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The map label for this gene is ppx [H]

Identifier: 15888482

GI number: 15888482

Start: 1135169

End: 1136692

Strand: Direct

Name: ppx [H]

Synonym: Atu1145

Alternate gene names: 15888482

Gene position: 1135169-1136692 (Clockwise)

Preceding gene: 159184636

Following gene: 15888491

Centisome position: 39.95

GC content: 60.04

Gene sequence:

>1524_bases
ATGACTCGATCAGAAGCACAGGGGCGGCTGACCGGCCTTGCCCCCGTTTCCGTCATAGATATTGGTTCGAACTCCGTTCG
TCTTGTCGTATATGAAGGTCTTTCCCGCGCGCCCGCGGTGCTGTTCAACGAAAAGGTCCTGTGCGGCCTTGGCAAGGGAC
TGGCGCTGACGGGCCGCATGCATGAGGAAGGCGTCACCCGGGCGCTGATGGCACTCAGGCGCTTCCATGTGCTTTCCGAA
CAGGCGCAGGCGCAGAAGCTTTATGTGCTTGCCACGGCGGCGGCGCGCGAGGCGGAAAACGGCCCGGATTTCATCCGCGA
GGCCGAAGCCATTCTCGGCTGCGAGATCGAGGTGCTCTCAGGCGAGAAGGAAGCGCTTTATTCGGCCTATGGCGTGATCA
GCGGTTTTTATCAACCCGATGGCATCGCCGGCGACCTTGGCGGCGGTTCACTCGAACTCATCGACATCAAGGACAAGAGC
TGCGGCGAGGGCATCACCCTGCCGCTCGGTGGCCTTCGGCTATCGGAACAATCGGACGGTTCGCTGGAAAAGGCGGCCAC
GATCGCCAGAAAACACGTCAAATCCTTCGCGAAGCTTCTGGCGGCGGGCGAGGGGCGCACCTTTTATGCGGTCGGTGGTA
CATGGCGAAACATCGCCAAGCTGCATATGGAGATTTCAGGCTATCCACTGCATATGATGCAGGGGTATGAATTGCCGCTG
GAAGAAATGCTGAATTTTCTCGAGGAGGTCATCGTCTCCCGGGATAGCAAGGATCCGGCCTGGCAGGCGGTCTCCAAGAA
CCGCCGTTCGCTCCTGCCATTTGGCGCCATCGCCATGCGGGAAGTTCTGAGAGCGATGAAGCCGGCCAAGATTGCCTTCT
CCGCGCAGGGCGTGCGTGAAGGGTATCTTTATTCGCTGCTGACGGAAGCCGAGCGCGAATCCGATCCGCTGCTGGTCGCG
GCGGATGAGCTTGCCATTTTGCGCGCCCGTTCGCCCGAACATGCGCGCGAACTGGCGGATTGGAGCGGTCGCACCTTTCC
TGTCTTCGGTATCGACGAGACGGAAGAAGAAAGCCGCTACAGGCAGGCGGCCTGCCTGCTGGCCGATATCAGCTGGCGGG
CGCATCCCGATTATCGCGGGTTGCAGGCGCTCAACATCATCGCCCATTCGTCTTTCGTTGCGATCACCCATCCCGGCCGC
GCCTATATTGCGCTTGCCAATTATTATCGCTTTGAGGGCCTGAACGATAACGGCACGACGGAACCGCTCGCCGCCATGGC
GGGCGAACGTCTGCAGGAACTCGGCAAGCTGCTGGGCGGCCTGCTGCGCGTCGTTTACCTCTTCTCAGCCTCGATGCCTG
GTGTCGTTGACCACCTGAAATTCCGCAAATCCGACAACCCCGATATAGATCTGGAATTCGTGGTGCCGCATGATTATTGC
GATTTCGCCGGCGAGCGGCTGGATGGCCGTTTGCAACAGTTGGCGAAGCTGACGGGCAAGCGGCTGGCCTTTGTGTTTGA
GTAA

Upstream 100 bases:

>100_bases
TCATGACCAATCCCAGCCTTTCCGGACGTGGTGAAGCCTTGAAATCCAGTGCGCCCAAATTGATTGCCGGGTTGATTTCG
TCCCGCAAGAAACAGGCTGA

Downstream 100 bases:

>100_bases
CGAACGGCAATGCCCTGTTTTGCGGCGCTGGCTACGACCAGCGCTCGCAAAAGGCTTCGATATCTCCTGACTGGAAGTCG
GCGAGCCGCGCCATGATCGT

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MTRSEAQGRLTGLAPVSVIDIGSNSVRLVVYEGLSRAPAVLFNEKVLCGLGKGLALTGRMHEEGVTRALMALRRFHVLSE
QAQAQKLYVLATAAAREAENGPDFIREAEAILGCEIEVLSGEKEALYSAYGVISGFYQPDGIAGDLGGGSLELIDIKDKS
CGEGITLPLGGLRLSEQSDGSLEKAATIARKHVKSFAKLLAAGEGRTFYAVGGTWRNIAKLHMEISGYPLHMMQGYELPL
EEMLNFLEEVIVSRDSKDPAWQAVSKNRRSLLPFGAIAMREVLRAMKPAKIAFSAQGVREGYLYSLLTEAERESDPLLVA
ADELAILRARSPEHARELADWSGRTFPVFGIDETEEESRYRQAACLLADISWRAHPDYRGLQALNIIAHSSFVAITHPGR
AYIALANYYRFEGLNDNGTTEPLAAMAGERLQELGKLLGGLLRVVYLFSASMPGVVDHLKFRKSDNPDIDLEFVVPHDYC
DFAGERLDGRLQQLAKLTGKRLAFVFE

Sequences:

>Translated_507_residues
MTRSEAQGRLTGLAPVSVIDIGSNSVRLVVYEGLSRAPAVLFNEKVLCGLGKGLALTGRMHEEGVTRALMALRRFHVLSE
QAQAQKLYVLATAAAREAENGPDFIREAEAILGCEIEVLSGEKEALYSAYGVISGFYQPDGIAGDLGGGSLELIDIKDKS
CGEGITLPLGGLRLSEQSDGSLEKAATIARKHVKSFAKLLAAGEGRTFYAVGGTWRNIAKLHMEISGYPLHMMQGYELPL
EEMLNFLEEVIVSRDSKDPAWQAVSKNRRSLLPFGAIAMREVLRAMKPAKIAFSAQGVREGYLYSLLTEAERESDPLLVA
ADELAILRARSPEHARELADWSGRTFPVFGIDETEEESRYRQAACLLADISWRAHPDYRGLQALNIIAHSSFVAITHPGR
AYIALANYYRFEGLNDNGTTEPLAAMAGERLQELGKLLGGLLRVVYLFSASMPGVVDHLKFRKSDNPDIDLEFVVPHDYC
DFAGERLDGRLQQLAKLTGKRLAFVFE
>Mature_506_residues
TRSEAQGRLTGLAPVSVIDIGSNSVRLVVYEGLSRAPAVLFNEKVLCGLGKGLALTGRMHEEGVTRALMALRRFHVLSEQ
AQAQKLYVLATAAAREAENGPDFIREAEAILGCEIEVLSGEKEALYSAYGVISGFYQPDGIAGDLGGGSLELIDIKDKSC
GEGITLPLGGLRLSEQSDGSLEKAATIARKHVKSFAKLLAAGEGRTFYAVGGTWRNIAKLHMEISGYPLHMMQGYELPLE
EMLNFLEEVIVSRDSKDPAWQAVSKNRRSLLPFGAIAMREVLRAMKPAKIAFSAQGVREGYLYSLLTEAERESDPLLVAA
DELAILRARSPEHARELADWSGRTFPVFGIDETEEESRYRQAACLLADISWRAHPDYRGLQALNIIAHSSFVAITHPGRA
YIALANYYRFEGLNDNGTTEPLAAMAGERLQELGKLLGGLLRVVYLFSASMPGVVDHLKFRKSDNPDIDLEFVVPHDYCD
FAGERLDGRLQQLAKLTGKRLAFVFE

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=301, Percent_Identity=24.2524916943522, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788848, Length=396, Percent_Identity=22.4747474747475, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321185, Length=361, Percent_Identity=26.5927977839335, Blast_Score=88, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 55591; Mature: 55460

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSEAQGRLTGLAPVSVIDIGSNSVRLVVYEGLSRAPAVLFNEKVLCGLGKGLALTGRM
CCCCCCCCCEECCCCEEEEEECCCCEEEEEECCCCCCCHHHCCCEEEEECCCCEEEECCH
HEEGVTRALMALRRFHVLSEQAQAQKLYVLATAAAREAENGPDFIREAEAILGCEIEVLS
HHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEHHHHCCCCCHHHHHHHHHHHCCEEEEEC
GEKEALYSAYGVISGFYQPDGIAGDLGGGSLELIDIKDKSCGEGITLPLGGLRLSEQSDG
CCHHHHHHHHHHHHCCCCCCCCEECCCCCEEEEEEECCCCCCCCCEECCCCEEECCCCCC
SLEKAATIARKHVKSFAKLLAAGEGRTFYAVGGTWRNIAKLHMEISGYPLHMMQGYELPL
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHEEEECCCCEEECCCCCCCH
EEMLNFLEEVIVSRDSKDPAWQAVSKNRRSLLPFGAIAMREVLRAMKPAKIAFSAQGVRE
HHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHH
GYLYSLLTEAERESDPLLVAADELAILRARSPEHARELADWSGRTFPVFGIDETEEESRY
HHHHHHHHHHHCCCCCEEEEECCEEEEECCCHHHHHHHHHCCCCEEEEECCCCCHHHHHH
RQAACLLADISWRAHPDYRGLQALNIIAHSSFVAITHPGRAYIALANYYRFEGLNDNGTT
HHHHHHHEECCCCCCCCCCCHHHHHHEECCCEEEEECCCCEEEEEEEEHEECCCCCCCCC
EPLAAMAGERLQELGKLLGGLLRVVYLFSASMPGVVDHLKFRKSDNPDIDLEFVVPHDYC
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEEECCCHH
DFAGERLDGRLQQLAKLTGKRLAFVFE
HHHHHHHHHHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure 
TRSEAQGRLTGLAPVSVIDIGSNSVRLVVYEGLSRAPAVLFNEKVLCGLGKGLALTGRM
CCCCCCCCEECCCCEEEEEECCCCEEEEEECCCCCCCHHHCCCEEEEECCCCEEEECCH
HEEGVTRALMALRRFHVLSEQAQAQKLYVLATAAAREAENGPDFIREAEAILGCEIEVLS
HHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEHHHHCCCCCHHHHHHHHHHHCCEEEEEC
GEKEALYSAYGVISGFYQPDGIAGDLGGGSLELIDIKDKSCGEGITLPLGGLRLSEQSDG
CCHHHHHHHHHHHHCCCCCCCCEECCCCCEEEEEEECCCCCCCCCEECCCCEEECCCCCC
SLEKAATIARKHVKSFAKLLAAGEGRTFYAVGGTWRNIAKLHMEISGYPLHMMQGYELPL
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHEEEECCCCEEECCCCCCCH
EEMLNFLEEVIVSRDSKDPAWQAVSKNRRSLLPFGAIAMREVLRAMKPAKIAFSAQGVRE
HHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHH
GYLYSLLTEAERESDPLLVAADELAILRARSPEHARELADWSGRTFPVFGIDETEEESRY
HHHHHHHHHHHCCCCCEEEEECCEEEEECCCHHHHHHHHHCCCCEEEEECCCCCHHHHHH
RQAACLLADISWRAHPDYRGLQALNIIAHSSFVAITHPGRAYIALANYYRFEGLNDNGTT
HHHHHHHEECCCCCCCCCCCHHHHHHEECCCEEEEECCCCEEEEEEEEHEECCCCCCCCC
EPLAAMAGERLQELGKLLGGLLRVVYLFSASMPGVVDHLKFRKSDNPDIDLEFVVPHDYC
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEEECCCHH
DFAGERLDGRLQQLAKLTGKRLAFVFE
HHHHHHHHHHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]