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The map label for this gene is ndhS [H]

Identifier: 239618440

GI number: 239618440

Start: 2207409

End: 2207882

Strand: Direct

Name: ndhS [H]

Synonym: Kole_2081

Alternate gene names: 239618440

Gene position: 2207409-2207882 (Clockwise)

Preceding gene: 239618439

Following gene: 239618441

Centisome position: 95.89

GC content: 42.41

Gene sequence:

>474_bases
ATGAGGATAAGTCTAGAAGTTAATGGAAAACTTCATGAAGTCGAAATTGATCCAGGAGAAATGCTTCTGGATGTTTTGAG
AAGACTTGGATATAAGAGTGTGAGAAGAAGCTGTAACTCAGCAAGCTGTGGAACCTGCACGGTGTTGCTCAACGGTAAAC
CAATTCTGTCGTGTAGTACCTTTGCAGCTTCTGTTGATGGCCAAAGCGTAGAAACCGTTGAATCCTTGAATGAAAATGAT
GAGCTACATCCAATTCAGGAAGCCCTTCTTGAAGAAGGTGGATCTCAATGTGGTTTTTGTATTCCGGGACTTACAATGAC
AACTAAAGCATTTCTTGAACAGAACCCTGACCCCACAGAAGAGGAGATCAGGGAAGCTTTGAACGGAAATATCTGTCGTT
GTACCGGTTATGAAGCCCAAACCAGAGCAATCAAAAAAGCAGCAAAACGTCTTAGGGGTGATGAGAATGTTTGA

Upstream 100 bases:

>100_bases
TTGAAGGCGGCAGTAATTTCCTCGCCACAGAAGAATACCGTAGGCACATGGCCTCTGTTTTGGCAGAAAGAGCAGCAAAG
GAAATTCGGGAGATGATAGC

Downstream 100 bases:

>100_bases
AACCCTGAATAGCAAAGAATTCAAAGTGATAAATAAATCAATAAAGAAAGTAGATGGAAGAGGTTTAGTTAGAGGAAAAC
CTGTTTATGCAGGAGACCTG

Product: (2Fe-2S)-binding domain protein

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase small FeS subunit; NAH [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MRISLEVNGKLHEVEIDPGEMLLDVLRRLGYKSVRRSCNSASCGTCTVLLNGKPILSCSTFAASVDGQSVETVESLNEND
ELHPIQEALLEEGGSQCGFCIPGLTMTTKAFLEQNPDPTEEEIREALNGNICRCTGYEAQTRAIKKAAKRLRGDENV

Sequences:

>Translated_157_residues
MRISLEVNGKLHEVEIDPGEMLLDVLRRLGYKSVRRSCNSASCGTCTVLLNGKPILSCSTFAASVDGQSVETVESLNEND
ELHPIQEALLEEGGSQCGFCIPGLTMTTKAFLEQNPDPTEEEIREALNGNICRCTGYEAQTRAIKKAAKRLRGDENV
>Mature_157_residues
MRISLEVNGKLHEVEIDPGEMLLDVLRRLGYKSVRRSCNSASCGTCTVLLNGKPILSCSTFAASVDGQSVETVESLNEND
ELHPIQEALLEEGGSQCGFCIPGLTMTTKAFLEQNPDPTEEEIREALNGNICRCTGYEAQTRAIKKAAKRLRGDENV

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=161, Percent_Identity=37.2670807453416, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI71773480, Length=158, Percent_Identity=36.0759493670886, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI1786480, Length=168, Percent_Identity=36.3095238095238, Blast_Score=114, Evalue=3e-27,
Organism=Escherichia coli, GI1789232, Length=140, Percent_Identity=40, Blast_Score=107, Evalue=3e-25,
Organism=Escherichia coli, GI1789246, Length=151, Percent_Identity=29.8013245033113, Blast_Score=74, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17540638, Length=166, Percent_Identity=38.5542168674699, Blast_Score=103, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17539860, Length=154, Percent_Identity=37.012987012987, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32566215, Length=147, Percent_Identity=35.3741496598639, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17737937, Length=158, Percent_Identity=36.0759493670886, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24647197, Length=173, Percent_Identity=32.9479768786127, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24647195, Length=173, Percent_Identity=32.9479768786127, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24647193, Length=169, Percent_Identity=32.5443786982249, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24647199, Length=167, Percent_Identity=32.3353293413174, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24647201, Length=167, Percent_Identity=31.7365269461078, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 17146; Mature: 17146

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
5.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISLEVNGKLHEVEIDPGEMLLDVLRRLGYKSVRRSCNSASCGTCTVLLNGKPILSCST
CEEEEEECCEEEEEEECHHHHHHHHHHHCCHHHHHHCCCCCCCCEEEEEECCCCEEEHHH
FAASVDGQSVETVESLNENDELHPIQEALLEEGGSQCGFCIPGLTMTTKAFLEQNPDPTE
HHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEECCCHHHHHHHHHHCCCCCCH
EEIREALNGNICRCTGYEAQTRAIKKAAKRLRGDENV
HHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRISLEVNGKLHEVEIDPGEMLLDVLRRLGYKSVRRSCNSASCGTCTVLLNGKPILSCST
CEEEEEECCEEEEEEECHHHHHHHHHHHCCHHHHHHCCCCCCCCEEEEEECCCCEEEHHH
FAASVDGQSVETVESLNENDELHPIQEALLEEGGSQCGFCIPGLTMTTKAFLEQNPDPTE
HHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEECCCHHHHHHHHHHCCCCCCH
EEIREALNGNICRCTGYEAQTRAIKKAAKRLRGDENV
HHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA