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The map label for this gene is thrB

Identifier: 15888118

GI number: 15888118

Start: 770874

End: 771842

Strand: Direct

Name: thrB

Synonym: Atu0775

Alternate gene names: 15888118

Gene position: 770874-771842 (Clockwise)

Preceding gene: 15888117

Following gene: 15888119

Centisome position: 27.13

GC content: 57.79

Gene sequence:

>969_bases
TTGGCAGTTTATACTGATATTACCGAAGACGAACTGAGGAATTTCCTCACGCAATATGACGTCGGCAGCCTCACCTCCTA
CAAGGGCATTGCCGAGGGTGTCGAAAACTCCAATTTCCTGCTGCACACCACCAAAGATCCGCTGATCCTCACGCTTTATG
AAAAGCGCGTGGAGAAAAACGATCTGCCCTTCTTCCTCGGCCTCATGCAGCATCTGGCCGCTAAGGGTCTGTCCTGCCCC
TTGCCCCTGCCGCGCAAGGATGGCGAATTGCTGGGCGAATTGTCGGGCCGGCCGGCAGCGCTCATTTCCTTCCTCGAAGG
CATGTGGCTGAGAAAACCGGAAGCGAAACATTGCCGGGAAGTCGGCAAGGCGCTGGCCGCCATGCATCTGGCGAGCGAAG
GGTTCGAGATCAAGCGGCCCAATGCGCTCTCGGTCGATGGCTGGAAAGTGCTGTGGGACAAATCCGAAGAGCGTGCCGAT
GAGGTGGAGAAGGGGTTGAGGGAAGAGATTCGCCCGGAGATCGATTATCTTGCCGCCCATTGGCCGAAAGATTTGCCGGC
AGGCGTCATCCATGCGGATCTGTTTCAGGACAATGTCTTCTTCCTCGGAGACGAGCTTTCCGGCCTGATCGATTTTTATT
TCGCCTGTAACGACCTGCTCGCTTATGACGTGTCGATCTGCCTGAACGCCTGGTGCTTCGAAAAGGATGGCGCTTACAAC
GTCACCAAGGGCAAGGCGCTGCTGGAAGGTTATCAGTCGGTTCGACCGCTGAGCGAAGCGGAGCTGGAAGCGCTGCCGCT
GCTGTCACGCGGTTCGGCGTTACGTTTCTTCCTGACCCGGCTTTACGACTGGCTGACGACGCCGGCCGGCGCGCTGGTGG
TGAAGAAGGATCCGCTGGAATATCTGCGCAAGCTGCGCTTCCACCGCACGATCGCCAATGTCGCCGAATATGGGCTGGCG
GGCGAATGA

Upstream 100 bases:

>100_bases
GTATCTGAAGCGGGGTGGCGCTGAGCAAGGGCGGTTTTCGTCCTACCTTTGGCATGCTCCCCCTAGATTTCTAGTCCTTC
CTTCATCAAGAGATATAAAA

Downstream 100 bases:

>100_bases
AACACGTCGATATTTTCACCGATGGCGCCTGCTCCGGCAATCCCGGGCCGGGCGGCTGGGGTGCGGTGCTGCGTTATGGC
GAGACCGAAAAGGAACTCTC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MAVYTDITEDELRNFLTQYDVGSLTSYKGIAEGVENSNFLLHTTKDPLILTLYEKRVEKNDLPFFLGLMQHLAAKGLSCP
LPLPRKDGELLGELSGRPAALISFLEGMWLRKPEAKHCREVGKALAAMHLASEGFEIKRPNALSVDGWKVLWDKSEERAD
EVEKGLREEIRPEIDYLAAHWPKDLPAGVIHADLFQDNVFFLGDELSGLIDFYFACNDLLAYDVSICLNAWCFEKDGAYN
VTKGKALLEGYQSVRPLSEAELEALPLLSRGSALRFFLTRLYDWLTTPAGALVVKKDPLEYLRKLRFHRTIANVAEYGLA
GE

Sequences:

>Translated_322_residues
MAVYTDITEDELRNFLTQYDVGSLTSYKGIAEGVENSNFLLHTTKDPLILTLYEKRVEKNDLPFFLGLMQHLAAKGLSCP
LPLPRKDGELLGELSGRPAALISFLEGMWLRKPEAKHCREVGKALAAMHLASEGFEIKRPNALSVDGWKVLWDKSEERAD
EVEKGLREEIRPEIDYLAAHWPKDLPAGVIHADLFQDNVFFLGDELSGLIDFYFACNDLLAYDVSICLNAWCFEKDGAYN
VTKGKALLEGYQSVRPLSEAELEALPLLSRGSALRFFLTRLYDWLTTPAGALVVKKDPLEYLRKLRFHRTIANVAEYGLA
GE
>Mature_321_residues
AVYTDITEDELRNFLTQYDVGSLTSYKGIAEGVENSNFLLHTTKDPLILTLYEKRVEKNDLPFFLGLMQHLAAKGLSCPL
PLPRKDGELLGELSGRPAALISFLEGMWLRKPEAKHCREVGKALAAMHLASEGFEIKRPNALSVDGWKVLWDKSEERADE
VEKGLREEIRPEIDYLAAHWPKDLPAGVIHADLFQDNVFFLGDELSGLIDFYFACNDLLAYDVSICLNAWCFEKDGAYNV
TKGKALLEGYQSVRPLSEAELEALPLLSRGSALRFFLTRLYDWLTTPAGALVVKKDPLEYLRKLRFHRTIANVAEYGLAG
E

Specific function: Unknown

COG id: COG2334

COG function: function code R; Putative homoserine kinase type II (protein kinase fold)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pseudomonas-type thrB family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_AGRT5 (Q8UHA8)

Other databases:

- EMBL:   AE007869
- PIR:   AI2671
- PIR:   G97453
- RefSeq:   NP_353799.1
- PDB:   2PPQ
- PDBsum:   2PPQ
- ProteinModelPortal:   Q8UHA8
- SMR:   Q8UHA8
- STRING:   Q8UHA8
- GeneID:   1132813
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0775
- HOGENOM:   HBG309377
- OMA:   ADLFRDN
- ProtClustDB:   PRK05231
- BioCyc:   ATUM176299-1:ATU0775-MONOMER
- HAMAP:   MF_00301
- InterPro:   IPR002575
- InterPro:   IPR005280
- InterPro:   IPR011009
- TIGRFAMs:   TIGR00938

Pfam domain/function: PF01636 APH; SSF56112 Kinase_like

EC number: =2.7.1.39

Molecular weight: Translated: 36243; Mature: 36112

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVYTDITEDELRNFLTQYDVGSLTSYKGIAEGVENSNFLLHTTKDPLILTLYEKRVEKN
CCEECCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEEECCCCEEEEHHHHHHCCC
DLPFFLGLMQHLAAKGLSCPLPLPRKDGELLGELSGRPAALISFLEGMWLRKPEAKHCRE
CCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHH
VGKALAAMHLASEGFEIKRPNALSVDGWKVLWDKSEERADEVEKGLREEIRPEIDYLAAH
HHHHHHHHHHHHCCCEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHHH
WPKDLPAGVIHADLFQDNVFFLGDELSGLIDFYFACNDLLAYDVSICLNAWCFEKDGAYN
CCCCCCCCHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
VTKGKALLEGYQSVRPLSEAELEALPLLSRGSALRFFLTRLYDWLTTPAGALVVKKDPLE
CCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHH
YLRKLRFHRTIANVAEYGLAGE
HHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AVYTDITEDELRNFLTQYDVGSLTSYKGIAEGVENSNFLLHTTKDPLILTLYEKRVEKN
CEECCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEEECCCCEEEEHHHHHHCCC
DLPFFLGLMQHLAAKGLSCPLPLPRKDGELLGELSGRPAALISFLEGMWLRKPEAKHCRE
CCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHH
VGKALAAMHLASEGFEIKRPNALSVDGWKVLWDKSEERADEVEKGLREEIRPEIDYLAAH
HHHHHHHHHHHHCCCEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHHH
WPKDLPAGVIHADLFQDNVFFLGDELSGLIDFYFACNDLLAYDVSICLNAWCFEKDGAYN
CCCCCCCCHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
VTKGKALLEGYQSVRPLSEAELEALPLLSRGSALRFFLTRLYDWLTTPAGALVVKKDPLE
CCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHH
YLRKLRFHRTIANVAEYGLAGE
HHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194