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The map label for this gene is lpxA

Identifier: 15888710

GI number: 15888710

Start: 1378412

End: 1379227

Strand: Direct

Name: lpxA

Synonym: Atu1384

Alternate gene names: 15888710

Gene position: 1378412-1379227 (Clockwise)

Preceding gene: 159184740

Following gene: 159184741

Centisome position: 48.51

GC content: 60.54

Gene sequence:

>816_bases
ATGAGCACGATCGCGGCTTCGGCGAAAATCCACCCGACTGCCGTTGTCGAGGATGGCGCAGTCATCGGTGAGAATGTCGT
CATCGGTGCACTTGCCTATGTCGGGCCGAAGGTGACGTTGCATGATGATGTCCGCCTGCACAACCACGCCGTGGTGTCGG
GCCTCACGGTCATCGGTCGCGGATCGGTCGTGCATCCCATGGCAGTCATCGGCGGCACGCCCCAGGCGGTTCGCCATGAT
GGTTCGGAAACAACGCTCGAAATCGGTGAACGCTGCATCATGCGCGAAGGCGTGACGATGAATGCCGGGAGTTCCGATGG
CGGCGGCAAGACCATTGTCGGCGACGACAATCTTTTCCTCGCCAATTCGCATGTGGCGCATGATTGCCGTCTCGGCCGCC
ACATCATCCTGTCCAACAATGTGATGCTGGCTGGCCATGTCACCATCGAGGACCGCGCTATTCTGGGTGGCGGCTGCGCC
GTGCACCAGTTTACCCGCATCGGCCGCCAGGCTTTCATTGGCGGATTGTCTGCGGTCAATTACGACGTCATCCCCTATGG
CATGCTGAATGGCAATCCCGGCATTCTCGGTGGCCTGAACGTCGTCGGCATGACACGCTCTGGCATCGAGCGTGCGGACA
TCCACAAGGTCAGGCGCGTCTACAAGGCGATCTTTGAGGCCGAAGGCACGATCCGCGGCAACGCGGCGGCTATCGATCGT
AACGACTATCTGGATTGCCCGCAGGCGCTCGAAATCATCGATTTCATCGGTGCGGGCAGCGACCGTGCGATTTCTTCGCC
CAACCGGGGCAAGTGA

Upstream 100 bases:

>100_bases
AGCGCGGCAATGTGTTTAAGTTCCATTGCGAAGCGAAGGTCGAAGGCGCGCTCGTGGCGGAAGCCGATGTCGGCGCGATG
ATGATCCCCGAGGGCCAGTA

Downstream 100 bases:

>100_bases
GCCGTGACAGGCGGCGGGCGTCTCGCCATCGTGGCCGGCAGCGGCCAGCTGCCGCTTTATGTGGCGGCGGCGGCCCGGGA
GATGGGCGAGAACCCCTTCA

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MSTIAASAKIHPTAVVEDGAVIGENVVIGALAYVGPKVTLHDDVRLHNHAVVSGLTVIGRGSVVHPMAVIGGTPQAVRHD
GSETTLEIGERCIMREGVTMNAGSSDGGGKTIVGDDNLFLANSHVAHDCRLGRHIILSNNVMLAGHVTIEDRAILGGGCA
VHQFTRIGRQAFIGGLSAVNYDVIPYGMLNGNPGILGGLNVVGMTRSGIERADIHKVRRVYKAIFEAEGTIRGNAAAIDR
NDYLDCPQALEIIDFIGAGSDRAISSPNRGK

Sequences:

>Translated_271_residues
MSTIAASAKIHPTAVVEDGAVIGENVVIGALAYVGPKVTLHDDVRLHNHAVVSGLTVIGRGSVVHPMAVIGGTPQAVRHD
GSETTLEIGERCIMREGVTMNAGSSDGGGKTIVGDDNLFLANSHVAHDCRLGRHIILSNNVMLAGHVTIEDRAILGGGCA
VHQFTRIGRQAFIGGLSAVNYDVIPYGMLNGNPGILGGLNVVGMTRSGIERADIHKVRRVYKAIFEAEGTIRGNAAAIDR
NDYLDCPQALEIIDFIGAGSDRAISSPNRGK
>Mature_270_residues
STIAASAKIHPTAVVEDGAVIGENVVIGALAYVGPKVTLHDDVRLHNHAVVSGLTVIGRGSVVHPMAVIGGTPQAVRHDG
SETTLEIGERCIMREGVTMNAGSSDGGGKTIVGDDNLFLANSHVAHDCRLGRHIILSNNVMLAGHVTIEDRAILGGGCAV
HQFTRIGRQAFIGGLSAVNYDVIPYGMLNGNPGILGGLNVVGMTRSGIERADIHKVRRVYKAIFEAEGTIRGNAAAIDRN
DYLDCPQALEIIDFIGAGSDRAISSPNRGK

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=228, Percent_Identity=45.1754385964912, Blast_Score=190, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_AGRT5 (Q8UFL3)

Other databases:

- EMBL:   AE007869
- PIR:   AH2746
- PIR:   G97527
- RefSeq:   NP_354391.1
- ProteinModelPortal:   Q8UFL3
- SMR:   Q8UFL3
- STRING:   Q8UFL3
- GeneID:   1133422
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1384
- eggNOG:   COG1043
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- PhylomeDB:   Q8UFL3
- ProtClustDB:   PRK05289
- BioCyc:   ATUM176299-1:ATU1384-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 28382; Mature: 28251

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIAASAKIHPTAVVEDGAVIGENVVIGALAYVGPKVTLHDDVRLHNHAVVSGLTVIGR
CCCCCCCCCCCCEEEEECCCEECCCCEEEHHHHHCCEEEEECCCEECCCCCEEEEEEEEC
GSVVHPMAVIGGTPQAVRHDGSETTLEIGERCIMREGVTMNAGSSDGGGKTIVGDDNLFL
CCEECCHHEECCCHHHHHCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCEEEECCCCEEE
ANSHVAHDCRLGRHIILSNNVMLAGHVTIEDRAILGGGCAVHQFTRIGRQAFIGGLSAVN
ECCCCCHHHHCCCEEEEECCEEEEEEEEEECCEEECCCHHHHHHHHHHHHHHHCCCCCCC
YDVIPYGMLNGNPGILGGLNVVGMTRSGIERADIHKVRRVYKAIFEAEGTIRGNAAAIDR
CCEEEEEEECCCCCEEECCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECC
NDYLDCPQALEIIDFIGAGSDRAISSPNRGK
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STIAASAKIHPTAVVEDGAVIGENVVIGALAYVGPKVTLHDDVRLHNHAVVSGLTVIGR
CCCCCCCCCCCEEEEECCCEECCCCEEEHHHHHCCEEEEECCCEECCCCCEEEEEEEEC
GSVVHPMAVIGGTPQAVRHDGSETTLEIGERCIMREGVTMNAGSSDGGGKTIVGDDNLFL
CCEECCHHEECCCHHHHHCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCEEEECCCCEEE
ANSHVAHDCRLGRHIILSNNVMLAGHVTIEDRAILGGGCAVHQFTRIGRQAFIGGLSAVN
ECCCCCHHHHCCCEEEEECCEEEEEEEEEECCEEECCCHHHHHHHHHHHHHHHCCCCCCC
YDVIPYGMLNGNPGILGGLNVVGMTRSGIERADIHKVRRVYKAIFEAEGTIRGNAAAIDR
CCEEEEEEECCCCCEEECCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECC
NDYLDCPQALEIIDFIGAGSDRAISSPNRGK
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194