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The map label for this gene is mtnA [H]

Identifier: 239617828

GI number: 239617828

Start: 1551026

End: 1552069

Strand: Direct

Name: mtnA [H]

Synonym: Kole_1454

Alternate gene names: 239617828

Gene position: 1551026-1552069 (Clockwise)

Preceding gene: 239617827

Following gene: 239617829

Centisome position: 67.37

GC content: 43.2

Gene sequence:

>1044_bases
ATGTCGAAGTTAAAAACTATGACGTTGGAATGGACAGGTGAATCCGTTATTTTTATCGACCAGCGCAAACTCCCAACCCA
GGAAATTTACGTTGAATGCGAAACGTACGAAGATGTTTACGTGGCTATAAAGGATATGATCGTTCGCGGAGCTCCTGCTA
TCGGTGCAAGTGCTGCCTTCGGTTATGTTTTGGGAGCCCAAAAATTCAATGGGGCCTTCGATTCAGCTGAAGGGTTAGCC
TATATGGAAAAGGTCAAAGAAAAACTAGCATCGAGCCGCCCAACGGCCGTTAATCTTTTCTGGGCTTTAGACAGAATGCA
TAGAACCTTTGAAAGTTTTAGAAATGAACCTGATGTAGTGAAGCTTTTAGAAGAAGAAGCTTTGAAAATTGCCTATGAAG
ATATAGAGGTTAACCGTGCCATCGGAAAGCATGGTGCTGAGGTCTTAAGAGACGGTGATACTGTTTTAACCCACTGTAAT
GCTGGAGCTCTTGCAACGGTAGATTATGGAACGGCCCTTGGTGTTATAAGAGCAGCGGTAGAACAAGGAAAGAAGATAAA
GGTGTTCGCTGATGAGACAAGACCTTATCTTCAGGGTGCCAGGCTAACCGCATGGGAACTAATGAAGGATGGCATAGATG
TTACTTTGATTTCTGATAATATGGCTGGCTGGGTAATGAAAAAAGGATGGATTAATGCTGTTGTTGTCGGCGCTGACAGG
ATTGCAGCCAATGGAGATGTTGCAAATAAAATCGGGACGTACTCCGTTGCCATCCTCGCACAGAAACATGGTATTCCTTT
TTATGTGGCGGCACCTTTATCAACGATTGATTTGAACACACCAACAGGTGATGAAATACCGATAGAGGAACGAAGTCATA
GAGAGATCACCCACGTTCAGGGAGTCCAGATTGCTCCCGATAATATCAAATGTTATAATCCTGCTTTCGATGTTACACCC
TCACACCTGATAACAGGTATAATAACAGAGAAGGGGATCGTTAGACCTCCATACGATGTGGAATTAAAAAAACTTTTTGA
ATGA

Upstream 100 bases:

>100_bases
GATAGAGGGGAAACAATAATCACTCATATGCGTGGTTCAATAGTGGAAAAATCTTTTAGGGATTTAGTAAAAAAGATAGT
TGAAGAGGTGGAGAGGTAAA

Downstream 100 bases:

>100_bases
GTGTTGGGATTTGATGTTCAATGTTATCTGACCCCCGTAAAGGGGGTCAGTTTTAGGAGGAATTCTGTGGCGGACTTTGC
GGTAATAAATTCACGTAGAG

Product: translation initiation factor, aIF-2BI family

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MSKLKTMTLEWTGESVIFIDQRKLPTQEIYVECETYEDVYVAIKDMIVRGAPAIGASAAFGYVLGAQKFNGAFDSAEGLA
YMEKVKEKLASSRPTAVNLFWALDRMHRTFESFRNEPDVVKLLEEEALKIAYEDIEVNRAIGKHGAEVLRDGDTVLTHCN
AGALATVDYGTALGVIRAAVEQGKKIKVFADETRPYLQGARLTAWELMKDGIDVTLISDNMAGWVMKKGWINAVVVGADR
IAANGDVANKIGTYSVAILAQKHGIPFYVAAPLSTIDLNTPTGDEIPIEERSHREITHVQGVQIAPDNIKCYNPAFDVTP
SHLITGIITEKGIVRPPYDVELKKLFE

Sequences:

>Translated_347_residues
MSKLKTMTLEWTGESVIFIDQRKLPTQEIYVECETYEDVYVAIKDMIVRGAPAIGASAAFGYVLGAQKFNGAFDSAEGLA
YMEKVKEKLASSRPTAVNLFWALDRMHRTFESFRNEPDVVKLLEEEALKIAYEDIEVNRAIGKHGAEVLRDGDTVLTHCN
AGALATVDYGTALGVIRAAVEQGKKIKVFADETRPYLQGARLTAWELMKDGIDVTLISDNMAGWVMKKGWINAVVVGADR
IAANGDVANKIGTYSVAILAQKHGIPFYVAAPLSTIDLNTPTGDEIPIEERSHREITHVQGVQIAPDNIKCYNPAFDVTP
SHLITGIITEKGIVRPPYDVELKKLFE
>Mature_346_residues
SKLKTMTLEWTGESVIFIDQRKLPTQEIYVECETYEDVYVAIKDMIVRGAPAIGASAAFGYVLGAQKFNGAFDSAEGLAY
MEKVKEKLASSRPTAVNLFWALDRMHRTFESFRNEPDVVKLLEEEALKIAYEDIEVNRAIGKHGAEVLRDGDTVLTHCNA
GALATVDYGTALGVIRAAVEQGKKIKVFADETRPYLQGARLTAWELMKDGIDVTLISDNMAGWVMKKGWINAVVVGADRI
AANGDVANKIGTYSVAILAQKHGIPFYVAAPLSTIDLNTPTGDEIPIEERSHREITHVQGVQIAPDNIKCYNPAFDVTPS
HLITGIITEKGIVRPPYDVELKKLFE

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=352, Percent_Identity=45.4545454545455, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI23943880, Length=338, Percent_Identity=39.9408284023669, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI4503503, Length=200, Percent_Identity=31, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI7657058, Length=188, Percent_Identity=27.1276595744681, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI78000158, Length=202, Percent_Identity=24.2574257425743, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI78000156, Length=202, Percent_Identity=24.2574257425743, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI187607323, Length=202, Percent_Identity=24.2574257425743, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17557462, Length=333, Percent_Identity=41.4414414414414, Blast_Score=230, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI17557123, Length=165, Percent_Identity=32.1212121212121, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325375, Length=380, Percent_Identity=38.6842105263158, Blast_Score=202, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6322878, Length=278, Percent_Identity=27.6978417266187, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21357667, Length=369, Percent_Identity=44.4444444444444, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24651647, Length=369, Percent_Identity=44.4444444444444, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI21358605, Length=214, Percent_Identity=27.1028037383178, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 38218; Mature: 38087

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLKTMTLEWTGESVIFIDQRKLPTQEIYVECETYEDVYVAIKDMIVRGAPAIGASAAF
CCCCEEEEEEECCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHH
GYVLGAQKFNGAFDSAEGLAYMEKVKEKLASSRPTAVNLFWALDRMHRTFESFRNEPDVV
HHHCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCCHHH
KLLEEEALKIAYEDIEVNRAIGKHGAEVLRDGDTVLTHCNAGALATVDYGTALGVIRAAV
HHHHHHHHHEEHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCHHHHHHHHHHH
EQGKKIKVFADETRPYLQGARLTAWELMKDGIDVTLISDNMAGWVMKKGWINAVVVGADR
HCCCEEEEEECCCCHHHCCCCCHHHHHHHCCCEEEEEECCCCCEEEECCCEEEEEEECCC
IAANGDVANKIGTYSVAILAQKHGIPFYVAAPLSTIDLNTPTGDEIPIEERSHREITHVQ
EECCCCCHHHCCCEEEEEEEECCCCCEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHCC
GVQIAPDNIKCYNPAFDVTPSHLITGIITEKGIVRPPYDVELKKLFE
CCEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHCC
>Mature Secondary Structure 
SKLKTMTLEWTGESVIFIDQRKLPTQEIYVECETYEDVYVAIKDMIVRGAPAIGASAAF
CCCEEEEEEECCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCHHHH
GYVLGAQKFNGAFDSAEGLAYMEKVKEKLASSRPTAVNLFWALDRMHRTFESFRNEPDVV
HHHCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCCHHH
KLLEEEALKIAYEDIEVNRAIGKHGAEVLRDGDTVLTHCNAGALATVDYGTALGVIRAAV
HHHHHHHHHEEHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCHHHHHHHHHHH
EQGKKIKVFADETRPYLQGARLTAWELMKDGIDVTLISDNMAGWVMKKGWINAVVVGADR
HCCCEEEEEECCCCHHHCCCCCHHHHHHHCCCEEEEEECCCCCEEEECCCEEEEEEECCC
IAANGDVANKIGTYSVAILAQKHGIPFYVAAPLSTIDLNTPTGDEIPIEERSHREITHVQ
EECCCCCHHHCCCEEEEEEEECCCCCEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHCC
GVQIAPDNIKCYNPAFDVTPSHLITGIITEKGIVRPPYDVELKKLFE
CCEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA