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The map label for this gene is groEL [H]

Identifier: 239617999

GI number: 239617999

Start: 1745618

End: 1747237

Strand: Direct

Name: groEL [H]

Synonym: Kole_1627

Alternate gene names: 239617999

Gene position: 1745618-1747237 (Clockwise)

Preceding gene: 239617998

Following gene: 239618000

Centisome position: 75.83

GC content: 46.98

Gene sequence:

>1620_bases
ATGCCAAAGATTCTTAAATTCAGTGAAGAAGCGAGAAGGTCTCTCGAAAGAGGTGTTGACGCTGTTGCAGAAGCTGTTAA
GATAACCCTTGGTCCTAAAGGGAGAAACGTTGTTCTTGAAAAGAGCTGGGGCTCTCCAACCATCACGAACGACGGTGTTT
CCATTGCCAAAGAGATCGAACTCGAAGATAAGTTTGAAAACCTTGGAGCTCAGCTCGTTAAAGAAGTTGCCTCCAAAACA
AATGATATAGCCGGTGACGGTACAACCACCGCAACAGTTCTTGCACAGGCCATGATTAAAGAAGGTCTGAAAAACGTTGC
TGCCGGTGCTAACCCGATACTTGTCAAAAAAGGAATCGAAAAGGCTGTTACCAAGGCCGTTGAAGAGATCCGCTCTATGT
CCAAGAAACTTTCCAGCAGAGAGGATATAGCCCATGTTGCTGCTATTTCTGCCAACGATCCCGAGATCGGTGAACTCATA
GCTGAAGCGATGGACAAGGTTGGAGAAGACGGAGTTATTACCGTTGAAGACTCCAAAACCCTCGAAACCTACGTGGAATT
TGTTGAAGGTATGCAGTTCGACAGGGGTTACATCTCTCCATACTTCGTCACCGACCCCGAAAAGATGGAAGCTGTTATAA
AAGAACCCTATATCCTCATCACCGACAAGAAACTTTCTGCGGTCAAACCCCTTGTTCCTATACTTGAAAAAGTCGCACAG
ACCGGTAAACCTCTCGTAATTATCGCAGAGGATGTCGAAGGTGAGGCTCTGTCTACCCTGGTTCTCAACAAACTGAGGGG
TACTCTTGAGTCTATCGCAGTTAAGGCACCTGGATTTGGCGACAGAAGAAAAGCCATGCTTCAGGATATCGCCATCCTGA
CCGGTGGAACTGTTATCAGTGAAGAGGTCGGCCTTACACTTGAAAATGCCACACTTGATGATCTTGGTACCGCTGGAATG
GTGAAGGTCAAGAAAGACGATACCATCATTGTTGATGGAAAAGGTGAACCCGAAAAGATCAAACAGAGAATAGGTCAGAT
TAAAGCTCAGATCGAACAGACAACATCTGAATACGAAAAGGAAACCCTTCAGGAGAGACTCGCGAAACTCGCCGGTGGTG
TTGCCGTTATCAAGGTCGGTGCTGCAACAGAAACCGAACTCAAAGAGAAGAAGCACAGAATCGAAGATGCTCTCAGCGCT
ACTAGAGCAGCTGTCGAGGAAGGAATCGTGGCCGGTGGTGGCGTTGCTCTGGCGAGAGCTAAAAAGACCGTTGAAAAACT
CATCGATGAGGTTGAAGATCCTGACATGAAGATCGGTGTTAAGATCGTTTACAAGTCTCTTGATGTTCCGATGAGACAGA
TCGCTGCTAACGCCGGTCTTGACGGAGCTGTCATCGTTGACAAAGTTCTTTCTGTTGACGATCCGTCCCATGGATACGAT
GCACTCCGTGACAAATTTACCGACATGTTTGAAGCTGGAATCGTCGATCCAGTCAAGGTTACAAGGAGCGCTCTCCAGAA
TGCAGCATCTATTGCTGGTATTCTACTTACAACAGAGGCTGCTGTTGTTGAGAAACCCGAAGAGAAGAAAGAAACTACCC
CACCGATGCCAGAGTACTGA

Upstream 100 bases:

>100_bases
ATACGCCGGTACTGAGATCAAGATCGATGACGAAGACTATATATTGATTGATCAGGATGATATTCTTGCCAAAGTCGAAG
AATGAAAGGGGGTAGTGTGA

Downstream 100 bases:

>100_bases
TGAAGTAATCCATTGAATCAATTAAGGGAGAGCGTTTAACGCTCTCCCTTTTTGTTCCTCAGGCACATAACAACAACTCT
AATTTCAGTTGATACATCCA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MPKILKFSEEARRSLERGVDAVAEAVKITLGPKGRNVVLEKSWGSPTITNDGVSIAKEIELEDKFENLGAQLVKEVASKT
NDIAGDGTTTATVLAQAMIKEGLKNVAAGANPILVKKGIEKAVTKAVEEIRSMSKKLSSREDIAHVAAISANDPEIGELI
AEAMDKVGEDGVITVEDSKTLETYVEFVEGMQFDRGYISPYFVTDPEKMEAVIKEPYILITDKKLSAVKPLVPILEKVAQ
TGKPLVIIAEDVEGEALSTLVLNKLRGTLESIAVKAPGFGDRRKAMLQDIAILTGGTVISEEVGLTLENATLDDLGTAGM
VKVKKDDTIIVDGKGEPEKIKQRIGQIKAQIEQTTSEYEKETLQERLAKLAGGVAVIKVGAATETELKEKKHRIEDALSA
TRAAVEEGIVAGGGVALARAKKTVEKLIDEVEDPDMKIGVKIVYKSLDVPMRQIAANAGLDGAVIVDKVLSVDDPSHGYD
ALRDKFTDMFEAGIVDPVKVTRSALQNAASIAGILLTTEAAVVEKPEEKKETTPPMPEY

Sequences:

>Translated_539_residues
MPKILKFSEEARRSLERGVDAVAEAVKITLGPKGRNVVLEKSWGSPTITNDGVSIAKEIELEDKFENLGAQLVKEVASKT
NDIAGDGTTTATVLAQAMIKEGLKNVAAGANPILVKKGIEKAVTKAVEEIRSMSKKLSSREDIAHVAAISANDPEIGELI
AEAMDKVGEDGVITVEDSKTLETYVEFVEGMQFDRGYISPYFVTDPEKMEAVIKEPYILITDKKLSAVKPLVPILEKVAQ
TGKPLVIIAEDVEGEALSTLVLNKLRGTLESIAVKAPGFGDRRKAMLQDIAILTGGTVISEEVGLTLENATLDDLGTAGM
VKVKKDDTIIVDGKGEPEKIKQRIGQIKAQIEQTTSEYEKETLQERLAKLAGGVAVIKVGAATETELKEKKHRIEDALSA
TRAAVEEGIVAGGGVALARAKKTVEKLIDEVEDPDMKIGVKIVYKSLDVPMRQIAANAGLDGAVIVDKVLSVDDPSHGYD
ALRDKFTDMFEAGIVDPVKVTRSALQNAASIAGILLTTEAAVVEKPEEKKETTPPMPEY
>Mature_538_residues
PKILKFSEEARRSLERGVDAVAEAVKITLGPKGRNVVLEKSWGSPTITNDGVSIAKEIELEDKFENLGAQLVKEVASKTN
DIAGDGTTTATVLAQAMIKEGLKNVAAGANPILVKKGIEKAVTKAVEEIRSMSKKLSSREDIAHVAAISANDPEIGELIA
EAMDKVGEDGVITVEDSKTLETYVEFVEGMQFDRGYISPYFVTDPEKMEAVIKEPYILITDKKLSAVKPLVPILEKVAQT
GKPLVIIAEDVEGEALSTLVLNKLRGTLESIAVKAPGFGDRRKAMLQDIAILTGGTVISEEVGLTLENATLDDLGTAGMV
KVKKDDTIIVDGKGEPEKIKQRIGQIKAQIEQTTSEYEKETLQERLAKLAGGVAVIKVGAATETELKEKKHRIEDALSAT
RAAVEEGIVAGGGVALARAKKTVEKLIDEVEDPDMKIGVKIVYKSLDVPMRQIAANAGLDGAVIVDKVLSVDDPSHGYDA
LRDKFTDMFEAGIVDPVKVTRSALQNAASIAGILLTTEAAVVEKPEEKKETTPPMPEY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=51.6007532956685, Blast_Score=526, Evalue=1e-149,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=51.6007532956685, Blast_Score=526, Evalue=1e-149,
Organism=Homo sapiens, GI38455427, Length=551, Percent_Identity=22.3230490018149, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI24307939, Length=573, Percent_Identity=21.6404886561955, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI302058290, Length=450, Percent_Identity=24, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI5453603, Length=571, Percent_Identity=23.4676007005254, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790586, Length=526, Percent_Identity=60.6463878326996, Blast_Score=627, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=51.5151515151515, Blast_Score=531, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI193210679, Length=208, Percent_Identity=52.8846153846154, Blast_Score=211, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI17564182, Length=546, Percent_Identity=21.978021978022, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI25144674, Length=541, Percent_Identity=23.8447319778189, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=52.6615969581749, Blast_Score=544, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6322350, Length=555, Percent_Identity=23.6036036036036, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6322524, Length=544, Percent_Identity=24.6323529411765, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320058, Length=144, Percent_Identity=28.4722222222222, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=52.2727272727273, Blast_Score=535, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=52.2727272727273, Blast_Score=535, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=49.0530303030303, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=49.0530303030303, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=49.0530303030303, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI17864606, Length=525, Percent_Identity=43.6190476190476, Blast_Score=438, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24584129, Length=537, Percent_Identity=34.0782122905028, Blast_Score=288, Evalue=9e-78,
Organism=Drosophila melanogaster, GI19921262, Length=537, Percent_Identity=34.0782122905028, Blast_Score=288, Evalue=9e-78,
Organism=Drosophila melanogaster, GI24583944, Length=568, Percent_Identity=22.1830985915493, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24645179, Length=509, Percent_Identity=21.8074656188605, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57816; Mature: 57685

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKILKFSEEARRSLERGVDAVAEAVKITLGPKGRNVVLEKSWGSPTITNDGVSIAKEIE
CCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHH
LEDKFENLGAQLVKEVASKTNDIAGDGTTTATVLAQAMIKEGLKNVAAGANPILVKKGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHH
KAVTKAVEEIRSMSKKLSSREDIAHVAAISANDPEIGELIAEAMDKVGEDGVITVEDSKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHCCCCCEEEECCCHH
LETYVEFVEGMQFDRGYISPYFVTDPEKMEAVIKEPYILITDKKLSAVKPLVPILEKVAQ
HHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHH
TGKPLVIIAEDVEGEALSTLVLNKLRGTLESIAVKAPGFGDRRKAMLQDIAILTGGTVIS
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCCEEEH
EEVGLTLENATLDDLGTAGMVKVKKDDTIIVDGKGEPEKIKQRIGQIKAQIEQTTSEYEK
HHHCCEECCCCHHHCCCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ETLQERLAKLAGGVAVIKVGAATETELKEKKHRIEDALSATRAAVEEGIVAGGGVALARA
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
KKTVEKLIDEVEDPDMKIGVKIVYKSLDVPMRQIAANAGLDGAVIVDKVLSVDDPSHGYD
HHHHHHHHHHHCCCCCEEEHHHEEHHHCCCHHHHHHHCCCCCHHHHHHHHCCCCCCCCHH
ALRDKFTDMFEAGIVDPVKVTRSALQNAASIAGILLTTEAAVVEKPEEKKETTPPMPEY
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHCCCCCCCCCC
>Mature Secondary Structure 
PKILKFSEEARRSLERGVDAVAEAVKITLGPKGRNVVLEKSWGSPTITNDGVSIAKEIE
CCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHH
LEDKFENLGAQLVKEVASKTNDIAGDGTTTATVLAQAMIKEGLKNVAAGANPILVKKGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHH
KAVTKAVEEIRSMSKKLSSREDIAHVAAISANDPEIGELIAEAMDKVGEDGVITVEDSKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHCCCCCEEEECCCHH
LETYVEFVEGMQFDRGYISPYFVTDPEKMEAVIKEPYILITDKKLSAVKPLVPILEKVAQ
HHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHH
TGKPLVIIAEDVEGEALSTLVLNKLRGTLESIAVKAPGFGDRRKAMLQDIAILTGGTVIS
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCCEEEH
EEVGLTLENATLDDLGTAGMVKVKKDDTIIVDGKGEPEKIKQRIGQIKAQIEQTTSEYEK
HHHCCEECCCCHHHCCCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ETLQERLAKLAGGVAVIKVGAATETELKEKKHRIEDALSATRAAVEEGIVAGGGVALARA
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
KKTVEKLIDEVEDPDMKIGVKIVYKSLDVPMRQIAANAGLDGAVIVDKVLSVDDPSHGYD
HHHHHHHHHHHCCCCCEEEHHHEEHHHCCCHHHHHHHCCCCCHHHHHHHHCCCCCCCCHH
ALRDKFTDMFEAGIVDPVKVTRSALQNAASIAGILLTTEAAVVEKPEEKKETTPPMPEY
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]