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The map label for this gene is aceA [H]

Identifier: 159184387

GI number: 159184387

Start: 593283

End: 594572

Strand: Reverse

Name: aceA [H]

Synonym: Atu0607

Alternate gene names: 159184387

Gene position: 594572-593283 (Counterclockwise)

Preceding gene: 159184389

Following gene: 159184386

Centisome position: 20.92

GC content: 61.16

Gene sequence:

>1290_bases
ATGACGGATTTTTACAAACTCGTTCCGGGCGCCCCGAAGGGACGTTTCGACGGCATCGAGCGCACCTACACCGCCGCCGA
CGTAGCGCGGCTGCGCGGCTCCGTCGAAATCCGCCATTCGCTGGCCGAGATGGGCGCGAACCGGCTGTGGAAGCTCATCA
ACGAGGAGAATTTCGTCAACGCGCTCGGCGCGCTTTCCGGCAACCAAGCCATGCAGATGGTTCGCGCAGGATTGAAGGCA
ATTTATCTTTCCGGCTGGCAGGTCGCCGCGGACGCCAACACGGCATCGGCCATGTATCCGGACCAGTCGCTTTATCCGGC
CAATGCGGCACCGGAGCTGGCCAAGCGCATCAACCGCACCTTGCAGCGCGCCGACCAGATCGAGACGGCAGAGGGCAAGG
GTCTTTCGGTCGACACCTGGTTTGCGCCGATCGTTGCCGATGCGGAGGCCGGGTTCGGCGGCCCACTCAACGCCTTCGAG
ATCATGAAGGCCTTTATCGAAGCGGGTGCGGCGGGTGTTCACTATGAAGACCAGCTGGCATCGGAAAAGAAGTGCGGCCA
TCTCGGCGGCAAGGTTCTGATCCCGACGGCGGCGCATATTCGCAACCTGACGGCAGCGCGGCTTGCTGCTGATGTCATGG
GTGTTCCAACGCTGGTTATCGCCCGCACCGATGCGGAGGCCGCCAAGCTGCTGACATCCGATATCGACGAGCGCGACCAG
CCCTTTGTGGATTACGATGCCGGCCGCACCGTCGAAGGTTTCTATCAGGTCAAGAACGGTCTTGAACCCTGCATCGCCCG
CGCGGTGGCCTATGCACCCTATTGCGACCTGATCTGGTGCGAAACGTCAAAGCCGGATCTCGAACAGGCACGCAGGTTTG
CGGAAGGCGTGCACAAGGTGCATCCCGGCAAGAAGCTGGCTTACAATTGCTCGCCGTCGTTCAACTGGAAAAAGAACCTC
GACGACGCGACGATTGCCAAGTTCCAGCGTGAACTGGGCGCGATGGGTTACAAGTTCCAGTTCATCACGCTTGCCGGTTT
CCACCAGCTGAATTTCGGCATGTTCGAACTGGCGCGCGGTTACAAGGACCGGCAGATGGCGGCCTATTCCGAGCTTCAGG
AAGCGGAATTTGCAGCCGAGGTCAACGGTTACACCGCCACCAAACACCAGCGCGAAGTCGGCACCGGCTATTTCGACGCC
GTGTCGCTCGCCATTTCCGGCGGCACGTCCTCGACCACCGCGATGAAGGAATCCACCGAGCACGACCAGTTCCGCCCGGC
GGCGGAATAA

Upstream 100 bases:

>100_bases
CTTAAATCTCCAAAAATGTAAATGTAGTCACATCAAACGGTGCTTCATAAATTGAAAGCAAGCCGTTTCCGAAACCGCAT
TTATCATGGGAGAGAGAAGT

Downstream 100 bases:

>100_bases
ATCGAGAAAACCGCCCTTCCCACTACAGGGAAGGGCTTGCAAACCGGATCAAAAACCCCTGACAATAATGAGAGGAGAAA
TGCCATGAATGCCCACAACC

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTDFYKLVPGAPKGRFDGIERTYTAADVARLRGSVEIRHSLAEMGANRLWKLINEENFVNALGALSGNQAMQMVRAGLKA
IYLSGWQVAADANTASAMYPDQSLYPANAAPELAKRINRTLQRADQIETAEGKGLSVDTWFAPIVADAEAGFGGPLNAFE
IMKAFIEAGAAGVHYEDQLASEKKCGHLGGKVLIPTAAHIRNLTAARLAADVMGVPTLVIARTDAEAAKLLTSDIDERDQ
PFVDYDAGRTVEGFYQVKNGLEPCIARAVAYAPYCDLIWCETSKPDLEQARRFAEGVHKVHPGKKLAYNCSPSFNWKKNL
DDATIAKFQRELGAMGYKFQFITLAGFHQLNFGMFELARGYKDRQMAAYSELQEAEFAAEVNGYTATKHQREVGTGYFDA
VSLAISGGTSSTTAMKESTEHDQFRPAAE

Sequences:

>Translated_429_residues
MTDFYKLVPGAPKGRFDGIERTYTAADVARLRGSVEIRHSLAEMGANRLWKLINEENFVNALGALSGNQAMQMVRAGLKA
IYLSGWQVAADANTASAMYPDQSLYPANAAPELAKRINRTLQRADQIETAEGKGLSVDTWFAPIVADAEAGFGGPLNAFE
IMKAFIEAGAAGVHYEDQLASEKKCGHLGGKVLIPTAAHIRNLTAARLAADVMGVPTLVIARTDAEAAKLLTSDIDERDQ
PFVDYDAGRTVEGFYQVKNGLEPCIARAVAYAPYCDLIWCETSKPDLEQARRFAEGVHKVHPGKKLAYNCSPSFNWKKNL
DDATIAKFQRELGAMGYKFQFITLAGFHQLNFGMFELARGYKDRQMAAYSELQEAEFAAEVNGYTATKHQREVGTGYFDA
VSLAISGGTSSTTAMKESTEHDQFRPAAE
>Mature_428_residues
TDFYKLVPGAPKGRFDGIERTYTAADVARLRGSVEIRHSLAEMGANRLWKLINEENFVNALGALSGNQAMQMVRAGLKAI
YLSGWQVAADANTASAMYPDQSLYPANAAPELAKRINRTLQRADQIETAEGKGLSVDTWFAPIVADAEAGFGGPLNAFEI
MKAFIEAGAAGVHYEDQLASEKKCGHLGGKVLIPTAAHIRNLTAARLAADVMGVPTLVIARTDAEAAKLLTSDIDERDQP
FVDYDAGRTVEGFYQVKNGLEPCIARAVAYAPYCDLIWCETSKPDLEQARRFAEGVHKVHPGKKLAYNCSPSFNWKKNLD
DATIAKFQRELGAMGYKFQFITLAGFHQLNFGMFELARGYKDRQMAAYSELQEAEFAAEVNGYTATKHQREVGTGYFDAV
SLAISGGTSSTTAMKESTEHDQFRPAAE

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=419, Percent_Identity=60.8591885441527, Blast_Score=516, Evalue=1e-147,
Organism=Escherichia coli, GI1786525, Length=194, Percent_Identity=32.9896907216495, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17561814, Length=428, Percent_Identity=68.9252336448598, Blast_Score=623, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI71982926, Length=428, Percent_Identity=68.9252336448598, Blast_Score=623, Evalue=1e-179,
Organism=Saccharomyces cerevisiae, GI6325263, Length=240, Percent_Identity=39.1666666666667, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320908, Length=260, Percent_Identity=36.1538461538462, Blast_Score=162, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 46848; Mature: 46717

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFYKLVPGAPKGRFDGIERTYTAADVARLRGSVEIRHSLAEMGANRLWKLINEENFVN
CCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCHHHHHH
ALGALSGNQAMQMVRAGLKAIYLSGWQVAADANTASAMYPDQSLYPANAAPELAKRINRT
HHHHCCCHHHHHHHHHHHHHEEECCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
LQRADQIETAEGKGLSVDTWFAPIVADAEAGFGGPLNAFEIMKAFIEAGAAGVHYEDQLA
HHHHHHHCCCCCCCCEEHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHH
SEKKCGHLGGKVLIPTAAHIRNLTAARLAADVMGVPTLVIARTDAEAAKLLTSDIDERDQ
HHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCC
PFVDYDAGRTVEGFYQVKNGLEPCIARAVAYAPYCDLIWCETSKPDLEQARRFAEGVHKV
CCEECCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHC
HPGKKLAYNCSPSFNWKKNLDDATIAKFQRELGAMGYKFQFITLAGFHQLNFGMFELARG
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEECHHHHCCHHHHHHCC
YKDRQMAAYSELQEAEFAAEVNGYTATKHQREVGTGYFDAVSLAISGGTSSTTAMKESTE
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHEEEEEEECCCCCCHHHHHCCC
HDQFRPAAE
CCCCCCCCC
>Mature Secondary Structure 
TDFYKLVPGAPKGRFDGIERTYTAADVARLRGSVEIRHSLAEMGANRLWKLINEENFVN
CCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCHHHHHH
ALGALSGNQAMQMVRAGLKAIYLSGWQVAADANTASAMYPDQSLYPANAAPELAKRINRT
HHHHCCCHHHHHHHHHHHHHEEECCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
LQRADQIETAEGKGLSVDTWFAPIVADAEAGFGGPLNAFEIMKAFIEAGAAGVHYEDQLA
HHHHHHHCCCCCCCCEEHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHH
SEKKCGHLGGKVLIPTAAHIRNLTAARLAADVMGVPTLVIARTDAEAAKLLTSDIDERDQ
HHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCC
PFVDYDAGRTVEGFYQVKNGLEPCIARAVAYAPYCDLIWCETSKPDLEQARRFAEGVHKV
CCEECCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHC
HPGKKLAYNCSPSFNWKKNLDDATIAKFQRELGAMGYKFQFITLAGFHQLNFGMFELARG
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEECHHHHCCHHHHHHCC
YKDRQMAAYSELQEAEFAAEVNGYTATKHQREVGTGYFDAVSLAISGGTSSTTAMKESTE
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHEEEEEEECCCCCCHHHHHCCC
HDQFRPAAE
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]