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The map label for this gene is add

Identifier: 15887491

GI number: 15887491

Start: 139319

End: 140296

Strand: Reverse

Name: add

Synonym: Atu0136

Alternate gene names: 15887491

Gene position: 140296-139319 (Counterclockwise)

Preceding gene: 15887492

Following gene: 15887490

Centisome position: 4.94

GC content: 60.94

Gene sequence:

>978_bases
TTGACATCGCATTTGCTGAAAGCGGAAATTCACTGCCACCTCGAAGGTGCAGCACCCCCCGCCCTCGTTGTGAAACAGGC
GGAGAAATACGGCATAGACACCAGCGGCTTTCTGCGCGACGGCCAATATGTCTGGTCGGATTTTGCGGAATTCATCCAGT
GCTACGATGCGGTGGCGCAGGTATTCAAGTCCGATGAGGACTATGCGGTCCTGACGGAAACCTATCTGACGGAACTGGCC
GAGGCCAATACGATCTATAGCGAACTGATCATTTCGCCGGATCATGGCGATCGCATCGGGCTTGGCGCGGACGCCTATCT
CGCCGGCGTTGCCGAGGGTATCCGCATCGCGAAAGAAAAGACCGGCATCGAAACCCGCATCATCGTCACGGGCGAGCGGC
ATTTCGGCCCCGAGCGGGTGATCGCGGCGGCCGAATATGCGGCGCGGATCAGGCATCCGCTGGTAACCGGCTTCAACATG
GCGGGCGAAGAACGCATGGGCCGGGTTGCCGATTACGCCCGCGCCTTCGATATCGCCCGTGATGCGGGACTTGGGTTGAC
GATCCATGCCGGTGAGGTTTGCGGGCCGGAAAGCGTTGCCGACGCGCTCGATCTCGTCAAACCGTCGCGTATCGGCCACG
GCGTGCGCGCTATCGAAGATGCCGCTCTCATCTCCCGGCTGGTCGAGACAGGAACAGTCCTCGAAGTCTGCCCCGGCTCC
AATATCGCGCTCAGCGTCTATCCCGATTTTGCCAGCCACCCGCTGAAAGCTCTGAGCGATGCCGGGGTGCGCGTCTGCAT
CAGTTCCGACGACCCGCCGTTCTTCTTCACCTCGCTTGCGCGGGAATATGCGCTGGCTGCGGACGCTTTCGGTTTCAACG
ATGCCGAGATCAACCGCATGACTCGCACCGCACTGGAATGCGCCTTTGTGGACGAGGCAACGCGCGAGCGGCTGCTTGCT
AGATTGGGTGACGCCTGA

Upstream 100 bases:

>100_bases
GTTCCCGCGATGTCGGTATTCGTTCAAGCTACGCCGATATTGGCGAAAGTATCGCCCACCATCTTGGCATAGAGGCCGGT
TCACACGGCAGGAGCTTCAT

Downstream 100 bases:

>100_bases
GACGGTTGTTGGCAGGGTAAAACCGCGAAGAAGGCTTGCGAAAAACGTGCTTTCGGTGAATTACAGGGCATAAGATAAAA
AGGAAGGCCAGTTTCATGGA

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MTSHLLKAEIHCHLEGAAPPALVVKQAEKYGIDTSGFLRDGQYVWSDFAEFIQCYDAVAQVFKSDEDYAVLTETYLTELA
EANTIYSELIISPDHGDRIGLGADAYLAGVAEGIRIAKEKTGIETRIIVTGERHFGPERVIAAAEYAARIRHPLVTGFNM
AGEERMGRVADYARAFDIARDAGLGLTIHAGEVCGPESVADALDLVKPSRIGHGVRAIEDAALISRLVETGTVLEVCPGS
NIALSVYPDFASHPLKALSDAGVRVCISSDDPPFFFTSLAREYALAADAFGFNDAEINRMTRTALECAFVDEATRERLLA
RLGDA

Sequences:

>Translated_325_residues
MTSHLLKAEIHCHLEGAAPPALVVKQAEKYGIDTSGFLRDGQYVWSDFAEFIQCYDAVAQVFKSDEDYAVLTETYLTELA
EANTIYSELIISPDHGDRIGLGADAYLAGVAEGIRIAKEKTGIETRIIVTGERHFGPERVIAAAEYAARIRHPLVTGFNM
AGEERMGRVADYARAFDIARDAGLGLTIHAGEVCGPESVADALDLVKPSRIGHGVRAIEDAALISRLVETGTVLEVCPGS
NIALSVYPDFASHPLKALSDAGVRVCISSDDPPFFFTSLAREYALAADAFGFNDAEINRMTRTALECAFVDEATRERLLA
RLGDA
>Mature_324_residues
TSHLLKAEIHCHLEGAAPPALVVKQAEKYGIDTSGFLRDGQYVWSDFAEFIQCYDAVAQVFKSDEDYAVLTETYLTELAE
ANTIYSELIISPDHGDRIGLGADAYLAGVAEGIRIAKEKTGIETRIIVTGERHFGPERVIAAAEYAARIRHPLVTGFNMA
GEERMGRVADYARAFDIARDAGLGLTIHAGEVCGPESVADALDLVKPSRIGHGVRAIEDAALISRLVETGTVLEVCPGSN
IALSVYPDFASHPLKALSDAGVRVCISSDDPPFFFTSLAREYALAADAFGFNDAEINRMTRTALECAFVDEATRERLLAR
LGDA

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=345, Percent_Identity=25.7971014492754, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI226693318, Length=333, Percent_Identity=24.6246246246246, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI61175224, Length=221, Percent_Identity=25.7918552036199, Blast_Score=78, Evalue=9e-15,
Organism=Escherichia coli, GI1787910, Length=329, Percent_Identity=30.3951367781155, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32565969, Length=151, Percent_Identity=30.4635761589404, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538512, Length=151, Percent_Identity=30.4635761589404, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115537133, Length=319, Percent_Identity=24.7648902821317, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324188, Length=334, Percent_Identity=27.2455089820359, Blast_Score=123, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24645260, Length=332, Percent_Identity=27.1084337349398, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45553183, Length=194, Percent_Identity=28.3505154639175, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737615, Length=194, Percent_Identity=28.3505154639175, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_AGRT5 (Q8UJ05)

Other databases:

- EMBL:   AE007869
- PIR:   AB2593
- PIR:   D97375
- RefSeq:   NP_353172.1
- ProteinModelPortal:   Q8UJ05
- SMR:   Q8UJ05
- STRING:   Q8UJ05
- GeneID:   1132174
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0136
- eggNOG:   COG1816
- HOGENOM:   HBG630382
- OMA:   VLEVCPG
- PhylomeDB:   Q8UJ05
- ProtClustDB:   PRK09358
- BioCyc:   ATUM176299-1:ATU0136-MONOMER
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 35127; Mature: 34996

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 192-192 BINDING 13-13 BINDING 15-15 BINDING 162-162 BINDING 271-271

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSHLLKAEIHCHLEGAAPPALVVKQAEKYGIDTSGFLRDGQYVWSDFAEFIQCYDAVAQ
CCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHH
VFKSDEDYAVLTETYLTELAEANTIYSELIISPDHGDRIGLGADAYLAGVAEGIRIAKEK
HHCCCCCCEEHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
TGIETRIIVTGERHFGPERVIAAAEYAARIRHPLVTGFNMAGEERMGRVADYARAFDIAR
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHH
DAGLGLTIHAGEVCGPESVADALDLVKPSRIGHGVRAIEDAALISRLVETGTVLEVCPGS
HCCCEEEEECCCCCCHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCC
NIALSVYPDFASHPLKALSDAGVRVCISSDDPPFFFTSLAREYALAADAFGFNDAEINRM
CEEEEECCCHHCCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
TRTALECAFVDEATRERLLARLGDA
HHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSHLLKAEIHCHLEGAAPPALVVKQAEKYGIDTSGFLRDGQYVWSDFAEFIQCYDAVAQ
CCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHH
VFKSDEDYAVLTETYLTELAEANTIYSELIISPDHGDRIGLGADAYLAGVAEGIRIAKEK
HHCCCCCCEEHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
TGIETRIIVTGERHFGPERVIAAAEYAARIRHPLVTGFNMAGEERMGRVADYARAFDIAR
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHH
DAGLGLTIHAGEVCGPESVADALDLVKPSRIGHGVRAIEDAALISRLVETGTVLEVCPGS
HCCCEEEEECCCCCCHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCC
NIALSVYPDFASHPLKALSDAGVRVCISSDDPPFFFTSLAREYALAADAFGFNDAEINRM
CEEEEECCCHHCCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
TRTALECAFVDEATRERLLARLGDA
HHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194