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The map label for this gene is htpx

Identifier: 15890072

GI number: 15890072

Start: 2831273

End: 2832238

Strand: Reverse

Name: htpx

Synonym: Atu2826

Alternate gene names: 15890072

Gene position: 2832238-2831273 (Counterclockwise)

Preceding gene: 159185404

Following gene: 159185402

Centisome position: 99.67

GC content: 58.28

Gene sequence:

>966_bases
ATGAACATGATGCGCACGGCAATGCTTCTGGCCTTCATGACGGCATTGTTCATGGGTGTCGGTTTTCTGATCGGTGGTAA
AGGCGGCATGATGATAGCGCTGCTGATTGCGGCCGGTATGAACCTTTTTTCCTATTGGAATTCGGACAAGATGGTCCTTT
CGGCCTATCGCGCCCGGGAGATCGACGAGGCGAATGCGCCCGAGTTCTTTCACATGATCCGGGATCTGTCGCAGAATGCC
GGTCTGCCCATGCCGAAGGTCTATATTTACGACAGTCCGCAGCCAAACGCCTTCGCGACCGGTCGAAATCCTGAGAATGC
GGCTGTTGCCGCTTCGACCGGGCTGCTGGAGCGTCTGACGCCCGAGGAAGTGGCCGGTGTCATGGCGCATGAACTCGCCC
ATGTGCAGAACCGCGATACCCTGACCATGACAATCACCGCCACGCTCGCGGGTGCGATCTCCATGCTCGGCAATTTTGCC
TTCTTCTTTGGCGGCAACAGGGAAAACAACAATAACCCCTTGGGCTTCATCGGTGTGCTGGTGGCGATGATAGTGGCGCC
GCTTGCGGCAATGTTGGTGCAGATGGCTATCAGTCGCACCCGCGAATATTCCGCCGACCGGCGCGGCGCGGAAATATGCG
GCAACCCGCTCTGGCTTGCCTCTGCCCTGCAGAAGATTTCAGGCATGGCACAGCAAATTCACAATGACGATGCCGAGCGC
AATCCGGCAACGGCGCATATGTTCATCATCAATCCGCTCTCCGGCGAGCGTATGGACAATCTTTTTTCCACCCATCCGAA
CACGGAAAACCGCGTGGCGGCGCTGCACGCGATGGCGCAGGAGTTTTCTCCGCGAGCATCGACGCCGCCGCCATCGGGTG
ATAGACCGGTGCGCAAATCAGGCTCCGTTCCCACAACGGGCTGGAGACGAGGCAATGAAAACGAGCGCAAGGGGCCGTGG
TCTTGA

Upstream 100 bases:

>100_bases
CGGGATATTGAAATATGTTTGCCGCTTACCAGATTATATAATCGAAGGGGTTTTATAAACCCAACAATATTTCAGGCGAG
TAAGAAGGAGAGTTCAACGG

Downstream 100 bases:

>100_bases
CATCCGATATTCAGAGTAAGCCGGCGCGGTCCAGAAAACCGAAGCCAGCGCATGCAAGGGGCCGTGAAGACGGCCCTTCG
TCTTTCGAGGACAAGCCGGG

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MNMMRTAMLLAFMTALFMGVGFLIGGKGGMMIALLIAAGMNLFSYWNSDKMVLSAYRAREIDEANAPEFFHMIRDLSQNA
GLPMPKVYIYDSPQPNAFATGRNPENAAVAASTGLLERLTPEEVAGVMAHELAHVQNRDTLTMTITATLAGAISMLGNFA
FFFGGNRENNNNPLGFIGVLVAMIVAPLAAMLVQMAISRTREYSADRRGAEICGNPLWLASALQKISGMAQQIHNDDAER
NPATAHMFIINPLSGERMDNLFSTHPNTENRVAALHAMAQEFSPRASTPPPSGDRPVRKSGSVPTTGWRRGNENERKGPW
S

Sequences:

>Translated_321_residues
MNMMRTAMLLAFMTALFMGVGFLIGGKGGMMIALLIAAGMNLFSYWNSDKMVLSAYRAREIDEANAPEFFHMIRDLSQNA
GLPMPKVYIYDSPQPNAFATGRNPENAAVAASTGLLERLTPEEVAGVMAHELAHVQNRDTLTMTITATLAGAISMLGNFA
FFFGGNRENNNNPLGFIGVLVAMIVAPLAAMLVQMAISRTREYSADRRGAEICGNPLWLASALQKISGMAQQIHNDDAER
NPATAHMFIINPLSGERMDNLFSTHPNTENRVAALHAMAQEFSPRASTPPPSGDRPVRKSGSVPTTGWRRGNENERKGPW
S
>Mature_321_residues
MNMMRTAMLLAFMTALFMGVGFLIGGKGGMMIALLIAAGMNLFSYWNSDKMVLSAYRAREIDEANAPEFFHMIRDLSQNA
GLPMPKVYIYDSPQPNAFATGRNPENAAVAASTGLLERLTPEEVAGVMAHELAHVQNRDTLTMTITATLAGAISMLGNFA
FFFGGNRENNNNPLGFIGVLVAMIVAPLAAMLVQMAISRTREYSADRRGAEICGNPLWLASALQKISGMAQQIHNDDAER
NPATAHMFIINPLSGERMDNLFSTHPNTENRVAALHAMAQEFSPRASTPPPSGDRPVRKSGSVPTTGWRRGNENERKGPW
S

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=298, Percent_Identity=32.2147651006711, Blast_Score=117, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_AGRT5 (Q8UBM5)

Other databases:

- EMBL:   AE007869
- PIR:   A97698
- PIR:   AI2923
- RefSeq:   NP_355753.1
- ProteinModelPortal:   Q8UBM5
- SMR:   Q8UBM5
- STRING:   Q8UBM5
- MEROPS:   M48.004
- GeneID:   1134864
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2826
- eggNOG:   COG0501
- HOGENOM:   HBG739460
- OMA:   RRGAEIC
- PhylomeDB:   Q8UBM5
- ProtClustDB:   PRK01345
- BioCyc:   ATUM176299-1:ATU2826-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 34933; Mature: 34933

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 131-131

Signals:

None

Transmembrane regions:

HASH(0x110ecc34)-; HASH(0x10e038a4)-; HASH(0x10c7b824)-; HASH(0xf473c68)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
6.9 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
6.9 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMMRTAMLLAFMTALFMGVGFLIGGKGGMMIALLIAAGMNLFSYWNSDKMVLSAYRARE
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IDEANAPEFFHMIRDLSQNAGLPMPKVYIYDSPQPNAFATGRNPENAAVAASTGLLERLT
CCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEECCCCCCCCCHHHHHHHHHHCC
PEEVAGVMAHELAHVQNRDTLTMTITATLAGAISMLGNFAFFFGGNRENNNNPLGFIGVL
HHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHH
VAMIVAPLAAMLVQMAISRTREYSADRRGAEICGNPLWLASALQKISGMAQQIHNDDAER
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
NPATAHMFIINPLSGERMDNLFSTHPNTENRVAALHAMAQEFSPRASTPPPSGDRPVRKS
CCCEEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GSVPTTGWRRGNENERKGPWS
CCCCCCCCCCCCCCCCCCCCH
>Mature Secondary Structure
MNMMRTAMLLAFMTALFMGVGFLIGGKGGMMIALLIAAGMNLFSYWNSDKMVLSAYRARE
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IDEANAPEFFHMIRDLSQNAGLPMPKVYIYDSPQPNAFATGRNPENAAVAASTGLLERLT
CCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEECCCCCCCCCHHHHHHHHHHCC
PEEVAGVMAHELAHVQNRDTLTMTITATLAGAISMLGNFAFFFGGNRENNNNPLGFIGVL
HHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHH
VAMIVAPLAAMLVQMAISRTREYSADRRGAEICGNPLWLASALQKISGMAQQIHNDDAER
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
NPATAHMFIINPLSGERMDNLFSTHPNTENRVAALHAMAQEFSPRASTPPPSGDRPVRKS
CCCEEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GSVPTTGWRRGNENERKGPWS
CCCCCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194