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The map label for this gene is fabH

Identifier: 15888517

GI number: 15888517

Start: 1172561

End: 1173532

Strand: Direct

Name: fabH

Synonym: Atu1179

Alternate gene names: 15888517

Gene position: 1172561-1173532 (Clockwise)

Preceding gene: 15888516

Following gene: 159184652

Centisome position: 41.26

GC content: 61.52

Gene sequence:

>972_bases
ATGATCCGCTCTATAGTCCGTGGTTTCGGGGCAGCGCTGCCGAAGCGTGTCATGACCAACAGTGAAATCGAAGGGGTCGT
AGAGACCTCCGATGAATGGATCGTGCAGCGCACCGGCATCAGGCAACGCTATATCGCCGGCGAAGGTGAAACCACCGCGT
CTCTCGGCGAGGCGGCGGCGCGTGCGGCGCTCGACAATGCCGGTCTGACGCCCGCCGATATCGACCTCATCATTCTGGCC
ACCTCGACCCCGGACAATACCTTTCCGGCAACAGCGGTGAACATACAGAACCGTCTTGGCATGACCCACGGTTTCGCCTT
CGACATGCAGGCCGTCTGCTCCGGTTTCGTTTACGCCGTGGCGACCGCCGATCTCTATATTCGCGGCGGAATGGCCAAGC
GCGTGCTGGTGATAGGCGCCGAAACATTCTCGCGCATTCTCGACTGGAAGGACCGCACCACCTGCGTTCTGTTCGGTGAT
GGCGCTGGCGCACTCGTTATCGAGGCCGGCGAAGGCGAGGGCACTTCCAGCGATCGCGGCATCCTCACCTCGCAGCTGCG
CTCCGACGGTTCGCACAAGGACAAGCTCTACGTCGATGGCGGACCTTCCACAACTGGCACGGTCGGCCATCTGCGCATGG
AAGGCCGGGAAGTGTTCAAGCATGCTGTCGGCATGATCACCGACGTCATCGAGCAGGCCTTCGAGGCGACGGGCACGACG
GCGGACGATCTCGACTGGCTCGTTCCGCATCAGGCCAACAAGCGCATTATCGACGGATCGGCGAAGAAGCTCAATATCGA
TCCGGAAAAGGTCGTCATCACCGTCGACAAACACGGCAATACCTCGGCCGCATCCATTCCGCTGGCGCTTGCAGTCGCGG
CCAGTGACGGCCGTATCAAGAAGGGCGATCTGGTGATGCTGGAGGCCATGGGCGGAGGTTTCACCTGGGGTGCAGTGCTG
CTGCGCTGGTAA

Upstream 100 bases:

>100_bases
GGCCTGACGGCAAAAATTGAAAATGATCTGAAAATTTACCACGCAAGACGGCTTCCGCCCCCGGCGCCCGAAGCTCTCGT
GGCTGACGAGGAATAAGGGA

Downstream 100 bases:

>100_bases
CGGCGTGTTCCCGTCTCTGATGGGGCAGGCGCGAAATCGGTTATGTTTTTCGCGCTCACGCCCCGCTCAGATGGCCCCAA
GCGGCACCAGCCTGTGGCAA

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MIRSIVRGFGAALPKRVMTNSEIEGVVETSDEWIVQRTGIRQRYIAGEGETTASLGEAAARAALDNAGLTPADIDLIILA
TSTPDNTFPATAVNIQNRLGMTHGFAFDMQAVCSGFVYAVATADLYIRGGMAKRVLVIGAETFSRILDWKDRTTCVLFGD
GAGALVIEAGEGEGTSSDRGILTSQLRSDGSHKDKLYVDGGPSTTGTVGHLRMEGREVFKHAVGMITDVIEQAFEATGTT
ADDLDWLVPHQANKRIIDGSAKKLNIDPEKVVITVDKHGNTSAASIPLALAVAASDGRIKKGDLVMLEAMGGGFTWGAVL
LRW

Sequences:

>Translated_323_residues
MIRSIVRGFGAALPKRVMTNSEIEGVVETSDEWIVQRTGIRQRYIAGEGETTASLGEAAARAALDNAGLTPADIDLIILA
TSTPDNTFPATAVNIQNRLGMTHGFAFDMQAVCSGFVYAVATADLYIRGGMAKRVLVIGAETFSRILDWKDRTTCVLFGD
GAGALVIEAGEGEGTSSDRGILTSQLRSDGSHKDKLYVDGGPSTTGTVGHLRMEGREVFKHAVGMITDVIEQAFEATGTT
ADDLDWLVPHQANKRIIDGSAKKLNIDPEKVVITVDKHGNTSAASIPLALAVAASDGRIKKGDLVMLEAMGGGFTWGAVL
LRW
>Mature_323_residues
MIRSIVRGFGAALPKRVMTNSEIEGVVETSDEWIVQRTGIRQRYIAGEGETTASLGEAAARAALDNAGLTPADIDLIILA
TSTPDNTFPATAVNIQNRLGMTHGFAFDMQAVCSGFVYAVATADLYIRGGMAKRVLVIGAETFSRILDWKDRTTCVLFGD
GAGALVIEAGEGEGTSSDRGILTSQLRSDGSHKDKLYVDGGPSTTGTVGHLRMEGREVFKHAVGMITDVIEQAFEATGTT
ADDLDWLVPHQANKRIIDGSAKKLNIDPEKVVITVDKHGNTSAASIPLALAVAASDGRIKKGDLVMLEAMGGGFTWGAVL
LRW

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=317, Percent_Identity=46.3722397476341, Blast_Score=288, Evalue=4e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_AGRT5 (Q8UG62)

Other databases:

- EMBL:   AE007869
- PIR:   AI2721
- PIR:   F97503
- RefSeq:   NP_354198.1
- ProteinModelPortal:   Q8UG62
- SMR:   Q8UG62
- STRING:   Q8UG62
- GeneID:   1133217
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1179
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   ICATSTP
- PhylomeDB:   Q8UG62
- ProtClustDB:   PRK09352
- BioCyc:   ATUM176299-1:ATU1179-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 34278; Mature: 34278

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: ACT_SITE 113-113 ACT_SITE 250-250 ACT_SITE 280-280

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRSIVRGFGAALPKRVMTNSEIEGVVETSDEWIVQRTGIRQRYIAGEGETTASLGEAAA
CHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCEEEECCCCCCHHHHHHHHH
RAALDNAGLTPADIDLIILATSTPDNTFPATAVNIQNRLGMTHGFAFDMQAVCSGFVYAV
HHHHCCCCCCCCCEEEEEEEECCCCCCCCCEEEEHHHHCCCCCCCCCCHHHHHHHHEEEE
ATADLYIRGGMAKRVLVIGAETFSRILDWKDRTTCVLFGDGAGALVIEAGEGEGTSSDRG
EEEEEEEECCCEEEEEEEEHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCC
ILTSQLRSDGSHKDKLYVDGGPSTTGTVGHLRMEGREVFKHAVGMITDVIEQAFEATGTT
HHHHHHHCCCCCCCEEEECCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCC
ADDLDWLVPHQANKRIIDGSAKKLNIDPEKVVITVDKHGNTSAASIPLALAVAASDGRIK
CCCCCEECCCCCCCEEECCCCCEECCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCEE
KGDLVMLEAMGGGFTWGAVLLRW
CCCEEEEEECCCCEEEHEEEECC
>Mature Secondary Structure
MIRSIVRGFGAALPKRVMTNSEIEGVVETSDEWIVQRTGIRQRYIAGEGETTASLGEAAA
CHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCEEEECCCCCCHHHHHHHHH
RAALDNAGLTPADIDLIILATSTPDNTFPATAVNIQNRLGMTHGFAFDMQAVCSGFVYAV
HHHHCCCCCCCCCEEEEEEEECCCCCCCCCEEEEHHHHCCCCCCCCCCHHHHHHHHEEEE
ATADLYIRGGMAKRVLVIGAETFSRILDWKDRTTCVLFGDGAGALVIEAGEGEGTSSDRG
EEEEEEEECCCEEEEEEEEHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCC
ILTSQLRSDGSHKDKLYVDGGPSTTGTVGHLRMEGREVFKHAVGMITDVIEQAFEATGTT
HHHHHHHCCCCCCCEEEECCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCC
ADDLDWLVPHQANKRIIDGSAKKLNIDPEKVVITVDKHGNTSAASIPLALAVAASDGRIK
CCCCCEECCCCCCCEEECCCCCEECCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCEE
KGDLVMLEAMGGGFTWGAVLLRW
CCCEEEEEECCCCEEEHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194