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The map label for this gene is exuR [H]

Identifier: 15890067

GI number: 15890067

Start: 2823977

End: 2824669

Strand: Direct

Name: exuR [H]

Synonym: Atu2821

Alternate gene names: 15890067

Gene position: 2823977-2824669 (Clockwise)

Preceding gene: 15890057

Following gene: 159185399

Centisome position: 99.38

GC content: 59.6

Gene sequence:

>693_bases
ATGAATGGTCAGGCCAAAATAGCGGAACCGCGCAGGCTTTATCAGCAGATTGCGGATCAGATACGCGAACTCATCGACGT
GGGTGAATTCCTGCCCGGGACGCGGCTTCCCGCCGAACGGGAATTGGCACAGAAACTCGGCGTGTCGAGACCCTCGTTGC
GTGAGGCGCTGATTGCGCTTGAAATCGACAACACCGTCGAAATTCGCATGGGTTCCGGCGTCTATGTATCTACCGAAGCG
CTTCAAACGACCCATCACACCAAGTCGCTGGGAGACAGCCCTTCCGAATTGATGCAGGCGCGGGCCGCGCTGGAGGGGGC
GACCATCGTGCTGGCAGCAAACCGGATGACCGATGAGACGATCGCGGCCCTCCGCCAGATTCTCAACACCATGCAAAAGG
AAATCGAGGCTGGCCGCAAACCCCTCGATCAGGATCGCCTGTTTCACGTGACCATTGCCGAGCAATCCGGCAACAGCGTT
CTGGCGAGGCTGGTGGCCAACCTCTTCGATGAGCGCCACAGCCCCATTTCGGCCCAGCTTCGCGTCAAATTTGAAGATCG
CGACACTTGGACCCGCGCCCTGCAGGAGCACGAAGCTATTCTGGCGGCGCTGGAGCTCAAGGATCCGCTGCTGGCGCAAG
CCGCCATGCACATCCATCTGGAAGGTTCGAAACGCCGCTGGGTGGATAGCTGA

Upstream 100 bases:

>100_bases
ACTGTATTTTCAGTTATTTAAGTAATTTCTTGCGTATTGGCACGCTTGACGTTACGGTAAGGCCAAATATAAGTATCACG
AAGGCTTCAGTAAAAAACAC

Downstream 100 bases:

>100_bases
ATGACAAACATAGCAGGCAATGTACCGGGAGGAGGAAAACCCGTGAGTGAGAATTCCGAGGCAACCATTTTGCTGAACGC
CAACGACAATGTCGCGGTGG

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MNGQAKIAEPRRLYQQIADQIRELIDVGEFLPGTRLPAERELAQKLGVSRPSLREALIALEIDNTVEIRMGSGVYVSTEA
LQTTHHTKSLGDSPSELMQARAALEGATIVLAANRMTDETIAALRQILNTMQKEIEAGRKPLDQDRLFHVTIAEQSGNSV
LARLVANLFDERHSPISAQLRVKFEDRDTWTRALQEHEAILAALELKDPLLAQAAMHIHLEGSKRRWVDS

Sequences:

>Translated_230_residues
MNGQAKIAEPRRLYQQIADQIRELIDVGEFLPGTRLPAERELAQKLGVSRPSLREALIALEIDNTVEIRMGSGVYVSTEA
LQTTHHTKSLGDSPSELMQARAALEGATIVLAANRMTDETIAALRQILNTMQKEIEAGRKPLDQDRLFHVTIAEQSGNSV
LARLVANLFDERHSPISAQLRVKFEDRDTWTRALQEHEAILAALELKDPLLAQAAMHIHLEGSKRRWVDS
>Mature_230_residues
MNGQAKIAEPRRLYQQIADQIRELIDVGEFLPGTRLPAERELAQKLGVSRPSLREALIALEIDNTVEIRMGSGVYVSTEA
LQTTHHTKSLGDSPSELMQARAALEGATIVLAANRMTDETIAALRQILNTMQKEIEAGRKPLDQDRLFHVTIAEQSGNSV
LARLVANLFDERHSPISAQLRVKFEDRDTWTRALQEHEAILAALELKDPLLAQAAMHIHLEGSKRRWVDS

Specific function: Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the exuT, uxaCA and uxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082208, Length=228, Percent_Identity=37.280701754386, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790780, Length=226, Percent_Identity=38.9380530973451, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1790032, Length=229, Percent_Identity=31.0043668122271, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786303, Length=189, Percent_Identity=32.8042328042328, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1789621, Length=226, Percent_Identity=28.3185840707965, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 25684; Mature: 25684

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGQAKIAEPRRLYQQIADQIRELIDVGEFLPGTRLPAERELAQKLGVSRPSLREALIAL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHEEEE
EIDNTVEIRMGSGVYVSTEALQTTHHTKSLGDSPSELMQARAALEGATIVLAANRMTDET
EECCEEEEEECCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCHHH
IAALRQILNTMQKEIEAGRKPLDQDRLFHVTIAEQSGNSVLARLVANLFDERHSPISAQL
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEE
RVKFEDRDTWTRALQEHEAILAALELKDPLLAQAAMHIHLEGSKRRWVDS
EEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEEECCCCCCCCC
>Mature Secondary Structure
MNGQAKIAEPRRLYQQIADQIRELIDVGEFLPGTRLPAERELAQKLGVSRPSLREALIAL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHEEEE
EIDNTVEIRMGSGVYVSTEALQTTHHTKSLGDSPSELMQARAALEGATIVLAANRMTDET
EECCEEEEEECCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCHHH
IAALRQILNTMQKEIEAGRKPLDQDRLFHVTIAEQSGNSVLARLVANLFDERHSPISAQL
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEE
RVKFEDRDTWTRALQEHEAILAALELKDPLLAQAAMHIHLEGSKRRWVDS
EEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]