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The map label for this gene is nuoD [H]

Identifier: 239618412

GI number: 239618412

Start: 2182406

End: 2183512

Strand: Reverse

Name: nuoD [H]

Synonym: Kole_2052

Alternate gene names: 239618412

Gene position: 2183512-2182406 (Counterclockwise)

Preceding gene: 239618413

Following gene: 239618411

Centisome position: 94.85

GC content: 45.44

Gene sequence:

>1107_bases
ATGGGTAAAGAGGTCAAACTTTTTATCGGTCCGAACCACCCTGGAATGCACGGGAATTCCAGCGTACATATCTATGTTGA
AGGTGACACCGTGGTCAAGGCACGATTAGTGCCCGGATTTCTTCATCGAGGGTTCGAAAAGCTTATGGAAAGAAGGAATT
GGTTCCAGAATCTCGCTTTGATTCCAAGAATATGTGTTCCAGAACCGGACATAAATGAAATGGTATTCGCAATGGGAGTG
GAAACTCTTGCTGGCATCGAGGTCCCGGAGAGAGCTCACTGGATTCGAATGATTATCCTTGAGCTAGCAAGAATGGCTGC
ACATCTAATGGCGATGGGAGGCATTGGAGGAGCTACCGGCCTCTATGCGATGCCGCAATGGACTCTGGCAGATAGAGATA
GAATTCTGGACATCTTTGAAAAAATTACAGGCGCAAGAATCTATCATATGTATATAATCCCCGGAGGAGTTAGAAAGGAT
CTTCCAGAAGGAATTGAAGAAGAAATCGAAGCTCTTCTGAACTATTTTGAAAGCAGGAGAACGGAATATGAAAATCTCCT
CTTAAAAAACCGGGTAATACATACACGTACCAAAGGGCTCGCAGTCCTTACAAAAGAGGAAGCATTAAAAATCGGTGTGA
CCGGTGTGGGGCTCAGAGCTACCGGAGTCCCTTATGATATCAGAAAAGTTGACCCTTATGCCCGCTATGCTGACGTAGAG
TTCGATGTTCCCACAGCGACAGAAGGGGATGCTTATGCGCGGTTCTCTTTGAAATATCTCGAATTTTTACAGAGTATTCG
AATAATAAGACAGTGTTTGAAAAAGATGCCCAAAGGTCCCGTAAACGTCAGGGTATCACGCGGAAGTGCGTTGCGTTGGA
GAGTACCTGCAGGCAAAGTTTACTCCCATATAGAATGTTCGAGAGGCGAATATGGATATCTCATCGTTTCTGATGGTGGA
GAAAAACCTTACAGAGTTCATGTAAGAGGCGCTTCCTTCCCACAGGGGCTATACGGTATTGAAAAGCTACTTCCGGGGAC
AAGAATCGAAGATGTGGCTCTCTGGTTAGGAACAATGGACTTCTGTCCACCGGAAATCGACAGATAA

Upstream 100 bases:

>100_bases
CCACCGATGAGAAAAGATTTCGATCCCCATAAATTCTCAAAGGAAAACTTCCCTGACAGAACATATGATGTTGATTTTAT
TCCAGAAGGAAGTGAAAAAG

Downstream 100 bases:

>100_bases
GGGAGGAGATGCGATGAATGCGAAAGAGATTTTCAAAAAAACCTTTTGGGGTCCAACTATCGCATGGAAATATCTATTTG
CGAAACCTATAACCATTACA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MGKEVKLFIGPNHPGMHGNSSVHIYVEGDTVVKARLVPGFLHRGFEKLMERRNWFQNLALIPRICVPEPDINEMVFAMGV
ETLAGIEVPERAHWIRMIILELARMAAHLMAMGGIGGATGLYAMPQWTLADRDRILDIFEKITGARIYHMYIIPGGVRKD
LPEGIEEEIEALLNYFESRRTEYENLLLKNRVIHTRTKGLAVLTKEEALKIGVTGVGLRATGVPYDIRKVDPYARYADVE
FDVPTATEGDAYARFSLKYLEFLQSIRIIRQCLKKMPKGPVNVRVSRGSALRWRVPAGKVYSHIECSRGEYGYLIVSDGG
EKPYRVHVRGASFPQGLYGIEKLLPGTRIEDVALWLGTMDFCPPEIDR

Sequences:

>Translated_368_residues
MGKEVKLFIGPNHPGMHGNSSVHIYVEGDTVVKARLVPGFLHRGFEKLMERRNWFQNLALIPRICVPEPDINEMVFAMGV
ETLAGIEVPERAHWIRMIILELARMAAHLMAMGGIGGATGLYAMPQWTLADRDRILDIFEKITGARIYHMYIIPGGVRKD
LPEGIEEEIEALLNYFESRRTEYENLLLKNRVIHTRTKGLAVLTKEEALKIGVTGVGLRATGVPYDIRKVDPYARYADVE
FDVPTATEGDAYARFSLKYLEFLQSIRIIRQCLKKMPKGPVNVRVSRGSALRWRVPAGKVYSHIECSRGEYGYLIVSDGG
EKPYRVHVRGASFPQGLYGIEKLLPGTRIEDVALWLGTMDFCPPEIDR
>Mature_367_residues
GKEVKLFIGPNHPGMHGNSSVHIYVEGDTVVKARLVPGFLHRGFEKLMERRNWFQNLALIPRICVPEPDINEMVFAMGVE
TLAGIEVPERAHWIRMIILELARMAAHLMAMGGIGGATGLYAMPQWTLADRDRILDIFEKITGARIYHMYIIPGGVRKDL
PEGIEEEIEALLNYFESRRTEYENLLLKNRVIHTRTKGLAVLTKEEALKIGVTGVGLRATGVPYDIRKVDPYARYADVEF
DVPTATEGDAYARFSLKYLEFLQSIRIIRQCLKKMPKGPVNVRVSRGSALRWRVPAGKVYSHIECSRGEYGYLIVSDGGE
KPYRVHVRGASFPQGLYGIEKLLPGTRIEDVALWLGTMDFCPPEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=387, Percent_Identity=36.1757105943152, Blast_Score=245, Evalue=5e-65,
Organism=Homo sapiens, GI260898743, Length=377, Percent_Identity=36.0742705570292, Blast_Score=238, Evalue=5e-63,
Organism=Escherichia coli, GI145693162, Length=384, Percent_Identity=33.59375, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1789076, Length=361, Percent_Identity=26.3157894736842, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1788832, Length=361, Percent_Identity=24.9307479224377, Blast_Score=118, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17555284, Length=383, Percent_Identity=34.4647519582245, Blast_Score=237, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI17568379, Length=383, Percent_Identity=34.4647519582245, Blast_Score=235, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24638644, Length=387, Percent_Identity=34.8837209302326, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI221459469, Length=385, Percent_Identity=34.025974025974, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 41553; Mature: 41422

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS00318 HMG_COA_REDUCTASE_2 ; PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKEVKLFIGPNHPGMHGNSSVHIYVEGDTVVKARLVPGFLHRGFEKLMERRNWFQNLAL
CCCEEEEEECCCCCCCCCCCEEEEEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
IPRICVPEPDINEMVFAMGVETLAGIEVPERAHWIRMIILELARMAAHLMAMGGIGGATG
CCEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LYAMPQWTLADRDRILDIFEKITGARIYHMYIIPGGVRKDLPEGIEEEIEALLNYFESRR
CCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
TEYENLLLKNRVIHTRTKGLAVLTKEEALKIGVTGVGLRATGVPYDIRKVDPYARYADVE
HHHHHHHHHCCEEEECCCCEEEEEECCCEEEEEEEECEEECCCCCEEECCCCCHHEECEE
FDVPTATEGDAYARFSLKYLEFLQSIRIIRQCLKKMPKGPVNVRVSRGSALRWRVPAGKV
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCHH
YSHIECSRGEYGYLIVSDGGEKPYRVHVRGASFPQGLYGIEKLLPGTRIEDVALWLGTMD
HHHEEECCCCEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHCCC
FCPPEIDR
CCCCCCCC
>Mature Secondary Structure 
GKEVKLFIGPNHPGMHGNSSVHIYVEGDTVVKARLVPGFLHRGFEKLMERRNWFQNLAL
CCEEEEEECCCCCCCCCCCEEEEEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
IPRICVPEPDINEMVFAMGVETLAGIEVPERAHWIRMIILELARMAAHLMAMGGIGGATG
CCEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LYAMPQWTLADRDRILDIFEKITGARIYHMYIIPGGVRKDLPEGIEEEIEALLNYFESRR
CCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
TEYENLLLKNRVIHTRTKGLAVLTKEEALKIGVTGVGLRATGVPYDIRKVDPYARYADVE
HHHHHHHHHCCEEEECCCCEEEEEECCCEEEEEEEECEEECCCCCEEECCCCCHHEECEE
FDVPTATEGDAYARFSLKYLEFLQSIRIIRQCLKKMPKGPVNVRVSRGSALRWRVPAGKV
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCHH
YSHIECSRGEYGYLIVSDGGEKPYRVHVRGASFPQGLYGIEKLLPGTRIEDVALWLGTMD
HHHEEECCCCEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHCCC
FCPPEIDR
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA