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The map label for this gene is mutY [H]

Identifier: 15888141

GI number: 15888141

Start: 793749

End: 794852

Strand: Reverse

Name: mutY [H]

Synonym: Atu0798

Alternate gene names: 15888141

Gene position: 794852-793749 (Counterclockwise)

Preceding gene: 15888145

Following gene: 15888140

Centisome position: 27.97

GC content: 62.14

Gene sequence:

>1104_bases
ATGCTTCAAAAAACCGCCCCGTCGTCTTATGCGCAGATGCTGCTCGCATGGTACGACCGGCATCATCGCGAACTGCCGTG
GCGCACCTCCCCGGCCATGGCGGCACGAGGAAAACGTGCCGATCCCTACCACGTCTGGCTTTCAGAAGTGATGCTGCAGC
AGACGACGGTGCAAGCGGTAAAGCCCTATTTCCTGAAGTTTCTTGCCGCCTGGCCACGTGTTGACGATCTGGCGACGGCA
CCGGTCGAGGATGTCATGGCCGCCTGGGCGGGACTTGGCTACTACGCCCGCGCCCGCAACCTTAAAAAATGCGCGGAAGC
CGTGGCGCGCGAGCATGGTGGCGTCTTTCCGGACACGGAAGAAGGTCTGAAGCAGTTGCCCGGCATCGGCGATTATACGT
CCGCCGCCGTCGCGGCCATCGCCTTCAACCGGCAGGCTGCTGTCATGGACGGCAATGTCGAGCGCGTGATTTCGCGGCTC
TTTGCCATCGACGCGCCCCTGCCCGGCTCCAAACCGGCGATGAAGGCGAAGGTGGCGGAATTGACCCCTGCCGAGAGGCC
AGGGGATTTTGCGCAGGCGATGATGGATCTCGGCGCAACGATCTGCACGCCGAAACGGCCGGCCTGCGCGCTCTGTCCCT
TCAATGGCGCCTGTCTGGCGCTTACCCGTGACGAGCCGGAACGTTTTCCGGTGAAAGCCGCAAAAAAGGCAAAGCCGGTG
CGGCTCGGGGCTGCTTTCGTCGCAGTGAATACAGAGGGCGAGATTCTGCTGCGGCGGCGCATCGACAGCGGGCTCCTCGG
CGGCATGACCGAGGTGCCGACAACGGCGTGGACTGCGCGGATGGATGGCGGCACGGAGGTGAGCCATGCACCCTTTGCTG
CCGGCTGGCAGATGGCGGGCGTGATCGGGCATGTCTTCACCCATTTCGAACTGCGTCTGACCGTCTATCGCGCGCAGGTT
CCGGATGGCCTTCAAACCGGACCGGATGACGGATGGTGGGAGCCGGTTACAAATCTTGACGCGCAGGCGCTGCCAACGGT
GATGAAAAAAGTCATTGCAGAGGCTATTCCATCCGCATTCGATAAAAGCAGGAAGTTTCGATGA

Upstream 100 bases:

>100_bases
ATGTTTCACTCACGTTTTGGGAGCCGGCGAATCCACATGTTCTTGATCGCCTGCTTCTTATGTCCCAACTATAGGCCAAA
TCGAACAGAAACGGCAAACC

Downstream 100 bases:

>100_bases
CCAAGATTGACCATATCGTATTCGACATCGGCAAGGTGCTGATCCATTACGATCCGCATATTCCCTATAGCCGCCTCATT
CCCGATGCCGATGAGCGCCA

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MLQKTAPSSYAQMLLAWYDRHHRELPWRTSPAMAARGKRADPYHVWLSEVMLQQTTVQAVKPYFLKFLAAWPRVDDLATA
PVEDVMAAWAGLGYYARARNLKKCAEAVAREHGGVFPDTEEGLKQLPGIGDYTSAAVAAIAFNRQAAVMDGNVERVISRL
FAIDAPLPGSKPAMKAKVAELTPAERPGDFAQAMMDLGATICTPKRPACALCPFNGACLALTRDEPERFPVKAAKKAKPV
RLGAAFVAVNTEGEILLRRRIDSGLLGGMTEVPTTAWTARMDGGTEVSHAPFAAGWQMAGVIGHVFTHFELRLTVYRAQV
PDGLQTGPDDGWWEPVTNLDAQALPTVMKKVIAEAIPSAFDKSRKFR

Sequences:

>Translated_367_residues
MLQKTAPSSYAQMLLAWYDRHHRELPWRTSPAMAARGKRADPYHVWLSEVMLQQTTVQAVKPYFLKFLAAWPRVDDLATA
PVEDVMAAWAGLGYYARARNLKKCAEAVAREHGGVFPDTEEGLKQLPGIGDYTSAAVAAIAFNRQAAVMDGNVERVISRL
FAIDAPLPGSKPAMKAKVAELTPAERPGDFAQAMMDLGATICTPKRPACALCPFNGACLALTRDEPERFPVKAAKKAKPV
RLGAAFVAVNTEGEILLRRRIDSGLLGGMTEVPTTAWTARMDGGTEVSHAPFAAGWQMAGVIGHVFTHFELRLTVYRAQV
PDGLQTGPDDGWWEPVTNLDAQALPTVMKKVIAEAIPSAFDKSRKFR
>Mature_367_residues
MLQKTAPSSYAQMLLAWYDRHHRELPWRTSPAMAARGKRADPYHVWLSEVMLQQTTVQAVKPYFLKFLAAWPRVDDLATA
PVEDVMAAWAGLGYYARARNLKKCAEAVAREHGGVFPDTEEGLKQLPGIGDYTSAAVAAIAFNRQAAVMDGNVERVISRL
FAIDAPLPGSKPAMKAKVAELTPAERPGDFAQAMMDLGATICTPKRPACALCPFNGACLALTRDEPERFPVKAAKKAKPV
RLGAAFVAVNTEGEILLRRRIDSGLLGGMTEVPTTAWTARMDGGTEVSHAPFAAGWQMAGVIGHVFTHFELRLTVYRAQV
PDGLQTGPDDGWWEPVTNLDAQALPTVMKKVIAEAIPSAFDKSRKFR

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=400, Percent_Identity=35.75, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI115298654, Length=399, Percent_Identity=35.3383458646617, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI115298652, Length=399, Percent_Identity=35.3383458646617, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI115298650, Length=399, Percent_Identity=35.3383458646617, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI190358497, Length=399, Percent_Identity=35.3383458646617, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI6912520, Length=399, Percent_Identity=35.3383458646617, Blast_Score=206, Evalue=2e-53,
Organism=Escherichia coli, GI1789331, Length=318, Percent_Identity=40.251572327044, Blast_Score=222, Evalue=3e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 40057; Mature: 40057

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQKTAPSSYAQMLLAWYDRHHRELPWRTSPAMAARGKRADPYHVWLSEVMLQQTTVQAV
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
KPYFLKFLAAWPRVDDLATAPVEDVMAAWAGLGYYARARNLKKCAEAVAREHGGVFPDTE
HHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
EGLKQLPGIGDYTSAAVAAIAFNRQAAVMDGNVERVISRLFAIDAPLPGSKPAMKAKVAE
HHHHHCCCCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LTPAERPGDFAQAMMDLGATICTPKRPACALCPFNGACLALTRDEPERFPVKAAKKAKPV
CCCCCCCCHHHHHHHHCCCEECCCCCCCEEECCCCCCEEEEECCCCCCCCCHHHHCCCCE
RLGAAFVAVNTEGEILLRRRIDSGLLGGMTEVPTTAWTARMDGGTEVSHAPFAAGWQMAG
EEEEEEEEECCCCCEEHHHHHCCHHHCCCHHCCCCCEEEECCCCCCCCCCCCCCCHHHHH
VIGHVFTHFELRLTVYRAQVPDGLQTGPDDGWWEPVTNLDAQALPTVMKKVIAEAIPSAF
HHHHHHHHHEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
DKSRKFR
HHHCCCC
>Mature Secondary Structure
MLQKTAPSSYAQMLLAWYDRHHRELPWRTSPAMAARGKRADPYHVWLSEVMLQQTTVQAV
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
KPYFLKFLAAWPRVDDLATAPVEDVMAAWAGLGYYARARNLKKCAEAVAREHGGVFPDTE
HHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
EGLKQLPGIGDYTSAAVAAIAFNRQAAVMDGNVERVISRLFAIDAPLPGSKPAMKAKVAE
HHHHHCCCCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LTPAERPGDFAQAMMDLGATICTPKRPACALCPFNGACLALTRDEPERFPVKAAKKAKPV
CCCCCCCCHHHHHHHHCCCEECCCCCCCEEECCCCCCEEEEECCCCCCCCCHHHHCCCCE
RLGAAFVAVNTEGEILLRRRIDSGLLGGMTEVPTTAWTARMDGGTEVSHAPFAAGWQMAG
EEEEEEEEECCCCCEEHHHHHCCHHHCCCHHCCCCCEEEECCCCCCCCCCCCCCCHHHHH
VIGHVFTHFELRLTVYRAQVPDGLQTGPDDGWWEPVTNLDAQALPTVMKKVIAEAIPSAF
HHHHHHHHHEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
DKSRKFR
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]