKKMFAYSVLYLFAIFSGLLADHFAPALKAVISGVL

Sequences:

>Translated_317_residues
MTVIDDRDMMGAESSELSEAGARDYFELLKPRVMSLVVFTAFAGLVLAPGEINPILGLIAILCIAVGAGASGALNMWYDA
DIDAVMTRTAKRPIPSGRIAPREALAFGLTLSAFSVVILGLAVNWFSAGLLAFTIFFYAVVYTMWLKRSTPQNIVIGGAA
GAFPPMLGWACVTGGVSLDSVILFLIIFLWTPAHFWALALFKMRDYGAVGIPMMPNVAGERSTKNQMIVYAVLTAAAAVA
PFFTGLASAGYGIFAAVLSAIFVYCSFDVRRMPEGDEKMLPAKKMFAYSVLYLFAIFSGLLADHFAPALKAVISGVL
>Mature_316_residues
TVIDDRDMMGAESSELSEAGARDYFELLKPRVMSLVVFTAFAGLVLAPGEINPILGLIAILCIAVGAGASGALNMWYDAD
IDAVMTRTAKRPIPSGRIAPREALAFGLTLSAFSVVILGLAVNWFSAGLLAFTIFFYAVVYTMWLKRSTPQNIVIGGAAG
AFPPMLGWACVTGGVSLDSVILFLIIFLWTPAHFWALALFKMRDYGAVGIPMMPNVAGERSTKNQMIVYAVLTAAAAVAP
FFTGLASAGYGIFAAVLSAIFVYCSFDVRRMPEGDEKMLPAKKMFAYSVLYLFAIFSGLLADHFAPALKAVISGVL

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=222, Percent_Identity=32.4324324324324, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786631, Length=302, Percent_Identity=27.4834437086093, Blast_Score=114, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI71998235, Length=269, Percent_Identity=28.996282527881, Blast_Score=88, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6325085, Length=195, Percent_Identity=31.2820512820513, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19921064, Length=274, Percent_Identity=27.007299270073, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_AGRT5 (A9CJX3)

Other databases:

- EMBL:   AE007869
- PIR:   A97453
- PIR:   AC2671
- RefSeq:   NP_353793.1
- STRING:   A9CJX3
- GeneID:   1132807
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0769
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   LLKPRIM
- PhylomeDB:   A9CJX3
- ProtClustDB:   PRK04375
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33888; Mature: 33757

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd7463bc)-; HASH(0xc70ef04)-; HASH(0xd4df57c)-; HASH(0xd333d9c)-; HASH(0xdaaa950)-; HASH(0xbcb6068)-; HASH(0xbce5354)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVIDDRDMMGAESSELSEAGARDYFELLKPRVMSLVVFTAFAGLVLAPGEINPILGLIA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHH
ILCIAVGAGASGALNMWYDADIDAVMTRTAKRPIPSGRIAPREALAFGLTLSAFSVVILG
HHHHHHCCCCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LAVNWFSAGLLAFTIFFYAVVYTMWLKRSTPQNIVIGGAAGAFPPMLGWACVTGGVSLDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHCCCCHHH
VILFLIIFLWTPAHFWALALFKMRDYGAVGIPMMPNVAGERSTKNQMIVYAVLTAAAAVA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
PFFTGLASAGYGIFAAVLSAIFVYCSFDVRRMPEGDEKMLPAKKMFAYSVLYLFAIFSGL
HHHHHHHHCCHHHHHHHHHHHHHHHCCHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHH
LADHFAPALKAVISGVL
HHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
TVIDDRDMMGAESSELSEAGARDYFELLKPRVMSLVVFTAFAGLVLAPGEINPILGLIA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHH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HHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194