Click here to switch to the map view.

The map label for this gene is lon [H]

Identifier: 15888590

GI number: 15888590

Start: 1248881

End: 1251298

Strand: Direct

Name: lon [H]

Synonym: Atu1261

Alternate gene names: 15888590

Gene position: 1248881-1251298 (Clockwise)

Preceding gene: 15888589

Following gene: 15888591

Centisome position: 43.95

GC content: 58.93

Gene sequence:

>2418_bases
ATGACGAACATCACGTCTGCGGCATCTGGCGGTACCTATCCGGTACTTCCCCTGCGCGACATTGTCGTTTTCCCGCATAT
GATCGTTCCCCTGTTCGTCGGGCGGGAAAAATCCATTCGTGCGCTCGAGGAAGTCATGGGCTCGGACAAGCAGATCATGC
TTGTCACCCAGATCAACGCCAGCGATGACGATCCGGCTCCCGAGGCCATCCACAAGGTTGGCACGGTCGCCAATGTGCTG
CAGCTTCTGAAGCTTCCTGATGGCACCGTGAAGGTGCTGGTGGAAGGCAAGGGCCGCGCCCAGATCGACAGCTATACCGG
CCGCGAGGATTTCTACGAAGCCTCCGCTACACCGCTGCAGGAACCCGCTGAAGATCCGGTCGAGATCGAGGCGCTGTCGC
GTTCGGTCGTTTCGGAATTCGAGAGCTATGTGAAGCTCAACAAGAAGATTTCGCCCGAGGTTGTCGGCGCTGCCGGCCAG
ATCGACGATTATTCGAAGCTGGCCGATACGGTTGCTTCGCACCTGTCGATCAAGATCACCGAAAAGCAGGAAATGCTTGA
AACCGTCAGCGTGAAGCAGCGGCTTGAAAAGGCGCTCGGCTTCATGGAAGGCGAAATTTCCGTGCTTCAGGTCGAAAAGC
GCATCCGCTCGCGCGTCAAGCGCCAGATGGAGAAGACCCAGCGCGAATATTATCTGAACGAGCAGATGAAGGCGATCCAG
AAGGAACTCGGCGACGGCGAAGACGGCCGTGACGAGATGGCCGAACTGGAAGAGCGCATCGCCAAGACCAAGCTTTCCAA
GGAGGCTAAGGAAAAGGCCGACGCGGAAATGAAGAAGCTGCGCCAGATGAGCCCGATGTCTGCCGAAGCGACCGTCGTGC
GCAACTATCTGGACTGGTTGCTTGGCCTGCCCTGGGGCAAGAAGTCGAAGATCAAGACCGATCTCAATGCCGCCGAGACG
ATCCTCGATCAGGATCACTTCGGTCTGGACAAGGTCAAGGAACGAATCGTCGAGTATCTGGCGGTCCAGGCGCGCGCGAC
CAAGATTCGCGGACCTATCCTGTGCCTCGTTGGTCCTCCCGGCGTCGGCAAGACCTCGCTCGCCAAGTCGATCGCCAAGG
CGACCGGCCGCGAATATGTGCGTATGGCGCTCGGTGGCGTGCGTGACGAAGCGGAAATCCGTGGTCACCGTCGCACCTAT
ATCGGCTCCATGCCGGGCAAGATTGTCCAGTCGATGAAGAAGGCCAAGAAGGCGAACCCGCTCTTCCTGCTCGATGAAAT
CGACAAGATGGGCATGGATTTCCGTGGCGACCCGTCATCTGCGCTTCTGGAGGTTCTCGATCCGGAACAGAACTCCACCT
TCATGGACCACTACCTTGAAGTGGAGTACGACCTGTCCGACGTGATGTTCGTGACCACGGCCAACACGCTGAACATTCCG
GGTCCCCTGATGGACCGTATGGAAGTGATCCGCATCGCCGGCTACACCGAAGACGAAAAGCGCGAAATCGCCAAGCGTCA
TCTGTTGCCAAAGGCGATCAAGGAACATGCCCTGCGTCCGGAAGAGTTCTCGGTCAGCGACGATGCCCTGATGGCCATCA
GCCAGCAGTACACCCGTGAAGCCGGTGTTCGTAATTTTGAACGCGAACTGATGAAGCTTGCCCGCAAGGCGGTGACCGAG
ATCATCAAGGGTAAATCCACGTCGGTTGCGGTCACCGCTGCAAACATCGAGGATTATCTGGGCATTCCGCGGTTCCGCCA
CGGCGAGGCCGAACGCGAGGATCAGGTTGGTGTCGTCACCGGTCTGGCGTGGACGGAAGTCGGCGGTGAGCTGCTCACCA
TCGAAGGCGTGATGATGCCGGGCAAGGGCCGCATGACGGTCACCGGCAACCTCAAGGAAGTGATGAAGGAATCCATTTCC
GCGGCGGCATCCTATGTCCGTTCGCGCGCCGTGGACTTCGGCATCGAGCCGCCGCGCTTCGACAAGAGCGACATCCACGT
TCACGTTCCCGAAGGCGCAACCCCGAAGGACGGACCGTCCGCCGGTGTTGCCATGGCAACCGCCATCGTCTCCATCATGA
CCGGTATTCCGGTCTCGAAGGATGTGGCGATGACAGGCGAGATCACACTGCGTGGTCGCGTGCTGCCGATCGGCGGCCTG
AAGGAAAAGCTGCTTGCGGCCCTGCGCGGCGGCATCAAGAAGGTGCTGATTCCGGAAGAAAACGCCAAGGATCTGGCGGA
GATTCCGGACAATGTGAAGAACGAGATGGAAATCATCCCGGTTTCGCGCATGGGCGAGGTTATCAAGCACGCTCTCATTC
GCCAGCCGGAACCCATCGAGTGGGATGGCAGCATTGAGACGCCTGTTATAGCAACGGTCGAAGGTGTCGACGACGGCAAC
CAGACGATCGCGCATTGA

Upstream 100 bases:

>100_bases
GTGTTTCGAAACTCCACTTTCAGTCTCGAGAAATGAATGTGCCGGATGCCCCCAAGATGTCCGGCAAAGTGTCCCGAAAG
GGACCAGGAAAGGAAATGAT

Downstream 100 bases:

>100_bases
TGGTGCGCATCGTCGCGGGGGCGAGAATCGCCTTTCGCGATGGGCAGTGCATAGAATCAATGCGTTAGGTGTCAGAGCGC
GTGCGCGGCGCTCAGCTCCG

Product: ATP-dependent protease LA

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 805; Mature: 804

Protein sequence:

>805_residues
MTNITSAASGGTYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGSDKQIMLVTQINASDDDPAPEAIHKVGTVANVL
QLLKLPDGTVKVLVEGKGRAQIDSYTGREDFYEASATPLQEPAEDPVEIEALSRSVVSEFESYVKLNKKISPEVVGAAGQ
IDDYSKLADTVASHLSIKITEKQEMLETVSVKQRLEKALGFMEGEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAIQ
KELGDGEDGRDEMAELEERIAKTKLSKEAKEKADAEMKKLRQMSPMSAEATVVRNYLDWLLGLPWGKKSKIKTDLNAAET
ILDQDHFGLDKVKERIVEYLAVQARATKIRGPILCLVGPPGVGKTSLAKSIAKATGREYVRMALGGVRDEAEIRGHRRTY
IGSMPGKIVQSMKKAKKANPLFLLDEIDKMGMDFRGDPSSALLEVLDPEQNSTFMDHYLEVEYDLSDVMFVTTANTLNIP
GPLMDRMEVIRIAGYTEDEKREIAKRHLLPKAIKEHALRPEEFSVSDDALMAISQQYTREAGVRNFERELMKLARKAVTE
IIKGKSTSVAVTAANIEDYLGIPRFRHGEAEREDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLKEVMKESIS
AAASYVRSRAVDFGIEPPRFDKSDIHVHVPEGATPKDGPSAGVAMATAIVSIMTGIPVSKDVAMTGEITLRGRVLPIGGL
KEKLLAALRGGIKKVLIPEENAKDLAEIPDNVKNEMEIIPVSRMGEVIKHALIRQPEPIEWDGSIETPVIATVEGVDDGN
QTIAH

Sequences:

>Translated_805_residues
MTNITSAASGGTYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGSDKQIMLVTQINASDDDPAPEAIHKVGTVANVL
QLLKLPDGTVKVLVEGKGRAQIDSYTGREDFYEASATPLQEPAEDPVEIEALSRSVVSEFESYVKLNKKISPEVVGAAGQ
IDDYSKLADTVASHLSIKITEKQEMLETVSVKQRLEKALGFMEGEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAIQ
KELGDGEDGRDEMAELEERIAKTKLSKEAKEKADAEMKKLRQMSPMSAEATVVRNYLDWLLGLPWGKKSKIKTDLNAAET
ILDQDHFGLDKVKERIVEYLAVQARATKIRGPILCLVGPPGVGKTSLAKSIAKATGREYVRMALGGVRDEAEIRGHRRTY
IGSMPGKIVQSMKKAKKANPLFLLDEIDKMGMDFRGDPSSALLEVLDPEQNSTFMDHYLEVEYDLSDVMFVTTANTLNIP
GPLMDRMEVIRIAGYTEDEKREIAKRHLLPKAIKEHALRPEEFSVSDDALMAISQQYTREAGVRNFERELMKLARKAVTE
IIKGKSTSVAVTAANIEDYLGIPRFRHGEAEREDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLKEVMKESIS
AAASYVRSRAVDFGIEPPRFDKSDIHVHVPEGATPKDGPSAGVAMATAIVSIMTGIPVSKDVAMTGEITLRGRVLPIGGL
KEKLLAALRGGIKKVLIPEENAKDLAEIPDNVKNEMEIIPVSRMGEVIKHALIRQPEPIEWDGSIETPVIATVEGVDDGN
QTIAH
>Mature_804_residues
TNITSAASGGTYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGSDKQIMLVTQINASDDDPAPEAIHKVGTVANVLQ
LLKLPDGTVKVLVEGKGRAQIDSYTGREDFYEASATPLQEPAEDPVEIEALSRSVVSEFESYVKLNKKISPEVVGAAGQI
DDYSKLADTVASHLSIKITEKQEMLETVSVKQRLEKALGFMEGEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAIQK
ELGDGEDGRDEMAELEERIAKTKLSKEAKEKADAEMKKLRQMSPMSAEATVVRNYLDWLLGLPWGKKSKIKTDLNAAETI
LDQDHFGLDKVKERIVEYLAVQARATKIRGPILCLVGPPGVGKTSLAKSIAKATGREYVRMALGGVRDEAEIRGHRRTYI
GSMPGKIVQSMKKAKKANPLFLLDEIDKMGMDFRGDPSSALLEVLDPEQNSTFMDHYLEVEYDLSDVMFVTTANTLNIPG
PLMDRMEVIRIAGYTEDEKREIAKRHLLPKAIKEHALRPEEFSVSDDALMAISQQYTREAGVRNFERELMKLARKAVTEI
IKGKSTSVAVTAANIEDYLGIPRFRHGEAEREDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLKEVMKESISA
AASYVRSRAVDFGIEPPRFDKSDIHVHVPEGATPKDGPSAGVAMATAIVSIMTGIPVSKDVAMTGEITLRGRVLPIGGLK
EKLLAALRGGIKKVLIPEENAKDLAEIPDNVKNEMEIIPVSRMGEVIKHALIRQPEPIEWDGSIETPVIATVEGVDDGNQ
TIAH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=663, Percent_Identity=42.8355957767722, Blast_Score=537, Evalue=1e-152,
Organism=Homo sapiens, GI31377667, Length=774, Percent_Identity=37.3385012919897, Blast_Score=511, Evalue=1e-144,
Organism=Escherichia coli, GI1786643, Length=764, Percent_Identity=64.3979057591623, Blast_Score=990, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=700, Percent_Identity=40.5714285714286, Blast_Score=514, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17556486, Length=543, Percent_Identity=38.8581952117864, Blast_Score=432, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319449, Length=714, Percent_Identity=39.6358543417367, Blast_Score=512, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221513036, Length=664, Percent_Identity=41.7168674698795, Blast_Score=517, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24666867, Length=664, Percent_Identity=41.7168674698795, Blast_Score=516, Evalue=1e-146,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 88751; Mature: 88620

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNITSAASGGTYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGSDKQIMLVTQINA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEECC
SDDDPAPEAIHKVGTVANVLQLLKLPDGTVKVLVEGKGRAQIDSYTGREDFYEASATPLQ
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCHHHHHHCCCCCCC
EPAEDPVEIEALSRSVVSEFESYVKLNKKISPEVVGAAGQIDDYSKLADTVASHLSIKIT
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHEEEEE
EKQEMLETVSVKQRLEKALGFMEGEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAIQ
CHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KELGDGEDGRDEMAELEERIAKTKLSKEAKEKADAEMKKLRQMSPMSAEATVVRNYLDWL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LGLPWGKKSKIKTDLNAAETILDQDHFGLDKVKERIVEYLAVQARATKIRGPILCLVGPP
HCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
GVGKTSLAKSIAKATGREYVRMALGGVRDEAEIRGHRRTYIGSMPGKIVQSMKKAKKANP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCC
LFLLDEIDKMGMDFRGDPSSALLEVLDPEQNSTFMDHYLEVEYDLSDVMFVTTANTLNIP
EEEEECHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHEEEEECCCCEEEEEECCCCCCC
GPLMDRMEVIRIAGYTEDEKREIAKRHLLPKAIKEHALRPEEFSVSDDALMAISQQYTRE
CHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
AGVRNFERELMKLARKAVTEIIKGKSTSVAVTAANIEDYLGIPRFRHGEAEREDQVGVVT
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHCCCCCCCCCCCCCCCCEEEE
GLAWTEVGGELLTIEGVMMPGKGRMTVTGNLKEVMKESISAAASYVRSRAVDFGIEPPRF
CCHHHHCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DKSDIHVHVPEGATPKDGPSAGVAMATAIVSIMTGIPVSKDVAMTGEITLRGRVLPIGGL
CCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECEEEEEEEEEECCCH
KEKLLAALRGGIKKVLIPEENAKDLAEIPDNVKNEMEIIPVSRMGEVIKHALIRQPEPIE
HHHHHHHHHCCCEEEECCCCCCHHHHHCCHHHCCCEEEEEHHHHHHHHHHHHHCCCCCCC
WDGSIETPVIATVEGVDDGNQTIAH
CCCCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TNITSAASGGTYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGSDKQIMLVTQINA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEECC
SDDDPAPEAIHKVGTVANVLQLLKLPDGTVKVLVEGKGRAQIDSYTGREDFYEASATPLQ
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCHHHHHHCCCCCCC
EPAEDPVEIEALSRSVVSEFESYVKLNKKISPEVVGAAGQIDDYSKLADTVASHLSIKIT
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHEEEEE
EKQEMLETVSVKQRLEKALGFMEGEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAIQ
CHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KELGDGEDGRDEMAELEERIAKTKLSKEAKEKADAEMKKLRQMSPMSAEATVVRNYLDWL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LGLPWGKKSKIKTDLNAAETILDQDHFGLDKVKERIVEYLAVQARATKIRGPILCLVGPP
HCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
GVGKTSLAKSIAKATGREYVRMALGGVRDEAEIRGHRRTYIGSMPGKIVQSMKKAKKANP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCC
LFLLDEIDKMGMDFRGDPSSALLEVLDPEQNSTFMDHYLEVEYDLSDVMFVTTANTLNIP
EEEEECHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHEEEEECCCCEEEEEECCCCCCC
GPLMDRMEVIRIAGYTEDEKREIAKRHLLPKAIKEHALRPEEFSVSDDALMAISQQYTRE
CHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
AGVRNFERELMKLARKAVTEIIKGKSTSVAVTAANIEDYLGIPRFRHGEAEREDQVGVVT
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHCCCCCCCCCCCCCCCCEEEE
GLAWTEVGGELLTIEGVMMPGKGRMTVTGNLKEVMKESISAAASYVRSRAVDFGIEPPRF
CCHHHHCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DKSDIHVHVPEGATPKDGPSAGVAMATAIVSIMTGIPVSKDVAMTGEITLRGRVLPIGGL
CCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECEEEEEEEEEECCCH
KEKLLAALRGGIKKVLIPEENAKDLAEIPDNVKNEMEIIPVSRMGEVIKHALIRQPEPIE
HHHHHHHHHCCCEEEECCCCCCHHHHHCCHHHCCCEEEEEHHHHHHHHHHHHHCCCCCCC
WDGSIETPVIATVEGVDDGNQTIAH
CCCCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10762258; 11481430 [H]