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The map label for this gene is fghA [H]

Identifier: 15888800

GI number: 15888800

Start: 1469404

End: 1470237

Strand: Reverse

Name: fghA [H]

Synonym: Atu1476

Alternate gene names: 15888800

Gene position: 1470237-1469404 (Counterclockwise)

Preceding gene: 15888801

Following gene: 15888793

Centisome position: 51.74

GC content: 58.03

Gene sequence:

>834_bases
ATGAACATCATTTCGCAGAATACGGCCTTTGGCGGCATGCAGGGCGTTTTTTCGCACCAATCCGAAACGCTCAAAAGCGA
GATGACCTTCGCAGTCTATGTGCCGCCGAAGGCGATCCATGAGCCCTGCCCGGTTGTCTGGTATCTCTCCGGCCTCACCT
GCACCCATGCCAATGTCATGGAAAAGGGCGAATATCGCCGCATGGCGTCTGAACTGGGTTTGGTCGTCGTCTGCCCGGAT
ACCAGCCCACGCGGCAATGACGTGCCGGATGAGCTGACCAACTGGCAGATGGGCAAGGGCGCCGGTTTTTATCTCGACGC
CACCGAGGAGCCCTGGTCGGAGCATTACCAGATGTACAGCTATGTGACGGAAGAGCTGCCTGCCCTCATCGGCCAGCATT
TTCGCGCCGATATGAGCCGCCAGTCCATTTTCGGCCATTCGATGGGCGGTCATGGTGCTATGACGATTGCGCTGAAAAAC
CCCGAGCGTTTCAAGAGCTGCTCGGCTTTTGCACCCATCGTTGCCCCCTCTTCGGCCGACTGGTCGGAACCGGCGCTGGA
GAAATATCTCGGTGCTGACAGGGCCGCATGGCGTCGCTATGACGCCTGCTCGCTGGTCGAGGATGGCGCACGGTTTCCCG
AGTTCCTGATCGACCAGGGCAAGGCCGATAGTTTCCTGGAAAAAGGCCTGCGCCCCTGGCTGTTCGAAGAGGCGATCAAG
GGCACAGATATCGGCCTGACGCTGCGCATGCATGATCGTTACGACCACTCCTATTATTTCATCTCCACTTTCATGGATGA
CCATCTGAAGTGGCATGCGGAGCGGCTTGGCTAA

Upstream 100 bases:

>100_bases
ATCGTTTCTTTTTTCTTCAACACGGTTCTGGTCGCGGCGGCGGTCAATGCCGCGGTCTCGCTTGCGGGCTGAACCGAAAT
TTTCTTAAGGGAATGGCTTC

Downstream 100 bases:

>100_bases
GGCTGGAGAAACAGGCCGGCGGCGCCCTGTGAGCGCCGCCGTTTCCGTCTTGATCCGGCGTCACGGGATGCGGGCAATGA
CCTTTATCTCGAAATCGAAG

Product: esterase D

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MNIISQNTAFGGMQGVFSHQSETLKSEMTFAVYVPPKAIHEPCPVVWYLSGLTCTHANVMEKGEYRRMASELGLVVVCPD
TSPRGNDVPDELTNWQMGKGAGFYLDATEEPWSEHYQMYSYVTEELPALIGQHFRADMSRQSIFGHSMGGHGAMTIALKN
PERFKSCSAFAPIVAPSSADWSEPALEKYLGADRAAWRRYDACSLVEDGARFPEFLIDQGKADSFLEKGLRPWLFEEAIK
GTDIGLTLRMHDRYDHSYYFISTFMDDHLKWHAERLG

Sequences:

>Translated_277_residues
MNIISQNTAFGGMQGVFSHQSETLKSEMTFAVYVPPKAIHEPCPVVWYLSGLTCTHANVMEKGEYRRMASELGLVVVCPD
TSPRGNDVPDELTNWQMGKGAGFYLDATEEPWSEHYQMYSYVTEELPALIGQHFRADMSRQSIFGHSMGGHGAMTIALKN
PERFKSCSAFAPIVAPSSADWSEPALEKYLGADRAAWRRYDACSLVEDGARFPEFLIDQGKADSFLEKGLRPWLFEEAIK
GTDIGLTLRMHDRYDHSYYFISTFMDDHLKWHAERLG
>Mature_277_residues
MNIISQNTAFGGMQGVFSHQSETLKSEMTFAVYVPPKAIHEPCPVVWYLSGLTCTHANVMEKGEYRRMASELGLVVVCPD
TSPRGNDVPDELTNWQMGKGAGFYLDATEEPWSEHYQMYSYVTEELPALIGQHFRADMSRQSIFGHSMGGHGAMTIALKN
PERFKSCSAFAPIVAPSSADWSEPALEKYLGADRAAWRRYDACSLVEDGARFPEFLIDQGKADSFLEKGLRPWLFEEAIK
GTDIGLTLRMHDRYDHSYYFISTFMDDHLKWHAERLG

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=276, Percent_Identity=53.2608695652174, Blast_Score=292, Evalue=2e-79,
Organism=Escherichia coli, GI1786551, Length=277, Percent_Identity=45.8483754512635, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI1788477, Length=278, Percent_Identity=46.4028776978417, Blast_Score=247, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI17510185, Length=281, Percent_Identity=46.6192170818505, Blast_Score=253, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6322393, Length=298, Percent_Identity=41.2751677852349, Blast_Score=226, Evalue=3e-60,
Organism=Drosophila melanogaster, GI45551932, Length=277, Percent_Identity=46.5703971119134, Blast_Score=257, Evalue=6e-69,
Organism=Drosophila melanogaster, GI24648347, Length=277, Percent_Identity=46.5703971119134, Blast_Score=256, Evalue=9e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31269; Mature: 31269

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIISQNTAFGGMQGVFSHQSETLKSEMTFAVYVPPKAIHEPCPVVWYLSGLTCTHANVM
CCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEEECHHHHCCCCCEEEEECCCEECHHHHH
EKGEYRRMASELGLVVVCPDTSPRGNDVPDELTNWQMGKGAGFYLDATEEPWSEHYQMYS
HHHHHHHHHHHCCEEEEECCCCCCCCCCCHHHHCCCCCCCCCEEEECCCCCHHHHHHHHH
YVTEELPALIGQHFRADMSRQSIFGHSMGGHGAMTIALKNPERFKSCSAFAPIVAPSSAD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHCCCCEECCCCCC
WSEPALEKYLGADRAAWRRYDACSLVEDGARFPEFLIDQGKADSFLEKGLRPWLFEEAIK
CCCHHHHHHHCCCHHHHHHCCHHHHHHCCCCCCHHHHCCCCCHHHHHHCCCHHHHHHHHC
GTDIGLTLRMHDRYDHSYYFISTFMDDHLKWHAERLG
CCCCEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIISQNTAFGGMQGVFSHQSETLKSEMTFAVYVPPKAIHEPCPVVWYLSGLTCTHANVM
CCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEEECHHHHCCCCCEEEEECCCEECHHHHH
EKGEYRRMASELGLVVVCPDTSPRGNDVPDELTNWQMGKGAGFYLDATEEPWSEHYQMYS
HHHHHHHHHHHCCEEEEECCCCCCCCCCCHHHHCCCCCCCCCEEEECCCCCHHHHHHHHH
YVTEELPALIGQHFRADMSRQSIFGHSMGGHGAMTIALKNPERFKSCSAFAPIVAPSSAD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHCCCCEECCCCCC
WSEPALEKYLGADRAAWRRYDACSLVEDGARFPEFLIDQGKADSFLEKGLRPWLFEEAIK
CCCHHHHHHHCCCHHHHHHCCHHHHHHCCCCCCHHHHCCCCCHHHHHHCCCHHHHHHHHC
GTDIGLTLRMHDRYDHSYYFISTFMDDHLKWHAERLG
CCCCEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]