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The map label for this gene is atzB [H]

Identifier: 239618426

GI number: 239618426

Start: 2192659

End: 2194014

Strand: Reverse

Name: atzB [H]

Synonym: Kole_2066

Alternate gene names: 239618426

Gene position: 2194014-2192659 (Counterclockwise)

Preceding gene: 239618445

Following gene: 239618423

Centisome position: 95.3

GC content: 44.25

Gene sequence:

>1356_bases
GTGAAGACTATACTCAAAAATATCAGCTATCTTGCTACAATGGACAATTCGATGTCAGAACTTACCGATGCGTACATAGT
CATCGACAACAATATTATCACTGCCGTTGGTAGTGGAGAAGCTCCAAAAGGTGATCGTGAGTTTGATATGTCCGGGCGTG
TGGTGCTTCCGGGATTTGTTAATACTCACCATCACCTTTATCAATCGCTTTTCAGAAATGTACCCGCTGTTTCATCCGCC
AAACTTTTCGACTGGCTCGTTTATCTGTATGAACTGTGGAAAAATATAGACAACGAAGCTGTTTACGTAAGCGCTGCGGT
GGGAATATATGAAATGATGTCCACAGGTGTTACAACCACCACCGATATGCTTTATCTTCACCCGAAAGGAAAAGAAAGGT
TCATAGATTCTGAAATTGAAGCTGCTATGCGTTGCGGCGTAAGGTTCCATCCAACGCGCGGTTCAATGTCACTTTCCAAA
AAAGATGGGGGGCTCCCCCCGGATTCAGTGGTTCAAACGGAAGAAAAAATTATCGAGGACTCCATTCGTTTGATTGAGAA
GTACCATGACAAAGATAAATACGCTATGGTAAGAATCGCCCTTGCTCCCTGTTCACCGTTCTCGGTTACAGAAGAATCGA
TGATTAAAACACTCGAACTAGCTGAAAAATATGACGTATTGTTACACACCCATCTTGCCGAAACCAAGGATGAGGAAGAA
TATTGTCTCGAAACCAAGGGATTGAGGCCAGTCGATTACATGGAAAAAATAGGATGGCTGAATCCCAGAGTCTGGTTCGC
ACACCTTGTGTGGCTTTCAGATGAGGATATAAAGAAACTTGCAGATAATGACTGTGGAATGGCCCATTGTCCAACTTCCA
ACATGAGGCTTGGCTCCGGAATAGCTCCGGTGAAAGAAATGAAGGAAGCGGGAATCAGAATCGGGCTGGCCGTTGATGGA
AGTGCTTCGAACGACACGGGTAACATGTTACACGAAATAAGAAACGCCATGCTACTTCAACGTGTTTCAAAAGGTGCGGA
TGCACTCACTCCACGCGATGTCCTTTACATGGGAACGATGGGCGGCGCAAAAGTTTTGAGGATGGATGATTATATTGGTT
CAATAGAACCGGGTAAAGCAGCAGATATTATTGCATTCGATCTGAACGTCCTCTCTCTTGCTGGCGGTCTGGCGGATCCA
ATAGGTGCAATCGTCATGTGTGACCCCGGTAAGGCAGACTTCGTCATGATAAATGGAAAAGTGAGAATTGAAAATGGAAA
GATCAATGATACCGAACTTCCGGAACTGATAAGAAAACAGAACGAGATATCACACAGACTATTAAACCAATCGTAA

Upstream 100 bases:

>100_bases
TAAAAACTTTTCAAAGAAAGGGCTTTATTAGTATTTTGCCATGAAATAGAATATTTTGCTTTACGGTGAGAAATGATAAA
ATTTTAATGGAGGTGAAAAT

Downstream 100 bases:

>100_bases
AAAGTTAAAGCTCCCCATCAGGGGAGCTTTTTAATAATCCCCTATCAAAACCGCAACTCCAACCAATCCACTTCCGGCAT
GAACCAGCAACGCTGAAGAA

Product: amidohydrolase

Products: NA

Alternate protein names: Hydroxyatrazine hydrolase [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MKTILKNISYLATMDNSMSELTDAYIVIDNNIITAVGSGEAPKGDREFDMSGRVVLPGFVNTHHHLYQSLFRNVPAVSSA
KLFDWLVYLYELWKNIDNEAVYVSAAVGIYEMMSTGVTTTTDMLYLHPKGKERFIDSEIEAAMRCGVRFHPTRGSMSLSK
KDGGLPPDSVVQTEEKIIEDSIRLIEKYHDKDKYAMVRIALAPCSPFSVTEESMIKTLELAEKYDVLLHTHLAETKDEEE
YCLETKGLRPVDYMEKIGWLNPRVWFAHLVWLSDEDIKKLADNDCGMAHCPTSNMRLGSGIAPVKEMKEAGIRIGLAVDG
SASNDTGNMLHEIRNAMLLQRVSKGADALTPRDVLYMGTMGGAKVLRMDDYIGSIEPGKAADIIAFDLNVLSLAGGLADP
IGAIVMCDPGKADFVMINGKVRIENGKINDTELPELIRKQNEISHRLLNQS

Sequences:

>Translated_451_residues
MKTILKNISYLATMDNSMSELTDAYIVIDNNIITAVGSGEAPKGDREFDMSGRVVLPGFVNTHHHLYQSLFRNVPAVSSA
KLFDWLVYLYELWKNIDNEAVYVSAAVGIYEMMSTGVTTTTDMLYLHPKGKERFIDSEIEAAMRCGVRFHPTRGSMSLSK
KDGGLPPDSVVQTEEKIIEDSIRLIEKYHDKDKYAMVRIALAPCSPFSVTEESMIKTLELAEKYDVLLHTHLAETKDEEE
YCLETKGLRPVDYMEKIGWLNPRVWFAHLVWLSDEDIKKLADNDCGMAHCPTSNMRLGSGIAPVKEMKEAGIRIGLAVDG
SASNDTGNMLHEIRNAMLLQRVSKGADALTPRDVLYMGTMGGAKVLRMDDYIGSIEPGKAADIIAFDLNVLSLAGGLADP
IGAIVMCDPGKADFVMINGKVRIENGKINDTELPELIRKQNEISHRLLNQS
>Mature_451_residues
MKTILKNISYLATMDNSMSELTDAYIVIDNNIITAVGSGEAPKGDREFDMSGRVVLPGFVNTHHHLYQSLFRNVPAVSSA
KLFDWLVYLYELWKNIDNEAVYVSAAVGIYEMMSTGVTTTTDMLYLHPKGKERFIDSEIEAAMRCGVRFHPTRGSMSLSK
KDGGLPPDSVVQTEEKIIEDSIRLIEKYHDKDKYAMVRIALAPCSPFSVTEESMIKTLELAEKYDVLLHTHLAETKDEEE
YCLETKGLRPVDYMEKIGWLNPRVWFAHLVWLSDEDIKKLADNDCGMAHCPTSNMRLGSGIAPVKEMKEAGIRIGLAVDG
SASNDTGNMLHEIRNAMLLQRVSKGADALTPRDVLYMGTMGGAKVLRMDDYIGSIEPGKAADIIAFDLNVLSLAGGLADP
IGAIVMCDPGKADFVMINGKVRIENGKINDTELPELIRKQNEISHRLLNQS

Specific function: Catalyzes the deamination reaction of hydroxyatrazine to N-isopropylammelide (dihydroxy-isopropyl-atrazine). The enzyme is also capable of catalyzing some dechlorinating reactions [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=345, Percent_Identity=28.1159420289855, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1789249, Length=360, Percent_Identity=29.4444444444444, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI87082177, Length=450, Percent_Identity=24.8888888888889, Blast_Score=90, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17540282, Length=369, Percent_Identity=27.3712737127371, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319963, Length=346, Percent_Identity=27.7456647398844, Blast_Score=113, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24643849, Length=374, Percent_Identity=26.2032085561497, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.99.3 [H]

Molecular weight: Translated: 50084; Mature: 50084

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTILKNISYLATMDNSMSELTDAYIVIDNNIITAVGSGEAPKGDREFDMSGRVVLPGFV
CCHHHHHHHHHHHCCCCHHHHCCEEEEEECCEEEEECCCCCCCCCCCCCCCCCEEECCHH
NTHHHLYQSLFRNVPAVSSAKLFDWLVYLYELWKNIDNEAVYVSAAVGIYEMMSTGVTTT
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCEE
TDMLYLHPKGKERFIDSEIEAAMRCGVRFHPTRGSMSLSKKDGGLPPDSVVQTEEKIIED
EEEEEECCCCCHHHHHHHHHHHHHCCCEEECCCCCCEECCCCCCCCCHHHHHHHHHHHHH
SIRLIEKYHDKDKYAMVRIALAPCSPFSVTEESMIKTLELAEKYDVLLHTHLAETKDEEE
HHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
YCLETKGLRPVDYMEKIGWLNPRVWFAHLVWLSDEDIKKLADNDCGMAHCPTSNMRLGSG
HHHHCCCCCCHHHHHHCCCCCCCEEEEEEEEECCHHHHHHHCCCCCCEECCCCCCCCCCC
IAPVKEMKEAGIRIGLAVDGSASNDTGNMLHEIRNAMLLQRVSKGADALTPRDVLYMGTM
CCHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECC
GGAKVLRMDDYIGSIEPGKAADIIAFDLNVLSLAGGLADPIGAIVMCDPGKADFVMINGK
CCCEEEEEHHCCCCCCCCCCCEEEEECHHHHHHHCCCCCCCCEEEEECCCCCCEEEECCE
VRIENGKINDTELPELIRKQNEISHRLLNQS
EEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTILKNISYLATMDNSMSELTDAYIVIDNNIITAVGSGEAPKGDREFDMSGRVVLPGFV
CCHHHHHHHHHHHCCCCHHHHCCEEEEEECCEEEEECCCCCCCCCCCCCCCCCEEECCHH
NTHHHLYQSLFRNVPAVSSAKLFDWLVYLYELWKNIDNEAVYVSAAVGIYEMMSTGVTTT
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCEE
TDMLYLHPKGKERFIDSEIEAAMRCGVRFHPTRGSMSLSKKDGGLPPDSVVQTEEKIIED
EEEEEECCCCCHHHHHHHHHHHHHCCCEEECCCCCCEECCCCCCCCCHHHHHHHHHHHHH
SIRLIEKYHDKDKYAMVRIALAPCSPFSVTEESMIKTLELAEKYDVLLHTHLAETKDEEE
HHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
YCLETKGLRPVDYMEKIGWLNPRVWFAHLVWLSDEDIKKLADNDCGMAHCPTSNMRLGSG
HHHHCCCCCCHHHHHHCCCCCCCEEEEEEEEECCHHHHHHHCCCCCCEECCCCCCCCCCC
IAPVKEMKEAGIRIGLAVDGSASNDTGNMLHEIRNAMLLQRVSKGADALTPRDVLYMGTM
CCHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECC
GGAKVLRMDDYIGSIEPGKAADIIAFDLNVLSLAGGLADPIGAIVMCDPGKADFVMINGK
CCCEEEEEHHCCCCCCCCCCCEEEEECHHHHHHHCCCCCCCCEEEEECCCCCCEEEECCE
VRIENGKINDTELPELIRKQNEISHRLLNQS
EEEECCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9055410 [H]