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The map label for this gene is glcD [H]

Identifier: 239618362

GI number: 239618362

Start: 2123395

End: 2124795

Strand: Direct

Name: glcD [H]

Synonym: Kole_2000

Alternate gene names: 239618362

Gene position: 2123395-2124795 (Clockwise)

Preceding gene: 239618361

Following gene: 239618368

Centisome position: 92.24

GC content: 45.11

Gene sequence:

>1401_bases
ATGATTGAGATACAAGAAGAGTTGCTTAACAGTCTAAAAGAGATCTTTGGAGATAGAATGAAACTCGAAAGAGATTTCCT
CGAGAAATACTCCCGGGATGAAACGGCTGAACTCGAAGGTTCGATGCCCGGGATAGTTCTGTTTCCCCTGACTCCAGAAG
AAATTTCCAGTGTCATGAAACTGGCGAATCAATACAAAGTACCCGTAACGCCAAGAGGGGCAGGAACGGGGCTTTCGGGA
GGAGCTATCCCGCCAAGTGGCGGAATTGTACTCTCGCTGGAAAAGATGAACAGGATAATCGAGTTCGATGAAGAAAACAT
GATGATAACCGTTGAACCGGGTGTTATAACCAATGAAATTCAGAAACTCGCTGACAGGCACGGCCTTATTTATGGGGGAG
ATCCATGCAGTAGCGATAGTTCCACAATAGGTGGGAATGTGGCTGAAAATGCCGGAGGAAACAAGGTCCTAAAATATGGC
CCGACCGGTTATCATGTGTACGCCCTTGAGGTTGTACTTCCTACCGGTGAGATAGTCCAGTTTGGCGGAAAAAGGATAAA
AGATGTTACCGGGTTCGATATGATTCATCTATTGATAGGTTCTGAGGGAACGTTGGGTATAGTTACAAAGATCACTCTCA
GACTGCTTCCAAAACCAAAATATTCTGTTGCCCTGTTGGCACCCTTCGAATCTGTTGAGAAAGCCATAGACGCTGTTCCG
AAACTCATGGTTAAATCCGGTACTATGCCTTCTTCACTGGAATTCATGGATCGATCTTCGATACAGTCTACATGTAAGTT
TTTGAATATAGAATTTCCGTACAGTGATGCGGGAGCACACCTCATAATAGAAGTGGAGGGCAACAACAAAACAGCTGTTT
CTGACGATTACGAAAGGATAGGAGATATCTGCCTGGAAGAGGGAGCGCTGGAGGTATTTGTAGCGGATAACAGAAACACT
CGCGAAAAGCTCTGGAAGGTGAGAAAGTCGATAGCAGAAGCCCTTTCGGTGTACAGTCCGGTTCATTGTATGGAAGATGT
TTCTGTTCCCATGGCAAGAATTCCGGAACTCATAAAAGGTGCGGAAAAGATTGCTGAGAAACACGGCCTTGAGATGTTGA
GTTTCGGTCATGCCGGCGACGGGAATGTTCACGTGACATTTGTCAAAGGTGATAGAACGGAAGAGTACTGGAAAGCACAT
CTGGAACCTGCACTGATTGAATTATATGAGCTCGCCAGAGATCTGGGGGGATGTATCAGCGGTGAACACGGTATTGGTCT
GAAGAGAAAGAAATACCTTCCTATAATCCTTGACGAGTCCCAGATCAGGTTGATAAAAGGAATAAAACGGATATTTGACC
CGAACAACATACTCAATCCTGGTAAGATCGTGGATCTTTAA

Upstream 100 bases:

>100_bases
CGATATTCGATTTCTCTGATATTGGTCTTGTGGGTGATGCGTCTGAAATCCTTGAGACCATTCTAAAGCGGTTGGAAGCA
CTGAAAGGAGAGAAAGTAAG

Downstream 100 bases:

>100_bases
TCGAAACACAACAACCCTATTTCACCATTGGTGAAACAAAAAAACATCCTTTGAATCGGTGATAATCCGCTTTTGGATGA
AGTTTTTTATGATTTCTCCT

Product: FAD linked oxidase domain protein

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MIEIQEELLNSLKEIFGDRMKLERDFLEKYSRDETAELEGSMPGIVLFPLTPEEISSVMKLANQYKVPVTPRGAGTGLSG
GAIPPSGGIVLSLEKMNRIIEFDEENMMITVEPGVITNEIQKLADRHGLIYGGDPCSSDSSTIGGNVAENAGGNKVLKYG
PTGYHVYALEVVLPTGEIVQFGGKRIKDVTGFDMIHLLIGSEGTLGIVTKITLRLLPKPKYSVALLAPFESVEKAIDAVP
KLMVKSGTMPSSLEFMDRSSIQSTCKFLNIEFPYSDAGAHLIIEVEGNNKTAVSDDYERIGDICLEEGALEVFVADNRNT
REKLWKVRKSIAEALSVYSPVHCMEDVSVPMARIPELIKGAEKIAEKHGLEMLSFGHAGDGNVHVTFVKGDRTEEYWKAH
LEPALIELYELARDLGGCISGEHGIGLKRKKYLPIILDESQIRLIKGIKRIFDPNNILNPGKIVDL

Sequences:

>Translated_466_residues
MIEIQEELLNSLKEIFGDRMKLERDFLEKYSRDETAELEGSMPGIVLFPLTPEEISSVMKLANQYKVPVTPRGAGTGLSG
GAIPPSGGIVLSLEKMNRIIEFDEENMMITVEPGVITNEIQKLADRHGLIYGGDPCSSDSSTIGGNVAENAGGNKVLKYG
PTGYHVYALEVVLPTGEIVQFGGKRIKDVTGFDMIHLLIGSEGTLGIVTKITLRLLPKPKYSVALLAPFESVEKAIDAVP
KLMVKSGTMPSSLEFMDRSSIQSTCKFLNIEFPYSDAGAHLIIEVEGNNKTAVSDDYERIGDICLEEGALEVFVADNRNT
REKLWKVRKSIAEALSVYSPVHCMEDVSVPMARIPELIKGAEKIAEKHGLEMLSFGHAGDGNVHVTFVKGDRTEEYWKAH
LEPALIELYELARDLGGCISGEHGIGLKRKKYLPIILDESQIRLIKGIKRIFDPNNILNPGKIVDL
>Mature_466_residues
MIEIQEELLNSLKEIFGDRMKLERDFLEKYSRDETAELEGSMPGIVLFPLTPEEISSVMKLANQYKVPVTPRGAGTGLSG
GAIPPSGGIVLSLEKMNRIIEFDEENMMITVEPGVITNEIQKLADRHGLIYGGDPCSSDSSTIGGNVAENAGGNKVLKYG
PTGYHVYALEVVLPTGEIVQFGGKRIKDVTGFDMIHLLIGSEGTLGIVTKITLRLLPKPKYSVALLAPFESVEKAIDAVP
KLMVKSGTMPSSLEFMDRSSIQSTCKFLNIEFPYSDAGAHLIIEVEGNNKTAVSDDYERIGDICLEEGALEVFVADNRNT
REKLWKVRKSIAEALSVYSPVHCMEDVSVPMARIPELIKGAEKIAEKHGLEMLSFGHAGDGNVHVTFVKGDRTEEYWKAH
LEPALIELYELARDLGGCISGEHGIGLKRKKYLPIILDESQIRLIKGIKRIFDPNNILNPGKIVDL

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=470, Percent_Identity=29.5744680851064, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI37595754, Length=493, Percent_Identity=28.3975659229209, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI119964728, Length=428, Percent_Identity=31.3084112149533, Blast_Score=206, Evalue=5e-53,
Organism=Homo sapiens, GI4501993, Length=455, Percent_Identity=27.032967032967, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1789351, Length=422, Percent_Identity=36.7298578199052, Blast_Score=267, Evalue=9e-73,
Organism=Escherichia coli, GI1787977, Length=540, Percent_Identity=25, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI48994907, Length=495, Percent_Identity=26.2626262626263, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI48994914, Length=142, Percent_Identity=28.169014084507, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71992373, Length=468, Percent_Identity=32.2649572649573, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17534361, Length=462, Percent_Identity=31.6017316017316, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI71992381, Length=468, Percent_Identity=30.7692307692308, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71992392, Length=386, Percent_Identity=32.1243523316062, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17556096, Length=220, Percent_Identity=27.2727272727273, Blast_Score=98, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6320764, Length=455, Percent_Identity=33.4065934065934, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6320023, Length=475, Percent_Identity=31.7894736842105, Blast_Score=213, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6320027, Length=436, Percent_Identity=28.6697247706422, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI18921117, Length=466, Percent_Identity=31.3304721030043, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24639277, Length=466, Percent_Identity=31.3304721030043, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24639275, Length=466, Percent_Identity=31.3304721030043, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24653753, Length=221, Percent_Identity=28.9592760180996, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 51183; Mature: 51183

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEIQEELLNSLKEIFGDRMKLERDFLEKYSRDETAELEGSMPGIVLFPLTPEEISSVMK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEECCHHHHHHHHH
LANQYKVPVTPRGAGTGLSGGAIPPSGGIVLSLEKMNRIIEFDEENMMITVEPGVITNEI
HHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHEEECCCCEEEEECCCCHHHHH
QKLADRHGLIYGGDPCSSDSSTIGGNVAENAGGNKVLKYGPTGYHVYALEVVLPTGEIVQ
HHHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEEEEECCCHHHH
FGGKRIKDVTGFDMIHLLIGSEGTLGIVTKITLRLLPKPKYSVALLAPFESVEKAIDAVP
HCCCCCCCCCCHHEEEEEECCCCCEEHHEEEHHHCCCCCCCCEEEECCHHHHHHHHHHHH
KLMVKSGTMPSSLEFMDRSSIQSTCKFLNIEFPYSDAGAHLIIEVEGNNKTAVSDDYERI
HHHHHCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEEECCCCCCCCHHHHHH
GDICLEEGALEVFVADNRNTREKLWKVRKSIAEALSVYSPVHCMEDVSVPMARIPELIKG
HHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHH
AEKIAEKHGLEMLSFGHAGDGNVHVTFVKGDRTEEYWKAHLEPALIELYELARDLGGCIS
HHHHHHHCCCEEEECCCCCCCCEEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHCCCCC
GEHGIGLKRKKYLPIILDESQIRLIKGIKRIFDPNNILNPGKIVDL
CCCCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCEECC
>Mature Secondary Structure
MIEIQEELLNSLKEIFGDRMKLERDFLEKYSRDETAELEGSMPGIVLFPLTPEEISSVMK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEECCHHHHHHHHH
LANQYKVPVTPRGAGTGLSGGAIPPSGGIVLSLEKMNRIIEFDEENMMITVEPGVITNEI
HHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHEEECCCCEEEEECCCCHHHHH
QKLADRHGLIYGGDPCSSDSSTIGGNVAENAGGNKVLKYGPTGYHVYALEVVLPTGEIVQ
HHHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEEEEECCCHHHH
FGGKRIKDVTGFDMIHLLIGSEGTLGIVTKITLRLLPKPKYSVALLAPFESVEKAIDAVP
HCCCCCCCCCCHHEEEEEECCCCCEEHHEEEHHHCCCCCCCCEEEECCHHHHHHHHHHHH
KLMVKSGTMPSSLEFMDRSSIQSTCKFLNIEFPYSDAGAHLIIEVEGNNKTAVSDDYERI
HHHHHCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEEECCCCCCCCHHHHHH
GDICLEEGALEVFVADNRNTREKLWKVRKSIAEALSVYSPVHCMEDVSVPMARIPELIKG
HHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHH
AEKIAEKHGLEMLSFGHAGDGNVHVTFVKGDRTEEYWKAHLEPALIELYELARDLGGCIS
HHHHHHHCCCEEEECCCCCCCCEEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHCCCCC
GEHGIGLKRKKYLPIILDESQIRLIKGIKRIFDPNNILNPGKIVDL
CCCCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]