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The map label for this gene is map [H]

Identifier: 239618243

GI number: 239618243

Start: 2012480

End: 2013232

Strand: Reverse

Name: map [H]

Synonym: Kole_1880

Alternate gene names: 239618243

Gene position: 2013232-2012480 (Counterclockwise)

Preceding gene: 239618244

Following gene: 239618242

Centisome position: 87.45

GC content: 41.97

Gene sequence:

>753_bases
ATGATAAGGTTGAAATCTCCTGAAGAAATCCGTAAAATCGAATATGCTGCTAAAATTGTTGCGGAAGTCCTAGAATTGAT
AAGTGAAAACATACTAAACGGTGCAACCGCATATGATCTGGAAAGGATAGCTGAAGAATTCATCCTTAACGCCGGGGCAA
AGCCAGCATTTAAAGGATACAACGGATATCCTTATGTACTTTGTGTTTCTGTGAACGAAGAAATTGTTCATGGATTTCCT
TTGAAGGACAAGATCTTCAAAAAGGGAGACCTTGTCACGGTTGACTGTGGTGTAATTAAGGATGGATATTACGGTGATGC
AGCACGGACATTCGTTGTTGACAACTTCAATAGTGAAAGAGACAGGAAACTGATGGAAATCACCGAACGTGCCCTTTATA
TGGCTATCGACGTAGCTGTTCCAGGTAACCGTGTTGGTGATATAGGGTACACGATCCAAAATTTCGTCGAAGCAAATGGG
TTTTCTGTAATAAGAGATTACGTAGGCCATGGAGTTGGGATTGCACTGCACGAAGATCCGCAAATACCCAATTATGGTAA
AAAAGGAATGGGTGCTTTGTTACGTGCAGGAATGACTATAGCAATCGAACCAATGATATCCAGTGGCAGTTACAGGGTAG
AGGTTCTCAATGATGGATGGACTGCTGTTACCATTGATCGTTCGAAGGCAGCTCATTTTGAGCATACAATCGTCATCGAG
AAGAATGGTTCGCGTATTCTCTCAAGCTTGTGA

Upstream 100 bases:

>100_bases
AATTACTACAGCGAACATGGCTCTCTGATAACCATTGACGGTTCTTTAGACATCGAAGCTGTAACTGAAGAAATATTTAA
AAATTTGGAGAATTTGTAAT

Downstream 100 bases:

>100_bases
GGGAGTGACGTCATGGCTGATAAAAGCGATGTAATTAAAATGGAAGGTGTGGTAATTGAATCAATGCCCAATGCCACATT
TAAGGTGAAACTCGACAATG

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MIRLKSPEEIRKIEYAAKIVAEVLELISENILNGATAYDLERIAEEFILNAGAKPAFKGYNGYPYVLCVSVNEEIVHGFP
LKDKIFKKGDLVTVDCGVIKDGYYGDAARTFVVDNFNSERDRKLMEITERALYMAIDVAVPGNRVGDIGYTIQNFVEANG
FSVIRDYVGHGVGIALHEDPQIPNYGKKGMGALLRAGMTIAIEPMISSGSYRVEVLNDGWTAVTIDRSKAAHFEHTIVIE
KNGSRILSSL

Sequences:

>Translated_250_residues
MIRLKSPEEIRKIEYAAKIVAEVLELISENILNGATAYDLERIAEEFILNAGAKPAFKGYNGYPYVLCVSVNEEIVHGFP
LKDKIFKKGDLVTVDCGVIKDGYYGDAARTFVVDNFNSERDRKLMEITERALYMAIDVAVPGNRVGDIGYTIQNFVEANG
FSVIRDYVGHGVGIALHEDPQIPNYGKKGMGALLRAGMTIAIEPMISSGSYRVEVLNDGWTAVTIDRSKAAHFEHTIVIE
KNGSRILSSL
>Mature_250_residues
MIRLKSPEEIRKIEYAAKIVAEVLELISENILNGATAYDLERIAEEFILNAGAKPAFKGYNGYPYVLCVSVNEEIVHGFP
LKDKIFKKGDLVTVDCGVIKDGYYGDAARTFVVDNFNSERDRKLMEITERALYMAIDVAVPGNRVGDIGYTIQNFVEANG
FSVIRDYVGHGVGIALHEDPQIPNYGKKGMGALLRAGMTIAIEPMISSGSYRVEVLNDGWTAVTIDRSKAAHFEHTIVIE
KNGSRILSSL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=248, Percent_Identity=35.8870967741936, Blast_Score=174, Evalue=9e-44,
Organism=Homo sapiens, GI40385867, Length=249, Percent_Identity=33.3333333333333, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1786364, Length=248, Percent_Identity=43.1451612903226, Blast_Score=225, Evalue=2e-60,
Organism=Escherichia coli, GI1788728, Length=223, Percent_Identity=27.3542600896861, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71996291, Length=248, Percent_Identity=35.8870967741936, Blast_Score=171, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6323273, Length=242, Percent_Identity=34.297520661157, Blast_Score=160, Evalue=2e-40,
Organism=Drosophila melanogaster, GI21355531, Length=247, Percent_Identity=36.4372469635627, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24583427, Length=245, Percent_Identity=33.8775510204082, Blast_Score=154, Evalue=8e-38,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27594; Mature: 27594

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRLKSPEEIRKIEYAAKIVAEVLELISENILNGATAYDLERIAEEFILNAGAKPAFKGY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
NGYPYVLCVSVNEEIVHGFPLKDKIFKKGDLVTVDCGVIKDGYYGDAARTFVVDNFNSER
CCCCEEEEEECCHHHHCCCCCHHHHHCCCCEEEEECCEECCCCCCCCEEEEEEECCCCHH
DRKLMEITERALYMAIDVAVPGNRVGDIGYTIQNFVEANGFSVIRDYVGHGVGIALHEDP
HHHHHHHHHHHEEEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCEEEEEECCC
QIPNYGKKGMGALLRAGMTIAIEPMISSGSYRVEVLNDGWTAVTIDRSKAAHFEHTIVIE
CCCCCCCHHHHHHHHCCCEEEEEEEECCCCEEEEEEECCCEEEEEECCCCCCCEEEEEEE
KNGSRILSSL
CCCCHHHHCC
>Mature Secondary Structure
MIRLKSPEEIRKIEYAAKIVAEVLELISENILNGATAYDLERIAEEFILNAGAKPAFKGY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
NGYPYVLCVSVNEEIVHGFPLKDKIFKKGDLVTVDCGVIKDGYYGDAARTFVVDNFNSER
CCCCEEEEEECCHHHHCCCCCHHHHHCCCCEEEEECCEECCCCCCCCEEEEEEECCCCHH
DRKLMEITERALYMAIDVAVPGNRVGDIGYTIQNFVEANGFSVIRDYVGHGVGIALHEDP
HHHHHHHHHHHEEEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCEEEEEECCC
QIPNYGKKGMGALLRAGMTIAIEPMISSGSYRVEVLNDGWTAVTIDRSKAAHFEHTIVIE
CCCCCCCHHHHHHHHCCCEEEEEEEECCCCEEEEEEECCCEEEEEECCCCCCCEEEEEEE
KNGSRILSSL
CCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842; 7559358 [H]