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The map label for this gene is ykoH [H]

Identifier: 239618222

GI number: 239618222

Start: 1989191

End: 1990471

Strand: Direct

Name: ykoH [H]

Synonym: Kole_1858

Alternate gene names: 239618222

Gene position: 1989191-1990471 (Clockwise)

Preceding gene: 239618221

Following gene: 239618232

Centisome position: 86.41

GC content: 37.55

Gene sequence:

>1281_bases
ATGTACTCAAAGTTGAGGGCTAATTTCTGGATGACGGTTATAAGTCTTATCGCGTCGCTGATAGTTGTTTTGCTGGCGTA
TGCGACCGTTTATCGCGTTGTTATTGTCAGTACCAGCAGGAATGCCCTTATCGCATTGAAACAGATTGATCGTGTTTATA
ATGAAAAAATTCTTCAAACGATTCCTCCAAAGATGTTTAATAGAATTCCCGCTACGGTTATTATCCTTAGGAATGATGAG
TATAAGGTTATTCAGGATGCTCTTGGAATTGGAGAACAGGTTGAAAAGATTTTGGTGCTCTCTGCAGAAAAAAAGATATT
CGATCTTAATGGTGAATACTTTTTAAAGACACAATTGAAAACAACACGTGGAATTATTGTTGCTATTCAACCTGCGAATC
ATATTGTCGAACTTTTAAAACGTACAGCTGGATTGTTCTTCATCGTCTGGTTGATAGGTGCAGGTGTAATCCTTTTCTTT
TCTTTCCTTTTCAGTTCACGGTTCATAAAGAGTATTGGAAGCATTATAAAGAGAGCCGAAAAGATATCGAGAGAGATGGA
AGGATTACTTCCTGAAGAAGGATTGAGCGGAGAGATGCTGGAGCTGACGAAGAGTCTTAATAAAATGATTCTTAGATTAA
GAAATGCTCTTGAAGATGAGAAAGCATTTTCTGTAAGTGCTGCTCATGAATTAAAAACCCCTCTGGCGAATATTATTGGA
TATGTTGGAATGCTGAGGCGCTGGGGGTTGCAACATGAGGATATAGCCTATGAATCTCTAGAAAGAATTGAAAGAACCGC
TATTGAACTGAATGATCTTGTATCGAAGTTTCTCAATCTTAACGAACCTATCGACCTTTCCAAGATGCTGGAAATACAGG
CGAGTGATTTTCTTAATGACTATATTGATGAACTTAAAGGCAGATTACCGAATAGGAAGATAGAAGTTGATTGTAAAGCC
GACCCGTTTTTGAAAATTCCCGATGGACTTTTAGAAAATATCCTCAATATACTTGTTGATAACGCAAACAAGTTTTCTCC
GGAGAATCTGCCGATAAGGATTGTTGTTGAGAACAATAAAATAGGTGTTATGAGTTACGGTCCAAAGATACTCGAGGAGT
ATAAAGAAAAAATATTTGAGCCGTTTTTCAGGCTGGATAAAGAAAAAAAAGGTCATGGACTTGGTTTAACCATCGCGAGA
CGATTGGCTAGAAAAGCGGGATGGGATGTTTACCTGGATATCTCAAAAGAAGGAAATATTTTCTGGATAAAATTTAACTG
A

Upstream 100 bases:

>100_bases
AGAGCTCCAAGCGAGAGTACAATACCTGTTTATATAAAGTATCTCAGGGAAAAATTAGAACCTTTGAAGATAAAGATTGA
GACTGTGAGAGGAGTTGGCT

Downstream 100 bases:

>100_bases
GGATGGCAGAAAGGTAGCCCACTGTATGATATTTATCTCCAGAAACGTCGCCGCTCGTGGCATGCTTTAATATTTTCAGT
TCGTCGAAAAGTTTCAGAAC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MYSKLRANFWMTVISLIASLIVVLLAYATVYRVVIVSTSRNALIALKQIDRVYNEKILQTIPPKMFNRIPATVIILRNDE
YKVIQDALGIGEQVEKILVLSAEKKIFDLNGEYFLKTQLKTTRGIIVAIQPANHIVELLKRTAGLFFIVWLIGAGVILFF
SFLFSSRFIKSIGSIIKRAEKISREMEGLLPEEGLSGEMLELTKSLNKMILRLRNALEDEKAFSVSAAHELKTPLANIIG
YVGMLRRWGLQHEDIAYESLERIERTAIELNDLVSKFLNLNEPIDLSKMLEIQASDFLNDYIDELKGRLPNRKIEVDCKA
DPFLKIPDGLLENILNILVDNANKFSPENLPIRIVVENNKIGVMSYGPKILEEYKEKIFEPFFRLDKEKKGHGLGLTIAR
RLARKAGWDVYLDISKEGNIFWIKFN

Sequences:

>Translated_426_residues
MYSKLRANFWMTVISLIASLIVVLLAYATVYRVVIVSTSRNALIALKQIDRVYNEKILQTIPPKMFNRIPATVIILRNDE
YKVIQDALGIGEQVEKILVLSAEKKIFDLNGEYFLKTQLKTTRGIIVAIQPANHIVELLKRTAGLFFIVWLIGAGVILFF
SFLFSSRFIKSIGSIIKRAEKISREMEGLLPEEGLSGEMLELTKSLNKMILRLRNALEDEKAFSVSAAHELKTPLANIIG
YVGMLRRWGLQHEDIAYESLERIERTAIELNDLVSKFLNLNEPIDLSKMLEIQASDFLNDYIDELKGRLPNRKIEVDCKA
DPFLKIPDGLLENILNILVDNANKFSPENLPIRIVVENNKIGVMSYGPKILEEYKEKIFEPFFRLDKEKKGHGLGLTIAR
RLARKAGWDVYLDISKEGNIFWIKFN
>Mature_426_residues
MYSKLRANFWMTVISLIASLIVVLLAYATVYRVVIVSTSRNALIALKQIDRVYNEKILQTIPPKMFNRIPATVIILRNDE
YKVIQDALGIGEQVEKILVLSAEKKIFDLNGEYFLKTQLKTTRGIIVAIQPANHIVELLKRTAGLFFIVWLIGAGVILFF
SFLFSSRFIKSIGSIIKRAEKISREMEGLLPEEGLSGEMLELTKSLNKMILRLRNALEDEKAFSVSAAHELKTPLANIIG
YVGMLRRWGLQHEDIAYESLERIERTAIELNDLVSKFLNLNEPIDLSKMLEIQASDFLNDYIDELKGRLPNRKIEVDCKA
DPFLKIPDGLLENILNILVDNANKFSPENLPIRIVVENNKIGVMSYGPKILEEYKEKIFEPFFRLDKEKKGHGLGLTIAR
RLARKAGWDVYLDISKEGNIFWIKFN

Specific function: Probable member of the two-component regulatory system ykoH/ykoG. Potentially phosphorylates ykoG [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790551, Length=306, Percent_Identity=25.4901960784314, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1786783, Length=286, Percent_Identity=25.1748251748252, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787894, Length=239, Percent_Identity=25.5230125523013, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1790346, Length=232, Percent_Identity=26.7241379310345, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1789403, Length=278, Percent_Identity=24.4604316546763, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48688; Mature: 48688

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSKLRANFWMTVISLIASLIVVLLAYATVYRVVIVSTSRNALIALKQIDRVYNEKILQT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHH
IPPKMFNRIPATVIILRNDEYKVIQDALGIGEQVEKILVLSAEKKIFDLNGEYFLKTQLK
CCHHHHCCCCEEEEEEECCCHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCCEEEEEEEC
TTRGIIVAIQPANHIVELLKRTAGLFFIVWLIGAGVILFFSFLFSSRFIKSIGSIIKRAE
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KISREMEGLLPEEGLSGEMLELTKSLNKMILRLRNALEDEKAFSVSAAHELKTPLANIIG
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVGMLRRWGLQHEDIAYESLERIERTAIELNDLVSKFLNLNEPIDLSKMLEIQASDFLND
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
YIDELKGRLPNRKIEVDCKADPFLKIPDGLLENILNILVDNANKFSPENLPIRIVVENNK
HHHHHHCCCCCCEEEEECCCCCCEECCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCE
IGVMSYGPKILEEYKEKIFEPFFRLDKEKKGHGLGLTIARRLARKAGWDVYLDISKEGNI
EEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCE
FWIKFN
EEEEEC
>Mature Secondary Structure
MYSKLRANFWMTVISLIASLIVVLLAYATVYRVVIVSTSRNALIALKQIDRVYNEKILQT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHH
IPPKMFNRIPATVIILRNDEYKVIQDALGIGEQVEKILVLSAEKKIFDLNGEYFLKTQLK
CCHHHHCCCCEEEEEEECCCHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCCEEEEEEEC
TTRGIIVAIQPANHIVELLKRTAGLFFIVWLIGAGVILFFSFLFSSRFIKSIGSIIKRAE
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KISREMEGLLPEEGLSGEMLELTKSLNKMILRLRNALEDEKAFSVSAAHELKTPLANIIG
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVGMLRRWGLQHEDIAYESLERIERTAIELNDLVSKFLNLNEPIDLSKMLEIQASDFLND
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
YIDELKGRLPNRKIEVDCKADPFLKIPDGLLENILNILVDNANKFSPENLPIRIVVENNK
HHHHHHCCCCCCEEEEECCCCCCEECCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCE
IGVMSYGPKILEEYKEKIFEPFFRLDKEKKGHGLGLTIARRLARKAGWDVYLDISKEGNI
EEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCE
FWIKFN
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]