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The map label for this gene is hisG

Identifier: 15888022

GI number: 15888022

Start: 673931

End: 674623

Strand: Direct

Name: hisG

Synonym: Atu0679

Alternate gene names: 15888022

Gene position: 673931-674623 (Clockwise)

Preceding gene: 15888021

Following gene: 15888027

Centisome position: 23.72

GC content: 62.63

Gene sequence:

>693_bases
ATGATCACCATCGCATTGCCCTCAAAAGGCCGGATGAAGGAAGACGCCTCCGCCGTTCTGGAACGCGCCGGGCTGAAGGT
TGCGTCAGTCGGTAACGACCGCTCCTATCGCGGTCGCATCGAAGGACGTGACGATATCGAGGTCGCCTATCTGTCGGCCT
CCGAGATCGCCCGCGAGATTGGCGCCGGCACGGTGGATTTCGGCGTGACCGGGGAAGACCTGGTGCGCGAGGGGTTGACC
AATGCCGACGCGCAGGTGGAGTTCTGCGCCCGCCTCGGTTTCGGCCATGCCGATGTCGTGGTCGCGGTGCCGGAAATCTG
GCTCGATGTGGACAGCATGGCCGATCTGGGCGATGTGGCATCCGAATTCCGCGCCCGCCATGGCCGGAGACTGGCGATCG
CCACCAAATATTGGCGGCTGACGCAGCAGTTCTTTTCACGCCAGCACGGCATTCAGCTTTACCGCATCGTCGAAAGCCTT
GGCGCCACTGAGGGCGCGCCTGCGGCAGGGCAGGCGGATATCATCGTCGATATCACCTCCACCGGCTCGACGCTGAAGGC
CAATCACCTGAAAATCCTCTCCGACGGCATCATCGTTCGCTCGGAAGCCTGCTTCGTGCGCGCCCGCAAACCGGAGCATG
AAGGCGATGCAGCGATTCAGGAAATCGCGTCGCGGATAAAAGCGGCCGTCTGA

Upstream 100 bases:

>100_bases
ACCGGCTGCTTACGCTTCTCGGCGCACAGGAAAAAATACCGGCCGTGGGCTTCTCGCTCTGGCTGGATCGCATCAAAGCG
GTGCGTGGGAGCGACAAACC

Downstream 100 bases:

>100_bases
AAACACAAAAGAAAAAAAGCCGCCGGATCGCTCCGGCGGCTTTTTTGTCGGACAGCCTGTTTACTCAGGCGCGAGCGGCA
ACAAAGCCGCGCTTCGCGTC

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MITIALPSKGRMKEDASAVLERAGLKVASVGNDRSYRGRIEGRDDIEVAYLSASEIAREIGAGTVDFGVTGEDLVREGLT
NADAQVEFCARLGFGHADVVVAVPEIWLDVDSMADLGDVASEFRARHGRRLAIATKYWRLTQQFFSRQHGIQLYRIVESL
GATEGAPAAGQADIIVDITSTGSTLKANHLKILSDGIIVRSEACFVRARKPEHEGDAAIQEIASRIKAAV

Sequences:

>Translated_230_residues
MITIALPSKGRMKEDASAVLERAGLKVASVGNDRSYRGRIEGRDDIEVAYLSASEIAREIGAGTVDFGVTGEDLVREGLT
NADAQVEFCARLGFGHADVVVAVPEIWLDVDSMADLGDVASEFRARHGRRLAIATKYWRLTQQFFSRQHGIQLYRIVESL
GATEGAPAAGQADIIVDITSTGSTLKANHLKILSDGIIVRSEACFVRARKPEHEGDAAIQEIASRIKAAV
>Mature_230_residues
MITIALPSKGRMKEDASAVLERAGLKVASVGNDRSYRGRIEGRDDIEVAYLSASEIAREIGAGTVDFGVTGEDLVREGLT
NADAQVEFCARLGFGHADVVVAVPEIWLDVDSMADLGDVASEFRARHGRRLAIATKYWRLTQQFFSRQHGIQLYRIVESL
GATEGAPAAGQADIIVDITSTGSTLKANHLKILSDGIIVRSEACFVRARKPEHEGDAAIQEIASRIKAAV

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=236, Percent_Identity=30.9322033898305, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_AGRT5 (Q8UHK1)

Other databases:

- EMBL:   AE007869
- PIR:   AI2659
- PIR:   G97441
- RefSeq:   NP_353703.1
- ProteinModelPortal:   Q8UHK1
- SMR:   Q8UHK1
- STRING:   Q8UHK1
- GeneID:   1132717
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0679
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   RMRVATK
- ProtClustDB:   PRK13583
- BioCyc:   ATUM176299-1:ATU0679-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 24806; Mature: 24806

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIALPSKGRMKEDASAVLERAGLKVASVGNDRSYRGRIEGRDDIEVAYLSASEIAREI
CEEEEECCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCEEEEEECHHHHHHHH
GAGTVDFGVTGEDLVREGLTNADAQVEFCARLGFGHADVVVAVPEIWLDVDSMADLGDVA
CCCCEECCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEECHHHHHCHHHHHHHHHHH
SEFRARHGRRLAIATKYWRLTQQFFSRQHGIQLYRIVESLGATEGAPAAGQADIIVDITS
HHHHHHCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEC
TGSTLKANHLKILSDGIIVRSEACFVRARKPEHEGDAAIQEIASRIKAAV
CCCEEECCCEEEEECCEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MITIALPSKGRMKEDASAVLERAGLKVASVGNDRSYRGRIEGRDDIEVAYLSASEIAREI
CEEEEECCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCEEEEEECHHHHHHHH
GAGTVDFGVTGEDLVREGLTNADAQVEFCARLGFGHADVVVAVPEIWLDVDSMADLGDVA
CCCCEECCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEECHHHHHCHHHHHHHHHHH
SEFRARHGRRLAIATKYWRLTQQFFSRQHGIQLYRIVESLGATEGAPAAGQADIIVDITS
HHHHHHCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEC
TGSTLKANHLKILSDGIIVRSEACFVRARKPEHEGDAAIQEIASRIKAAV
CCCEEECCCEEEEECCEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194