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The map label for this gene is ffh [H]

Identifier: 239617834

GI number: 239617834

Start: 1561420

End: 1562736

Strand: Direct

Name: ffh [H]

Synonym: Kole_1460

Alternate gene names: 239617834

Gene position: 1561420-1562736 (Clockwise)

Preceding gene: 239617833

Following gene: 239617835

Centisome position: 67.83

GC content: 41.76

Gene sequence:

>1317_bases
ATGTTTGAATCGCTACAGGAGAAACTAAGCAGAGCATTCAAGACGTTAAGCGGTAAAGGGAGAATAACAGAAAGTAATAT
AAAAGAGGCTGTTAAGCAGATAAAACTTTCTTTGCTGGAAGCTGATGTTAATTATAAAGTTGTCAAGGAATTTATCAAAT
CAGTTCAGGAAAAAGCTCTGGGCGAAGAAGTTCTGAAGAGTTTTACGCCTGATCAGCAGTTTATAAAAATAGTACGTGAT
GAACTGATAAAGGTTCTTGGTGAAAAGAAAGTCGGGTTGAATTTATCCGGAAGCCCGGCGAAGATAATGCTGGTGGGTCT
TCAGGGAAGCGGAAAGACTACTACCAGTGCAAAGCTTGCGTTAATGCTGAAAAAAGAAGGAAAACATCCGTTGCTCGTTG
CTGCCGATGTCTACAGACCGGCCGCTGTTGACCAGCTCATCCAGCTGGGAAAACAGATAGAGGTTCCCGTTTATACGGGA
GACAGAAAGGATCCGTTGAAGATTGTGCAGGAAGCTTTGGATGAGGCTGTAAAAAATGTTCATGATGTGATTATTTTTGA
TACGGCGGGTCGATTGCATGTTGACGAAAAGATGATGGAAGAAGTCAGGAGGATCGCTGAAATTGTTAAGCCTGACGAAA
TTTTGATGGTTATCGATGCAATGACTGGTCAGGATGCGGTCAATTCCGCTAAGAAGTTCAATGATGAACTTGAGTTGACA
GGATTTGTAGTTACGAAAATTGACGGTGACGCCAGGGGTGGAGTGATACTTTCTGTAAGGCATGTTACCGGGAAACCTGT
AAAATTTGTTGGTATTTCCGAAAAGATGGATGGGCTTGAATACTTCTATCCCGATAGAATAGCTGGCAGGATACTCGGGA
TGGGAGATGTCTTGAGTTTGATCGATAAATTGCAGGCATCGGTGGATCAGGAAAAAGCAAAAAAACTCGAGGAGAAGTTC
GCTAAGAACAAATTTGATCTGGAAGACTTTTTGGAACAGTTGAGAGAAATAAAAAAGCTTGGTTCAATTGGTGAGATCCT
GGAAATGATTCCAGGTGCCCCGAAGAATGTTGACTTTTCTGCGGGTGAGAAAAGTCTTAAGCAAACAGAAGCGATCATAT
CGTCCATGACTCGAGAGGAACGACGAAATCCGAAAATCATTAACTACAGTCGTAAACAGAGAATTGCGCGTGGAAGCGGG
ACATCTGTAACAGAGGTAAATAAAGTGCTTCGTTCTTACGATCAGATGAAGCAGATGATGAAGAAGCTGAATAAGGCACC
AAAGTTTATGAAAAAATTCAAAGGATTTCCATTCTAA

Upstream 100 bases:

>100_bases
TAACCTAAGTAAGAGATAATCTCAAGCGTTGTTAGAAAAAGCTTCACCAAAAGGTATTTTGGTCTGGTGTATACTATTCC
GGCATGCCGGAGGTGTTTTG

Downstream 100 bases:

>100_bases
ATATATATATGTTCAGGAGGTGTGTTCTAGATGGTAAAAATTCGTCTAACAAGGATGGGAAGAAGAAACAGGCCTTTCTA
CCGAATCGTTGTTGTGGACT

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MFESLQEKLSRAFKTLSGKGRITESNIKEAVKQIKLSLLEADVNYKVVKEFIKSVQEKALGEEVLKSFTPDQQFIKIVRD
ELIKVLGEKKVGLNLSGSPAKIMLVGLQGSGKTTTSAKLALMLKKEGKHPLLVAADVYRPAAVDQLIQLGKQIEVPVYTG
DRKDPLKIVQEALDEAVKNVHDVIIFDTAGRLHVDEKMMEEVRRIAEIVKPDEILMVIDAMTGQDAVNSAKKFNDELELT
GFVVTKIDGDARGGVILSVRHVTGKPVKFVGISEKMDGLEYFYPDRIAGRILGMGDVLSLIDKLQASVDQEKAKKLEEKF
AKNKFDLEDFLEQLREIKKLGSIGEILEMIPGAPKNVDFSAGEKSLKQTEAIISSMTREERRNPKIINYSRKQRIARGSG
TSVTEVNKVLRSYDQMKQMMKKLNKAPKFMKKFKGFPF

Sequences:

>Translated_438_residues
MFESLQEKLSRAFKTLSGKGRITESNIKEAVKQIKLSLLEADVNYKVVKEFIKSVQEKALGEEVLKSFTPDQQFIKIVRD
ELIKVLGEKKVGLNLSGSPAKIMLVGLQGSGKTTTSAKLALMLKKEGKHPLLVAADVYRPAAVDQLIQLGKQIEVPVYTG
DRKDPLKIVQEALDEAVKNVHDVIIFDTAGRLHVDEKMMEEVRRIAEIVKPDEILMVIDAMTGQDAVNSAKKFNDELELT
GFVVTKIDGDARGGVILSVRHVTGKPVKFVGISEKMDGLEYFYPDRIAGRILGMGDVLSLIDKLQASVDQEKAKKLEEKF
AKNKFDLEDFLEQLREIKKLGSIGEILEMIPGAPKNVDFSAGEKSLKQTEAIISSMTREERRNPKIINYSRKQRIARGSG
TSVTEVNKVLRSYDQMKQMMKKLNKAPKFMKKFKGFPF
>Mature_438_residues
MFESLQEKLSRAFKTLSGKGRITESNIKEAVKQIKLSLLEADVNYKVVKEFIKSVQEKALGEEVLKSFTPDQQFIKIVRD
ELIKVLGEKKVGLNLSGSPAKIMLVGLQGSGKTTTSAKLALMLKKEGKHPLLVAADVYRPAAVDQLIQLGKQIEVPVYTG
DRKDPLKIVQEALDEAVKNVHDVIIFDTAGRLHVDEKMMEEVRRIAEIVKPDEILMVIDAMTGQDAVNSAKKFNDELELT
GFVVTKIDGDARGGVILSVRHVTGKPVKFVGISEKMDGLEYFYPDRIAGRILGMGDVLSLIDKLQASVDQEKAKKLEEKF
AKNKFDLEDFLEQLREIKKLGSIGEILEMIPGAPKNVDFSAGEKSLKQTEAIISSMTREERRNPKIINYSRKQRIARGSG
TSVTEVNKVLRSYDQMKQMMKKLNKAPKFMKKFKGFPF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=431, Percent_Identity=34.8027842227378, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI226371618, Length=335, Percent_Identity=37.6119402985075, Blast_Score=205, Evalue=9e-53,
Organism=Homo sapiens, GI89061728, Length=149, Percent_Identity=35.5704697986577, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI23308697, Length=296, Percent_Identity=25.3378378378378, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI295424842, Length=296, Percent_Identity=25.3378378378378, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1788963, Length=425, Percent_Identity=51.2941176470588, Blast_Score=433, Evalue=1e-123,
Organism=Escherichia coli, GI1789874, Length=255, Percent_Identity=36.078431372549, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17539958, Length=430, Percent_Identity=30.9302325581395, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI193206261, Length=295, Percent_Identity=29.1525423728814, Blast_Score=105, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=427, Percent_Identity=34.8946135831382, Blast_Score=232, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6320498, Length=211, Percent_Identity=31.2796208530806, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17647949, Length=430, Percent_Identity=32.3255813953488, Blast_Score=205, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24641198, Length=305, Percent_Identity=25.9016393442623, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49028; Mature: 49028

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFESLQEKLSRAFKTLSGKGRITESNIKEAVKQIKLSLLEADVNYKVVKEFIKSVQEKAL
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GEEVLKSFTPDQQFIKIVRDELIKVLGEKKVGLNLSGSPAKIMLVGLQGSGKTTTSAKLA
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHH
LMLKKEGKHPLLVAADVYRPAAVDQLIQLGKQIEVPVYTGDRKDPLKIVQEALDEAVKNV
EEECCCCCCCEEEEECCCCHHHHHHHHHCCCCEECEEEECCCCCHHHHHHHHHHHHHHHH
HDVIIFDTAGRLHVDEKMMEEVRRIAEIVKPDEILMVIDAMTGQDAVNSAKKFNDELELT
HHEEEEECCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCEEE
GFVVTKIDGDARGGVILSVRHVTGKPVKFVGISEKMDGLEYFYPDRIAGRILGMGDVLSL
EEEEEEECCCCCCCEEEEEEECCCCCEEEEECCHHHCCCHHCCCHHHHHHHCCHHHHHHH
IDKLQASVDQEKAKKLEEKFAKNKFDLEDFLEQLREIKKLGSIGEILEMIPGAPKNVDFS
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCC
AGEKSLKQTEAIISSMTREERRNPKIINYSRKQRIARGSGTSVTEVNKVLRSYDQMKQMM
CCHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KKLNKAPKFMKKFKGFPF
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFESLQEKLSRAFKTLSGKGRITESNIKEAVKQIKLSLLEADVNYKVVKEFIKSVQEKAL
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GEEVLKSFTPDQQFIKIVRDELIKVLGEKKVGLNLSGSPAKIMLVGLQGSGKTTTSAKLA
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHH
LMLKKEGKHPLLVAADVYRPAAVDQLIQLGKQIEVPVYTGDRKDPLKIVQEALDEAVKNV
EEECCCCCCCEEEEECCCCHHHHHHHHHCCCCEECEEEECCCCCHHHHHHHHHHHHHHHH
HDVIIFDTAGRLHVDEKMMEEVRRIAEIVKPDEILMVIDAMTGQDAVNSAKKFNDELELT
HHEEEEECCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCEEE
GFVVTKIDGDARGGVILSVRHVTGKPVKFVGISEKMDGLEYFYPDRIAGRILGMGDVLSL
EEEEEEECCCCCCCEEEEEEECCCCCEEEEECCHHHCCCHHCCCHHHHHHHCCHHHHHHH
IDKLQASVDQEKAKKLEEKFAKNKFDLEDFLEQLREIKKLGSIGEILEMIPGAPKNVDFS
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCC
AGEKSLKQTEAIISSMTREERRNPKIINYSRKQRIARGSGTSVTEVNKVLRSYDQMKQMM
CCHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KKLNKAPKFMKKFKGFPF
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]