Click here to switch to the map view.

The map label for this gene is pyrC [H]

Identifier: 15888632

GI number: 15888632

Start: 1298997

End: 1300289

Strand: Reverse

Name: pyrC [H]

Synonym: Atu1307

Alternate gene names: 15888632

Gene position: 1300289-1298997 (Counterclockwise)

Preceding gene: 159184703

Following gene: 159184702

Centisome position: 45.76

GC content: 61.56

Gene sequence:

>1293_bases
ATGAGTGCCGTTACCGTTCTCAAGAACCTCCGAATCGTCGACCCCTCCCGCAATCTGGATGAGACCGGCAGTATCGTCAT
CGGAGCCGATGGCACCATTCTCGCCGCCGGCAAGGATGCGCACAATCAAGGCGCGCCTGATGGTGCGACGGTGCGCGACT
GCACGGGTATCGTGGCCGTTCCCGGTCTGGTGGATGCCCGCGTCTTTGTCGGCGAACCCGGCGGCGAACACCGCGAGACC
ATCGAATCCGCCTCGCGCGCGGCAGCGGCCGGCGGTGTCACCAGCATCATCGTGATGCCGGACACCGATCCTGTAATCGA
TGACATCGCGCTGGTCGAATATGTGAAGAAGACGGCCCGCGACAAGGCAATCGTCAATGTCCACCCGGCAGCGGCCCTGA
CCAAGGGCCTCCGCGGCGAGGAAATGACCGAGTTCGGCATGTTGAAGGAAGCCGGTGCGGTGGCCTTCACCAATGGCCGC
AAGGCGCTTTCCGACACGCTGGTGCTGCGCCGCGCCATGACCTATGCCCGCGAACTGGGGGCTGTGATCGCGCTGGAGAC
CCGCGATAAATATATCGGCGGTGGTGATATGAACGAGGGGCTTTTTGCAAGCTGGCTCGGGCTGTCAGGTGTTCCGAAGG
AAGCCGAGATCATTCCGCTGGAGCGTGACCTGCGCATTGCCGGCCTGACGCAGGCGATCTACCACGCCGCCAAGATTTCC
GTACCGGAATCGGCAGAGGCGATCCGTATCGCCCGGCAGCGGGGTGTGAAAGCCACTTGTGGCATTTCCATTAATCATCT
GACGCTCAACGAAAACGATATCGGCGAATACCGTACCTTCTTTAAGCTCTCGCCGCCGCTGCGCGCCGAAGACGACCGCA
AGGCGATGGTGGAGGCGCTGAAGGACGGCACGATCGATATCATAGTTTCTTCGCATGACCCGCAGGATGTCGATACCAAG
CGCCTGCCGTTTTCGGATGCGGCGAGCGGCGCGGTGGGGCTGGAAACCATGCTGGCGGCGGCGCTGCGCCTCTACCACAG
TGGCGAAGTTCCGCTGATGCGGCTGATCGATGCGCTTTCCACCCGCCCGGCGAAGATATTCGGTCTCGACGCTGGAACGC
TTAAAGCCGGTGCGAAGGCCGATATCACGCTGATCGATCTCGATGAGCCATGGCTCGTGGCACGCGACCAACTGGTGTCG
AAATCCAAGAATACGCCGTTCGAGGATGCCCGCTTCAGCGGCCGTGCTGTGGCCACTTATGTGGCTGGCAAAGCCGTTCA
TTCCTTGGCATAA

Upstream 100 bases:

>100_bases
GTCCGCAGAGCGTCATCGAAAGCCAGGTGGAAATGGGGGTTGCCGTGCGCATGGCCGTCATGGAAACCCTGCTTGTCTCG
CAAAACCAGGGTGAGCGCGT

Downstream 100 bases:

>100_bases
GATCACGGCAAGAGATCACGCGGACGGCGCGACAGAGGGGACATTTCAATGAGTGCTTTGACTGACTGGCAGACGGCGCC
TGCCCTTCTCGCGCTGGCAG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSAVTVLKNLRIVDPSRNLDETGSIVIGADGTILAAGKDAHNQGAPDGATVRDCTGIVAVPGLVDARVFVGEPGGEHRET
IESASRAAAAGGVTSIIVMPDTDPVIDDIALVEYVKKTARDKAIVNVHPAAALTKGLRGEEMTEFGMLKEAGAVAFTNGR
KALSDTLVLRRAMTYARELGAVIALETRDKYIGGGDMNEGLFASWLGLSGVPKEAEIIPLERDLRIAGLTQAIYHAAKIS
VPESAEAIRIARQRGVKATCGISINHLTLNENDIGEYRTFFKLSPPLRAEDDRKAMVEALKDGTIDIIVSSHDPQDVDTK
RLPFSDAASGAVGLETMLAAALRLYHSGEVPLMRLIDALSTRPAKIFGLDAGTLKAGAKADITLIDLDEPWLVARDQLVS
KSKNTPFEDARFSGRAVATYVAGKAVHSLA

Sequences:

>Translated_430_residues
MSAVTVLKNLRIVDPSRNLDETGSIVIGADGTILAAGKDAHNQGAPDGATVRDCTGIVAVPGLVDARVFVGEPGGEHRET
IESASRAAAAGGVTSIIVMPDTDPVIDDIALVEYVKKTARDKAIVNVHPAAALTKGLRGEEMTEFGMLKEAGAVAFTNGR
KALSDTLVLRRAMTYARELGAVIALETRDKYIGGGDMNEGLFASWLGLSGVPKEAEIIPLERDLRIAGLTQAIYHAAKIS
VPESAEAIRIARQRGVKATCGISINHLTLNENDIGEYRTFFKLSPPLRAEDDRKAMVEALKDGTIDIIVSSHDPQDVDTK
RLPFSDAASGAVGLETMLAAALRLYHSGEVPLMRLIDALSTRPAKIFGLDAGTLKAGAKADITLIDLDEPWLVARDQLVS
KSKNTPFEDARFSGRAVATYVAGKAVHSLA
>Mature_429_residues
SAVTVLKNLRIVDPSRNLDETGSIVIGADGTILAAGKDAHNQGAPDGATVRDCTGIVAVPGLVDARVFVGEPGGEHRETI
ESASRAAAAGGVTSIIVMPDTDPVIDDIALVEYVKKTARDKAIVNVHPAAALTKGLRGEEMTEFGMLKEAGAVAFTNGRK
ALSDTLVLRRAMTYARELGAVIALETRDKYIGGGDMNEGLFASWLGLSGVPKEAEIIPLERDLRIAGLTQAIYHAAKISV
PESAEAIRIARQRGVKATCGISINHLTLNENDIGEYRTFFKLSPPLRAEDDRKAMVEALKDGTIDIIVSSHDPQDVDTKR
LPFSDAASGAVGLETMLAAALRLYHSGEVPLMRLIDALSTRPAKIFGLDAGTLKAGAKADITLIDLDEPWLVARDQLVSK
SKNTPFEDARFSGRAVATYVAGKAVHSLA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=391, Percent_Identity=28.1329923273657, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1786722, Length=418, Percent_Identity=27.511961722488, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87082175, Length=424, Percent_Identity=25, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193204318, Length=384, Percent_Identity=27.0833333333333, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322218, Length=438, Percent_Identity=24.2009132420091, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24642586, Length=392, Percent_Identity=26.7857142857143, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45610; Mature: 45478

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVTVLKNLRIVDPSRNLDETGSIVIGADGTILAAGKDAHNQGAPDGATVRDCTGIVAV
CCHHHEECCCEEECCCCCCCCCCCEEEECCCEEEECCCCCCCCCCCCCCCHHHCCCEEEC
PGLVDARVFVGEPGGEHRETIESASRAAAAGGVTSIIVMPDTDPVIDDIALVEYVKKTAR
CCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHC
DKAIVNVHPAAALTKGLRGEEMTEFGMLKEAGAVAFTNGRKALSDTLVLRRAMTYARELG
CCEEEEECCHHHHHHCCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCC
AVIALETRDKYIGGGDMNEGLFASWLGLSGVPKEAEIIPLERDLRIAGLTQAIYHAAKIS
CEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCC
VPESAEAIRIARQRGVKATCGISINHLTLNENDIGEYRTFFKLSPPLRAEDDRKAMVEAL
CCCCHHHHHHHHHCCCEEECCEEEEEEEECCCCCCCHHEEEEECCCCCCCCHHHHHHHHH
KDGTIDIIVSSHDPQDVDTKRLPFSDAASGAVGLETMLAAALRLYHSGEVPLMRLIDALS
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
TRPAKIFGLDAGTLKAGAKADITLIDLDEPWLVARDQLVSKSKNTPFEDARFSGRAVATY
CCCCEEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEH
VAGKAVHSLA
HHHHHHHHCC
>Mature Secondary Structure 
SAVTVLKNLRIVDPSRNLDETGSIVIGADGTILAAGKDAHNQGAPDGATVRDCTGIVAV
CHHHEECCCEEECCCCCCCCCCCEEEECCCEEEECCCCCCCCCCCCCCCHHHCCCEEEC
PGLVDARVFVGEPGGEHRETIESASRAAAAGGVTSIIVMPDTDPVIDDIALVEYVKKTAR
CCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHC
DKAIVNVHPAAALTKGLRGEEMTEFGMLKEAGAVAFTNGRKALSDTLVLRRAMTYARELG
CCEEEEECCHHHHHHCCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCC
AVIALETRDKYIGGGDMNEGLFASWLGLSGVPKEAEIIPLERDLRIAGLTQAIYHAAKIS
CEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCC
VPESAEAIRIARQRGVKATCGISINHLTLNENDIGEYRTFFKLSPPLRAEDDRKAMVEAL
CCCCHHHHHHHHHCCCEEECCEEEEEEEECCCCCCCHHEEEEECCCCCCCCHHHHHHHHH
KDGTIDIIVSSHDPQDVDTKRLPFSDAASGAVGLETMLAAALRLYHSGEVPLMRLIDALS
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
TRPAKIFGLDAGTLKAGAKADITLIDLDEPWLVARDQLVSKSKNTPFEDARFSGRAVATY
CCCCEEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEH
VAGKAVHSLA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA