Click here to switch to the map view.

The map label for this gene is ham1 [C]

Identifier: 159184260

GI number: 159184260

Start: 320384

End: 321028

Strand: Reverse

Name: ham1 [C]

Synonym: Atu0326

Alternate gene names: 159184260

Gene position: 321028-320384 (Counterclockwise)

Preceding gene: 159184261

Following gene: 159184259

Centisome position: 11.3

GC content: 60.78

Gene sequence:

>645_bases
ATGCGCAAGCTCGATACCAGAACGATCGTCGTCGCCAGCCACAACAAGGGCAAGATCGCCGAGATCGCCGATCTGATCGG
GCCTTTCGGTTTCTCCGCCAAATCGGCGGCGGAGCTGAACTTCTCCGAGCCGGAAGAGACGGGTACTACCTTCGAGGAAA
ATGCCGCCATCAAGGCGCTCGCGTCTGCGAAGGCGTCCGGCCTGCCGGCATTGTCCGACGATTCCGGCCTCGTGATTGAC
GCGCTCGATGGTGCACCCGGTGTCTATACCGCCAATTGGGCGGAAACGGCCGATGGCACGCGCGATTTCGCCATGGCGAT
GCAGAAGGTCGAGGATGCGCTGGCCGAGCGCGGAGCCTCCAAGCCGGAAGATCGCACGGCCCGCTTTGTCAGCGTGCTGT
GCCTGGCCTGGCCGGATGGGCATGTCGAATATTTCCGTGGCGAGGTCGAAGGCACCGTGGTGTGGCCGCCGCGCGGTACG
AGCGGTTTCGGTTATGATCCCATCTTTAAACCCGATGGATATGACACCACATTCGGCGAAATGAGCGCGGATGAAAAACA
CGGCTGGAAACATGGCGACGCTTTCGCACTTTCTCACCGCGCCCGGGCGTTCAAAAAATTCGTAGAAACCTGCCTGGAGG
CATGA

Upstream 100 bases:

>100_bases
AGGAAGAGTTCCTGACGCTGCTCGGTCTTGCCAAGGCCGGTTGCAGCGAACTGGTTGCCCTTCAGAAACAGGCAATCGCC
TGAGCCGACAGGAAAACGTC

Downstream 100 bases:

>100_bases
ACCCGATGGTCGGGGAGCACCAACTTTCTGCCCCCGGCGCATCGCTTCTGCCGGATACGGGCGATCCCGGTTTCGGGATC
TATCTGCACTGGCCCTTCTG

Product: putative deoxyribonucleotide triphosphate pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRKLDTRTIVVASHNKGKIAEIADLIGPFGFSAKSAAELNFSEPEETGTTFEENAAIKALASAKASGLPALSDDSGLVID
ALDGAPGVYTANWAETADGTRDFAMAMQKVEDALAERGASKPEDRTARFVSVLCLAWPDGHVEYFRGEVEGTVVWPPRGT
SGFGYDPIFKPDGYDTTFGEMSADEKHGWKHGDAFALSHRARAFKKFVETCLEA

Sequences:

>Translated_214_residues
MRKLDTRTIVVASHNKGKIAEIADLIGPFGFSAKSAAELNFSEPEETGTTFEENAAIKALASAKASGLPALSDDSGLVID
ALDGAPGVYTANWAETADGTRDFAMAMQKVEDALAERGASKPEDRTARFVSVLCLAWPDGHVEYFRGEVEGTVVWPPRGT
SGFGYDPIFKPDGYDTTFGEMSADEKHGWKHGDAFALSHRARAFKKFVETCLEA
>Mature_214_residues
MRKLDTRTIVVASHNKGKIAEIADLIGPFGFSAKSAAELNFSEPEETGTTFEENAAIKALASAKASGLPALSDDSGLVID
ALDGAPGVYTANWAETADGTRDFAMAMQKVEDALAERGASKPEDRTARFVSVLCLAWPDGHVEYFRGEVEGTVVWPPRGT
SGFGYDPIFKPDGYDTTFGEMSADEKHGWKHGDAFALSHRARAFKKFVETCLEA

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family

Homologues:

Organism=Homo sapiens, GI15626999, Length=205, Percent_Identity=29.2682926829268, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI31657144, Length=143, Percent_Identity=32.8671328671329, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1789324, Length=210, Percent_Identity=36.1904761904762, Blast_Score=118, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322529, Length=158, Percent_Identity=31.0126582278481, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19920712, Length=202, Percent_Identity=28.2178217821782, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NTPA_AGRT5 (Q8UIG9)

Other databases:

- EMBL:   AE007869
- PIR:   AF2616
- PIR:   F97398
- RefSeq:   NP_353358.2
- ProteinModelPortal:   Q8UIG9
- SMR:   Q8UIG9
- STRING:   Q8UIG9
- GeneID:   1132364
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0326
- eggNOG:   COG0127
- HOGENOM:   HBG697237
- OMA:   VYTADWA
- PhylomeDB:   Q8UIG9
- ProtClustDB:   PRK00120
- BioCyc:   ATUM176299-1:ATU0326-MONOMER
- HAMAP:   MF_01405
- InterPro:   IPR002637
- InterPro:   IPR020922
- PANTHER:   PTHR11067

Pfam domain/function: PF01725 Ham1p_like

EC number: =3.6.1.15

Molecular weight: Translated: 23040; Mature: 23040

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLDTRTIVVASHNKGKIAEIADLIGPFGFSAKSAAELNFSEPEETGTTFEENAAIKAL
CCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHH
ASAKASGLPALSDDSGLVIDALDGAPGVYTANWAETADGTRDFAMAMQKVEDALAERGAS
HHHHHCCCCCCCCCCCEEEEECCCCCCCEECCCHHCCCCHHHHHHHHHHHHHHHHHCCCC
KPEDRTARFVSVLCLAWPDGHVEYFRGEVEGTVVWPPRGTSGFGYDPIFKPDGYDTTFGE
CCHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
MSADEKHGWKHGDAFALSHRARAFKKFVETCLEA
CCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKLDTRTIVVASHNKGKIAEIADLIGPFGFSAKSAAELNFSEPEETGTTFEENAAIKAL
CCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHH
ASAKASGLPALSDDSGLVIDALDGAPGVYTANWAETADGTRDFAMAMQKVEDALAERGAS
HHHHHCCCCCCCCCCCEEEEECCCCCCCEECCCHHCCCCHHHHHHHHHHHHHHHHHCCCC
KPEDRTARFVSVLCLAWPDGHVEYFRGEVEGTVVWPPRGTSGFGYDPIFKPDGYDTTFGE
CCHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
MSADEKHGWKHGDAFALSHRARAFKKFVETCLEA
CCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194