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The map label for this gene is murB

Identifier: 15889376

GI number: 15889376

Start: 2055066

End: 2056031

Strand: Reverse

Name: murB

Synonym: Atu2092

Alternate gene names: 15889376

Gene position: 2056031-2055066 (Counterclockwise)

Preceding gene: 15889377

Following gene: 159185045

Centisome position: 72.36

GC content: 60.87

Gene sequence:

>966_bases
ATGAGACAGGTCGATGGGGTTAAATTGCTGGGGAGGCTCGGCGACGGGGTAAATGAATTGCGGGGACGTCTGACACCGGA
TGCGCCCATGGACCGCGTGACGTGGTTCAGAGCCGGCGGTCTTGCGGAGGTGATGTTCCAGCCGCACGATACCGACGATC
TGATCGCCTTCCTGAAAATTCTGCCGGAAGACGTGCCGTTGACCGTGGTCGGCGTTGGCTCGAACCTGCTGGTGCGTGAT
GGCGGCATTCCGGGCGTTGTCGTGCGTCTGTCCGCCAAAGGCTTCGGCTCGGTGGAGCTTGCGGACGAAAACCGCATCAA
GGCCGGTGCGATCTGCCCGGACAAGCACATTGCCGCCATGGCCATGGATAATGGCATTGGCGGTTTCCACTTCTATTACG
GCATTCCCGGCTCCATCGGTGGTGCGCTGCGCATGAATGCCGGCGCCAATGGCGGTGAAACGCGTGAGCGTGTCGTTGAG
GTCTATGCGGTCGACCGTCAGGGCAACCAACATGTGCTTTCCAATGCGGATATGGGCTACAGCTATCGCCATTCCGGCGC
CGATGCCGGCCTGATCTTCACCGGGGCGCTGTTTGAGGGTTATCCGGAAGACAAGGCAAAGATCCGGGCGGATATGGACG
CTGTGCGGCATCACCGCGAGACCGTGCAGCCGATCCGCGAACAGACCGGTGGTTCCACCTTCAAGAACCCTGAAGGTCAT
TCCGCCTGGGAACTGATCGACGAGGCGGGTGGCCGCGGTCTGGTCATCGGCGGCGCGCAAATGTCGTCGCTGCATTGCAA
TTTCATGATCAATACCGGCCATGCGACCGGCTACGATCTGGAATATCTGGGCGAGACCATCCGCAGGCGCGTGTTCGAGA
AATCGGGCATCCGGCTGGAATGGGAAATCAAGCGCCTTGGCCTCTTCATGCCGGGCCGTGAAGTGGAGCCGTTCCTCGGG
GCGTAA

Upstream 100 bases:

>100_bases
CGAATCCGGGTGATTTTGTGGTTCTCTTGGGGGCTGGAAATATCACACAATGGGCAGCCGCGCTGCCTTCGGAATTGAAG
AGCATATCAGGAAAGTCTGA

Downstream 100 bases:

>100_bases
GCCTTGATCGCGCTTCTATACTGAAAGAAAATACGAGTGTTGATAAGACCGTTGCGTTTATCGTAACGGTCGATCAACGA
TTTTTGCCATAATCTTGGCG

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MRQVDGVKLLGRLGDGVNELRGRLTPDAPMDRVTWFRAGGLAEVMFQPHDTDDLIAFLKILPEDVPLTVVGVGSNLLVRD
GGIPGVVVRLSAKGFGSVELADENRIKAGAICPDKHIAAMAMDNGIGGFHFYYGIPGSIGGALRMNAGANGGETRERVVE
VYAVDRQGNQHVLSNADMGYSYRHSGADAGLIFTGALFEGYPEDKAKIRADMDAVRHHRETVQPIREQTGGSTFKNPEGH
SAWELIDEAGGRGLVIGGAQMSSLHCNFMINTGHATGYDLEYLGETIRRRVFEKSGIRLEWEIKRLGLFMPGREVEPFLG
A

Sequences:

>Translated_321_residues
MRQVDGVKLLGRLGDGVNELRGRLTPDAPMDRVTWFRAGGLAEVMFQPHDTDDLIAFLKILPEDVPLTVVGVGSNLLVRD
GGIPGVVVRLSAKGFGSVELADENRIKAGAICPDKHIAAMAMDNGIGGFHFYYGIPGSIGGALRMNAGANGGETRERVVE
VYAVDRQGNQHVLSNADMGYSYRHSGADAGLIFTGALFEGYPEDKAKIRADMDAVRHHRETVQPIREQTGGSTFKNPEGH
SAWELIDEAGGRGLVIGGAQMSSLHCNFMINTGHATGYDLEYLGETIRRRVFEKSGIRLEWEIKRLGLFMPGREVEPFLG
A
>Mature_321_residues
MRQVDGVKLLGRLGDGVNELRGRLTPDAPMDRVTWFRAGGLAEVMFQPHDTDDLIAFLKILPEDVPLTVVGVGSNLLVRD
GGIPGVVVRLSAKGFGSVELADENRIKAGAICPDKHIAAMAMDNGIGGFHFYYGIPGSIGGALRMNAGANGGETRERVVE
VYAVDRQGNQHVLSNADMGYSYRHSGADAGLIFTGALFEGYPEDKAKIRADMDAVRHHRETVQPIREQTGGSTFKNPEGH
SAWELIDEAGGRGLVIGGAQMSSLHCNFMINTGHATGYDLEYLGETIRRRVFEKSGIRLEWEIKRLGLFMPGREVEPFLG
A

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_AGRT5 (Q8UDN0)

Other databases:

- EMBL:   AE007869
- PIR:   A97611
- PIR:   AE2833
- RefSeq:   NP_355057.1
- ProteinModelPortal:   Q8UDN0
- STRING:   Q8UDN0
- GeneID:   1134130
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2092
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK13905
- BioCyc:   ATUM176299-1:ATU2092-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 34833; Mature: 34833

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 183-183 ACT_SITE 232-232 ACT_SITE 302-302

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQVDGVKLLGRLGDGVNELRGRLTPDAPMDRVTWFRAGGLAEVMFQPHDTDDLIAFLKI
CCCCCHHHHHHHHCCCHHHHHCCCCCCCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHH
LPEDVPLTVVGVGSNLLVRDGGIPGVVVRLSAKGFGSVELADENRIKAGAICPDKHIAAM
CCCCCCEEEEECCCCEEEECCCCCEEEEEEECCCCCCEEECCCCCEEECCCCCCCCEEEE
AMDNGIGGFHFYYGIPGSIGGALRMNAGANGGETRERVVEVYAVDRQGNQHVLSNADMGY
EECCCCCCEEEEEECCCCCCCEEEECCCCCCCHHHHHEEEEEEECCCCCEEEECCCCCCC
SYRHSGADAGLIFTGALFEGYPEDKAKIRADMDAVRHHRETVQPIREQTGGSTFKNPEGH
EEECCCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SAWELIDEAGGRGLVIGGAQMSSLHCNFMINTGHATGYDLEYLGETIRRRVFEKSGIRLE
HHHHHHHHCCCCEEEEECCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEE
WEIKRLGLFMPGREVEPFLGA
EEEEEECEECCCCCCCHHCCC
>Mature Secondary Structure
MRQVDGVKLLGRLGDGVNELRGRLTPDAPMDRVTWFRAGGLAEVMFQPHDTDDLIAFLKI
CCCCCHHHHHHHHCCCHHHHHCCCCCCCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHH
LPEDVPLTVVGVGSNLLVRDGGIPGVVVRLSAKGFGSVELADENRIKAGAICPDKHIAAM
CCCCCCEEEEECCCCEEEECCCCCEEEEEEECCCCCCEEECCCCCEEECCCCCCCCEEEE
AMDNGIGGFHFYYGIPGSIGGALRMNAGANGGETRERVVEVYAVDRQGNQHVLSNADMGY
EECCCCCCEEEEEECCCCCCCEEEECCCCCCCHHHHHEEEEEEECCCCCEEEECCCCCCC
SYRHSGADAGLIFTGALFEGYPEDKAKIRADMDAVRHHRETVQPIREQTGGSTFKNPEGH
EEECCCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SAWELIDEAGGRGLVIGGAQMSSLHCNFMINTGHATGYDLEYLGETIRRRVFEKSGIRLE
HHHHHHHHCCCCEEEEECCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEE
WEIKRLGLFMPGREVEPFLGA
EEEEEECEECCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194