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The map label for this gene is arlR [H]

Identifier: 239618221

GI number: 239618221

Start: 1988527

End: 1989213

Strand: Direct

Name: arlR [H]

Synonym: Kole_1857

Alternate gene names: 239618221

Gene position: 1988527-1989213 (Clockwise)

Preceding gene: 239618194

Following gene: 239618222

Centisome position: 86.38

GC content: 40.03

Gene sequence:

>687_bases
TTGAAAGTACTGGTAGTTGAGGACGATGAAGGTTTGAGAAGGCTGCTAAATCTAGAATTAACTCACTATGGTTATGAAGT
GAAAACATCTGGAAAAGGAATAGATGCATTAAGGATGTACAGGGATTTCTGCCCGGATATAGTGTTGCTCGACATTTTAT
TGCCTCAACTTGATGGCTTTGAATTGCTGGTGGCTTTTCGGGAGATCTTTCCGGGTGCCGGAATAATTATATTAAGTGTG
ATAAATGACAAAGAGAGCAAGCTTAAAGCCTTCAGGCTTGGTGTTGATGATTATGTGACTAAGCCTTTTGACATGGAGGA
ATTACTGGCGAGAATAGAAGCTCTTGCACGCAGGGCTTTTTTACATGAAAGGGTCAAGAATAATGAAAGGCTATCCGATA
TATCTTCCCGCATTGAGATAGATGATAAAAGCAGAACCCTGCGGAGTGGTGAAATCGAAGTCAGGTTGTCTTCCCTTGAA
TTCAGAATATTTAAAATACTTTATTCGAACACGGGAACCGTTGTCGAAAAAGATCAGATTATAGCAGTTCTTTGGGGACA
GGAAAGAGCTCCAAGCGAGAGTACAATACCTGTTTATATAAAGTATCTCAGGGAAAAATTAGAACCTTTGAAGATAAAGA
TTGAGACTGTGAGAGGAGTTGGCTATGTACTCAAAGTTGAGGGCTAA

Upstream 100 bases:

>100_bases
AATCAGTATAATAACCAGGTATCTCACCTGATCACCTCCCATTAAATTATATCATGTTAATTCTGCCGAAATCTGAAGAG
ATGCGGAAAGGAGGCAATAT

Downstream 100 bases:

>100_bases
TTTCTGGATGACGGTTATAAGTCTTATCGCGTCGCTGATAGTTGTTTTGCTGGCGTATGCGACCGTTTATCGCGTTGTTA
TTGTCAGTACCAGCAGGAAT

Product: two component transcriptional regulator, winged helix family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKVLVVEDDEGLRRLLNLELTHYGYEVKTSGKGIDALRMYRDFCPDIVLLDILLPQLDGFELLVAFREIFPGAGIIILSV
INDKESKLKAFRLGVDDYVTKPFDMEELLARIEALARRAFLHERVKNNERLSDISSRIEIDDKSRTLRSGEIEVRLSSLE
FRIFKILYSNTGTVVEKDQIIAVLWGQERAPSESTIPVYIKYLREKLEPLKIKIETVRGVGYVLKVEG

Sequences:

>Translated_228_residues
MKVLVVEDDEGLRRLLNLELTHYGYEVKTSGKGIDALRMYRDFCPDIVLLDILLPQLDGFELLVAFREIFPGAGIIILSV
INDKESKLKAFRLGVDDYVTKPFDMEELLARIEALARRAFLHERVKNNERLSDISSRIEIDDKSRTLRSGEIEVRLSSLE
FRIFKILYSNTGTVVEKDQIIAVLWGQERAPSESTIPVYIKYLREKLEPLKIKIETVRGVGYVLKVEG
>Mature_228_residues
MKVLVVEDDEGLRRLLNLELTHYGYEVKTSGKGIDALRMYRDFCPDIVLLDILLPQLDGFELLVAFREIFPGAGIIILSV
INDKESKLKAFRLGVDDYVTKPFDMEELLARIEALARRAFLHERVKNNERLSDISSRIEIDDKSRTLRSGEIEVRLSSLE
FRIFKILYSNTGTVVEKDQIIAVLWGQERAPSESTIPVYIKYLREKLEPLKIKIETVRGVGYVLKVEG

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786911, Length=229, Percent_Identity=31.8777292576419, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787375, Length=231, Percent_Identity=32.034632034632, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1786784, Length=233, Percent_Identity=31.7596566523605, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=29.3859649122807, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=27.7533039647577, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=28, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=31.5555555555556, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=30.3571428571429, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=29.8701298701299, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=34.5794392523364, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI2367329, Length=233, Percent_Identity=30.9012875536481, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787229, Length=234, Percent_Identity=28.2051282051282, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=28.0701754385965, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1790299, Length=128, Percent_Identity=32.03125, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787487, Length=131, Percent_Identity=30.5343511450382, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1790437, Length=146, Percent_Identity=27.3972602739726, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=26.0683760683761, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI145693157, Length=118, Percent_Identity=31.3559322033898, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26173; Mature: 26173

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVVEDDEGLRRLLNLELTHYGYEVKTSGKGIDALRMYRDFCPDIVLLDILLPQLDGF
CEEEEEECCHHHHHHHHHEHHHCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHCCCCCH
ELLVAFREIFPGAGIIILSVINDKESKLKAFRLGVDDYVTKPFDMEELLARIEALARRAF
HHHHHHHHHCCCCCEEEEEEECCCHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHH
LHERVKNNERLSDISSRIEIDDKSRTLRSGEIEVRLSSLEFRIFKILYSNTGTVVEKDQI
HHHHHCCCCHHHHHHHHEEECCCCCCEECCEEEEEEEHHHEEEEEEEECCCCCEEECCCE
IAVLWGQERAPSESTIPVYIKYLREKLEPLKIKIETVRGVGYVLKVEG
EEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCEEEEEECC
>Mature Secondary Structure
MKVLVVEDDEGLRRLLNLELTHYGYEVKTSGKGIDALRMYRDFCPDIVLLDILLPQLDGF
CEEEEEECCHHHHHHHHHEHHHCCEEEEECCCCHHHHHHHHHHCCHHHHHHHHHCCCCCH
ELLVAFREIFPGAGIIILSVINDKESKLKAFRLGVDDYVTKPFDMEELLARIEALARRAF
HHHHHHHHHCCCCCEEEEEEECCCHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHH
LHERVKNNERLSDISSRIEIDDKSRTLRSGEIEVRLSSLEFRIFKILYSNTGTVVEKDQI
HHHHHCCCCHHHHHHHHEEECCCCCCEECCEEEEEEEHHHEEEEEEEECCCCCEEECCCE
IAVLWGQERAPSESTIPVYIKYLREKLEPLKIKIETVRGVGYVLKVEG
EEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA