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The map label for this gene is cobC [H]

Identifier: 15890057

GI number: 15890057

Start: 2813348

End: 2814394

Strand: Direct

Name: cobC [H]

Synonym: Atu2810

Alternate gene names: 15890057

Gene position: 2813348-2814394 (Clockwise)

Preceding gene: 15890055

Following gene: 15890067

Centisome position: 99.01

GC content: 62.56

Gene sequence:

>1047_bases
ATGGGCGAGACAGTACCAGAAAAAGCTCAGGGAGCGATCCGTCACGGCGGCAATCTCGGCAAGGCGCGCCTGATGTTTCG
GCAAGCACCTGAACCGTGGATCGACCTTTCGACCGGTATCAATCCGCACTCCTACCCGCATTCGCCCATTCCCGCCAGCG
CATTCGCCCGCCTGCCGGAACCCGGCGCCGCCGAGGAGCTGAAACAGCTGGCGGCGGCCCATTTCGGCGCGCCTTCCGCG
CAGCATGTCACGCTTTCTCCCGGCACCCAGATGTTGATGCCGCTGCTGGCGCAGATCGCCATCAATCGTGGAGCCCAAAG
CGGTGCCGTGCTTTCACCCGCCTATGCGGAACATGCCCGCACCGCCCGCATGGCGGGGCTGACCGTCACCGAAGTGGAAA
ACATCGGCGATCTCTCAGCTTACGGCTATGCGGTGGTGGTCAATCCCAACAATCCCGATGGTCGCATCACGGACCGCGAA
GCTTTACTCGCGCTAGCCGGAACGATAGGCCGCAAAGGCGGTCTGCTCGTCGTGGATGAAGCCTTCATCGAAACGGGCGG
GGCCGAAAGCCTGGCGGTTGCAACCAATGGCGAAGCGCTGGTGGTCCTGCGATCCTTCGGAAAATTTTACGGCATGGCGG
GCGTGCGCCTGGGTTTCGCAATTGCGCATCCCGAGATCGCTGCCGAACTGGAAGCGAGGCTTGGCCCCTGGGCGGTTTCC
GGTCCGGCACTGCATATCGCGACAGAAGCTCTGGCGGACAGGGAGTGGCAATCATCCATGCGTCTACGGCTCGCGGAGGA
AGCGAGGCGCATGAACGAGTTGCTGGAAAAGGCAGGACTGAAAATCGCCGGCGGCACTTCCCTGTTCACGCTGGTGCGGG
ACGAGCGCAGCAGGGCACTGTTCGGGCATCTCGGCCGTCGCGGCATTCTGGTGCGCATCTTTGACGAAAGGCCTGATGAC
ATGCGTTTCGGCCTTCCCGGCAGCGAAGCGGATTGGCAGCGCGTCGAAGAGGCGCTGCGATCTTTCGATCACTCCTCGAA
AGTGTAA

Upstream 100 bases:

>100_bases
ACCGATCCAGGTGACGGGGTGGCCGATGCGTTTGAACAGCCAGTCCGGATAGCCGGTCAGGCGTTCGATCACGAGCGACA
GGAAAGCGAGAGCAAAGAAC

Downstream 100 bases:

>100_bases
GTCTCGATCGACTCCGGCTTCATTTCGATGGAGAAGCCCGGCAGCTTCGGCGGCATATAAGCGGCGTTGCGGATATCGCA
GGGCTCGATGAAGTGCTCAT

Product: cobalamin biosynthetic protein

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MGETVPEKAQGAIRHGGNLGKARLMFRQAPEPWIDLSTGINPHSYPHSPIPASAFARLPEPGAAEELKQLAAAHFGAPSA
QHVTLSPGTQMLMPLLAQIAINRGAQSGAVLSPAYAEHARTARMAGLTVTEVENIGDLSAYGYAVVVNPNNPDGRITDRE
ALLALAGTIGRKGGLLVVDEAFIETGGAESLAVATNGEALVVLRSFGKFYGMAGVRLGFAIAHPEIAAELEARLGPWAVS
GPALHIATEALADREWQSSMRLRLAEEARRMNELLEKAGLKIAGGTSLFTLVRDERSRALFGHLGRRGILVRIFDERPDD
MRFGLPGSEADWQRVEEALRSFDHSSKV

Sequences:

>Translated_348_residues
MGETVPEKAQGAIRHGGNLGKARLMFRQAPEPWIDLSTGINPHSYPHSPIPASAFARLPEPGAAEELKQLAAAHFGAPSA
QHVTLSPGTQMLMPLLAQIAINRGAQSGAVLSPAYAEHARTARMAGLTVTEVENIGDLSAYGYAVVVNPNNPDGRITDRE
ALLALAGTIGRKGGLLVVDEAFIETGGAESLAVATNGEALVVLRSFGKFYGMAGVRLGFAIAHPEIAAELEARLGPWAVS
GPALHIATEALADREWQSSMRLRLAEEARRMNELLEKAGLKIAGGTSLFTLVRDERSRALFGHLGRRGILVRIFDERPDD
MRFGLPGSEADWQRVEEALRSFDHSSKV
>Mature_347_residues
GETVPEKAQGAIRHGGNLGKARLMFRQAPEPWIDLSTGINPHSYPHSPIPASAFARLPEPGAAEELKQLAAAHFGAPSAQ
HVTLSPGTQMLMPLLAQIAINRGAQSGAVLSPAYAEHARTARMAGLTVTEVENIGDLSAYGYAVVVNPNNPDGRITDREA
LLALAGTIGRKGGLLVVDEAFIETGGAESLAVATNGEALVVLRSFGKFYGMAGVRLGFAIAHPEIAAELEARLGPWAVSG
PALHIATEALADREWQSSMRLRLAEEARRMNELLEKAGLKIAGGTSLFTLVRDERSRALFGHLGRRGILVRIFDERPDDM
RFGLPGSEADWQRVEEALRSFDHSSKV

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=329, Percent_Identity=26.7477203647416, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 37245; Mature: 37114

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGETVPEKAQGAIRHGGNLGKARLMFRQAPEPWIDLSTGINPHSYPHSPIPASAFARLPE
CCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCHHHHHCCCC
PGAAEELKQLAAAHFGAPSAQHVTLSPGTQMLMPLLAQIAINRGAQSGAVLSPAYAEHAR
CCCHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHH
TARMAGLTVTEVENIGDLSAYGYAVVVNPNNPDGRITDREALLALAGTIGRKGGLLVVDE
HHHHCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCEEHHHHHHHHHHHCCCCCCEEEEEH
AFIETGGAESLAVATNGEALVVLRSFGKFYGMAGVRLGFAIAHPEIAAELEARLGPWAVS
HHHCCCCCCEEEEEECCCEEEEEEHHHHHHCCCHHHHEEEEECCHHHHHHHHHCCCEEEC
GPALHIATEALADREWQSSMRLRLAEEARRMNELLEKAGLKIAGGTSLFTLVRDERSRAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEEHHHHHHHH
FGHLGRRGILVRIFDERPDDMRFGLPGSEADWQRVEEALRSFDHSSKV
HHHCCCCCEEEEEECCCCCCCEECCCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GETVPEKAQGAIRHGGNLGKARLMFRQAPEPWIDLSTGINPHSYPHSPIPASAFARLPE
CCCCCHHHHHHHHCCCCCCHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCHHHHHCCCC
PGAAEELKQLAAAHFGAPSAQHVTLSPGTQMLMPLLAQIAINRGAQSGAVLSPAYAEHAR
CCCHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHH
TARMAGLTVTEVENIGDLSAYGYAVVVNPNNPDGRITDREALLALAGTIGRKGGLLVVDE
HHHHCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCEEHHHHHHHHHHHCCCCCCEEEEEH
AFIETGGAESLAVATNGEALVVLRSFGKFYGMAGVRLGFAIAHPEIAAELEARLGPWAVS
HHHCCCCCCEEEEEECCCEEEEEEHHHHHHCCCHHHHEEEEECCHHHHHHHHHCCCEEEC
GPALHIATEALADREWQSSMRLRLAEEARRMNELLEKAGLKIAGGTSLFTLVRDERSRAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEEHHHHHHHH
FGHLGRRGILVRIFDERPDDMRFGLPGSEADWQRVEEALRSFDHSSKV
HHHCCCCCEEEEEECCCCCCCEECCCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]