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The map label for this gene is guaA

Identifier: 15887630

GI number: 15887630

Start: 275073

End: 276650

Strand: Reverse

Name: guaA

Synonym: Atu0281

Alternate gene names: 15887630

Gene position: 276650-275073 (Counterclockwise)

Preceding gene: 15887631

Following gene: 15887627

Centisome position: 9.74

GC content: 61.22

Gene sequence:

>1578_bases
ATGACCCAGATAGCCCATCCCGACAGCATTCTCATCATCGATTTCGGCAGCCAGGTGACGCAGCTGATTGCGCGCCGCAT
CCGCGAAGCCGGGGTCTATTGCGAAATCCACCCGTTCCAGAATGCCGCAGAGGCTTTCGAGAAGCTTCAGCCCAAGGGCG
TGATCTTCTCCGGCGGCCCCGCATCCGTAACGGCTGAAGGCAGCCCGCGCGCGCCGCAGGCGGTGTTCGACAGCAAGGTT
CCGATCCTCGGCATCTGCTACGGCCAGCAGACGCTCTGCACGCAGCTCGGCGGTGTGGTCGAAGGTGGCCACGCGGCGGA
ATTCGGCCGTGCGGATATCGATATCAAGAAGGCTAGCCCGCTGTTCGAAGGTTTCTGGGAACAGGGCAAGAGCTACCCGG
TGTGGATGAGCCATGGCGACCGCGTAACAAAGCTGCCGGAAGGTTTCGAGGTCATCGCGACCTCCGAGAACGCTCCTTTC
GCCATCGCGGCTGACGAGAAGCGTCACTATTACACCACCATGTTCCACCCGGAGGTGGTGCATACGCCTGACGGCGGCAA
GCTGCTCTCCAATTTCGTGCACAAGATCGTCGGCCTCAAATCCGACTGGACGATGGCTGCCTACCGCGCCGAGATGATCC
GCAAGATCCGCGAGCAGGTCGGCACTGGCCGGGTGCTCTGCGCACTTTCCGGCGGCGTCGATTCCTCGGTTGCAGCCATT
CTCATTCATGAGGCGATCGGTGATCAGCTGACCTGCGTTTATGTCGACCACGGCCTGATGCGGCTTGGCGAAAGCGAGCA
GGTCGTCGGCATGTTCCGCGATCACTACAATATTCCGCTTGTTCACGTCGACGCCGCCGATCTGTTCCTCGGCGAATTGT
CTGGCGTTTCCGATCCGGAAGTGAAGCGCAAGACCATCGGCCGCCTGTTCATCGAGGTGTTCGAAGCTGAGGCGGCCAAG
ATTGCCGCCGATGGCAAGGGTGCGCCCAAGTTCCTCGCTCAGGGCACGCTTTACCCTGACGTCATCGAAAGTGTATCCTT
CTCCGGTGGCCCTTCGGTCACCATCAAGAGTCACCACAATGTCGGTGGCCTTCCCGAGCGCATGAACATGCAGCTCGTCG
AGCCGCTGCGTGAACTCTTCAAGGATGAAGTGCGCGCACTTGGCCGCGAACTCGGCCTGCCGGAAAGCTTCATCGGTCGT
CATCCCTTCCCCGGTCCAGGTCTCGCGATCCGCTGCCCGGGCGCGATCACTCGTGAGAAGCTCGATATCCTGCGCAAGGC
GGATGCGATCTATCTCGACGAAATCCGCAAGGCCGGTCTCTACGATACCATCTGGCAGGCCTTTGCCGTGCTGCTGCCGG
TGCAGACCGTGGGCGTGATGGGCGACTACCGCACCTACGACTTCGTCTGCGCGCTGCGCGCCGTGACGTCAGTGGATGGC
ATGACGGCGGATTTCTATCCCTACGACATGAACTTCCTCGGTCGTGCGGCAACCCGCATCATCAACGAAGTGCGCGGCAT
TAACCGTGTGGTCTACGACGTGACGAGCAAGCCGCCCGGCACGATCGAGTGGGAGTAA

Upstream 100 bases:

>100_bases
GGGTGATTGCCCTTTGAAACCTTGCGATTTTCGCAAATTTCCGCCCTTTGACGCCCGCTTCCGGGTTGCCTAAAGCCCCG
CTTTTCTTTAAAGGCTCGCC

Downstream 100 bases:

>100_bases
GGACTATAATCGACACAGCGTGTTGCTGCGGCAATACCACTGTGTCGAGCACAGTTTGAACGATAACGCCGCGACTAGTT
CGCGGCGTTTCTGTTTTGTC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MTQIAHPDSILIIDFGSQVTQLIARRIREAGVYCEIHPFQNAAEAFEKLQPKGVIFSGGPASVTAEGSPRAPQAVFDSKV
PILGICYGQQTLCTQLGGVVEGGHAAEFGRADIDIKKASPLFEGFWEQGKSYPVWMSHGDRVTKLPEGFEVIATSENAPF
AIAADEKRHYYTTMFHPEVVHTPDGGKLLSNFVHKIVGLKSDWTMAAYRAEMIRKIREQVGTGRVLCALSGGVDSSVAAI
LIHEAIGDQLTCVYVDHGLMRLGESEQVVGMFRDHYNIPLVHVDAADLFLGELSGVSDPEVKRKTIGRLFIEVFEAEAAK
IAADGKGAPKFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGLPERMNMQLVEPLRELFKDEVRALGRELGLPESFIGR
HPFPGPGLAIRCPGAITREKLDILRKADAIYLDEIRKAGLYDTIWQAFAVLLPVQTVGVMGDYRTYDFVCALRAVTSVDG
MTADFYPYDMNFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE

Sequences:

>Translated_525_residues
MTQIAHPDSILIIDFGSQVTQLIARRIREAGVYCEIHPFQNAAEAFEKLQPKGVIFSGGPASVTAEGSPRAPQAVFDSKV
PILGICYGQQTLCTQLGGVVEGGHAAEFGRADIDIKKASPLFEGFWEQGKSYPVWMSHGDRVTKLPEGFEVIATSENAPF
AIAADEKRHYYTTMFHPEVVHTPDGGKLLSNFVHKIVGLKSDWTMAAYRAEMIRKIREQVGTGRVLCALSGGVDSSVAAI
LIHEAIGDQLTCVYVDHGLMRLGESEQVVGMFRDHYNIPLVHVDAADLFLGELSGVSDPEVKRKTIGRLFIEVFEAEAAK
IAADGKGAPKFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGLPERMNMQLVEPLRELFKDEVRALGRELGLPESFIGR
HPFPGPGLAIRCPGAITREKLDILRKADAIYLDEIRKAGLYDTIWQAFAVLLPVQTVGVMGDYRTYDFVCALRAVTSVDG
MTADFYPYDMNFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE
>Mature_524_residues
TQIAHPDSILIIDFGSQVTQLIARRIREAGVYCEIHPFQNAAEAFEKLQPKGVIFSGGPASVTAEGSPRAPQAVFDSKVP
ILGICYGQQTLCTQLGGVVEGGHAAEFGRADIDIKKASPLFEGFWEQGKSYPVWMSHGDRVTKLPEGFEVIATSENAPFA
IAADEKRHYYTTMFHPEVVHTPDGGKLLSNFVHKIVGLKSDWTMAAYRAEMIRKIREQVGTGRVLCALSGGVDSSVAAIL
IHEAIGDQLTCVYVDHGLMRLGESEQVVGMFRDHYNIPLVHVDAADLFLGELSGVSDPEVKRKTIGRLFIEVFEAEAAKI
AADGKGAPKFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGLPERMNMQLVEPLRELFKDEVRALGRELGLPESFIGRH
PFPGPGLAIRCPGAITREKLDILRKADAIYLDEIRKAGLYDTIWQAFAVLLPVQTVGVMGDYRTYDFVCALRAVTSVDGM
TADFYPYDMNFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=555, Percent_Identity=35.6756756756757, Blast_Score=295, Evalue=5e-80,
Organism=Escherichia coli, GI1788854, Length=530, Percent_Identity=54.1509433962264, Blast_Score=583, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI133901714, Length=578, Percent_Identity=34.083044982699, Blast_Score=271, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI71992710, Length=578, Percent_Identity=34.083044982699, Blast_Score=271, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI71992717, Length=578, Percent_Identity=34.083044982699, Blast_Score=271, Evalue=7e-73,
Organism=Saccharomyces cerevisiae, GI6323873, Length=520, Percent_Identity=52.3076923076923, Blast_Score=529, Evalue=1e-151,
Organism=Drosophila melanogaster, GI281365319, Length=553, Percent_Identity=35.8047016274864, Blast_Score=285, Evalue=6e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_AGRT5 (Q8UIL2)

Other databases:

- EMBL:   AE007869
- PIR:   AI2610
- PIR:   G97392
- RefSeq:   NP_353311.1
- ProteinModelPortal:   Q8UIL2
- SMR:   Q8UIL2
- STRING:   Q8UIL2
- GeneID:   1132319
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0281
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- PhylomeDB:   Q8UIL2
- ProtClustDB:   PRK00074
- BioCyc:   ATUM176299-1:ATU0281-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729
- InterPro:   IPR004506
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF03054 tRNA_Me_trans

EC number: =6.3.5.2

Molecular weight: Translated: 57522; Mature: 57390

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 86-86 ACT_SITE 176-176 ACT_SITE 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQIAHPDSILIIDFGSQVTQLIARRIREAGVYCEIHPFQNAAEAFEKLQPKGVIFSGGP
CCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCCEEEECCC
ASVTAEGSPRAPQAVFDSKVPILGICYGQQTLCTQLGGVVEGGHAAEFGRADIDIKKASP
CEEECCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCEEECCCCH
LFEGFWEQGKSYPVWMSHGDRVTKLPEGFEVIATSENAPFAIAADEKRHYYTTMFHPEVV
HHHHHHHCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCEEEEEECCEEE
HTPDGGKLLSNFVHKIVGLKSDWTMAAYRAEMIRKIREQVGTGRVLCALSGGVDSSVAAI
ECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHH
LIHEAIGDQLTCVYVDHGLMRLGESEQVVGMFRDHYNIPLVHVDAADLFLGELSGVSDPE
HHHHHHCCCEEEEEECCHHHHCCCCHHHHHHHHCCCCCCEEEECHHHHHHHHHCCCCCCH
VKRKTIGRLFIEVFEAEAAKIAADGKGAPKFLAQGTLYPDVIESVSFSGGPSVTIKSHHN
HHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHCCCCCHHHHHHCCCCCCCEEEEECCCC
VGGLPERMNMQLVEPLRELFKDEVRALGRELGLPESFIGRHPFPGPGLAIRCPGAITREK
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEECCCCHHHHH
LDILRKADAIYLDEIRKAGLYDTIWQAFAVLLPVQTVGVMGDYRTYDFVCALRAVTSVDG
HHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
MTADFYPYDMNFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE
CCCCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TQIAHPDSILIIDFGSQVTQLIARRIREAGVYCEIHPFQNAAEAFEKLQPKGVIFSGGP
CCCCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCCEEEECCC
ASVTAEGSPRAPQAVFDSKVPILGICYGQQTLCTQLGGVVEGGHAAEFGRADIDIKKASP
CEEECCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCEEECCCCH
LFEGFWEQGKSYPVWMSHGDRVTKLPEGFEVIATSENAPFAIAADEKRHYYTTMFHPEVV
HHHHHHHCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCEEEEEECCEEE
HTPDGGKLLSNFVHKIVGLKSDWTMAAYRAEMIRKIREQVGTGRVLCALSGGVDSSVAAI
ECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHH
LIHEAIGDQLTCVYVDHGLMRLGESEQVVGMFRDHYNIPLVHVDAADLFLGELSGVSDPE
HHHHHHCCCEEEEEECCHHHHCCCCHHHHHHHHCCCCCCEEEECHHHHHHHHHCCCCCCH
VKRKTIGRLFIEVFEAEAAKIAADGKGAPKFLAQGTLYPDVIESVSFSGGPSVTIKSHHN
HHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHCCCCCHHHHHHCCCCCCCEEEEECCCC
VGGLPERMNMQLVEPLRELFKDEVRALGRELGLPESFIGRHPFPGPGLAIRCPGAITREK
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEECCCCHHHHH
LDILRKADAIYLDEIRKAGLYDTIWQAFAVLLPVQTVGVMGDYRTYDFVCALRAVTSVDG
HHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
MTADFYPYDMNFLGRAATRIINEVRGINRVVYDVTSKPPGTIEWE
CCCCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194