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The map label for this gene is metC [H]

Identifier: 15888893

GI number: 15888893

Start: 1560819

End: 1562006

Strand: Reverse

Name: metC [H]

Synonym: Atu1575

Alternate gene names: 15888893

Gene position: 1562006-1560819 (Counterclockwise)

Preceding gene: 15888900

Following gene: 159184821

Centisome position: 54.97

GC content: 58.75

Gene sequence:

>1188_bases
ATGACCAAGACCAATGACCTGCGTTCCGCCGCAGGTGTGAATACGCGCCTGACCCATGGCGGCAACGATCCCGCGGACTG
TTTCGGTTTCGTCAATCCTCCCATCGTGCGTGGCTCGACCGTGCTTTTTCCCGATGCGGAGACGCTTTCGACCGAAGACC
AGAAATACACCTATGGCACCCATGGTACGCCGACGACGGACGCGCTCTGCAATCTGGTCAACGAGCTGGAAGGTTCTTTC
GGAACCATTCTCGTCCCGTCGGGCCTTGCGGCGATTACCGTGCCGTTCCTTGCCTATCTCGGTGCTGGCGATCATGCGCT
GATCGTTGATTCCGTCTATTTCCCCACCCGCCGTTTCTGCAACACCATGCTGAAGAAGCTGGGCGTGGAGGTGGAGTATT
ACGATCCCGCGATCGGGGCTGGCATCGAGGCGCTTATCCGACCAAATACGAAGCTCGTGCATCTGGAAGCGCCGGGTTCC
AACACCTTCGAGATTCAGGATGTCCGGCTGATCACTGACATCGCTCACCGGCATGATTGCGTGGTGACCATGGACAATAC
CTGGGCGACGCCGCTTTATTTCAAGCCGCTCGATTTCGGCGTCGATGTCTCCATTCACGCCGCCACCAAATATCCCTCGG
GCCATTCCGACGTGCTGATGGGCTTCGTTTCGGCCAATGAAAAGTACTGGAAAGCGCTTTATCAGGCCAACACCAATCTC
GGCATCTGCGTCACCCCCGACGATGCCTATCAGATCCTGCGCGGCATGCGCACCATGGGGATCAGGCTGGAACACCATCA
GAAGAGCGCGCTGGATATCGCGCAATGGCTCGAGGGTCGCGACGACGTTGTGCGCGTGCTGCATCCGGCCTTGCCGAGCT
TTGCCGGGCATGAACTCTGGAAGCGTGATTTCAAGGGCGCGAGCGGTGTCTTCTCCTTCGTATTGAAGGCGGAAGAGGGC
AAATACAAACAGACGGCATCTGCCTTCCTTGATGCGCTGACGTTCTTCGGGCTCGGCTATTCCTGGGGCGGCTACGAATC
GCTTGCCGTATCGGTATCGCTCGTCGACAGAACGATTGCGAAGGGCCCGTCGGAAGGACCGGTCATCCGTCTGCAGATCG
GGCTCGAGGATGTCGCCGATCTCAAGAAAGACCTCGAGGCCGGTTTTTCAGCCGCGGCCGGGGTCTGA

Upstream 100 bases:

>100_bases
GATCAATTTGCCCGCCTCGAGGCTCTTCGCGGGACTTGACCTTGCGGTGTGCTCTCAGCATTGTCGCACGCGTCACTGTT
CCTTCGAAAGCTGATCTGAA

Downstream 100 bases:

>100_bases
GCCCAGCCCTCAGCCCCTGGCGTGATAGCCGTAGAGCCAGTCGAAGTCCTTCAGGAAAGCTTCCGGGGGACGGGTGGAAA
ATACCAGGTCCCGTGCGATG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MTKTNDLRSAAGVNTRLTHGGNDPADCFGFVNPPIVRGSTVLFPDAETLSTEDQKYTYGTHGTPTTDALCNLVNELEGSF
GTILVPSGLAAITVPFLAYLGAGDHALIVDSVYFPTRRFCNTMLKKLGVEVEYYDPAIGAGIEALIRPNTKLVHLEAPGS
NTFEIQDVRLITDIAHRHDCVVTMDNTWATPLYFKPLDFGVDVSIHAATKYPSGHSDVLMGFVSANEKYWKALYQANTNL
GICVTPDDAYQILRGMRTMGIRLEHHQKSALDIAQWLEGRDDVVRVLHPALPSFAGHELWKRDFKGASGVFSFVLKAEEG
KYKQTASAFLDALTFFGLGYSWGGYESLAVSVSLVDRTIAKGPSEGPVIRLQIGLEDVADLKKDLEAGFSAAAGV

Sequences:

>Translated_395_residues
MTKTNDLRSAAGVNTRLTHGGNDPADCFGFVNPPIVRGSTVLFPDAETLSTEDQKYTYGTHGTPTTDALCNLVNELEGSF
GTILVPSGLAAITVPFLAYLGAGDHALIVDSVYFPTRRFCNTMLKKLGVEVEYYDPAIGAGIEALIRPNTKLVHLEAPGS
NTFEIQDVRLITDIAHRHDCVVTMDNTWATPLYFKPLDFGVDVSIHAATKYPSGHSDVLMGFVSANEKYWKALYQANTNL
GICVTPDDAYQILRGMRTMGIRLEHHQKSALDIAQWLEGRDDVVRVLHPALPSFAGHELWKRDFKGASGVFSFVLKAEEG
KYKQTASAFLDALTFFGLGYSWGGYESLAVSVSLVDRTIAKGPSEGPVIRLQIGLEDVADLKKDLEAGFSAAAGV
>Mature_394_residues
TKTNDLRSAAGVNTRLTHGGNDPADCFGFVNPPIVRGSTVLFPDAETLSTEDQKYTYGTHGTPTTDALCNLVNELEGSFG
TILVPSGLAAITVPFLAYLGAGDHALIVDSVYFPTRRFCNTMLKKLGVEVEYYDPAIGAGIEALIRPNTKLVHLEAPGSN
TFEIQDVRLITDIAHRHDCVVTMDNTWATPLYFKPLDFGVDVSIHAATKYPSGHSDVLMGFVSANEKYWKALYQANTNLG
ICVTPDDAYQILRGMRTMGIRLEHHQKSALDIAQWLEGRDDVVRVLHPALPSFAGHELWKRDFKGASGVFSFVLKAEEGK
YKQTASAFLDALTFFGLGYSWGGYESLAVSVSLVDRTIAKGPSEGPVIRLQIGLEDVADLKKDLEAGFSAAAGV

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=338, Percent_Identity=36.094674556213, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI299473759, Length=243, Percent_Identity=37.4485596707819, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI25453487, Length=337, Percent_Identity=32.0474777448071, Blast_Score=149, Evalue=3e-36,
Organism=Escherichia coli, GI1789383, Length=390, Percent_Identity=42.8205128205128, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1790375, Length=378, Percent_Identity=33.0687830687831, Blast_Score=179, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17538055, Length=375, Percent_Identity=34.6666666666667, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI17560056, Length=368, Percent_Identity=35.054347826087, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI71980708, Length=386, Percent_Identity=30.0518134715026, Blast_Score=193, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6321170, Length=336, Percent_Identity=44.6428571428571, Blast_Score=308, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6319307, Length=392, Percent_Identity=29.3367346938776, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323333, Length=408, Percent_Identity=24.7549019607843, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321904, Length=391, Percent_Identity=25.5754475703325, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321254, Length=378, Percent_Identity=26.4550264550265, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI19922554, Length=394, Percent_Identity=36.8020304568528, Blast_Score=231, Evalue=7e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42938; Mature: 42807

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTNDLRSAAGVNTRLTHGGNDPADCFGFVNPPIVRGSTVLFPDAETLSTEDQKYTYGT
CCCCCCHHHHCCCCCEEECCCCCHHHHHCCCCCCEECCCEEEECCCHHCCCCCCCEEECC
HGTPTTDALCNLVNELEGSFGTILVPSGLAAITVPFLAYLGAGDHALIVDSVYFPTRRFC
CCCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCCCEEEEECHHCCHHHHH
NTMLKKLGVEVEYYDPAIGAGIEALIRPNTKLVHLEAPGSNTFEIQDVRLITDIAHRHDC
HHHHHHHCCEEEEECCCCCCCHHEEECCCCEEEEEECCCCCCEEEEHHHHHHHHHHCCCE
VVTMDNTWATPLYFKPLDFGVDVSIHAATKYPSGHSDVLMGFVSANEKYWKALYQANTNL
EEEECCCCCCCEEEECCCCCCEEEEEEEECCCCCCHHHEEEEHHCCHHHHHHHHHCCCCE
GICVTPDDAYQILRGMRTMGIRLEHHQKSALDIAQWLEGRDDVVRVLHPALPSFAGHELW
EEEECCHHHHHHHHHHHHHCEEEECHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHH
KRDFKGASGVFSFVLKAEEGKYKQTASAFLDALTFFGLGYSWGGYESLAVSVSLVDRTIA
HHHCCCCHHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEHHHHHHHHH
KGPSEGPVIRLQIGLEDVADLKKDLEAGFSAAAGV
CCCCCCCEEEEEECHHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
TKTNDLRSAAGVNTRLTHGGNDPADCFGFVNPPIVRGSTVLFPDAETLSTEDQKYTYGT
CCCCCHHHHCCCCCEEECCCCCHHHHHCCCCCCEECCCEEEECCCHHCCCCCCCEEECC
HGTPTTDALCNLVNELEGSFGTILVPSGLAAITVPFLAYLGAGDHALIVDSVYFPTRRFC
CCCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCCCEEEEECHHCCHHHHH
NTMLKKLGVEVEYYDPAIGAGIEALIRPNTKLVHLEAPGSNTFEIQDVRLITDIAHRHDC
HHHHHHHCCEEEEECCCCCCCHHEEECCCCEEEEEECCCCCCEEEEHHHHHHHHHHCCCE
VVTMDNTWATPLYFKPLDFGVDVSIHAATKYPSGHSDVLMGFVSANEKYWKALYQANTNL
EEEECCCCCCCEEEECCCCCCEEEEEEEECCCCCCHHHEEEEHHCCHHHHHHHHHCCCCE
GICVTPDDAYQILRGMRTMGIRLEHHQKSALDIAQWLEGRDDVVRVLHPALPSFAGHELW
EEEECCHHHHHHHHHHHHHCEEEECHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHH
KRDFKGASGVFSFVLKAEEGKYKQTASAFLDALTFFGLGYSWGGYESLAVSVSLVDRTIA
HHHCCCCHHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEHHHHHHHHH
KGPSEGPVIRLQIGLEDVADLKKDLEAGFSAAAGV
CCCCCCCEEEEEECHHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]