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The map label for this gene is cysD [H]

Identifier: 15888581

GI number: 15888581

Start: 1239469

End: 1240752

Strand: Direct

Name: cysD [H]

Synonym: Atu1251

Alternate gene names: 15888581

Gene position: 1239469-1240752 (Clockwise)

Preceding gene: 15888580

Following gene: 15888582

Centisome position: 43.62

GC content: 62.46

Gene sequence:

>1284_bases
ATGTCGAGCAACAATCCCGGATTTTCGACGTTGGCCGTTCACGCCGGTGCGCAGCCTGATCCGACCACCGGCGCGCGCGC
GACGCCGATTTATCAGACGACGGCCTATGCTTTCCGCGATGCCGATCACGCCGCCGCTTTGTTCGGATTGAAAGAGTTCG
GCAATATCTACACCCGCATCATGAACCCCACCCAGGCAGTTCTGGAGGAGCGCGTGGCGGCGCTCGAAGGCGGCACGGCG
GCGCTCGCTGTCGCTTCCGGTCACGCAGCACAATTGCTGGTTTTCCATACGCTCATGCAATCCGGTGATAATTTCGTCGC
GGCCCGCCAGCTTTATGGCGGCTCGATCAACCAGTTCGGCCACGCCTTCAAGGGTTTCGACTGGCAGGTGCGCTGGGCGG
ACGCGGCAGACCCGGCGAGCTTCGAGGCGCAGATCAATGAGCGCACGCGCGCCATCTTCATCGAAAGCCTCGCCAATCCC
GGCGGCACCTTCGTCGATATTGCCGCGATTGCCGATGTCGCCCATCGTCACGGCCTGCCGCTTATCGTCGACAATACCAT
GGCGAGCCCCTATCTGCTGCGGCCGCTGGAACACGGCGCTGACATCGTGCTGCATTCGCTGACGAAATTCCTTGGCGGAC
ACGGCAATTCCATGGGTGGCATCATTGTCGATGGCGGCACCTTCGACTGGTCGGCGACAGACAGATTTCCGGCGCTGTCG
CAGCCGCGGCCGGAATATTCCGGCGTCCTGTTGCACCAGACCTTCGGCAATTTCGCCTTTGCCATCGCCTGCCGCGTTCT
GGGATTGCGTGATCTCGGCCCGGCAATCTCGCCCTTCAACGCCTTCCTTATCCTGACCGGCATCGAGACGCTGCCGCTGC
GCGTTCAGCGCCATTCCGACAATGCACTCGCCGTCGCGAAATGGCTGAAGGCACATCCAAAGGTCGGCTGGGTGCATTAT
GCGGGCCTGGAGGACAGCGACAACCACGCCATCCAGCAGCATTATTCGCCGAAGGGGGCGGGCTCCGTCTTTACCTTCGG
CGTCAAGGGCGGTTATGCCGCCGGCAAGGCGCTGGTGGAGGGGCTGCAGCTTTTCTCCCATCTGGCCAATATCGGCGATA
CGCGCTCGCTCGTCATCCATCCGGCCTCCACCACCCACGCCCAGCTGACACCGGAACAGCAGACGGCAGCCGGCGCCGGG
CCAGACGTGGTGCGCCTGTCGATCGGCATCGAAGACGTCAAGGACATCATCGCCGATCTCGAACAGTCATTTGCCAAGGT
GTGA

Upstream 100 bases:

>100_bases
TATCCGCGTCTCAATATTGCGCGATAGTTGGTACGGATTGCACTTATCATTTGACGCCAAGGCATTATGATCCCTCCAAA
ATTCCAATGGAGGAAACATA

Downstream 100 bases:

>100_bases
GGAGTTTCGTCACGCACGTCTACCCGCGTGACGGCCGACTTGTAACCACGCAGCCGCCGGAAAGCCCCTTGAAAACAAGG
TGTTTTCGGCAGCTGCGACC

Product: O-acetylhomoserine aminocarboxypropyltransferase

Products: NA

Alternate protein names: L-methioninase [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSSNNPGFSTLAVHAGAQPDPTTGARATPIYQTTAYAFRDADHAAALFGLKEFGNIYTRIMNPTQAVLEERVAALEGGTA
ALAVASGHAAQLLVFHTLMQSGDNFVAARQLYGGSINQFGHAFKGFDWQVRWADAADPASFEAQINERTRAIFIESLANP
GGTFVDIAAIADVAHRHGLPLIVDNTMASPYLLRPLEHGADIVLHSLTKFLGGHGNSMGGIIVDGGTFDWSATDRFPALS
QPRPEYSGVLLHQTFGNFAFAIACRVLGLRDLGPAISPFNAFLILTGIETLPLRVQRHSDNALAVAKWLKAHPKVGWVHY
AGLEDSDNHAIQQHYSPKGAGSVFTFGVKGGYAAGKALVEGLQLFSHLANIGDTRSLVIHPASTTHAQLTPEQQTAAGAG
PDVVRLSIGIEDVKDIIADLEQSFAKV

Sequences:

>Translated_427_residues
MSSNNPGFSTLAVHAGAQPDPTTGARATPIYQTTAYAFRDADHAAALFGLKEFGNIYTRIMNPTQAVLEERVAALEGGTA
ALAVASGHAAQLLVFHTLMQSGDNFVAARQLYGGSINQFGHAFKGFDWQVRWADAADPASFEAQINERTRAIFIESLANP
GGTFVDIAAIADVAHRHGLPLIVDNTMASPYLLRPLEHGADIVLHSLTKFLGGHGNSMGGIIVDGGTFDWSATDRFPALS
QPRPEYSGVLLHQTFGNFAFAIACRVLGLRDLGPAISPFNAFLILTGIETLPLRVQRHSDNALAVAKWLKAHPKVGWVHY
AGLEDSDNHAIQQHYSPKGAGSVFTFGVKGGYAAGKALVEGLQLFSHLANIGDTRSLVIHPASTTHAQLTPEQQTAAGAG
PDVVRLSIGIEDVKDIIADLEQSFAKV
>Mature_426_residues
SSNNPGFSTLAVHAGAQPDPTTGARATPIYQTTAYAFRDADHAAALFGLKEFGNIYTRIMNPTQAVLEERVAALEGGTAA
LAVASGHAAQLLVFHTLMQSGDNFVAARQLYGGSINQFGHAFKGFDWQVRWADAADPASFEAQINERTRAIFIESLANPG
GTFVDIAAIADVAHRHGLPLIVDNTMASPYLLRPLEHGADIVLHSLTKFLGGHGNSMGGIIVDGGTFDWSATDRFPALSQ
PRPEYSGVLLHQTFGNFAFAIACRVLGLRDLGPAISPFNAFLILTGIETLPLRVQRHSDNALAVAKWLKAHPKVGWVHYA
GLEDSDNHAIQQHYSPKGAGSVFTFGVKGGYAAGKALVEGLQLFSHLANIGDTRSLVIHPASTTHAQLTPEQQTAAGAGP
DVVRLSIGIEDVKDIIADLEQSFAKV

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG2873

COG function: function code E; O-acetylhomoserine sulfhydrylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=411, Percent_Identity=29.9270072992701, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI299473759, Length=412, Percent_Identity=26.6990291262136, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI25453487, Length=411, Percent_Identity=25.5474452554745, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1790375, Length=416, Percent_Identity=31.4903846153846, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1789383, Length=429, Percent_Identity=23.5431235431235, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71980708, Length=419, Percent_Identity=30.5489260143198, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17560056, Length=411, Percent_Identity=31.3868613138686, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17538055, Length=411, Percent_Identity=29.9270072992701, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6323333, Length=435, Percent_Identity=46.4367816091954, Blast_Score=355, Evalue=7e-99,
Organism=Saccharomyces cerevisiae, GI6319307, Length=426, Percent_Identity=30.5164319248826, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6321254, Length=440, Percent_Identity=26.8181818181818, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6321170, Length=368, Percent_Identity=25.5434782608696, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6321904, Length=435, Percent_Identity=23.6781609195402, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI19922554, Length=425, Percent_Identity=31.0588235294118, Blast_Score=183, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006237
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.11 [H]

Molecular weight: Translated: 45475; Mature: 45344

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNNPGFSTLAVHAGAQPDPTTGARATPIYQTTAYAFRDADHAAALFGLKEFGNIYTRI
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
MNPTQAVLEERVAALEGGTAALAVASGHAAQLLVFHTLMQSGDNFVAARQLYGGSINQFG
CCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEHHHHHCCCHHHHH
HAFKGFDWQVRWADAADPASFEAQINERTRAIFIESLANPGGTFVDIAAIADVAHRHGLP
HHHCCCCEEEEECCCCCCCCHHHHHCCCHHEEEEEHHCCCCCCEEEHHHHHHHHHHCCCC
LIVDNTMASPYLLRPLEHGADIVLHSLTKFLGGHGNSMGGIIVDGGTFDWSATDRFPALS
EEEECCCCCCHHCCHHHCCHHHHHHHHHHHHCCCCCCCCCEEEECCEECCCCCCCCCCCC
QPRPEYSGVLLHQTFGNFAFAIACRVLGLRDLGPAISPFNAFLILTGIETLPLRVQRHSD
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEEECCC
NALAVAKWLKAHPKVGWVHYAGLEDSDNHAIQQHYSPKGAGSVFTFGVKGGYAAGKALVE
CHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHH
GLQLFSHLANIGDTRSLVIHPASTTHAQLTPEQQTAAGAGPDVVRLSIGIEDVKDIIADL
HHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHCCCCCCCEEEEEECHHHHHHHHHHH
EQSFAKV
HHHHHCC
>Mature Secondary Structure 
SSNNPGFSTLAVHAGAQPDPTTGARATPIYQTTAYAFRDADHAAALFGLKEFGNIYTRI
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
MNPTQAVLEERVAALEGGTAALAVASGHAAQLLVFHTLMQSGDNFVAARQLYGGSINQFG
CCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEHHHHHCCCHHHHH
HAFKGFDWQVRWADAADPASFEAQINERTRAIFIESLANPGGTFVDIAAIADVAHRHGLP
HHHCCCCEEEEECCCCCCCCHHHHHCCCHHEEEEEHHCCCCCCEEEHHHHHHHHHHCCCC
LIVDNTMASPYLLRPLEHGADIVLHSLTKFLGGHGNSMGGIIVDGGTFDWSATDRFPALS
EEEECCCCCCHHCCHHHCCHHHHHHHHHHHHCCCCCCCCCEEEECCEECCCCCCCCCCCC
QPRPEYSGVLLHQTFGNFAFAIACRVLGLRDLGPAISPFNAFLILTGIETLPLRVQRHSD
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEEECCC
NALAVAKWLKAHPKVGWVHYAGLEDSDNHAIQQHYSPKGAGSVFTFGVKGGYAAGKALVE
CHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHH
GLQLFSHLANIGDTRSLVIHPASTTHAQLTPEQQTAAGAGPDVVRLSIGIEDVKDIIADL
HHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHCCCCCCCEEEEEECHHHHHHHHHHH
EQSFAKV
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8586629; 9190812; 3365412 [H]