Click here to switch to the map view.

The map label for this gene is xdhD [H]

Identifier: 239618441

GI number: 239618441

Start: 2207875

End: 2210214

Strand: Direct

Name: xdhD [H]

Synonym: Kole_2082

Alternate gene names: 239618441

Gene position: 2207875-2210214 (Clockwise)

Preceding gene: 239618440

Following gene: 239618442

Centisome position: 95.91

GC content: 42.01

Gene sequence:

>2340_bases
ATGTTTGAAACCCTGAATAGCAAAGAATTCAAAGTGATAAATAAATCAATAAAGAAAGTAGATGGAAGAGGTTTAGTTAG
AGGAAAACCTGTTTATGCAGGAGACCTGGATATTCCTAACGCTCTTCATGTCAAACTAGTCCGCAGTCCTCATGCTCACG
CCATAATAAAGAAAATAGATAAAACCAAAGCTCTTGCAATTCCTGGAGTTGTAGCGGTCATTACCTATGAAGATCTTCCG
AGAATTGCCTTTACGAGAGCCGGTCAGGGATATCCTGAACCATCACCTTATGATACCTTTGTTCTTGATAGGAAAGTCAG
GTACGTTGGTGATCCAGTTGCAATTGTTGCTGCCGAAACGGAAAGAGCTGCAATTCTTGGAGCTAATGCCGTTGAAGTTG
AATACGAGATCTTGCCTGCTATACTCAATTTCGAAGAAGCAATGAAAGAAGATGCACCTATCATACATGATGAAGAAGAT
ATTTCTGGTGCTTTTGACCCGAAAAAAAATATTGCAGCTCACTTTGAGATGGAAATTGGCGATCTGGACGATGCCTTCAA
AAAATGCGACAAAGTAATTACTCGAACATACTATGTTAACACCCAGCTTCACGCTATGCTGGAACCTCACACCGCTACAA
GTTACTATGACTCGAATGGAAGGTTGGTTATAGTTTCTTCAACGCAGGTACCTTTCCATGTAAGAAGAATTATCAGCAGA
ATTTTTGAAATTCCTATTTCCAAGATACGTGTTATAAAACCAAGAATAGGCGGTGGATTTGGTGGCAAGCAGGCAATTCA
TCAAGAAGCCTATGTTGTGGCTGTCACTTTGAAAACCGGTAGACCAGCGAAAATCGTTTACGAACGCCCGGAAGTCTCCA
TGGCTACCAATATCAGGCATGAAATGAAATTCACAGTAACAGTTGGTGCCACCAGTGATGGAAAGATAAAAGCTATATCG
ATGGAAGGACTATCAAATACAGGAGCTTATGGTGAACATGCTCTAACAACCTTTATGGTTGCCGGTTCTAAGACCCTTCC
GTTATACAACAAAGTTGATGCTGTTAAATTTGTCGGTGATGTAGTTTACACGAATCTTCCACCTGCAGGTGCTTACAGAG
GTTATGGTGCTCCTCAGGGGCTATTTGCATTGGATTGTACAATTGATGAACTGGCTCACGAGCTTGGTCTTGACCCTCTT
GAGGTTAAGGAGAAAAATTCTATCAGGGAAGGTGAAACTTCACCTATATTCAAGATAATGGGTGAAGGTCGTGAGGGCGT
AGACCAGATAGTGAGAAGCTGTAAACTTCAGGAATGTATCGACAAGGGCAAAAAGGCCATCGGTTGGAATGAAAAGCACG
GAAAGGCGATAAGAAACGGAAATAAAGTTAGAGGTGTAGGATGCTCAATTGCAATGCAGGGATCTGGAATAGCAAAAATA
GACATGGCTGCTGCGACCATAAAAATGAATGATGACGGATCCTTCAATCTTCTTATAGGTGCCACAGATCTTGGAACTGG
AAGCGATACAATAATGGCACAAATAGCTGCTGAGGTTTTAGACGTTCCGGTTGAGAAGATAATCGTTTACTCTTCGGATA
CTGATATGACGCCTTTCGATACTGGCGCTTATGCTTCCAGTACGACCTACGTATCTGGAAACGCTGTGAGAAAAGCAGCA
GAAGAGGTAAAGAAACAGATCATCGAGAGTGCTTCAAAATATCTTGAAGAACCCATCGAAGATCTTTACGTAAAAGATGA
AAAGGTGATATCCAAAAAGAGTGGAAAAGAAGTGACTTATGCTGAACTTTGTACAAAACTCTTCTACACATTCGAACAAA
AGCAGATAGCAGCAACTGCTTCTTACGTGGGTGAAGAGTCACCACCACCGTTCCTCGCTACCTTTGCTGAGGTAGAAGTT
GATCTGGATACTGGAAAAATAGATATAGTAAAATTGGTTTCTTATGCAGATTGTGGGACACCACTTAACCCGATACAGGC
TAGAGGACAGCTGGAAGGCGCGACAATGCAGGGTATAGGTTGGGCGTTGTATGAAGATGTTATCTATTCTAACAATGGGC
GTATGCTGACAAACGACTTCTTTACTTACAAAGTGCCATCTCGTTTGGATTATGGTGAGTTAGAATGTGGACTTGTCGAT
AGTTACGAGCCAACAGGGCCTTTCGGGGCGAAGAGTATTGCCGAAATTGGTATTGATACACCAATCCCCGCTATTGCAAA
TGCAATATTTGACGCAACCGGAATAAGACTCCGAGAAGCGCCTTTCAGAAGCGAAAAGCTCTTCTTTGAGATCTTAAAGA
AGGAGAAAGAGCAAAAATGA

Upstream 100 bases:

>100_bases
ATCAGGGAAGCTTTGAACGGAAATATCTGTCGTTGTACCGGTTATGAAGCCCAAACCAGAGCAATCAAAAAAGCAGCAAA
ACGTCTTAGGGGTGATGAGA

Downstream 100 bases:

>100_bases
AAAAAGTTTTACTGGTAACACTTGTGTTAATCCTGGTGGCTACCTTCTGTTTTGCTGAAGAACTAACCATCTGGATTAGC
TGGGAAGGCGAAGAGTTTTT

Product: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 779; Mature: 779

Protein sequence:

>779_residues
MFETLNSKEFKVINKSIKKVDGRGLVRGKPVYAGDLDIPNALHVKLVRSPHAHAIIKKIDKTKALAIPGVVAVITYEDLP
RIAFTRAGQGYPEPSPYDTFVLDRKVRYVGDPVAIVAAETERAAILGANAVEVEYEILPAILNFEEAMKEDAPIIHDEED
ISGAFDPKKNIAAHFEMEIGDLDDAFKKCDKVITRTYYVNTQLHAMLEPHTATSYYDSNGRLVIVSSTQVPFHVRRIISR
IFEIPISKIRVIKPRIGGGFGGKQAIHQEAYVVAVTLKTGRPAKIVYERPEVSMATNIRHEMKFTVTVGATSDGKIKAIS
MEGLSNTGAYGEHALTTFMVAGSKTLPLYNKVDAVKFVGDVVYTNLPPAGAYRGYGAPQGLFALDCTIDELAHELGLDPL
EVKEKNSIREGETSPIFKIMGEGREGVDQIVRSCKLQECIDKGKKAIGWNEKHGKAIRNGNKVRGVGCSIAMQGSGIAKI
DMAAATIKMNDDGSFNLLIGATDLGTGSDTIMAQIAAEVLDVPVEKIIVYSSDTDMTPFDTGAYASSTTYVSGNAVRKAA
EEVKKQIIESASKYLEEPIEDLYVKDEKVISKKSGKEVTYAELCTKLFYTFEQKQIAATASYVGEESPPPFLATFAEVEV
DLDTGKIDIVKLVSYADCGTPLNPIQARGQLEGATMQGIGWALYEDVIYSNNGRMLTNDFFTYKVPSRLDYGELECGLVD
SYEPTGPFGAKSIAEIGIDTPIPAIANAIFDATGIRLREAPFRSEKLFFEILKKEKEQK

Sequences:

>Translated_779_residues
MFETLNSKEFKVINKSIKKVDGRGLVRGKPVYAGDLDIPNALHVKLVRSPHAHAIIKKIDKTKALAIPGVVAVITYEDLP
RIAFTRAGQGYPEPSPYDTFVLDRKVRYVGDPVAIVAAETERAAILGANAVEVEYEILPAILNFEEAMKEDAPIIHDEED
ISGAFDPKKNIAAHFEMEIGDLDDAFKKCDKVITRTYYVNTQLHAMLEPHTATSYYDSNGRLVIVSSTQVPFHVRRIISR
IFEIPISKIRVIKPRIGGGFGGKQAIHQEAYVVAVTLKTGRPAKIVYERPEVSMATNIRHEMKFTVTVGATSDGKIKAIS
MEGLSNTGAYGEHALTTFMVAGSKTLPLYNKVDAVKFVGDVVYTNLPPAGAYRGYGAPQGLFALDCTIDELAHELGLDPL
EVKEKNSIREGETSPIFKIMGEGREGVDQIVRSCKLQECIDKGKKAIGWNEKHGKAIRNGNKVRGVGCSIAMQGSGIAKI
DMAAATIKMNDDGSFNLLIGATDLGTGSDTIMAQIAAEVLDVPVEKIIVYSSDTDMTPFDTGAYASSTTYVSGNAVRKAA
EEVKKQIIESASKYLEEPIEDLYVKDEKVISKKSGKEVTYAELCTKLFYTFEQKQIAATASYVGEESPPPFLATFAEVEV
DLDTGKIDIVKLVSYADCGTPLNPIQARGQLEGATMQGIGWALYEDVIYSNNGRMLTNDFFTYKVPSRLDYGELECGLVD
SYEPTGPFGAKSIAEIGIDTPIPAIANAIFDATGIRLREAPFRSEKLFFEILKKEKEQK
>Mature_779_residues
MFETLNSKEFKVINKSIKKVDGRGLVRGKPVYAGDLDIPNALHVKLVRSPHAHAIIKKIDKTKALAIPGVVAVITYEDLP
RIAFTRAGQGYPEPSPYDTFVLDRKVRYVGDPVAIVAAETERAAILGANAVEVEYEILPAILNFEEAMKEDAPIIHDEED
ISGAFDPKKNIAAHFEMEIGDLDDAFKKCDKVITRTYYVNTQLHAMLEPHTATSYYDSNGRLVIVSSTQVPFHVRRIISR
IFEIPISKIRVIKPRIGGGFGGKQAIHQEAYVVAVTLKTGRPAKIVYERPEVSMATNIRHEMKFTVTVGATSDGKIKAIS
MEGLSNTGAYGEHALTTFMVAGSKTLPLYNKVDAVKFVGDVVYTNLPPAGAYRGYGAPQGLFALDCTIDELAHELGLDPL
EVKEKNSIREGETSPIFKIMGEGREGVDQIVRSCKLQECIDKGKKAIGWNEKHGKAIRNGNKVRGVGCSIAMQGSGIAKI
DMAAATIKMNDDGSFNLLIGATDLGTGSDTIMAQIAAEVLDVPVEKIIVYSSDTDMTPFDTGAYASSTTYVSGNAVRKAA
EEVKKQIIESASKYLEEPIEDLYVKDEKVISKKSGKEVTYAELCTKLFYTFEQKQIAATASYVGEESPPPFLATFAEVEV
DLDTGKIDIVKLVSYADCGTPLNPIQARGQLEGATMQGIGWALYEDVIYSNNGRMLTNDFFTYKVPSRLDYGELECGLVD
SYEPTGPFGAKSIAEIGIDTPIPAIANAIFDATGIRLREAPFRSEKLFFEILKKEKEQK

Specific function: Probably has no xanthine dehydrogenase activity; however deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=695, Percent_Identity=28.3453237410072, Blast_Score=224, Evalue=3e-58,
Organism=Homo sapiens, GI71773480, Length=758, Percent_Identity=26.7810026385224, Blast_Score=198, Evalue=2e-50,
Organism=Escherichia coli, GI1789246, Length=794, Percent_Identity=40.6801007556675, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1789230, Length=765, Percent_Identity=34.5098039215686, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI1786478, Length=771, Percent_Identity=27.7561608300908, Blast_Score=223, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17540638, Length=738, Percent_Identity=25.609756097561, Blast_Score=211, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17539860, Length=700, Percent_Identity=26.2857142857143, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI32566215, Length=553, Percent_Identity=27.124773960217, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17737937, Length=729, Percent_Identity=26.0631001371742, Blast_Score=202, Evalue=7e-52,
Organism=Drosophila melanogaster, GI24647193, Length=750, Percent_Identity=25.2, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24647195, Length=736, Percent_Identity=24.5923913043478, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24647197, Length=716, Percent_Identity=25, Blast_Score=134, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24647201, Length=733, Percent_Identity=23.1923601637108, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24647199, Length=716, Percent_Identity=23.1843575418994, Blast_Score=130, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR001041
- InterPro:   IPR017699 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2; PF01799 Fer2_2 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 85239; Mature: 85239

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFETLNSKEFKVINKSIKKVDGRGLVRGKPVYAGDLDIPNALHVKLVRSPHAHAIIKKID
CCCCCCCCHHHHHHHHHHHCCCCCCEECCCEEECCCCCCCCEEEEEECCCCHHHHHHHHH
KTKALAIPGVVAVITYEDLPRIAFTRAGQGYPEPSPYDTFVLDRKVRYVGDPVAIVAAET
HHHEEECCCEEEEEEECCCCCHHEECCCCCCCCCCCCCEEEECCCHHCCCCCEEEEEECC
ERAAILGANAVEVEYEILPAILNFEEAMKEDAPIIHDEEDISGAFDPKKNIAAHFEMEIG
CCEEEECCCEEEEEHHHHHHHHCHHHHHHHCCCCEECCCCCCCCCCCCCCCEEEEEEECC
DLDDAFKKCDKVITRTYYVNTQLHAMLEPHTATSYYDSNGRLVIVSSTQVPFHVRRIISR
CHHHHHHHHHHHHHEEEEECCEEEEEECCCCCCEEECCCCEEEEEECCCCCHHHHHHHHH
IFEIPISKIRVIKPRIGGGFGGKQAIHQEAYVVAVTLKTGRPAKIVYERPEVSMATNIRH
HHHCCCCCEEEECCCCCCCCCCHHHHCCCEEEEEEEEECCCCEEEEEECCCCCHHHCCCE
EMKFTVTVGATSDGKIKAISMEGLSNTGAYGEHALTTFMVAGSKTLPLYNKVDAVKFVGD
EEEEEEEEECCCCCCEEEEEECCCCCCCCCCCHHHEEEEEECCCCCCCHHHHHHHHHHHH
VVYTNLPPAGAYRGYGAPQGLFALDCTIDELAHELGLDPLEVKEKNSIREGETSPIFKIM
HHCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHEE
GEGREGVDQIVRSCKLQECIDKGKKAIGWNEKHGKAIRNGNKVRGVGCSIAMQGSGIAKI
CCCHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCHHHHCCCEEEEEEEEEEECCCCCEEE
DMAAATIKMNDDGSFNLLIGATDLGTGSDTIMAQIAAEVLDVPVEKIIVYSSDTDMTPFD
EEEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
TGAYASSTTYVSGNAVRKAAEEVKKQIIESASKYLEEPIEDLYVKDEKVISKKSGKEVTY
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHH
AELCTKLFYTFEQKQIAATASYVGEESPPPFLATFAEVEVDLDTGKIDIVKLVSYADCGT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCEEEEEEEHHHCCCC
PLNPIQARGQLEGATMQGIGWALYEDVIYSNNGRMLTNDFFTYKVPSRLDYGELECGLVD
CCCCHHHCCCCCCCEECCCCHHHHHHHEECCCCCEEECCEEEEECCCCCCCCCCCCCEEC
SYEPTGPFGAKSIAEIGIDTPIPAIANAIFDATGIRLREAPFRSEKLFFEILKKEKEQK
CCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFETLNSKEFKVINKSIKKVDGRGLVRGKPVYAGDLDIPNALHVKLVRSPHAHAIIKKID
CCCCCCCCHHHHHHHHHHHCCCCCCEECCCEEECCCCCCCCEEEEEECCCCHHHHHHHHH
KTKALAIPGVVAVITYEDLPRIAFTRAGQGYPEPSPYDTFVLDRKVRYVGDPVAIVAAET
HHHEEECCCEEEEEEECCCCCHHEECCCCCCCCCCCCCEEEECCCHHCCCCCEEEEEECC
ERAAILGANAVEVEYEILPAILNFEEAMKEDAPIIHDEEDISGAFDPKKNIAAHFEMEIG
CCEEEECCCEEEEEHHHHHHHHCHHHHHHHCCCCEECCCCCCCCCCCCCCCEEEEEEECC
DLDDAFKKCDKVITRTYYVNTQLHAMLEPHTATSYYDSNGRLVIVSSTQVPFHVRRIISR
CHHHHHHHHHHHHHEEEEECCEEEEEECCCCCCEEECCCCEEEEEECCCCCHHHHHHHHH
IFEIPISKIRVIKPRIGGGFGGKQAIHQEAYVVAVTLKTGRPAKIVYERPEVSMATNIRH
HHHCCCCCEEEECCCCCCCCCCHHHHCCCEEEEEEEEECCCCEEEEEECCCCCHHHCCCE
EMKFTVTVGATSDGKIKAISMEGLSNTGAYGEHALTTFMVAGSKTLPLYNKVDAVKFVGD
EEEEEEEEECCCCCCEEEEEECCCCCCCCCCCHHHEEEEEECCCCCCCHHHHHHHHHHHH
VVYTNLPPAGAYRGYGAPQGLFALDCTIDELAHELGLDPLEVKEKNSIREGETSPIFKIM
HHCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHEE
GEGREGVDQIVRSCKLQECIDKGKKAIGWNEKHGKAIRNGNKVRGVGCSIAMQGSGIAKI
CCCHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCHHHHCCCEEEEEEEEEEECCCCCEEE
DMAAATIKMNDDGSFNLLIGATDLGTGSDTIMAQIAAEVLDVPVEKIIVYSSDTDMTPFD
EEEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
TGAYASSTTYVSGNAVRKAAEEVKKQIIESASKYLEEPIEDLYVKDEKVISKKSGKEVTY
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHH
AELCTKLFYTFEQKQIAATASYVGEESPPPFLATFAEVEVDLDTGKIDIVKLVSYADCGT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCEEEEEEEHHHCCCC
PLNPIQARGQLEGATMQGIGWALYEDVIYSNNGRMLTNDFFTYKVPSRLDYGELECGLVD
CCCCHHHCCCCCCCEECCCCHHHHHHHEECCCCCEEECCEEEEECCCCCCCCCCCCCEEC
SYEPTGPFGAKSIAEIGIDTPIPAIANAIFDATGIRLREAPFRSEKLFFEILKKEKEQK
CCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Two 2Fe-2S centers [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]