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The map label for this gene is copR [H]

Identifier: 15887970

GI number: 15887970

Start: 618020

End: 618697

Strand: Reverse

Name: copR [H]

Synonym: Atu0629

Alternate gene names: 15887970

Gene position: 618697-618020 (Counterclockwise)

Preceding gene: 15887972

Following gene: 15887969

Centisome position: 21.77

GC content: 55.75

Gene sequence:

>678_bases
ATGAAAATACTTCTTGTAGAAGACGATAATACAACCGGGAACTATGTTACAAAGGGACTTGCCTCCGCCGGCCACATAGT
TGACTGGGTAAAGGACGGGCGTGAGGCGCTGGCTGCCGGCCTCGACGGAGGATACGACGTCGCCATCGTGGACCGCATGA
TCCCCGGACTCGACGGCCTTAATCTGGTCAAGAGCCTGCGCGCGGCCTCGATACGCATACCCATCCTTTTTCTGACAGCG
ATGAGCGGTGTGGATGACCGTGTCGAAGGGCTGGAAGCCGGCGGTGACGACTATCTGGTAAAGCCCTTCGCTTTTTCTGA
ACTGACGGCGAGAATCAATGCTCTCGTCCGTCGACCGCCCATCACCACGGAGAAGACGCGCCTGCGTGTCGGCGACCTCG
AAATGAACCTTGTCACCAGAACAACATCGCGCGGAGGACAGCGGATTGATCTGCTGCCACGCGAGTTCTCGCTTCTGGAA
CTGCTCATGCGTAACGAAGGTCGAATCCTGACGAAAACGATGTTTCTCGAGAAAATCTGGAACTTCAATTTCGATCCGCA
GAGCTCCGTCGTGGAAACGCACATCAGCCGGCTGAGGGCGAAAATCGACAAACCGTTTGATCAGCCACTTCTGCATACCG
TCAAAAACACGGGCTATACGCTTCATGCCCGGCGCTAG

Upstream 100 bases:

>100_bases
AACCCGCCAATGCCTTAACTGCCGCAAGAAAGCCCGATTTGCGGCGTGAGCAGAAGCGGTGTGATCTTTAAGAACTGTAT
TTAAGACAACGTCATCGCCC

Downstream 100 bases:

>100_bases
CTTTCTGAAGAGCACTGCCGTCAGACTGGCGATCATCTACATCGTCCTGTTTGTAACCGCATCGCTTGGCGCGAACATCA
CGGCCTATCAGATGGTCGTG

Product: two component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKILLVEDDNTTGNYVTKGLASAGHIVDWVKDGREALAAGLDGGYDVAIVDRMIPGLDGLNLVKSLRAASIRIPILFLTA
MSGVDDRVEGLEAGGDDYLVKPFAFSELTARINALVRRPPITTEKTRLRVGDLEMNLVTRTTSRGGQRIDLLPREFSLLE
LLMRNEGRILTKTMFLEKIWNFNFDPQSSVVETHISRLRAKIDKPFDQPLLHTVKNTGYTLHARR

Sequences:

>Translated_225_residues
MKILLVEDDNTTGNYVTKGLASAGHIVDWVKDGREALAAGLDGGYDVAIVDRMIPGLDGLNLVKSLRAASIRIPILFLTA
MSGVDDRVEGLEAGGDDYLVKPFAFSELTARINALVRRPPITTEKTRLRVGDLEMNLVTRTTSRGGQRIDLLPREFSLLE
LLMRNEGRILTKTMFLEKIWNFNFDPQSSVVETHISRLRAKIDKPFDQPLLHTVKNTGYTLHARR
>Mature_225_residues
MKILLVEDDNTTGNYVTKGLASAGHIVDWVKDGREALAAGLDGGYDVAIVDRMIPGLDGLNLVKSLRAASIRIPILFLTA
MSGVDDRVEGLEAGGDDYLVKPFAFSELTARINALVRRPPITTEKTRLRVGDLEMNLVTRTTSRGGQRIDLLPREFSLLE
LLMRNEGRILTKTMFLEKIWNFNFDPQSSVVETHISRLRAKIDKPFDQPLLHTVKNTGYTLHARR

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=42.6008968609865, Blast_Score=205, Evalue=2e-54,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=43.0493273542601, Blast_Score=188, Evalue=3e-49,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=40.2714932126697, Blast_Score=165, Evalue=2e-42,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=36.322869955157, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=32.7510917030568, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=31.4159292035398, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786911, Length=217, Percent_Identity=31.3364055299539, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=32.8828828828829, Blast_Score=110, Evalue=5e-26,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=29.9559471365639, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=32.4561403508772, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=29.5154185022026, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=27.8761061946903, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=28.5087719298246, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=27.8260869565217, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788550, Length=117, Percent_Identity=32.4786324786325, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790437, Length=110, Percent_Identity=33.6363636363636, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=32.4324324324324, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=33.0578512396694, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25129; Mature: 25129

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILLVEDDNTTGNYVTKGLASAGHIVDWVKDGREALAAGLDGGYDVAIVDRMIPGLDGL
CEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHEEHHHHCCCCCHH
NLVKSLRAASIRIPILFLTAMSGVDDRVEGLEAGGDDYLVKPFAFSELTARINALVRRPP
HHHHHHHHHHEEHHHHEEEHHCCCCHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHCCCC
ITTEKTRLRVGDLEMNLVTRTTSRGGQRIDLLPREFSLLELLMRNEGRILTKTMFLEKIW
CCCCCCEEEECCEEEEEEEEECCCCCCEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
NFNFDPQSSVVETHISRLRAKIDKPFDQPLLHTVKNTGYTLHARR
CCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEECC
>Mature Secondary Structure
MKILLVEDDNTTGNYVTKGLASAGHIVDWVKDGREALAAGLDGGYDVAIVDRMIPGLDGL
CEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHEEHHHHCCCCCHH
NLVKSLRAASIRIPILFLTAMSGVDDRVEGLEAGGDDYLVKPFAFSELTARINALVRRPP
HHHHHHHHHHEEHHHHEEEHHCCCCHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHCCCC
ITTEKTRLRVGDLEMNLVTRTTSRGGQRIDLLPREFSLLELLMRNEGRILTKTMFLEKIW
CCCCCCEEEECCEEEEEEEEECCCCCCEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
NFNFDPQSSVVETHISRLRAKIDKPFDQPLLHTVKNTGYTLHARR
CCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]