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The map label for this gene is envZ [H]

Identifier: 15889484

GI number: 15889484

Start: 2177183

End: 2178562

Strand: Direct

Name: envZ [H]

Synonym: Atu2207

Alternate gene names: 15889484

Gene position: 2177183-2178562 (Clockwise)

Preceding gene: 159185100

Following gene: 15889489

Centisome position: 76.62

GC content: 59.71

Gene sequence:

>1380_bases
ATGGCGAGCCTCGATTTTTTCGACACGTTCAAAAAGAGCCCCGTGGCCAAGGCATGGCGCTCCGCCGGCAGATGGCTGCG
CCACTGGCTGCCAACAGGCCTTTACACCCGCTCGCTACTCATCATCATCCTGCCGATGATCCTGCTTCAGGCCGTGGTCG
CGGCCGTGTTCATGGAACGTCACTGGCAATTGGTGACGGAGCGCCTGTCCGCGGCCGTGACACGCGATATCTCTGCCGTC
ATCGAGCTTCTGCAGACGGACCCCGAAGAAGACGATTATCAGCGCGTCATCCGCATCGCGCGAGAGAAACTCGACCTCAG
CGTCTACATCGAGCCCAAGACCGATCTGCCGGCCCCCAAACCCGAGCCGCTGTTTTCGATCCTCGACAGGATCCTTGCCG
ATCAGTTGAAACAGCAAATCGGCAGGCCGTTCTGGATCGACACCTATGGCAACGGCTCGCTGGTGGAAATCCGCGTTCAG
CTCGAAGACAAGACGTTGCGCGTCTTCACCAGCCGCAGTTCCGCCTATGCCTCCAATACCCATATCTTCCTCGTCTGGAT
GGTCGGCGCGTCACTGGTGCTGATTGCCATTTCCATCCTGTTCCTGCGCGGGCAGATCAAACCCATCGAAGCACTTGCCA
AGGCGGCCGAAAACTTCGGCAAGGGCCAGAAGATCAGCGGCTATTCCCCACGCGGCGCGGACGAGGTGCGGCGCGCCGGT
CTTGCCTTCATCCTGATGCGCGAGCGTATCGAGCGGCAGATGGAACAGCGCACCGCCATGTTGAATGGTGTAAGCCATGA
CCTGCGCACCATTCTCACCCGCTTCAAGCTGCAACTGGCGCTCGCCGGCGACAATCCTGATCTCGAAGGGCTCGATAAGG
ATGTGGACGACATGCAGTCGATGCTGGAGGCCTATCTGACCTTCGCCCGCACCGAGGTCGAAGAGGATGTCGGCACGCTG
GAGCTTCCGGCGCTTCTGGAGAAGATCGGCCATGATTTCGAGCTGCATGGCAAGAAATTCAGCTACCAACTTTATAATAT
CGAGAGGATCATCGCCCGGCCGAATGCGCTGTCACGCCTCGTCGCCAATCTGGCCGAAAATGCGCGGCGTTACGCCAGCA
ATCTCCACGTCGATATCCGCAAGGCGCCACGCTCCATCATCATGACCTTCGACGATGACGGTCCGGGTATTCCGGAAATC
TCCCGCGAGGATGTGTTCAAGCCATTCTTCCGGCTGGACGAGGCACGCAACCTCAATGCTTCGGGCACGGGCCTTGGCCT
CTCCATCGTGCGCGATATCGCCCGCAGCCATGGCGGCGACGTGTCGCTCGATGAAAGCCCGATGGGCGGATTGCGGGTCA
TCGTCAAGATTCCGGCTTAA

Upstream 100 bases:

>100_bases
GACGACCCTGCCAATCCTGTCTATCTGCAAACGGTGCGTGGCATCGGTTACCGCCTGAGCGTGGACTGACGGGCACTCAA
AGAAGGGCAAACGCACGACC

Downstream 100 bases:

>100_bases
CGGCAAACGGCCGTCAGCACATCTTCTCACCGTTCGGCACAGGGCGTTCAACCGCGGCCAACACGATATCGCCGTTTGCA
TCGGCAAAACCGAGCGTCAG

Product: two component sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MASLDFFDTFKKSPVAKAWRSAGRWLRHWLPTGLYTRSLLIIILPMILLQAVVAAVFMERHWQLVTERLSAAVTRDISAV
IELLQTDPEEDDYQRVIRIAREKLDLSVYIEPKTDLPAPKPEPLFSILDRILADQLKQQIGRPFWIDTYGNGSLVEIRVQ
LEDKTLRVFTSRSSAYASNTHIFLVWMVGASLVLIAISILFLRGQIKPIEALAKAAENFGKGQKISGYSPRGADEVRRAG
LAFILMRERIERQMEQRTAMLNGVSHDLRTILTRFKLQLALAGDNPDLEGLDKDVDDMQSMLEAYLTFARTEVEEDVGTL
ELPALLEKIGHDFELHGKKFSYQLYNIERIIARPNALSRLVANLAENARRYASNLHVDIRKAPRSIIMTFDDDGPGIPEI
SREDVFKPFFRLDEARNLNASGTGLGLSIVRDIARSHGGDVSLDESPMGGLRVIVKIPA

Sequences:

>Translated_459_residues
MASLDFFDTFKKSPVAKAWRSAGRWLRHWLPTGLYTRSLLIIILPMILLQAVVAAVFMERHWQLVTERLSAAVTRDISAV
IELLQTDPEEDDYQRVIRIAREKLDLSVYIEPKTDLPAPKPEPLFSILDRILADQLKQQIGRPFWIDTYGNGSLVEIRVQ
LEDKTLRVFTSRSSAYASNTHIFLVWMVGASLVLIAISILFLRGQIKPIEALAKAAENFGKGQKISGYSPRGADEVRRAG
LAFILMRERIERQMEQRTAMLNGVSHDLRTILTRFKLQLALAGDNPDLEGLDKDVDDMQSMLEAYLTFARTEVEEDVGTL
ELPALLEKIGHDFELHGKKFSYQLYNIERIIARPNALSRLVANLAENARRYASNLHVDIRKAPRSIIMTFDDDGPGIPEI
SREDVFKPFFRLDEARNLNASGTGLGLSIVRDIARSHGGDVSLDESPMGGLRVIVKIPA
>Mature_458_residues
ASLDFFDTFKKSPVAKAWRSAGRWLRHWLPTGLYTRSLLIIILPMILLQAVVAAVFMERHWQLVTERLSAAVTRDISAVI
ELLQTDPEEDDYQRVIRIAREKLDLSVYIEPKTDLPAPKPEPLFSILDRILADQLKQQIGRPFWIDTYGNGSLVEIRVQL
EDKTLRVFTSRSSAYASNTHIFLVWMVGASLVLIAISILFLRGQIKPIEALAKAAENFGKGQKISGYSPRGADEVRRAGL
AFILMRERIERQMEQRTAMLNGVSHDLRTILTRFKLQLALAGDNPDLEGLDKDVDDMQSMLEAYLTFARTEVEEDVGTLE
LPALLEKIGHDFELHGKKFSYQLYNIERIIARPNALSRLVANLAENARRYASNLHVDIRKAPRSIIMTFDDDGPGIPEIS
REDVFKPFFRLDEARNLNASGTGLGLSIVRDIARSHGGDVSLDESPMGGLRVIVKIPA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=334, Percent_Identity=30.8383233532934, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1790346, Length=271, Percent_Identity=32.8413284132841, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1787894, Length=288, Percent_Identity=28.8194444444444, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788393, Length=279, Percent_Identity=25.089605734767, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87082128, Length=275, Percent_Identity=26.9090909090909, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786600, Length=237, Percent_Identity=24.8945147679325, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789149, Length=232, Percent_Identity=25.8620689655172, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786783, Length=289, Percent_Identity=22.4913494809689, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51746; Mature: 51614

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLDFFDTFKKSPVAKAWRSAGRWLRHWLPTGLYTRSLLIIILPMILLQAVVAAVFMER
CCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HWQLVTERLSAAVTRDISAVIELLQTDPEEDDYQRVIRIAREKLDLSVYIEPKTDLPAPK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCC
PEPLFSILDRILADQLKQQIGRPFWIDTYGNGSLVEIRVQLEDKTLRVFTSRSSAYASNT
CCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEECCCEEEEEECCCCCCCCCC
HIFLVWMVGASLVLIAISILFLRGQIKPIEALAKAAENFGKGQKISGYSPRGADEVRRAG
EEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
LAFILMRERIERQMEQRTAMLNGVSHDLRTILTRFKLQLALAGDNPDLEGLDKDVDDMQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHH
MLEAYLTFARTEVEEDVGTLELPALLEKIGHDFELHGKKFSYQLYNIERIIARPNALSRL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCEEEEEHHHHHHHHHCCHHHHHH
VANLAENARRYASNLHVDIRKAPRSIIMTFDDDGPGIPEISREDVFKPFFRLDEARNLNA
HHHHHHHHHHHHHHCCEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
SGTGLGLSIVRDIARSHGGDVSLDESPMGGLRVIVKIPA
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure 
ASLDFFDTFKKSPVAKAWRSAGRWLRHWLPTGLYTRSLLIIILPMILLQAVVAAVFMER
CCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HWQLVTERLSAAVTRDISAVIELLQTDPEEDDYQRVIRIAREKLDLSVYIEPKTDLPAPK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCC
PEPLFSILDRILADQLKQQIGRPFWIDTYGNGSLVEIRVQLEDKTLRVFTSRSSAYASNT
CCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEECCCEEEEEECCCCCCCCCC
HIFLVWMVGASLVLIAISILFLRGQIKPIEALAKAAENFGKGQKISGYSPRGADEVRRAG
EEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
LAFILMRERIERQMEQRTAMLNGVSHDLRTILTRFKLQLALAGDNPDLEGLDKDVDDMQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHH
MLEAYLTFARTEVEEDVGTLELPALLEKIGHDFELHGKKFSYQLYNIERIIARPNALSRL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCEEEEEHHHHHHHHHCCHHHHHH
VANLAENARRYASNLHVDIRKAPRSIIMTFDDDGPGIPEISREDVFKPFFRLDEARNLNA
HHHHHHHHHHHHHHCCEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
SGTGLGLSIVRDIARSHGGDVSLDESPMGGLRVIVKIPA
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]