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The map label for this gene is clpA [C]

Identifier: 15888690

GI number: 15888690

Start: 1358343

End: 1360853

Strand: Direct

Name: clpA [C]

Synonym: Atu1364

Alternate gene names: 15888690

Gene position: 1358343-1360853 (Clockwise)

Preceding gene: 15888689

Following gene: 159185433

Centisome position: 47.8

GC content: 59.46

Gene sequence:

>2511_bases
GTGCCAACTTTTTCCCCAAGTCTCGAGAAGGCGCTGCACCAGGCACTGACCTTTGCGAATGAGCGTCACCACGAATATGC
GACGCTCGAACACCTGCTTCTGGCGCTGATCGACGACGCGGATGCCGCCGCCGTTATGGCTGCCTGCAATGTCGATCTCG
ACGCGCTGCGCAAGACCGTCAGCGATTACGTCGACAATGAACTGACTAACCTCGTCACCGGTTATGACGAGGATTCCAAA
CCCACATCCGGCTTCCAGCGCGTCATCCAGCGCGCCGTCATCCATGTTCAGTCGTCCGGCCGCGAGGAAGTGACTGGCGC
CAATGTGCTTGTGGCCATTTTTGCCGAGCGCGAAAGCCATGCCGCCTATTTCCTGCAGGAACAGGAAATGACCCGTTACG
ATGCGGTCAATTACATCTCTCACGGCATCGGCAAGCGTCCGGGCACGTCGCAGACGCGCGCGCCGCGCGGTGCCGATGAG
CCCGAAAGCGAAAGCAAGCCCAGCCGCGGTAATCCCGAGGAAGACGGATCGTCCGCCAAGAAGCAGCAGGATGCGCTGAA
GGCCTATTGCGTCAACCTCAACGACAAGGCGAGGAACGGCAAGATCGACCCGCTGATCGGCCGTCACGACGAGGTCAATC
GCACCATCCAGATTCTCTGCCGCCGCTCCAAGAACAACCCGCTTTATGTGGGTGATCCGGGCGTGGGCAAGACGGCGATC
GCCGAGGGCCTGGCCAAGCGTATCGTCGAAGGTAAGGTGCCGGAGGCGCTCGCCAATGACACCATCTTCTCGCTCGACAT
GGGCACGCTGCTTGCCGGCACCCGTTATCGCGGTGATTTCGAGGAGCGTCTGAAGCAGGTCGTCAAGGAACTGGAAGAGT
TTCCGGGCGCGGTTCTGTTCATCGATGAAATCCATACCGTCATCGGTGCCGGCGCCACATCCGGCGGCGCGATGGATGCA
TCGAACCTGTTGAAGCCTGCGCTGTCATCGGGTGCTATCCGTTGCATCGGTTCGACCACCTACAAGGAATATCGCCAGTT
CTTCGAAAAGGACCGCGCGCTGGTGCGTCGTTTCCAGAAGATCGACGTCAACGAGCCGTCGATCGATGATGCCATTGCGA
TCATGAAGGGTCTGAAGCCCTATTTCGAGGATTATCATCACCTCAGATATTCCAACGAGGCGATCAAGGCCGCCGTTGAA
TTGTCGGCTCGCTATATCTCCGACCGCAAGCTGCCGGACAAGGCGATCGACGTGATCGACGAGACAGGTGCCGCACAGAT
GCTGCTGCCAGCCTCCAAGCGCCGCAAGCTGATCACCGAACGGGAAATCGAGGCCACCATCGCGACGATGGCCCGCATTC
CGCCGAAGACGGTTTCCAAGGATGACGAGATGGTTCTCGCCAATCTTGAAAAGGAACTGCGCTCGGTCGTTTATGGTCAG
GACATCGCCATCGAGGCGCTGGCGACCGCCATCAAGCTGGCGCGTGCCGGCTTGCGCGAGCCGAACAAGCCGATCGGCTC
CTATGTCTTCTCCGGCCCGACGGGCGTGGGCAAGACGGAAGTGGCCAAGCAGCTTGCCGCCTCGCTCGGTGTCGAGATGC
TGCGCTTCGACATGTCGGAATATATGGAGCGCCATACCGTCTCACGTCTGCTCGGCGCACCTCCCGGTTATGTCGGCTTC
GATCAGGGCGGTCTTTTGACCGACGGCGTCGATCAACATCCACATTCCGTGGTGCTGCTGGACGAAATCGAAAAGGCGCA
TCCTGATATCTACAACATCCTGTTGCAGGTGATGGACCACGGCTCGCTGACCGACCATAACGGCAAGAAGATCGACTTCC
GCAACGTCATCCTGATCATGACGACCAATGCGGGTGCGTCCGAAATGGCGAAATCGGCGATCGGTTTCGGCTCTTCGCGC
CGCACGGGTGAGGATGAAGAGGCGATCAACCGCCTGTTCACGCCGGAGTTCCGCAACCGTCTGGATGCGATCATTCCGTT
CTCGCCGCTGCCAACAGCCGTTATACACAAGGTGGTGCAGAAGTTCGTCATGCAGCTGGAAACCCAGCTCTCCGAACGTA
ACGTCACCTTCGACCTGCATGAGGATGCGATCTCCTGGCTGGCGGAAAAGGGTTACGACGAAAAGATGGGTGCCCGCCCG
CTGTCGCGCGTGATCCAGGAACACATCAAGAAGCCGCTCGCCAATGAAATCCTCTTCGGCAAGCTGAAGAAGGGTGGCGT
CGTCAGTGTCACCGTTGGCAAGAAGGATGACGGCGCCGACGGTCTGATTCTCGAGGTTCTGCCGGAGACCGCGCCCGTGA
AACCGCAGCCGGAAGCCGAGCTGAAGGCGGCGAAATCGCCGGGCAAGCCGAAAGCCAAAGCGAAAACGGCTTCCAAGGCG
GCAAAGACTGCCGATGAGGCTGAGATTCTGGTGGCCGAGGCCGACAAGTCTGATGAGGACAAGCCGCGCCGCAAGACCAA
TACGGTGCCGAAAGTACCGAAGAAGAAGTAG

Upstream 100 bases:

>100_bases
TATGAGGTCGCAGAGACGAAAGTAAGCCAGGTCATGGATTTCGCCCGACAGCACCAGCACCCGCTGCAGTGCGTCATGGA
AAAGAAATGAGGATCGCAAC

Downstream 100 bases:

>100_bases
TCCAGGTCTTTGACCTATAGACGGATGCCGGGCGAGAGCCCGGCATTTTCATGCCTGTCCATTCCTGATGGAATTCAAAT
GCAGACTGCCGAAAGCGACG

Product: ATP-dependent Clp protease, ATP-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 836; Mature: 835

Protein sequence:

>836_residues
MPTFSPSLEKALHQALTFANERHHEYATLEHLLLALIDDADAAAVMAACNVDLDALRKTVSDYVDNELTNLVTGYDEDSK
PTSGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESHAAYFLQEQEMTRYDAVNYISHGIGKRPGTSQTRAPRGADE
PESESKPSRGNPEEDGSSAKKQQDALKAYCVNLNDKARNGKIDPLIGRHDEVNRTIQILCRRSKNNPLYVGDPGVGKTAI
AEGLAKRIVEGKVPEALANDTIFSLDMGTLLAGTRYRGDFEERLKQVVKELEEFPGAVLFIDEIHTVIGAGATSGGAMDA
SNLLKPALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQKIDVNEPSIDDAIAIMKGLKPYFEDYHHLRYSNEAIKAAVE
LSARYISDRKLPDKAIDVIDETGAAQMLLPASKRRKLITEREIEATIATMARIPPKTVSKDDEMVLANLEKELRSVVYGQ
DIAIEALATAIKLARAGLREPNKPIGSYVFSGPTGVGKTEVAKQLAASLGVEMLRFDMSEYMERHTVSRLLGAPPGYVGF
DQGGLLTDGVDQHPHSVVLLDEIEKAHPDIYNILLQVMDHGSLTDHNGKKIDFRNVILIMTTNAGASEMAKSAIGFGSSR
RTGEDEEAINRLFTPEFRNRLDAIIPFSPLPTAVIHKVVQKFVMQLETQLSERNVTFDLHEDAISWLAEKGYDEKMGARP
LSRVIQEHIKKPLANEILFGKLKKGGVVSVTVGKKDDGADGLILEVLPETAPVKPQPEAELKAAKSPGKPKAKAKTASKA
AKTADEAEILVAEADKSDEDKPRRKTNTVPKVPKKK

Sequences:

>Translated_836_residues
MPTFSPSLEKALHQALTFANERHHEYATLEHLLLALIDDADAAAVMAACNVDLDALRKTVSDYVDNELTNLVTGYDEDSK
PTSGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESHAAYFLQEQEMTRYDAVNYISHGIGKRPGTSQTRAPRGADE
PESESKPSRGNPEEDGSSAKKQQDALKAYCVNLNDKARNGKIDPLIGRHDEVNRTIQILCRRSKNNPLYVGDPGVGKTAI
AEGLAKRIVEGKVPEALANDTIFSLDMGTLLAGTRYRGDFEERLKQVVKELEEFPGAVLFIDEIHTVIGAGATSGGAMDA
SNLLKPALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQKIDVNEPSIDDAIAIMKGLKPYFEDYHHLRYSNEAIKAAVE
LSARYISDRKLPDKAIDVIDETGAAQMLLPASKRRKLITEREIEATIATMARIPPKTVSKDDEMVLANLEKELRSVVYGQ
DIAIEALATAIKLARAGLREPNKPIGSYVFSGPTGVGKTEVAKQLAASLGVEMLRFDMSEYMERHTVSRLLGAPPGYVGF
DQGGLLTDGVDQHPHSVVLLDEIEKAHPDIYNILLQVMDHGSLTDHNGKKIDFRNVILIMTTNAGASEMAKSAIGFGSSR
RTGEDEEAINRLFTPEFRNRLDAIIPFSPLPTAVIHKVVQKFVMQLETQLSERNVTFDLHEDAISWLAEKGYDEKMGARP
LSRVIQEHIKKPLANEILFGKLKKGGVVSVTVGKKDDGADGLILEVLPETAPVKPQPEAELKAAKSPGKPKAKAKTASKA
AKTADEAEILVAEADKSDEDKPRRKTNTVPKVPKKK
>Mature_835_residues
PTFSPSLEKALHQALTFANERHHEYATLEHLLLALIDDADAAAVMAACNVDLDALRKTVSDYVDNELTNLVTGYDEDSKP
TSGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESHAAYFLQEQEMTRYDAVNYISHGIGKRPGTSQTRAPRGADEP
ESESKPSRGNPEEDGSSAKKQQDALKAYCVNLNDKARNGKIDPLIGRHDEVNRTIQILCRRSKNNPLYVGDPGVGKTAIA
EGLAKRIVEGKVPEALANDTIFSLDMGTLLAGTRYRGDFEERLKQVVKELEEFPGAVLFIDEIHTVIGAGATSGGAMDAS
NLLKPALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQKIDVNEPSIDDAIAIMKGLKPYFEDYHHLRYSNEAIKAAVEL
SARYISDRKLPDKAIDVIDETGAAQMLLPASKRRKLITEREIEATIATMARIPPKTVSKDDEMVLANLEKELRSVVYGQD
IAIEALATAIKLARAGLREPNKPIGSYVFSGPTGVGKTEVAKQLAASLGVEMLRFDMSEYMERHTVSRLLGAPPGYVGFD
QGGLLTDGVDQHPHSVVLLDEIEKAHPDIYNILLQVMDHGSLTDHNGKKIDFRNVILIMTTNAGASEMAKSAIGFGSSRR
TGEDEEAINRLFTPEFRNRLDAIIPFSPLPTAVIHKVVQKFVMQLETQLSERNVTFDLHEDAISWLAEKGYDEKMGARPL
SRVIQEHIKKPLANEILFGKLKKGGVVSVTVGKKDDGADGLILEVLPETAPVKPQPEAELKAAKSPGKPKAKAKTASKAA
KTADEAEILVAEADKSDEDKPRRKTNTVPKVPKKK

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=367, Percent_Identity=30.7901907356948, Blast_Score=164, Evalue=3e-40,
Organism=Escherichia coli, GI1787109, Length=756, Percent_Identity=57.9365079365079, Blast_Score=903, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=258, Percent_Identity=55.4263565891473, Blast_Score=305, Evalue=9e-84,
Organism=Saccharomyces cerevisiae, GI6320464, Length=322, Percent_Identity=43.4782608695652, Blast_Score=268, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6323002, Length=387, Percent_Identity=38.2428940568475, Blast_Score=251, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 91783; Mature: 91651

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTFSPSLEKALHQALTFANERHHEYATLEHLLLALIDDADAAAVMAACNVDLDALRKTV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHH
SDYVDNELTNLVTGYDEDSKPTSGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESH
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCC
AAYFLQEQEMTRYDAVNYISHGIGKRPGTSQTRAPRGADEPESESKPSRGNPEEDGSSAK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
KQQDALKAYCVNLNDKARNGKIDPLIGRHDEVNRTIQILCRRSKNNPLYVGDPGVGKTAI
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHH
AEGLAKRIVEGKVPEALANDTIFSLDMGTLLAGTRYRGDFEERLKQVVKELEEFPGAVLF
HHHHHHHHHCCCCCHHHHCCCEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
IDEIHTVIGAGATSGGAMDASNLLKPALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQK
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHH
IDVNEPSIDDAIAIMKGLKPYFEDYHHLRYSNEAIKAAVELSARYISDRKLPDKAIDVID
CCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ETGAAQMLLPASKRRKLITEREIEATIATMARIPPKTVSKDDEMVLANLEKELRSVVYGQ
CCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHCCC
DIAIEALATAIKLARAGLREPNKPIGSYVFSGPTGVGKTEVAKQLAASLGVEMLRFDMSE
CHHHHHHHHHHHHHHHHCCCCCCCHHCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YMERHTVSRLLGAPPGYVGFDQGGLLTDGVDQHPHSVVLLDEIEKAHPDIYNILLQVMDH
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHCCHHHHHHHHHHHC
GSLTDHNGKKIDFRNVILIMTTNAGASEMAKSAIGFGSSRRTGEDEEAINRLFTPEFRNR
CCCCCCCCCEEEECCEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHH
LDAIIPFSPLPTAVIHKVVQKFVMQLETQLSERNVTFDLHEDAISWLAEKGYDEKMGARP
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCHHHCCHH
LSRVIQEHIKKPLANEILFGKLKKGGVVSVTVGKKDDGADGLILEVLPETAPVKPQPEAE
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCHH
LKAAKSPGKPKAKAKTASKAAKTADEAEILVAEADKSDEDKPRRKTNTVPKVPKKK
HHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCCCCCCCCC
>Mature Secondary Structure 
PTFSPSLEKALHQALTFANERHHEYATLEHLLLALIDDADAAAVMAACNVDLDALRKTV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHH
SDYVDNELTNLVTGYDEDSKPTSGFQRVIQRAVIHVQSSGREEVTGANVLVAIFAERESH
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCC
AAYFLQEQEMTRYDAVNYISHGIGKRPGTSQTRAPRGADEPESESKPSRGNPEEDGSSAK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
KQQDALKAYCVNLNDKARNGKIDPLIGRHDEVNRTIQILCRRSKNNPLYVGDPGVGKTAI
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCHHHH
AEGLAKRIVEGKVPEALANDTIFSLDMGTLLAGTRYRGDFEERLKQVVKELEEFPGAVLF
HHHHHHHHHCCCCCHHHHCCCEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
IDEIHTVIGAGATSGGAMDASNLLKPALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQK
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHH
IDVNEPSIDDAIAIMKGLKPYFEDYHHLRYSNEAIKAAVELSARYISDRKLPDKAIDVID
CCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ETGAAQMLLPASKRRKLITEREIEATIATMARIPPKTVSKDDEMVLANLEKELRSVVYGQ
CCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHCCC
DIAIEALATAIKLARAGLREPNKPIGSYVFSGPTGVGKTEVAKQLAASLGVEMLRFDMSE
CHHHHHHHHHHHHHHHHCCCCCCCHHCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YMERHTVSRLLGAPPGYVGFDQGGLLTDGVDQHPHSVVLLDEIEKAHPDIYNILLQVMDH
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHCCHHHHHHHHHHHC
GSLTDHNGKKIDFRNVILIMTTNAGASEMAKSAIGFGSSRRTGEDEEAINRLFTPEFRNR
CCCCCCCCCEEEECCEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHH
LDAIIPFSPLPTAVIHKVVQKFVMQLETQLSERNVTFDLHEDAISWLAEKGYDEKMGARP
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCHHHCCHH
LSRVIQEHIKKPLANEILFGKLKKGGVVSVTVGKKDDGADGLILEVLPETAPVKPQPEAE
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCHH
LKAAKSPGKPKAKAKTASKAAKTADEAEILVAEADKSDEDKPRRKTNTVPKVPKKK
HHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]