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The map label for this gene is dxr

Identifier: 15889868

GI number: 15889868

Start: 2590929

End: 2592122

Strand: Direct

Name: dxr

Synonym: Atu2612

Alternate gene names: 15889868

Gene position: 2590929-2592122 (Clockwise)

Preceding gene: 15889865

Following gene: 159185291

Centisome position: 91.18

GC content: 61.73

Gene sequence:

>1194_bases
ATGACGAATGCCAGTGAAATGCCACGCAAGCTGACCATATTGGGTTCGACGGGTTCCATCGGCACCAATACTCTGGATGT
CGTGCGTCAACTGGGTGGCCGCGACGGGTTCGAGATCATGGCGCTGACCGGCGCGGGAAACATCGCGCTTCTGGCCGAAC
AGGCGCGGGAATTTGGCGCGCAGCTCGCGGTCACTGCGGACGATGATAAATATGAAGCGCTGAAATCGGCGCTGGCAGGC
ACCGGCATCAAAGTCGCCGCAGGCATGGCCGGCCTTGAAGAGGCAGCCTCGATGGATGCCGGCTGGGTGATGGCCGCGAT
TGCCGGCACCCCCGGCCTCGCCCCGACACTGACGGCCGCCCGGCGTGGTGCCGATATTGCACTTGCCAACAAGGAATGCC
TCGTTTCGGCGGGCGATGTTTTTCTGCGCACTGTCAAACAGGGCGGCGGCCGGCTGATCCCGGTCGACAGCGAACACAGC
GCAATCTTCCAGTGCCTGACGGGTGAATACAAACAGGCGGTGGAACGCATCGTGCTGACGGCTTCCGGCGGGCCGTTCCG
CACCTGGTCGCGGGACGAGATGTCCAACGTCACGGCGGATATCGCCCGCGCCCATCCCAACTGGTCGATGGGGCTGAAGG
TCTCGATCGGCAGTGCCTCCATGTTCAACAAGGGCCTGGAAATGATCGAGGCGAAATATCTCTTCGATCTCAGGCCTGAT
CAGGTGGACGTGATTGTCCATCCACAATCGATCATCCATTCGATGGTTGGCTACACTGACGGCTCCTATATCGCGCAGCT
CGGCTCTCCCGACATGCGCACCGCCATCTCCTATGCCCTCACCTATCCTGAGCGCGGCAATCTAAGCGTCGAGCGCCTGG
ATTTCGCGAAACTGGCACGGCTCGATTTCGAAGCACCGGACGAAGCCCGCTTCCCGGCGCTGCGGCTTGCGCGCATGGCG
CTGGAGCGTGGCGGTTTGCAGGGCGCGGCCCTGAACGCAGCCGAGGAGACCGCCTTTCACGCCTTTGTCGCTGGTGGCAT
CGGTTTTCTCGACATGGCCGAAATTGTTGAAACGGTGATGGACCGTATGCATGACGGCCGCACCGCCGAGACGATGGACG
ACGTTTTTTCGGCAGACGAAGAGGCCCGCCGCCATGCACTGGAACTCATCGCCACAAAAGAAAAGGCCGCGTGA

Upstream 100 bases:

>100_bases
GCTTTGCGCCTCACAAAAACAATAGCCTGGGCTTTGTCCTTGTTATGGCGGGTTTTCGCGAGTAGAGCCTAATTCTGCCA
ATAAAACCGACGGGCTGAAG

Downstream 100 bases:

>100_bases
ACGCGGCCCTGACCTCTTCAATCTGAACGGTTGCCTTAAGCCACCGCACGCGCCAGTGCGCAATGCGACCAGAGCTGATG
CAGCGCACCGACAAGCTGCT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MTNASEMPRKLTILGSTGSIGTNTLDVVRQLGGRDGFEIMALTGAGNIALLAEQAREFGAQLAVTADDDKYEALKSALAG
TGIKVAAGMAGLEEAASMDAGWVMAAIAGTPGLAPTLTAARRGADIALANKECLVSAGDVFLRTVKQGGGRLIPVDSEHS
AIFQCLTGEYKQAVERIVLTASGGPFRTWSRDEMSNVTADIARAHPNWSMGLKVSIGSASMFNKGLEMIEAKYLFDLRPD
QVDVIVHPQSIIHSMVGYTDGSYIAQLGSPDMRTAISYALTYPERGNLSVERLDFAKLARLDFEAPDEARFPALRLARMA
LERGGLQGAALNAAEETAFHAFVAGGIGFLDMAEIVETVMDRMHDGRTAETMDDVFSADEEARRHALELIATKEKAA

Sequences:

>Translated_397_residues
MTNASEMPRKLTILGSTGSIGTNTLDVVRQLGGRDGFEIMALTGAGNIALLAEQAREFGAQLAVTADDDKYEALKSALAG
TGIKVAAGMAGLEEAASMDAGWVMAAIAGTPGLAPTLTAARRGADIALANKECLVSAGDVFLRTVKQGGGRLIPVDSEHS
AIFQCLTGEYKQAVERIVLTASGGPFRTWSRDEMSNVTADIARAHPNWSMGLKVSIGSASMFNKGLEMIEAKYLFDLRPD
QVDVIVHPQSIIHSMVGYTDGSYIAQLGSPDMRTAISYALTYPERGNLSVERLDFAKLARLDFEAPDEARFPALRLARMA
LERGGLQGAALNAAEETAFHAFVAGGIGFLDMAEIVETVMDRMHDGRTAETMDDVFSADEEARRHALELIATKEKAA
>Mature_396_residues
TNASEMPRKLTILGSTGSIGTNTLDVVRQLGGRDGFEIMALTGAGNIALLAEQAREFGAQLAVTADDDKYEALKSALAGT
GIKVAAGMAGLEEAASMDAGWVMAAIAGTPGLAPTLTAARRGADIALANKECLVSAGDVFLRTVKQGGGRLIPVDSEHSA
IFQCLTGEYKQAVERIVLTASGGPFRTWSRDEMSNVTADIARAHPNWSMGLKVSIGSASMFNKGLEMIEAKYLFDLRPDQ
VDVIVHPQSIIHSMVGYTDGSYIAQLGSPDMRTAISYALTYPERGNLSVERLDFAKLARLDFEAPDEARFPALRLARMAL
ERGGLQGAALNAAEETAFHAFVAGGIGFLDMAEIVETVMDRMHDGRTAETMDDVFSADEEARRHALELIATKEKAA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=388, Percent_Identity=47.1649484536082, Blast_Score=323, Evalue=2e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_AGRT5 (Q8UC86)

Other databases:

- EMBL:   AE007869
- PIR:   AC2897
- PIR:   E97672
- RefSeq:   NP_355549.1
- ProteinModelPortal:   Q8UC86
- SMR:   Q8UC86
- STRING:   Q8UC86
- GeneID:   1134650
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2612
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q8UC86
- ProtClustDB:   PRK05447
- BioCyc:   ATUM176299-1:ATU2612-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42304; Mature: 42172

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: BINDING 131-131 BINDING 158-158 BINDING 182-182 BINDING 205-205 BINDING 227-227

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNASEMPRKLTILGSTGSIGTNTLDVVRQLGGRDGFEIMALTGAGNIALLAEQAREFGA
CCCCHHCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCEEHHHHHHHHCCC
QLAVTADDDKYEALKSALAGTGIKVAAGMAGLEEAASMDAGWVMAAIAGTPGLAPTLTAA
EEEEECCCHHHHHHHHHHHCCCEEEHHCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHH
RRGADIALANKECLVSAGDVFLRTVKQGGGRLIPVDSEHSAIFQCLTGEYKQAVERIVLT
HCCCCEEEECCHHEEEHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEEE
ASGGPFRTWSRDEMSNVTADIARAHPNWSMGLKVSIGSASMFNKGLEMIEAKYLFDLRPD
ECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHEECCCC
QVDVIVHPQSIIHSMVGYTDGSYIAQLGSPDMRTAISYALTYPERGNLSVERLDFAKLAR
CEEEEECCHHHHHHHHCCCCCCHHEECCCCHHHHHHHHHEECCCCCCCCHHHHHHHHHHH
LDFEAPDEARFPALRLARMALERGGLQGAALNAAEETAFHAFVAGGIGFLDMAEIVETVM
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
DRMHDGRTAETMDDVFSADEEARRHALELIATKEKAA
HHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TNASEMPRKLTILGSTGSIGTNTLDVVRQLGGRDGFEIMALTGAGNIALLAEQAREFGA
CCCHHCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCEEHHHHHHHHCCC
QLAVTADDDKYEALKSALAGTGIKVAAGMAGLEEAASMDAGWVMAAIAGTPGLAPTLTAA
EEEEECCCHHHHHHHHHHHCCCEEEHHCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHH
RRGADIALANKECLVSAGDVFLRTVKQGGGRLIPVDSEHSAIFQCLTGEYKQAVERIVLT
HCCCCEEEECCHHEEEHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEEE
ASGGPFRTWSRDEMSNVTADIARAHPNWSMGLKVSIGSASMFNKGLEMIEAKYLFDLRPD
ECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHEECCCC
QVDVIVHPQSIIHSMVGYTDGSYIAQLGSPDMRTAISYALTYPERGNLSVERLDFAKLAR
CEEEEECCHHHHHHHHCCCCCCHHEECCCCHHHHHHHHHEECCCCCCCCHHHHHHHHHHH
LDFEAPDEARFPALRLARMALERGGLQGAALNAAEETAFHAFVAGGIGFLDMAEIVETVM
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
DRMHDGRTAETMDDVFSADEEARRHALELIATKEKAA
HHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194