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The map label for this gene is disA [H]

Identifier: 239618403

GI number: 239618403

Start: 2171681

End: 2172748

Strand: Direct

Name: disA [H]

Synonym: Kole_2043

Alternate gene names: 239618403

Gene position: 2171681-2172748 (Clockwise)

Preceding gene: 239618402

Following gene: 239618406

Centisome position: 94.33

GC content: 44.01

Gene sequence:

>1068_bases
ATGGATCATAAGGAACTTGCCGAAAGGATTCGTGTGGTTGCTCCTGGAACACAGCTTCGTTTTGCTCTCGATAAGATCGT
GGCTGCTAATACTGGGGCACTTATTTTTTTAGTAGATGACTTTGAAAAGTACAAGGATCTAATGCAGGTTGGTTTTTTCC
TCAATTGCCCGTTCAATCCCAATAAACTCTATGAGTTATCAAAAATGGATGGAGCAATTGTTGTGGATGAGAGTCTTAAC
AAAATAATCGCTGCTAATGTTCAGCTGACTCCCGATCCCTCTATTCCTTCTTTACAGACAGGTATGCGCCACCGAACCGC
TGAAAGAATGGCACGCCAGACGGGGAAAATGCTTCTTGCTATTTCCAAAAGGCAGGGAACAATCACCATATTTTTTGGTG
AGAATTCTCATGTCCTGGCCCCTGTGGAAATTTTGCTTCCAAGAGTCAATCAGGTTATTAGAACGGTTGAACAATACCGC
CAAACTTTTGCATACGGTCTTGATCAGATAGACGTGCTTGAACGCGCGAGCGTTTTAACCCTTTACGATGTCTTGAAAAC
GCTGGAGAAAGGCCTTATGGTTTTGTTGATCTCTAAAGAAGCGGAACTAACCCTTGTGGAACTGGGAAAGTTCGGTCTGC
CTTCCCGAATGCAATTGGACGAAATCACCGATGGAATACCGGAAGAGATAGAAAATCTTGTTCTTGATTTTGCCAAAGAA
CAGGTAACGATCGACAAAATAGAGGAACTCATGGAGAAACTTTTGAGTCTCACAGAGCGTGAGATTTCGAACTATGTGAC
TCTGGCGAGGGTGCTTGGTTATGACATCTCATCGAGTTCTCAGGCAATGGAATTGAACATGCGCTCCAGGGGTATTAGAT
TTGTTAGAAAGATTCCGAAAATCCCGTTGCAGGTTGCGTTAAACGTGGGAGCAAAATACGGTTCACTTGCCAGACTTCTG
AAGACAAGTGTTGAAGAACTTAAAGAGGTCGAAGGAGTCGGGGAAAAACGTGCCCGAGCAATCAGGCACGCCATCGATAT
ACACAACAAACGAGAGGAATTGGAGTAA

Upstream 100 bases:

>100_bases
AGATTAAAAGAATCTGGTTTTTCCGAAGTGCTTTCTCCTAATGGAAATATCAGGATACAAAATATTGCTGATTTGGTTCG
CTTTGTCGGGGGGATGAGTG

Downstream 100 bases:

>100_bases
GTTACAACTCCAGCTTTCTTATTTCGTCATACAGGTTATTGAGTTCTTCTTCAGACAGTTTAGCTGGTTTTCCATTTTCG
AGCACTAATTCTCCCTGATT

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MDHKELAERIRVVAPGTQLRFALDKIVAANTGALIFLVDDFEKYKDLMQVGFFLNCPFNPNKLYELSKMDGAIVVDESLN
KIIAANVQLTPDPSIPSLQTGMRHRTAERMARQTGKMLLAISKRQGTITIFFGENSHVLAPVEILLPRVNQVIRTVEQYR
QTFAYGLDQIDVLERASVLTLYDVLKTLEKGLMVLLISKEAELTLVELGKFGLPSRMQLDEITDGIPEEIENLVLDFAKE
QVTIDKIEELMEKLLSLTEREISNYVTLARVLGYDISSSSQAMELNMRSRGIRFVRKIPKIPLQVALNVGAKYGSLARLL
KTSVEELKEVEGVGEKRARAIRHAIDIHNKREELE

Sequences:

>Translated_355_residues
MDHKELAERIRVVAPGTQLRFALDKIVAANTGALIFLVDDFEKYKDLMQVGFFLNCPFNPNKLYELSKMDGAIVVDESLN
KIIAANVQLTPDPSIPSLQTGMRHRTAERMARQTGKMLLAISKRQGTITIFFGENSHVLAPVEILLPRVNQVIRTVEQYR
QTFAYGLDQIDVLERASVLTLYDVLKTLEKGLMVLLISKEAELTLVELGKFGLPSRMQLDEITDGIPEEIENLVLDFAKE
QVTIDKIEELMEKLLSLTEREISNYVTLARVLGYDISSSSQAMELNMRSRGIRFVRKIPKIPLQVALNVGAKYGSLARLL
KTSVEELKEVEGVGEKRARAIRHAIDIHNKREELE
>Mature_355_residues
MDHKELAERIRVVAPGTQLRFALDKIVAANTGALIFLVDDFEKYKDLMQVGFFLNCPFNPNKLYELSKMDGAIVVDESLN
KIIAANVQLTPDPSIPSLQTGMRHRTAERMARQTGKMLLAISKRQGTITIFFGENSHVLAPVEILLPRVNQVIRTVEQYR
QTFAYGLDQIDVLERASVLTLYDVLKTLEKGLMVLLISKEAELTLVELGKFGLPSRMQLDEITDGIPEEIENLVLDFAKE
QVTIDKIEELMEKLLSLTEREISNYVTLARVLGYDISSSSQAMELNMRSRGIRFVRKIPKIPLQVALNVGAKYGSLARLL
KTSVEELKEVEGVGEKRARAIRHAIDIHNKREELE

Specific function: Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions [H]

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994 [H]

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N; PF00633 HHH [H]

EC number: NA

Molecular weight: Translated: 40076; Mature: 40076

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHKELAERIRVVAPGTQLRFALDKIVAANTGALIFLVDDFEKYKDLMQVGFFLNCPFNP
CCHHHHHHHHEEECCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCEEECCCCC
NKLYELSKMDGAIVVDESLNKIIAANVQLTPDPSIPSLQTGMRHRTAERMARQTGKMLLA
CHHHHHHCCCCCEEEECHHCHHEEECEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEEEE
ISKRQGTITIFFGENSHVLAPVEILLPRVNQVIRTVEQYRQTFAYGLDQIDVLERASVLT
EECCCCEEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LYDVLKTLEKGLMVLLISKEAELTLVELGKFGLPSRMQLDEITDGIPEEIENLVLDFAKE
HHHHHHHHHCCEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHH
QVTIDKIEELMEKLLSLTEREISNYVTLARVLGYDISSSSQAMELNMRSRGIRFVRKIPK
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEHHHHHHHHHHHHCCC
IPLQVALNVGAKYGSLARLLKTSVEELKEVEGVGEKRARAIRHAIDIHNKREELE
CCEEHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHCC
>Mature Secondary Structure
MDHKELAERIRVVAPGTQLRFALDKIVAANTGALIFLVDDFEKYKDLMQVGFFLNCPFNP
CCHHHHHHHHEEECCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCEEECCCCC
NKLYELSKMDGAIVVDESLNKIIAANVQLTPDPSIPSLQTGMRHRTAERMARQTGKMLLA
CHHHHHHCCCCCEEEECHHCHHEEECEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEEEE
ISKRQGTITIFFGENSHVLAPVEILLPRVNQVIRTVEQYRQTFAYGLDQIDVLERASVLT
EECCCCEEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LYDVLKTLEKGLMVLLISKEAELTLVELGKFGLPSRMQLDEITDGIPEEIENLVLDFAKE
HHHHHHHHHCCEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHH
QVTIDKIEELMEKLLSLTEREISNYVTLARVLGYDISSSSQAMELNMRSRGIRFVRKIPK
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEHHHHHHHHHHHHCCC
IPLQVALNVGAKYGSLARLLKTSVEELKEVEGVGEKRARAIRHAIDIHNKREELE
CCEEHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]