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The map label for this gene is pgcA [H]

Identifier: 239618281

GI number: 239618281

Start: 2040191

End: 2041840

Strand: Reverse

Name: pgcA [H]

Synonym: Kole_1918

Alternate gene names: 239618281

Gene position: 2041840-2040191 (Counterclockwise)

Preceding gene: 239618282

Following gene: 239618280

Centisome position: 88.69

GC content: 41.03

Gene sequence:

>1650_bases
ATGATACGAACAGAAAAGGAAATACTTCAGGAATACCAGCGTTGGCTAGAAAATGCTTCGGCTGAACTTGTTCAGGAATT
AAAGAGCCTTCCAGAAAACGAAATTAAAGAACGCTTTTTCAAAGATCTGGAATTTGGCACAGGAGGTATGCGCGGAAAAA
TCGGAGCTGGAACCAACAGGATGAACGTTCATACCGTTTCTCGTGCTACTTTAGGTTTTGCAGATTGGTTGCTATCTCAA
TACAGTGATCCATCCGTTGTTATCGCGTACGATACAAGAAAAATGTCGAAAGAATTTGCAGAAACCGCAGCAAATATTCT
TTCAGGTAAGAAAATTCAGGTGTATCTATTTGAAGCCCCGGCTCCCACCCCTCTCCTGAGTTACTCTGTGAGAACTTTAA
AATGTAGTGGAGGAATCGTTATAACCGCGAGTCACAACCCACCGGAATACAATGGATACAAAGTTTATACCCATGACGGT
ACACAGGCTGTTCCCAGATATGCTAATCAGATAATAACGAAAGTCAATGCCAATGACTTCTTCAATGATATACAAAAAGA
CTCATCATTGATCTCTCCAGTACCTGAAGATGTTATATCTTCATACACTGCTCATATAATTAACCTAATGGAAGAACTTT
TCAGTGCAAAAGAAAGTCTTAAGGTTGTTTACACCCCTTTGCACGGTACGGGACGCGATTACGTAACAAAAGTTCTTGAA
AAATTAGGACACGAGGTTATCAAAGTGGAAGAACAGTTCACTCACGATGGGAATTTTCCAACGGTGAAGTACCCCAACCC
GGAGGATCCTGAGGCTTTTAAGTTAGCGCTAAGGTATGCCGGAAAAGAAGGCGCAGACCTTGTAATTGCAACCGATCCAG
ATGCTGATAGAATGGGTGTTGTATGCAAAACACGGGAAGGTTACAAAGCTTTGACTGGAAATCAGGTGGGGGTCATTTTC
ACCGCCTATCTGCTGGAAACTCTCAAGAACAAATTACCTGAAAAACCCTTTATAGTGAAAACCATTGTTACCACTGATAT
GGCCAAAACAATAGCTTCTAACTACAACGTTGAAACCCGTGAAACACTCACAGGATTCAAATTCATAGGAGAACTTATTG
AGGAATCTATAATAAAGAAAACCGGGAACTTTATCTTTGGATTTGAAGAAAGCTATGGTTACCTCTATGGAATGCATGCA
AGAGACAAGGATGCTGTTGTCGCTTCCGCATTGGTTGTAACCGTCGCAGCAGTTCTAAAAAAACGCGGGATCACCCTATG
GCAGTATCTTGAGGAGCTCTATAGGCAATATGGCTATTACGACGAGAAACTCCTCAATTTCACTTACGAAGGAATTGAAG
GGCTTGAAAAGATATCGAACATAATGAACTCTTTACGGGAGAAAACTCCGTCAGAAGTGGCGGGACACAGGCTCCTGAAA
TTTGAGGATTACTTAGAAGGGATTAAAGGGTTACCCAAATCCAACGTAATATCCTTAACCTTTGAAGAAGATTTGAAACT
AATCGTCAGACCTTCTGGAACAGAACCAAAAATAAAATTTTATCTGATGACTAGAGGAAATTCTAAACAGGAAAGCACTC
AAAAACTCCAGAAGCTCACAGATCTGGTAGAGAGGATTGTTGGAAGATGA

Upstream 100 bases:

>100_bases
GACTTTTCACCAAAATTCGAAGAATCCCGTCTTGACGTGATAGAGGTTTTATCCAACGGCGAGATAAATCATCTAAAAGG
TGTTGGAAGGTGGTAGTAAT

Downstream 100 bases:

>100_bases
ACAGATACGCACACATTCTATACGATGATAATTCCTATTGTTCACCGAAAAGAGCCACCTTTGACTTTCGAACCAAAACG
GGCCTGATGACAACCTGGTC

Product: Glucose-1,6-bisphosphate synthase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MIRTEKEILQEYQRWLENASAELVQELKSLPENEIKERFFKDLEFGTGGMRGKIGAGTNRMNVHTVSRATLGFADWLLSQ
YSDPSVVIAYDTRKMSKEFAETAANILSGKKIQVYLFEAPAPTPLLSYSVRTLKCSGGIVITASHNPPEYNGYKVYTHDG
TQAVPRYANQIITKVNANDFFNDIQKDSSLISPVPEDVISSYTAHIINLMEELFSAKESLKVVYTPLHGTGRDYVTKVLE
KLGHEVIKVEEQFTHDGNFPTVKYPNPEDPEAFKLALRYAGKEGADLVIATDPDADRMGVVCKTREGYKALTGNQVGVIF
TAYLLETLKNKLPEKPFIVKTIVTTDMAKTIASNYNVETRETLTGFKFIGELIEESIIKKTGNFIFGFEESYGYLYGMHA
RDKDAVVASALVVTVAAVLKKRGITLWQYLEELYRQYGYYDEKLLNFTYEGIEGLEKISNIMNSLREKTPSEVAGHRLLK
FEDYLEGIKGLPKSNVISLTFEEDLKLIVRPSGTEPKIKFYLMTRGNSKQESTQKLQKLTDLVERIVGR

Sequences:

>Translated_549_residues
MIRTEKEILQEYQRWLENASAELVQELKSLPENEIKERFFKDLEFGTGGMRGKIGAGTNRMNVHTVSRATLGFADWLLSQ
YSDPSVVIAYDTRKMSKEFAETAANILSGKKIQVYLFEAPAPTPLLSYSVRTLKCSGGIVITASHNPPEYNGYKVYTHDG
TQAVPRYANQIITKVNANDFFNDIQKDSSLISPVPEDVISSYTAHIINLMEELFSAKESLKVVYTPLHGTGRDYVTKVLE
KLGHEVIKVEEQFTHDGNFPTVKYPNPEDPEAFKLALRYAGKEGADLVIATDPDADRMGVVCKTREGYKALTGNQVGVIF
TAYLLETLKNKLPEKPFIVKTIVTTDMAKTIASNYNVETRETLTGFKFIGELIEESIIKKTGNFIFGFEESYGYLYGMHA
RDKDAVVASALVVTVAAVLKKRGITLWQYLEELYRQYGYYDEKLLNFTYEGIEGLEKISNIMNSLREKTPSEVAGHRLLK
FEDYLEGIKGLPKSNVISLTFEEDLKLIVRPSGTEPKIKFYLMTRGNSKQESTQKLQKLTDLVERIVGR
>Mature_549_residues
MIRTEKEILQEYQRWLENASAELVQELKSLPENEIKERFFKDLEFGTGGMRGKIGAGTNRMNVHTVSRATLGFADWLLSQ
YSDPSVVIAYDTRKMSKEFAETAANILSGKKIQVYLFEAPAPTPLLSYSVRTLKCSGGIVITASHNPPEYNGYKVYTHDG
TQAVPRYANQIITKVNANDFFNDIQKDSSLISPVPEDVISSYTAHIINLMEELFSAKESLKVVYTPLHGTGRDYVTKVLE
KLGHEVIKVEEQFTHDGNFPTVKYPNPEDPEAFKLALRYAGKEGADLVIATDPDADRMGVVCKTREGYKALTGNQVGVIF
TAYLLETLKNKLPEKPFIVKTIVTTDMAKTIASNYNVETRETLTGFKFIGELIEESIIKKTGNFIFGFEESYGYLYGMHA
RDKDAVVASALVVTVAAVLKKRGITLWQYLEELYRQYGYYDEKLLNFTYEGIEGLEKISNIMNSLREKTPSEVAGHRLLK
FEDYLEGIKGLPKSNVISLTFEEDLKLIVRPSGTEPKIKFYLMTRGNSKQESTQKLQKLTDLVERIVGR

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI31377548, Length=588, Percent_Identity=33.5034013605442, Blast_Score=261, Evalue=2e-69,
Organism=Homo sapiens, GI63055049, Length=590, Percent_Identity=32.0338983050847, Blast_Score=246, Evalue=3e-65,
Organism=Escherichia coli, GI1786904, Length=514, Percent_Identity=24.7081712062257, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789566, Length=283, Percent_Identity=28.9752650176678, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71993870, Length=549, Percent_Identity=31.8761384335155, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71993878, Length=287, Percent_Identity=35.191637630662, Blast_Score=162, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6323934, Length=577, Percent_Identity=30.8492201039861, Blast_Score=230, Evalue=5e-61,
Organism=Drosophila melanogaster, GI20129809, Length=586, Percent_Identity=28.4982935153584, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24651977, Length=459, Percent_Identity=30.0653594771242, Blast_Score=215, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24653722, Length=586, Percent_Identity=27.9863481228669, Blast_Score=199, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 61926; Mature: 61926

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRTEKEILQEYQRWLENASAELVQELKSLPENEIKERFFKDLEFGTGGMRGKIGAGTNR
CCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
MNVHTVSRATLGFADWLLSQYSDPSVVIAYDTRKMSKEFAETAANILSGKKIQVYLFEAP
EEEEEHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHCCCEEEEEEEECC
APTPLLSYSVRTLKCSGGIVITASHNPPEYNGYKVYTHDGTQAVPRYANQIITKVNANDF
CCCCHHHCCEEEEEECCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCHHH
FNDIQKDSSLISPVPEDVISSYTAHIINLMEELFSAKESLKVVYTPLHGTGRDYVTKVLE
HHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHH
KLGHEVIKVEEQFTHDGNFPTVKYPNPEDPEAFKLALRYAGKEGADLVIATDPDADRMGV
HHCHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCE
VCKTREGYKALTGNQVGVIFTAYLLETLKNKLPEKPFIVKTIVTTDMAKTIASNYNVETR
EEECCCCCEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCCCCHH
ETLTGFKFIGELIEESIIKKTGNFIFGFEESYGYLYGMHARDKDAVVASALVVTVAAVLK
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHH
KRGITLWQYLEELYRQYGYYDEKLLNFTYEGIEGLEKISNIMNSLREKTPSEVAGHRLLK
HCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FEDYLEGIKGLPKSNVISLTFEEDLKLIVRPSGTEPKIKFYLMTRGNSKQESTQKLQKLT
HHHHHHHHHCCCCCCEEEEEECCCCEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHH
DLVERIVGR
HHHHHHHCC
>Mature Secondary Structure
MIRTEKEILQEYQRWLENASAELVQELKSLPENEIKERFFKDLEFGTGGMRGKIGAGTNR
CCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
MNVHTVSRATLGFADWLLSQYSDPSVVIAYDTRKMSKEFAETAANILSGKKIQVYLFEAP
EEEEEHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHCCCEEEEEEEECC
APTPLLSYSVRTLKCSGGIVITASHNPPEYNGYKVYTHDGTQAVPRYANQIITKVNANDF
CCCCHHHCCEEEEEECCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCHHH
FNDIQKDSSLISPVPEDVISSYTAHIINLMEELFSAKESLKVVYTPLHGTGRDYVTKVLE
HHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHH
KLGHEVIKVEEQFTHDGNFPTVKYPNPEDPEAFKLALRYAGKEGADLVIATDPDADRMGV
HHCHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCE
VCKTREGYKALTGNQVGVIFTAYLLETLKNKLPEKPFIVKTIVTTDMAKTIASNYNVETR
EEECCCCCEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCCCCHH
ETLTGFKFIGELIEESIIKKTGNFIFGFEESYGYLYGMHARDKDAVVASALVVTVAAVLK
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHH
KRGITLWQYLEELYRQYGYYDEKLLNFTYEGIEGLEKISNIMNSLREKTPSEVAGHRLLK
HCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FEDYLEGIKGLPKSNVISLTFEEDLKLIVRPSGTEPKIKFYLMTRGNSKQESTQKLQKLT
HHHHHHHHHCCCCCCEEEEEECCCCEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHH
DLVERIVGR
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]