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The map label for this gene is nuoE [H]

Identifier: 15888603

GI number: 15888603

Start: 1259678

End: 1260787

Strand: Direct

Name: nuoE [H]

Synonym: Atu1274

Alternate gene names: 15888603

Gene position: 1259678-1260787 (Clockwise)

Preceding gene: 15888602

Following gene: 15888604

Centisome position: 44.33

GC content: 60.54

Gene sequence:

>1110_bases
ATGTCCGTTCGTCGACTAGCCGAAGATCAGTTCCAGCCCGTGGCATTTGCCTTCAATGCGGATAATACCGCATGGGCGGA
AAAGACGATCCAGAAATACCCCGCGGGACGCCAGCAATCGGCGGTTATCCCGCTGCTCATGCGCGCGCAGGAGCAGGACG
GCTGGGTTACCCGCGCCGCCATCGAAAAAGTCGCAGACATGCTGGATATGGCCTATATCCGTGTTCTTGAGGTGGCGACC
TTCTATACCCAGTTCCAGCTGAAGCCGGTTGGCACGCGTGCCCACGTTCAGGTTTGCGGCACCACGCCCTGCATGCTGCG
CGGTTCCGAAGCGCTGATGGATGTCTGCCGCAAGAAGATCCACCACGATCCGCTGCATACCAATGACAGCGGCACGCTGT
CCTGGGAAGAGGTGGAATGTCAGGGCGCCTGCGTCAACGCGCCGATGGTCATCATCTTCAAGGATGCCTATGAGGACCTG
ACGCCCGAGCGTCTGGAAGAGATCATCGACACATTCGAGGCCGGCAAGGGCGACACGGTCAAGACCGGACCGCAGATCGA
CCGTCACGAGTCGGTCCCGGTCGGCGGCCTGACGACGCTGACGGAAGAGATCAAGCCCGATCGTTCCAATCTCGACAAGC
CGGCTGAACCGCCGGCTGAGGCGGCACCCGTTCCCCCGTCTAATGCCGCCAAGCCGAAGACCGACGCACCGGAAACCGAT
CCGAAGCTGAAAACGCCGGTCACGGAACCGAAGGCTGCTGCGGAAAACGCAAAGGCCGGAGAAAAAGAATCGGCCGGAAA
GGAAGCGGTTGCATCGAAGCCGTCGCTCGAGTCCGCTGATCGTCCCGCTGGCATCGACAAGCCGGCGACCCCAGATGACC
TGAAGCTTATTTCCGGCGTTGGCCCGAAGATCGAAGGCACGCTGAACGGGCTCGGCATCTTCACCTATGCGCAGATCGCC
GCCTGGAAACAGGCTGAATGCGACTGGGTGGATGGATATCTGAATTTCAAAGGCCGTATCGGCCGTGATGACTGGGTCAA
ACAGGCCGAGGCGCTCGCCAAGGGTGGTGAAGCCGAGTATATCAGGGTCTTCGGCAAGAAGCCGCGGTAA

Upstream 100 bases:

>100_bases
ATCGTGTTCATGCAAAAAGACAAGGCGGCTTACGCCTGCGAATTCGTCACGGTGGCGAGATCGCGTTGTGAGACGTTAAA
CTGAAAAGGCGTGAGGAAGT

Downstream 100 bases:

>100_bases
AGGGTGAAGCATGTTAAAAGATCAGGATCGCATCTTTACCAATCTCTACGGCCTCAAGGACAAGTCCCTGAAGGGCGTGA
TGGCGCGCGGCCACTGGGAC

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E 1; NDH-1 subunit E 1 [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MSVRRLAEDQFQPVAFAFNADNTAWAEKTIQKYPAGRQQSAVIPLLMRAQEQDGWVTRAAIEKVADMLDMAYIRVLEVAT
FYTQFQLKPVGTRAHVQVCGTTPCMLRGSEALMDVCRKKIHHDPLHTNDSGTLSWEEVECQGACVNAPMVIIFKDAYEDL
TPERLEEIIDTFEAGKGDTVKTGPQIDRHESVPVGGLTTLTEEIKPDRSNLDKPAEPPAEAAPVPPSNAAKPKTDAPETD
PKLKTPVTEPKAAAENAKAGEKESAGKEAVASKPSLESADRPAGIDKPATPDDLKLISGVGPKIEGTLNGLGIFTYAQIA
AWKQAECDWVDGYLNFKGRIGRDDWVKQAEALAKGGEAEYIRVFGKKPR

Sequences:

>Translated_369_residues
MSVRRLAEDQFQPVAFAFNADNTAWAEKTIQKYPAGRQQSAVIPLLMRAQEQDGWVTRAAIEKVADMLDMAYIRVLEVAT
FYTQFQLKPVGTRAHVQVCGTTPCMLRGSEALMDVCRKKIHHDPLHTNDSGTLSWEEVECQGACVNAPMVIIFKDAYEDL
TPERLEEIIDTFEAGKGDTVKTGPQIDRHESVPVGGLTTLTEEIKPDRSNLDKPAEPPAEAAPVPPSNAAKPKTDAPETD
PKLKTPVTEPKAAAENAKAGEKESAGKEAVASKPSLESADRPAGIDKPATPDDLKLISGVGPKIEGTLNGLGIFTYAQIA
AWKQAECDWVDGYLNFKGRIGRDDWVKQAEALAKGGEAEYIRVFGKKPR
>Mature_368_residues
SVRRLAEDQFQPVAFAFNADNTAWAEKTIQKYPAGRQQSAVIPLLMRAQEQDGWVTRAAIEKVADMLDMAYIRVLEVATF
YTQFQLKPVGTRAHVQVCGTTPCMLRGSEALMDVCRKKIHHDPLHTNDSGTLSWEEVECQGACVNAPMVIIFKDAYEDLT
PERLEEIIDTFEAGKGDTVKTGPQIDRHESVPVGGLTTLTEEIKPDRSNLDKPAEPPAEAAPVPPSNAAKPKTDAPETDP
KLKTPVTEPKAAAENAKAGEKESAGKEAVASKPSLESADRPAGIDKPATPDDLKLISGVGPKIEGTLNGLGIFTYAQIAA
WKQAECDWVDGYLNFKGRIGRDDWVKQAEALAKGGEAEYIRVFGKKPR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=187, Percent_Identity=47.0588235294118, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1788621, Length=164, Percent_Identity=31.0975609756098, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17561328, Length=202, Percent_Identity=41.5841584158416, Blast_Score=157, Evalue=6e-39,
Organism=Drosophila melanogaster, GI18859877, Length=192, Percent_Identity=44.2708333333333, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21355353, Length=204, Percent_Identity=34.3137254901961, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 40223; Mature: 40092

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRRLAEDQFQPVAFAFNADNTAWAEKTIQKYPAGRQQSAVIPLLMRAQEQDGWVTRAA
CCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHH
IEKVADMLDMAYIRVLEVATFYTQFQLKPVGTRAHVQVCGTTPCMLRGSEALMDVCRKKI
HHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEECCCCCCEECCCHHHHHHHHHHH
HHDPLHTNDSGTLSWEEVECQGACVNAPMVIIFKDAYEDLTPERLEEIIDTFEAGKGDTV
CCCCCCCCCCCCEEHHEEEECCEEECCCEEEEECCHHHCCCHHHHHHHHHHHHCCCCCCC
KTGPQIDRHESVPVGGLTTLTEEIKPDRSNLDKPAEPPAEAAPVPPSNAAKPKTDAPETD
CCCCCCCCCCCCCCCCHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PKLKTPVTEPKAAAENAKAGEKESAGKEAVASKPSLESADRPAGIDKPATPDDLKLISGV
CCCCCCCCCCHHHHHCCCCCCHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCC
GPKIEGTLNGLGIFTYAQIAAWKQAECDWVDGYLNFKGRIGRDDWVKQAEALAKGGEAEY
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEECCEEECCCCCCCHHHHHHHHHHHCCCCCEE
IRVFGKKPR
EEEECCCCC
>Mature Secondary Structure 
SVRRLAEDQFQPVAFAFNADNTAWAEKTIQKYPAGRQQSAVIPLLMRAQEQDGWVTRAA
CHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHH
IEKVADMLDMAYIRVLEVATFYTQFQLKPVGTRAHVQVCGTTPCMLRGSEALMDVCRKKI
HHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEECCCCCCEECCCHHHHHHHHHHH
HHDPLHTNDSGTLSWEEVECQGACVNAPMVIIFKDAYEDLTPERLEEIIDTFEAGKGDTV
CCCCCCCCCCCCEEHHEEEECCEEECCCEEEEECCHHHCCCHHHHHHHHHHHHCCCCCCC
KTGPQIDRHESVPVGGLTTLTEEIKPDRSNLDKPAEPPAEAAPVPPSNAAKPKTDAPETD
CCCCCCCCCCCCCCCCHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PKLKTPVTEPKAAAENAKAGEKESAGKEAVASKPSLESADRPAGIDKPATPDDLKLISGV
CCCCCCCCCCHHHHHCCCCCCHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCC
GPKIEGTLNGLGIFTYAQIAAWKQAECDWVDGYLNFKGRIGRDDWVKQAEALAKGGEAEY
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEECCEEECCCCCCCHHHHHHHHHHHCCCCCEE
IRVFGKKPR
EEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]