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The map label for this gene is mro [H]

Identifier: 15889971

GI number: 15889971

Start: 2704613

End: 2705632

Strand: Direct

Name: mro [H]

Synonym: Atu2719

Alternate gene names: 15889971

Gene position: 2704613-2705632 (Clockwise)

Preceding gene: 159185345

Following gene: 15889973

Centisome position: 95.18

GC content: 59.51

Gene sequence:

>1020_bases
ATGAGCGACGGTGCGGCACGAGAAGATTTTGGTTTCACGGCGACCGGCGAAAAGGTCGAACGCGTCACCATCTCGAAAGA
CGGTTTGACGGCGAAAGTCATCACCTGGGGCGCTGTTATCCAGGATCTGCGGCTTGACGGCCACCAGGCCCCGTTGGTGC
TTGGCTTCGACAAATTCGAGGATTACAAATACTCCTCCTATTTCGGCGCCACGCCCGGCCGCAATGCCAACCGTATCGGC
AACGGCAGGTTCGCGATCGACGGCCATGAATACCAGCTAGAACTGAACGAAAAGGGCGTGACCCATCTGCACGGCGGCAG
CGACGGCATGGGCAAGCGCAACTGGATGCTGATGGAGCATGGCGAAAGCCACGCCGTCCTGCAGATTATCGACCCCGATG
GACGCGCCGGTTATCCCGGCAATTGCACGGTCACTGCTACCTATACGATCCGCGATGGCGGCGTGCTTTCGGTTGTTTAT
GAAACGGTGACCGACCAGCCGACCATCGCCAATGTGTGCCAGCACTCCTATTTCAACCTCGACGGCGCGGATACCGCACT
TGGCCATGAGATCAGCATCGCCGCTGACTTTTACCTGCCGACCAACGAACAGCAGATACCGACCGGCGAAATCCGCTCCG
TCGAAGGCACCGTCTTCGACCTGCGCCACCCGACGCCGATGCGGCGCAAGGAGAATGGCGAACAGGTTCTCTACGACCAC
AATTTCTGCCTTTCGCCCGAGCGTCGCGCCAAGCGCAAGGTCGCCCGCGCCTATTCACCTGCCTCCGATATCGCCCTTGA
AGTCCACACGACAGAGCCCGGTGTGCAGTTCTATTCAGCCTTCAAGCTCGACGTTCCCGTTCCGGGCCTCGATGGCCGCC
ATTATGGCCCCTTCGCCGGTTTCTGCCTTGAAACGCAGATTTGGCCCGATGCCGTCAATCACCCGGATTTTCCGCACGCC
ATCCTGCGGCCGGGCGAAACGCTGCGTCAGGAAACGGATTATATTTTCAGGAAGGGCTGA

Upstream 100 bases:

>100_bases
AGCCATCGGGAAACTGGCGGCGTAAACTGCGGGATTGCGAATTGCCGGAAAATGACGCAACGTCCGCCCGGCAATTTGCG
ATACCAGGGAGAATGACGAG

Downstream 100 bases:

>100_bases
GGCAGAGGGTCGGGATCAGTCAAGCACGCAGGATCAGTCAAGCACGCAGCCGACATAGCCGCCCGAGGCGCGGGCCCGAC
GCTCGATAAGGCCGGCCAGC

Product: aldose epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSDGAAREDFGFTATGEKVERVTISKDGLTAKVITWGAVIQDLRLDGHQAPLVLGFDKFEDYKYSSYFGATPGRNANRIG
NGRFAIDGHEYQLELNEKGVTHLHGGSDGMGKRNWMLMEHGESHAVLQIIDPDGRAGYPGNCTVTATYTIRDGGVLSVVY
ETVTDQPTIANVCQHSYFNLDGADTALGHEISIAADFYLPTNEQQIPTGEIRSVEGTVFDLRHPTPMRRKENGEQVLYDH
NFCLSPERRAKRKVARAYSPASDIALEVHTTEPGVQFYSAFKLDVPVPGLDGRHYGPFAGFCLETQIWPDAVNHPDFPHA
ILRPGETLRQETDYIFRKG

Sequences:

>Translated_339_residues
MSDGAAREDFGFTATGEKVERVTISKDGLTAKVITWGAVIQDLRLDGHQAPLVLGFDKFEDYKYSSYFGATPGRNANRIG
NGRFAIDGHEYQLELNEKGVTHLHGGSDGMGKRNWMLMEHGESHAVLQIIDPDGRAGYPGNCTVTATYTIRDGGVLSVVY
ETVTDQPTIANVCQHSYFNLDGADTALGHEISIAADFYLPTNEQQIPTGEIRSVEGTVFDLRHPTPMRRKENGEQVLYDH
NFCLSPERRAKRKVARAYSPASDIALEVHTTEPGVQFYSAFKLDVPVPGLDGRHYGPFAGFCLETQIWPDAVNHPDFPHA
ILRPGETLRQETDYIFRKG
>Mature_338_residues
SDGAAREDFGFTATGEKVERVTISKDGLTAKVITWGAVIQDLRLDGHQAPLVLGFDKFEDYKYSSYFGATPGRNANRIGN
GRFAIDGHEYQLELNEKGVTHLHGGSDGMGKRNWMLMEHGESHAVLQIIDPDGRAGYPGNCTVTATYTIRDGGVLSVVYE
TVTDQPTIANVCQHSYFNLDGADTALGHEISIAADFYLPTNEQQIPTGEIRSVEGTVFDLRHPTPMRRKENGEQVLYDHN
FCLSPERRAKRKVARAYSPASDIALEVHTTEPGVQFYSAFKLDVPVPGLDGRHYGPFAGFCLETQIWPDAVNHPDFPHAI
LRPGETLRQETDYIFRKG

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=342, Percent_Identity=42.9824561403509, Blast_Score=237, Evalue=1e-62,
Organism=Escherichia coli, GI1786971, Length=325, Percent_Identity=34.4615384615385, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17557428, Length=320, Percent_Identity=31.875, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI115533334, Length=320, Percent_Identity=31.875, Blast_Score=160, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6319493, Length=330, Percent_Identity=29.6969696969697, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6322004, Length=348, Percent_Identity=29.5977011494253, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324399, Length=363, Percent_Identity=25.6198347107438, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24659048, Length=346, Percent_Identity=40.4624277456647, Blast_Score=221, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24668278, Length=358, Percent_Identity=36.5921787709497, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24668282, Length=345, Percent_Identity=32.463768115942, Blast_Score=184, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24583720, Length=358, Percent_Identity=33.7988826815642, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24641876, Length=348, Percent_Identity=33.0459770114943, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 37575; Mature: 37444

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDGAAREDFGFTATGEKVERVTISKDGLTAKVITWGAVIQDLRLDGHQAPLVLGFDKFE
CCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEHHHHHHHHHCCCCCCCEEEECHHCC
DYKYSSYFGATPGRNANRIGNGRFAIDGHEYQLELNEKGVTHLHGGSDGMGKRNWMLMEH
CCEECCEECCCCCCCCCCCCCCEEEECCCEEEEEECCCCCEEEECCCCCCCCCCEEEEEC
GESHAVLQIIDPDGRAGYPGNCTVTATYTIRDGGVLSVVYETVTDQPTIANVCQHSYFNL
CCCEEEEEEECCCCCCCCCCCEEEEEEEEEECCCEEEEEEEHHCCCCHHHHHHHHHHCCC
DGADTALGHEISIAADFYLPTNEQQIPTGEIRSVEGTVFDLRHPTPMRRKENGEQVLYDH
CCCCCCCCCEEEEEEEEEECCCCCCCCCCCEEECCCEEEECCCCCCCCCCCCCCEEEEEC
NFCLSPERRAKRKVARAYSPASDIALEVHTTEPGVQFYSAFKLDVPVPGLDGRHYGPFAG
CCCCCCHHHHHHHHHHHCCCHHHEEEEEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCC
FCLETQIWPDAVNHPDFPHAILRPGETLRQETDYIFRKG
EEEEECCCCCCCCCCCCCHHHHCCCHHHHHHHCEEEECC
>Mature Secondary Structure 
SDGAAREDFGFTATGEKVERVTISKDGLTAKVITWGAVIQDLRLDGHQAPLVLGFDKFE
CCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEHHHHHHHHHCCCCCCCEEEECHHCC
DYKYSSYFGATPGRNANRIGNGRFAIDGHEYQLELNEKGVTHLHGGSDGMGKRNWMLMEH
CCEECCEECCCCCCCCCCCCCCEEEECCCEEEEEECCCCCEEEECCCCCCCCCCEEEEEC
GESHAVLQIIDPDGRAGYPGNCTVTATYTIRDGGVLSVVYETVTDQPTIANVCQHSYFNL
CCCEEEEEEECCCCCCCCCCCEEEEEEEEEECCCEEEEEEEHHCCCCHHHHHHHHHHCCC
DGADTALGHEISIAADFYLPTNEQQIPTGEIRSVEGTVFDLRHPTPMRRKENGEQVLYDH
CCCCCCCCCEEEEEEEEEECCCCCCCCCCCEEECCCEEEECCCCCCCCCCCCCCEEEEEC
NFCLSPERRAKRKVARAYSPASDIALEVHTTEPGVQFYSAFKLDVPVPGLDGRHYGPFAG
CCCCCCHHHHHHHHHHHCCCHHHEEEEEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCC
FCLETQIWPDAVNHPDFPHAILRPGETLRQETDYIFRKG
EEEEECCCCCCCCCCCCCHHHHCCCHHHHHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]