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The map label for this gene is 239618037

Identifier: 239618037

GI number: 239618037

Start: 1795384

End: 1796037

Strand: Direct

Name: 239618037

Synonym: Kole_1666

Alternate gene names: NA

Gene position: 1795384-1796037 (Clockwise)

Preceding gene: 239618036

Following gene: 239618038

Centisome position: 77.99

GC content: 38.99

Gene sequence:

>654_bases
ATGATAATAGGTATTTGCGGAAATATAGGAGCCGGGAAATCTTCTTTGACATCGCTTTTACAAAAAGAATTGGGATTTAC
AGCCGTTTACGAAGCGGTAGATGAAAACCCATTCCTCGAAGATTTTTATAGGGATATGCATAGATGGGCCTTTCATTCTC
AACTCTTTTTTCTAATAAAGCGTTTTGATTTCCTGAAGAAGGTGAAGGATGAGGGAACGGTTATCCTGCAAGACAGGACT
ATTTACGAAGATGTTGAAATATTTGCCCGAAACCTTCATATGATGAAATACATAGATGAAAGAGATTGGAAGCTGTATCA
TGATACCTTTACAACCCTTTCGGACCATTTAACCCCGCCTTCAGGACTGATATATATAAAATGCTCACTGCCGACGCTGT
TGAAGCGTATCCAGAAACGCGGCCGGGGTTACGAGTCGGATATCGATCCCAGGTATCTGGAAAGGCTCAATAATCTTTAT
GAAGAATGGTTTAGCAGATTTGAATTATCTCCAAAACTTGTGGTTGATGGTGATAAATTGGATTTCGTGGAAAACCCAGA
GGATAGAAAAATAGTTTTGGAACAGGTTAGCGGTTTTGTAAAAAATATTGCAACAGGTGTTCAATCAAAACTTTTCAACG
GTGGCAAAACATAA

Upstream 100 bases:

>100_bases
CATGCGCGCCGGTGTTGAAAATCGATACGACAGAAATGGACTTTGTGAGAAACCACAGTGATCTCAAAAAGATATACTCG
TTGATAGAGGAGAGATTACC

Downstream 100 bases:

>100_bases
TTCGGCAAAACATAATTCATTGTAAAAGAAAACGTTAATTTGGAAAGCTGCCGACAATAAACGATCCCTGAGTTTGGGAA
TGTGGTGATTAACCAATCTT

Product: deoxynucleoside kinase

Products: NA

Alternate protein names: DGK; DGUO kinase; Deoxynucleoside kinase complex I F-component [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MIIGICGNIGAGKSSLTSLLQKELGFTAVYEAVDENPFLEDFYRDMHRWAFHSQLFFLIKRFDFLKKVKDEGTVILQDRT
IYEDVEIFARNLHMMKYIDERDWKLYHDTFTTLSDHLTPPSGLIYIKCSLPTLLKRIQKRGRGYESDIDPRYLERLNNLY
EEWFSRFELSPKLVVDGDKLDFVENPEDRKIVLEQVSGFVKNIATGVQSKLFNGGKT

Sequences:

>Translated_217_residues
MIIGICGNIGAGKSSLTSLLQKELGFTAVYEAVDENPFLEDFYRDMHRWAFHSQLFFLIKRFDFLKKVKDEGTVILQDRT
IYEDVEIFARNLHMMKYIDERDWKLYHDTFTTLSDHLTPPSGLIYIKCSLPTLLKRIQKRGRGYESDIDPRYLERLNNLY
EEWFSRFELSPKLVVDGDKLDFVENPEDRKIVLEQVSGFVKNIATGVQSKLFNGGKT
>Mature_217_residues
MIIGICGNIGAGKSSLTSLLQKELGFTAVYEAVDENPFLEDFYRDMHRWAFHSQLFFLIKRFDFLKKVKDEGTVILQDRT
IYEDVEIFARNLHMMKYIDERDWKLYHDTFTTLSDHLTPPSGLIYIKCSLPTLLKRIQKRGRGYESDIDPRYLERLNNLY
EEWFSRFELSPKLVVDGDKLDFVENPEDRKIVLEQVSGFVKNIATGVQSKLFNGGKT

Specific function: DGK/DAK plays an essential role in generating the deoxyribonucleotide precursors, dGTP and dATP, for DNA metabolism [H]

COG id: COG1428

COG function: function code F; Deoxynucleoside kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DCK/DGK family [H]

Homologues:

Organism=Homo sapiens, GI18426967, Length=239, Percent_Identity=27.1966527196653, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4503269, Length=193, Percent_Identity=28.4974093264249, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002624 [H]

Pfam domain/function: PF01712 dNK [H]

EC number: =2.7.1.113 [H]

Molecular weight: Translated: 25361; Mature: 25361

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIGICGNIGAGKSSLTSLLQKELGFTAVYEAVDENPFLEDFYRDMHRWAFHSQLFFLIK
CEEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
RFDFLKKVKDEGTVILQDRTIYEDVEIFARNLHMMKYIDERDWKLYHDTFTTLSDHLTPP
HHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
SGLIYIKCSLPTLLKRIQKRGRGYESDIDPRYLERLNNLYEEWFSRFELSPKLVVDGDKL
CCEEEEEECHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCC
DFVENPEDRKIVLEQVSGFVKNIATGVQSKLFNGGKT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIIGICGNIGAGKSSLTSLLQKELGFTAVYEAVDENPFLEDFYRDMHRWAFHSQLFFLIK
CEEEEECCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
RFDFLKKVKDEGTVILQDRTIYEDVEIFARNLHMMKYIDERDWKLYHDTFTTLSDHLTPP
HHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
SGLIYIKCSLPTLLKRIQKRGRGYESDIDPRYLERLNNLYEEWFSRFELSPKLVVDGDKL
CCEEEEEECHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCC
DFVENPEDRKIVLEQVSGFVKNIATGVQSKLFNGGKT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7896798; 8172906 [H]