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The map label for this gene is ntrC [H]

Identifier: 15888771

GI number: 15888771

Start: 1439299

End: 1440750

Strand: Direct

Name: ntrC [H]

Synonym: Atu1446

Alternate gene names: 15888771

Gene position: 1439299-1440750 (Clockwise)

Preceding gene: 15888770

Following gene: 15888772

Centisome position: 50.65

GC content: 61.57

Gene sequence:

>1452_bases
ATGACAGCTACGATCCTCGTCGCCGATGATGATGCCGCAATCCGCACGGTGCTGAACCAGGCGCTCAGCCGTGCCGGTTA
TGACGTGCGCATCACCTCCAATGCCGCAACGCTTTGGCGCTGGGTGTCGGCGGGTGAGGGCGATCTCGTCGTGACCGATG
TTGTGATGCCGGATGAAAACGCCTTCGACCTTCTGCCGCGCATCAAGAAGGCCCGCCCGGACCTGCCGGTTCTCGTCATG
AGCGCGCAGAACACCTTCATGACGGCCATCAAGGCTTCGGAAAAGGGCGCTTATGATTATCTGCCCAAGCCCTTCGACCT
GACGGAACTGATCGCCATCATCGGCCGCGCGCTCTCCGAGCCGAAGCGCAAGCCCGCCAAGCTCGATGACGACATGCAGG
ACGGCATGCCGCTCGTCGGCCGCTCCGCAGCGATGCAGGAAATCTACCGCGTTCTCGCGCGCCTGATGCAGACCGATCTG
ACGCTGATGATCACGGGTGAATCCGGTACCGGCAAGGAGCTGGTGGCGCGGGCGCTGCATGATTACGGCAAGCGCCGCAA
CGGTCCCTTTGTCGCCATCAATATGGCCGCCATCCCGCGCGACCTGATCGAATCGGAACTGTTCGGCCATGAGAAGGGCG
CCTTCACCGGCGCACAGAACCGTTCCACCGGCCGTTTCGAGCAGGCCGAGGGTGGCACACTGTTCCTAGATGAAATCGGC
GACATGCCGATGGATGCCCAGACGCGTCTGCTGCGTGTGTTGCAGCAGGGCGAATATACGACCGTGGGCGGGCGCACGCC
GATCCGCACCGATGTCCGCATCGTTGCCGCCACCAACAAGGACCTGAAACAGTCGATCAATCAGGGCCTCTTCCGCGAGG
ACCTTTATTATCGCCTCAACGTCGTGCCGTTGCGCCTGCCGCCGCTGCGCGATCGTGCCGAGGATATTCCTGATCTCGTC
CGCCATTTCATCCAGACGGGTGAGAAAGAAGGGCTGGAGGGCAAGCGTTTCGAGACGGAGGCGCTGGAAGTCATGAAGGC
CTATGCCTGGCCGGGCAACGTCCGCGAGTTGGAAAACCTGATCCGCCGCCTGATGGCGCTTTATCCGCAGGAAGTCATCA
CCCGCGAAATCATCGAGCAGGAATTACAGTCGGATGTTCCCGATAGCCCGTTGGACAAGATGGCGGTTCGCACCGGTTCG
CTCACCATTTCGCAGGCTGTCGAGGAGAACATGCGGGATTATTTCGCCAGCTTCGGCGATGGCCTGCCGCCGCCCGGCCT
TTACGACCGCGTGCTGCGCGAACTCGAATATCCGCTGATTCTCGCGGCTCTGACGGCAACCCGCGGCAACCAGATCAAGG
CCGCCGATCTTCTTGGCCTCAACCGCAATACGTTGCGCAAGAAAATCCGCGAGCTCGGCGTTTCCGTCTATCGTAGTTCC
CGCCCCAGCTGA

Upstream 100 bases:

>100_bases
ACAGCCAGAACCACCGCACGACTTTCCGCGTATTGATGCCCGTCTCGCCGGAAGTGGCGCTTGACGACAGCTCTTTGCCG
AACACGACAGGAAATGACAG

Downstream 100 bases:

>100_bases
CAATGTTGACAAGGCCACAGTTGTCGTTGCATTTTCGCCACATTGTGTTGCTTGGAAAACACTAGGAAGGATATAGATTC
GCCTGATGGGGGAGTCTTGC

Product: two component response regulator

Products: NADP; 2 glutathione [C]

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MTATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWVSAGEGDLVVTDVVMPDENAFDLLPRIKKARPDLPVLVM
SAQNTFMTAIKASEKGAYDYLPKPFDLTELIAIIGRALSEPKRKPAKLDDDMQDGMPLVGRSAAMQEIYRVLARLMQTDL
TLMITGESGTGKELVARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQNRSTGRFEQAEGGTLFLDEIG
DMPMDAQTRLLRVLQQGEYTTVGGRTPIRTDVRIVAATNKDLKQSINQGLFREDLYYRLNVVPLRLPPLRDRAEDIPDLV
RHFIQTGEKEGLEGKRFETEALEVMKAYAWPGNVRELENLIRRLMALYPQEVITREIIEQELQSDVPDSPLDKMAVRTGS
LTISQAVEENMRDYFASFGDGLPPPGLYDRVLRELEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIRELGVSVYRSS
RPS

Sequences:

>Translated_483_residues
MTATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWVSAGEGDLVVTDVVMPDENAFDLLPRIKKARPDLPVLVM
SAQNTFMTAIKASEKGAYDYLPKPFDLTELIAIIGRALSEPKRKPAKLDDDMQDGMPLVGRSAAMQEIYRVLARLMQTDL
TLMITGESGTGKELVARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQNRSTGRFEQAEGGTLFLDEIG
DMPMDAQTRLLRVLQQGEYTTVGGRTPIRTDVRIVAATNKDLKQSINQGLFREDLYYRLNVVPLRLPPLRDRAEDIPDLV
RHFIQTGEKEGLEGKRFETEALEVMKAYAWPGNVRELENLIRRLMALYPQEVITREIIEQELQSDVPDSPLDKMAVRTGS
LTISQAVEENMRDYFASFGDGLPPPGLYDRVLRELEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIRELGVSVYRSS
RPS
>Mature_482_residues
TATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWVSAGEGDLVVTDVVMPDENAFDLLPRIKKARPDLPVLVMS
AQNTFMTAIKASEKGAYDYLPKPFDLTELIAIIGRALSEPKRKPAKLDDDMQDGMPLVGRSAAMQEIYRVLARLMQTDLT
LMITGESGTGKELVARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQNRSTGRFEQAEGGTLFLDEIGD
MPMDAQTRLLRVLQQGEYTTVGGRTPIRTDVRIVAATNKDLKQSINQGLFREDLYYRLNVVPLRLPPLRDRAEDIPDLVR
HFIQTGEKEGLEGKRFETEALEVMKAYAWPGNVRELENLIRRLMALYPQEVITREIIEQELQSDVPDSPLDKMAVRTGSL
TISQAVEENMRDYFASFGDGLPPPGLYDRVLRELEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIRELGVSVYRSSR
PS

Specific function: Member of the two-component regulatory system ntrB/ntrC involved in the activation of nitrogen assimilatory genes such as glnA. NtrC is phosphorylated by ntrB and interacts with sigma-54 [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790299, Length=476, Percent_Identity=44.7478991596639, Blast_Score=407, Evalue=1e-115,
Organism=Escherichia coli, GI1788550, Length=486, Percent_Identity=37.6543209876543, Blast_Score=322, Evalue=5e-89,
Organism=Escherichia coli, GI1790437, Length=466, Percent_Identity=40.9871244635193, Blast_Score=317, Evalue=7e-88,
Organism=Escherichia coli, GI1788905, Length=384, Percent_Identity=40.1041666666667, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI87082117, Length=231, Percent_Identity=53.2467532467532, Blast_Score=249, Evalue=4e-67,
Organism=Escherichia coli, GI1789233, Length=338, Percent_Identity=41.7159763313609, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1789087, Length=341, Percent_Identity=41.6422287390029, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI87082152, Length=282, Percent_Identity=40.7801418439716, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI87081872, Length=228, Percent_Identity=46.9298245614035, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1786524, Length=295, Percent_Identity=41.0169491525424, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI1787583, Length=347, Percent_Identity=35.4466858789625, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1789828, Length=291, Percent_Identity=34.020618556701, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87081858, Length=319, Percent_Identity=30.0940438871473, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1786784, Length=108, Percent_Identity=31.4814814814815, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789809, Length=110, Percent_Identity=33.6363636363636, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790552, Length=114, Percent_Identity=38.5964912280702, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR010114
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53918; Mature: 53786

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWVSAGEGDLVVTDVVMPDEN
CCEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCCCEEEEEEECCCCC
AFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIAIIGRALSE
HHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHC
PKRKPAKLDDDMQDGMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVARALH
CCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHH
DYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQNRSTGRFEQAEGGTLFLDEIG
HHHHCCCCCEEEEEHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHC
DMPMDAQTRLLRVLQQGEYTTVGGRTPIRTDVRIVAATNKDLKQSINQGLFREDLYYRLN
CCCCCHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCHHHHHHHHHCHHHHHHHEEEE
VVPLRLPPLRDRAEDIPDLVRHFIQTGEKEGLEGKRFETEALEVMKAYAWPGNVRELENL
EEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHH
IRRLMALYPQEVITREIIEQELQSDVPDSPLDKMAVRTGSLTISQAVEENMRDYFASFGD
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
GLPPPGLYDRVLRELEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIRELGVSVYRSS
CCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCEEHHHHHCCCHHHHHHHHHHHHHHHHHCC
RPS
CCC
>Mature Secondary Structure 
TATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWVSAGEGDLVVTDVVMPDEN
CEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCCCEEEEEEECCCCC
AFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIAIIGRALSE
HHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHC
PKRKPAKLDDDMQDGMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVARALH
CCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHH
DYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQNRSTGRFEQAEGGTLFLDEIG
HHHHCCCCCEEEEEHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHC
DMPMDAQTRLLRVLQQGEYTTVGGRTPIRTDVRIVAATNKDLKQSINQGLFREDLYYRLN
CCCCCHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCHHHHHHHHHCHHHHHHHEEEE
VVPLRLPPLRDRAEDIPDLVRHFIQTGEKEGLEGKRFETEALEVMKAYAWPGNVRELENL
EEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHH
IRRLMALYPQEVITREIIEQELQSDVPDSPLDKMAVRTGSLTISQAVEENMRDYFASFGD
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
GLPPPGLYDRVLRELEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIRELGVSVYRSS
CCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCEEHHHHHCCCHHHHHHHHHHHHHHHHHCC
RPS
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADPH2; oxidized glutathione [C]

Specific reaction: NADPH2 + oxidized glutathione = NADP + 2 glutathione [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2881918; 11481430; 8478331 [H]