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The map label for this gene is hflC [H]

Identifier: 15889331

GI number: 15889331

Start: 2003144

End: 2004067

Strand: Reverse

Name: hflC [H]

Synonym: Atu2044

Alternate gene names: 15889331

Gene position: 2004067-2003144 (Counterclockwise)

Preceding gene: 159185025

Following gene: 159185024

Centisome position: 70.53

GC content: 61.04

Gene sequence:

>924_bases
ATGGGTAACCGTCTTACGGCCGTTCTTGTCGGTCTCGCCGTCCTGCTTTTCCTCGGTTATTCGTCGATCTTCGTCGTCAA
CGAGCGCCAGCAGGCCATCGTCGTCCGCTTCGGTCAGATCCAGGATGTGAAAACGGCGCCGGGCCTCTATTTCAAGCTGC
CCTTCGCCTTCATGGATGCCGACCGCGTGCAATATGTCGAGAACCGCGCGCTGCGCTTCGATCACGACAATATCCGTGTT
CAGGTCTCCGGCGGCAAGTTCTATGAGGTCGATGCCTTCGTGGTCTATCGCATCACGGATGCGCGCCGCTTCCGGCAGAC
GGTCTCAGGTGACCAGATGTCGGCGGAATCGCGCCTGCGCACCCGTCTCGACGCATCGTTGCGCCGGGTCTACGGTCTGC
GCGGCTTTGAATCCGCACTTTCGGATGCGCGTGCATCGATGATGCAGGAAGTGCGTGACGATCTGCGTCCCGATGCGGAA
TCGCTCGGCATCAGCATCGTGGATGTCCGCATCCGTCGTACCGATCTGACGCAGGAAGTGTCGCAGCAGACCTTCGAGCG
CATGAAGTCGGAACGTCTTGCCGAAGCCGAACTTATCCGCGCACGCGGTAACGAGGCGGCGCAGCGTCGCCGGGCCGTTG
CCGACCGTGAGGTTGTGGAACTCGAGTCCACGGCCCAGCGGCAGTCCGAAGTGCTGCGCGGTGAAGGCGATGCCGAACGC
AACAAGGTCTTCGGTGTGGCTTTCCAGCGCGATCCTGATTTCTTCGAGTTCTATCGCTCCATGTCTGCTTACGCCAATGC
GTTGAACGGTAACGGCACGACGCTGGTCCTGTCCCCGGATTCGACCTTCTTCCGTTATTTCAACAATATCAACGGTGCGC
CACCTGCGGCTCCCGCCGCACCTGCGCCAGCGCCGGCGAACTGA

Upstream 100 bases:

>100_bases
AAGATCATCATCGACGAGAAACAGGGCGTGGTGCCTTATCTGCCTCTGAACGAGATCATGCGCAACAATCCGGGCGCAGC
ACAGCAGGGAGGCAACTGAT

Downstream 100 bases:

>100_bases
TAGCGGATCGAATGATTTTGGAGGGGCCGGTTTTTACCGGCCCTTTCTTTTTACTCCGCTTTCGTGCCAATGCTGTGGCT
ACGGGCAGGACATCCCCGCC

Product: HFLC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MGNRLTAVLVGLAVLLFLGYSSIFVVNERQQAIVVRFGQIQDVKTAPGLYFKLPFAFMDADRVQYVENRALRFDHDNIRV
QVSGGKFYEVDAFVVYRITDARRFRQTVSGDQMSAESRLRTRLDASLRRVYGLRGFESALSDARASMMQEVRDDLRPDAE
SLGISIVDVRIRRTDLTQEVSQQTFERMKSERLAEAELIRARGNEAAQRRRAVADREVVELESTAQRQSEVLRGEGDAER
NKVFGVAFQRDPDFFEFYRSMSAYANALNGNGTTLVLSPDSTFFRYFNNINGAPPAAPAAPAPAPAN

Sequences:

>Translated_307_residues
MGNRLTAVLVGLAVLLFLGYSSIFVVNERQQAIVVRFGQIQDVKTAPGLYFKLPFAFMDADRVQYVENRALRFDHDNIRV
QVSGGKFYEVDAFVVYRITDARRFRQTVSGDQMSAESRLRTRLDASLRRVYGLRGFESALSDARASMMQEVRDDLRPDAE
SLGISIVDVRIRRTDLTQEVSQQTFERMKSERLAEAELIRARGNEAAQRRRAVADREVVELESTAQRQSEVLRGEGDAER
NKVFGVAFQRDPDFFEFYRSMSAYANALNGNGTTLVLSPDSTFFRYFNNINGAPPAAPAAPAPAPAN
>Mature_306_residues
GNRLTAVLVGLAVLLFLGYSSIFVVNERQQAIVVRFGQIQDVKTAPGLYFKLPFAFMDADRVQYVENRALRFDHDNIRVQ
VSGGKFYEVDAFVVYRITDARRFRQTVSGDQMSAESRLRTRLDASLRRVYGLRGFESALSDARASMMQEVRDDLRPDAES
LGISIVDVRIRRTDLTQEVSQQTFERMKSERLAEAELIRARGNEAAQRRRAVADREVVELESTAQRQSEVLRGEGDAERN
KVFGVAFQRDPDFFEFYRSMSAYANALNGNGTTLVLSPDSTFFRYFNNINGAPPAAPAAPAPAPAN

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=324, Percent_Identity=35.4938271604938, Blast_Score=172, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 34555; Mature: 34424

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNRLTAVLVGLAVLLFLGYSSIFVVNERQQAIVVRFGQIQDVKTAPGLYFKLPFAFMDA
CCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCCCCCCCEEEECCHHHHCH
DRVQYVENRALRFDHDNIRVQVSGGKFYEVDAFVVYRITDARRFRQTVSGDQMSAESRLR
HHHHHHHCCCEEEECCCEEEEECCCEEEEEEEEEEEEEHHHHHHHHHHCCCHHHHHHHHH
TRLDASLRRVYGLRGFESALSDARASMMQEVRDDLRPDAESLGISIVDVRIRRTDLTQEV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCEEEEEEEEEHHHHHHHH
SQQTFERMKSERLAEAELIRARGNEAAQRRRAVADREVVELESTAQRQSEVLRGEGDAER
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NKVFGVAFQRDPDFFEFYRSMSAYANALNGNGTTLVLSPDSTFFRYFNNINGAPPAAPAA
CEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHCCCCCCCCCCCC
PAPAPAN
CCCCCCC
>Mature Secondary Structure 
GNRLTAVLVGLAVLLFLGYSSIFVVNERQQAIVVRFGQIQDVKTAPGLYFKLPFAFMDA
CCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCCCCCCCEEEECCHHHHCH
DRVQYVENRALRFDHDNIRVQVSGGKFYEVDAFVVYRITDARRFRQTVSGDQMSAESRLR
HHHHHHHCCCEEEECCCEEEEECCCEEEEEEEEEEEEEHHHHHHHHHHCCCHHHHHHHHH
TRLDASLRRVYGLRGFESALSDARASMMQEVRDDLRPDAESLGISIVDVRIRRTDLTQEV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCEEEEEEEEEHHHHHHHH
SQQTFERMKSERLAEAELIRARGNEAAQRRRAVADREVVELESTAQRQSEVLRGEGDAER
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NKVFGVAFQRDPDFFEFYRSMSAYANALNGNGTTLVLSPDSTFFRYFNNINGAPPAAPAA
CEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHCCCCCCCCCCCC
PAPAPAN
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]