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The map label for this gene is adk

Identifier: 239618244

GI number: 239618244

Start: 2013234

End: 2013881

Strand: Reverse

Name: adk

Synonym: Kole_1881

Alternate gene names: 239618244

Gene position: 2013881-2013234 (Counterclockwise)

Preceding gene: 239618245

Following gene: 239618243

Centisome position: 87.48

GC content: 43.36

Gene sequence:

>648_bases
ATGAACATTATTTTGCTCGGTCCTCCCGGTGCGGGTAAAGGAACCCAGGCAAAAAAAATTGCTATGAGATATGGAATCCC
TCATATATCGACGGGGGATATGCTCAGGGAAGCCGTGGCTGCTGGCACAGAACTGGGAAAGAAAGTGAAAGAGATCATTG
AAAAAGGATTGCTCGTACCTGATGACCTTATGGTTGCTATTGTTGAAGACCGCTTGAAGAAACCCGACAGCGCTAAGGGA
TTCATCCTTGATGGATTTCCAAGAACTGTCCAGCAAGCGGAAAGTCTGTCGGGGATTTTGGGTAATCTTGGGAAGGAACT
TGACGCTGTTATACTCATTGATGCTCCCGAAGAAGTTGTAGTTGAGAGGATATCAAGCAGACGTGTTTGCCCCTCGTGTG
GAAAGGTGTATAACCTTCTCACGATTAAACCAAAAAACGATATGCTTTGCGATGATTGTAATATCGGATTGATTCAGAGA
GAGGATGACAAACCAGCAACAGTTCGCGAACGTTACAGAGTTTACATGGAAAAAACAGCGCCGGTGATTAATTACTACAG
CGAACATGGCTCTCTGATAACCATTGACGGTTCTTTAGACATCGAAGCTGTAACTGAAGAAATATTTAAAAATTTGGAGA
ATTTGTAA

Upstream 100 bases:

>100_bases
TCGCTTTAGACATCCTTCAGCAGATAGAATCCCACCTTATCGTTAGACACTACGAAGGATTCATCAAAAAGGGTAGACTG
CGCGGGAGGAGATGATACAA

Downstream 100 bases:

>100_bases
TATGATAAGGTTGAAATCTCCTGAAGAAATCCGTAAAATCGAATATGCTGCTAAAATTGTTGCGGAAGTCCTAGAATTGA
TAAGTGAAAACATACTAAAC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MNIILLGPPGAGKGTQAKKIAMRYGIPHISTGDMLREAVAAGTELGKKVKEIIEKGLLVPDDLMVAIVEDRLKKPDSAKG
FILDGFPRTVQQAESLSGILGNLGKELDAVILIDAPEEVVVERISSRRVCPSCGKVYNLLTIKPKNDMLCDDCNIGLIQR
EDDKPATVRERYRVYMEKTAPVINYYSEHGSLITIDGSLDIEAVTEEIFKNLENL

Sequences:

>Translated_215_residues
MNIILLGPPGAGKGTQAKKIAMRYGIPHISTGDMLREAVAAGTELGKKVKEIIEKGLLVPDDLMVAIVEDRLKKPDSAKG
FILDGFPRTVQQAESLSGILGNLGKELDAVILIDAPEEVVVERISSRRVCPSCGKVYNLLTIKPKNDMLCDDCNIGLIQR
EDDKPATVRERYRVYMEKTAPVINYYSEHGSLITIDGSLDIEAVTEEIFKNLENL
>Mature_215_residues
MNIILLGPPGAGKGTQAKKIAMRYGIPHISTGDMLREAVAAGTELGKKVKEIIEKGLLVPDDLMVAIVEDRLKKPDSAKG
FILDGFPRTVQQAESLSGILGNLGKELDAVILIDAPEEVVVERISSRRVCPSCGKVYNLLTIKPKNDMLCDDCNIGLIQR
EDDKPATVRERYRVYMEKTAPVINYYSEHGSLITIDGSLDIEAVTEEIFKNLENL

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=206, Percent_Identity=41.2621359223301, Blast_Score=164, Evalue=5e-41,
Organism=Homo sapiens, GI4502013, Length=206, Percent_Identity=41.2621359223301, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI19923437, Length=198, Percent_Identity=38.8888888888889, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI310110345, Length=202, Percent_Identity=40.5940594059406, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI53832003, Length=202, Percent_Identity=40.5940594059406, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI8051579, Length=202, Percent_Identity=40.5940594059406, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI53832001, Length=202, Percent_Identity=40.5940594059406, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI4502011, Length=214, Percent_Identity=31.7757009345794, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI22749187, Length=207, Percent_Identity=32.3671497584541, Blast_Score=107, Evalue=6e-24,
Organism=Homo sapiens, GI28144897, Length=213, Percent_Identity=28.6384976525822, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI28144899, Length=213, Percent_Identity=28.6384976525822, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI7706497, Length=214, Percent_Identity=26.6355140186916, Blast_Score=91, Evalue=9e-19,
Organism=Escherichia coli, GI1786680, Length=188, Percent_Identity=48.4042553191489, Blast_Score=174, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17552384, Length=215, Percent_Identity=38.6046511627907, Blast_Score=162, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17567503, Length=213, Percent_Identity=29.5774647887324, Blast_Score=113, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17537943, Length=217, Percent_Identity=29.0322580645161, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17550688, Length=211, Percent_Identity=27.0142180094787, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17533833, Length=211, Percent_Identity=27.4881516587678, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI25147457, Length=212, Percent_Identity=25, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=213, Percent_Identity=39.4366197183099, Blast_Score=168, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6321018, Length=213, Percent_Identity=34.7417840375587, Blast_Score=119, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322828, Length=211, Percent_Identity=28.436018957346, Blast_Score=96, Evalue=4e-21,
Organism=Drosophila melanogaster, GI22026816, Length=213, Percent_Identity=38.9671361502347, Blast_Score=160, Evalue=4e-40,
Organism=Drosophila melanogaster, GI17737899, Length=210, Percent_Identity=38.5714285714286, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24645822, Length=210, Percent_Identity=38.5714285714286, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24663208, Length=212, Percent_Identity=26.4150943396226, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17647141, Length=212, Percent_Identity=26.4150943396226, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI221459597, Length=211, Percent_Identity=28.9099526066351, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356893, Length=211, Percent_Identity=28.9099526066351, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_KOSOT (C5CGI1)

Other databases:

- EMBL:   CP001634
- RefSeq:   YP_002941566.1
- GeneID:   7967803
- GenomeReviews:   CP001634_GR
- KEGG:   kol:Kole_1881
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid; SSF57774 Adenylate_kinase_Znf_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23609; Mature: 23609

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIILLGPPGAGKGTQAKKIAMRYGIPHISTGDMLREAVAAGTELGKKVKEIIEKGLLVP
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DDLMVAIVEDRLKKPDSAKGFILDGFPRTVQQAESLSGILGNLGKELDAVILIDAPEEVV
HHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHH
VERISSRRVCPSCGKVYNLLTIKPKNDMLCDDCNIGLIQREDDKPATVRERYRVYMEKTA
HHHHHCCCCCCCCHHHEEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCC
PVINYYSEHGSLITIDGSLDIEAVTEEIFKNLENL
HHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIILLGPPGAGKGTQAKKIAMRYGIPHISTGDMLREAVAAGTELGKKVKEIIEKGLLVP
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DDLMVAIVEDRLKKPDSAKGFILDGFPRTVQQAESLSGILGNLGKELDAVILIDAPEEVV
HHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHH
VERISSRRVCPSCGKVYNLLTIKPKNDMLCDDCNIGLIQREDDKPATVRERYRVYMEKTA
HHHHHCCCCCCCCHHHEEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCC
PVINYYSEHGSLITIDGSLDIEAVTEEIFKNLENL
HHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA