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The map label for this gene is accA [C]

Identifier: 239617744

GI number: 239617744

Start: 1452869

End: 1454422

Strand: Reverse

Name: accA [C]

Synonym: Kole_1368

Alternate gene names: 239617744

Gene position: 1454422-1452869 (Counterclockwise)

Preceding gene: 239617745

Following gene: 239617743

Centisome position: 63.18

GC content: 45.17

Gene sequence:

>1554_bases
ATGGGGGGTGATGAGTTGAACGAAAAACTCGAGAAGTTCAAAAAGCTAGATGAAAAAATAACCCTTGGCGGTGGAAAAGA
GAGAATAGAGAAACAGCATGCTCAGGGAAAACTTACCGCCAGGGAACGAATAGAATTGCTGTGCGATCCTGGAAGCTTTG
AAGAAATCGATAAATTCGTCAAACACCGTTCAACCTTCTTTGGACTTGATAAAAAAGATTTCCCGGCAGATGGTGTTGTT
ACCGGAATTGGTGAAATAAACGGCAGAAAAGTCGCTGTTTTTTCACAGGATTTCACAGTTCAAGGTGGTTCTCTTGGTGA
AATGCATGCGAAAAAAATCATGAAGATCCAGGATCTCGCCATTAAGCTGGGAATCCCGATAATCGGGATAAACGATTCTG
GTGGTGCCCGTATTCAGGAAGGCGTCGATTCCCTGTATGGTTACGGCGGTATATTCTATCGAAACACCCTTGCTTCTGGT
GTCATACCACAGATAACCGTAATTGCCGGTCCCTGCGCCGGTGGAGCGGTTTACTCTCCTGCAATCACAGATTTCATAAT
AATGGTTAATCAGATATCCCAGATGTTTATCACCGGTCCACAGGTTATCAAAGCGGTTACCGGCGAAGATATAGACAAAA
ATGGACTCGGTGGTGCCATGATCCACAACAGCAAAAGCGGTGTTGCTCACTTCATAACTGAGACCGATAGCGACGCCATG
CAGCTCGTCAGGAAACTTATTTCCTACATTCCGCAGAACAATTCAGAAGAACCTGAAATTACCGAACCAATGTCAGTCTC
GCAAGTACCGGAACTAAGAGAAATCGTGCCAGAGAATCCAAAACAAGCTTACGATGTAAAAAAAGTAATAGAACTCGTTG
TAGATAACGGCGAATTCCTTGAAGTCCACAAACACTACGCAAAAAATATAGTGATAGGATTTGCCAGGATCGCTGGCCGT
TCTGTCGGAATTATCGCCAATCAACCTTCTGTTTATGCTGGCGTGCTGGACATCGACTCTTCCGATAAAGCAGCAAGATT
TATACGATTCCTCGATGCTTTCAACATCCCAATAATCACATTCGTTGACACTCCAGGATTCCTTCCCGGCATTTCCCAGG
AACACGGCGGCATCATCAGACACGGTGCCAAGCTTCTTTACGCTTACAGTGAAGCAACCGTCCCGAAAATTACAACCATC
ATCAGAAAGGCTTATGGCGGCGCTTATATAGCAATGGGAAGTCAGCATCTTGGAGCCGATATGGTCTTTGCCTGGCCCGG
AGCTGAGATAGCGGTCATGGGACCGGAGGGTGCGGCAAACATCATATTCAGAAAAGAGATCCAGGCAGCCGAAGATTCCG
AAAAAGTACGTAAAGAAAGGATAGAAGAATACAAAGAAATGTTTGCAAATCCCTATACGGCTGCTGCGAGGGGATACATA
GAAGAAGTAATAGATCCAGCGGATACAAGACTAAAAATTGCCAGAGCACTGGAGATTTTAGATAGCAAGGTTGAAGGAAG
GCCAACGAAAAAGCATGGAAACATTCCCCTGTGA

Upstream 100 bases:

>100_bases
GCGATGAACCTCAGCCGGGTGCCGGTGGAACAAAAGTGATCTTCCTGCACCCAAAAACCACCGGCGGTGTTCTCATAGAA
ATGGTAGAAGGTCAACACTA

Downstream 100 bases:

>100_bases
GGAGTGACATTTTGTGGATTTGACAGTAGGTCAGGTTACCCTGATAGGCCTCTCGGTAGTTTTCCTAACCTTTGTAATAC
TGTACGTCTTTTTTGTTAGC

Product: carboxyl transferase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MGGDELNEKLEKFKKLDEKITLGGGKERIEKQHAQGKLTARERIELLCDPGSFEEIDKFVKHRSTFFGLDKKDFPADGVV
TGIGEINGRKVAVFSQDFTVQGGSLGEMHAKKIMKIQDLAIKLGIPIIGINDSGGARIQEGVDSLYGYGGIFYRNTLASG
VIPQITVIAGPCAGGAVYSPAITDFIIMVNQISQMFITGPQVIKAVTGEDIDKNGLGGAMIHNSKSGVAHFITETDSDAM
QLVRKLISYIPQNNSEEPEITEPMSVSQVPELREIVPENPKQAYDVKKVIELVVDNGEFLEVHKHYAKNIVIGFARIAGR
SVGIIANQPSVYAGVLDIDSSDKAARFIRFLDAFNIPIITFVDTPGFLPGISQEHGGIIRHGAKLLYAYSEATVPKITTI
IRKAYGGAYIAMGSQHLGADMVFAWPGAEIAVMGPEGAANIIFRKEIQAAEDSEKVRKERIEEYKEMFANPYTAAARGYI
EEVIDPADTRLKIARALEILDSKVEGRPTKKHGNIPL

Sequences:

>Translated_517_residues
MGGDELNEKLEKFKKLDEKITLGGGKERIEKQHAQGKLTARERIELLCDPGSFEEIDKFVKHRSTFFGLDKKDFPADGVV
TGIGEINGRKVAVFSQDFTVQGGSLGEMHAKKIMKIQDLAIKLGIPIIGINDSGGARIQEGVDSLYGYGGIFYRNTLASG
VIPQITVIAGPCAGGAVYSPAITDFIIMVNQISQMFITGPQVIKAVTGEDIDKNGLGGAMIHNSKSGVAHFITETDSDAM
QLVRKLISYIPQNNSEEPEITEPMSVSQVPELREIVPENPKQAYDVKKVIELVVDNGEFLEVHKHYAKNIVIGFARIAGR
SVGIIANQPSVYAGVLDIDSSDKAARFIRFLDAFNIPIITFVDTPGFLPGISQEHGGIIRHGAKLLYAYSEATVPKITTI
IRKAYGGAYIAMGSQHLGADMVFAWPGAEIAVMGPEGAANIIFRKEIQAAEDSEKVRKERIEEYKEMFANPYTAAARGYI
EEVIDPADTRLKIARALEILDSKVEGRPTKKHGNIPL
>Mature_516_residues
GGDELNEKLEKFKKLDEKITLGGGKERIEKQHAQGKLTARERIELLCDPGSFEEIDKFVKHRSTFFGLDKKDFPADGVVT
GIGEINGRKVAVFSQDFTVQGGSLGEMHAKKIMKIQDLAIKLGIPIIGINDSGGARIQEGVDSLYGYGGIFYRNTLASGV
IPQITVIAGPCAGGAVYSPAITDFIIMVNQISQMFITGPQVIKAVTGEDIDKNGLGGAMIHNSKSGVAHFITETDSDAMQ
LVRKLISYIPQNNSEEPEITEPMSVSQVPELREIVPENPKQAYDVKKVIELVVDNGEFLEVHKHYAKNIVIGFARIAGRS
VGIIANQPSVYAGVLDIDSSDKAARFIRFLDAFNIPIITFVDTPGFLPGISQEHGGIIRHGAKLLYAYSEATVPKITTII
RKAYGGAYIAMGSQHLGADMVFAWPGAEIAVMGPEGAANIIFRKEIQAAEDSEKVRKERIEEYKEMFANPYTAAARGYIE
EVIDPADTRLKIARALEILDSKVEGRPTKKHGNIPL

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=519, Percent_Identity=57.0327552986513, Blast_Score=587, Evalue=1e-168,
Organism=Homo sapiens, GI295821216, Length=539, Percent_Identity=54.9165120593692, Blast_Score=575, Evalue=1e-164,
Organism=Homo sapiens, GI11545863, Length=504, Percent_Identity=35.515873015873, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI134142062, Length=391, Percent_Identity=24.8081841432225, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI38679977, Length=347, Percent_Identity=24.7838616714697, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI38679967, Length=347, Percent_Identity=24.7838616714697, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI38679974, Length=347, Percent_Identity=24.7838616714697, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI38679971, Length=347, Percent_Identity=24.7838616714697, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI38679960, Length=347, Percent_Identity=24.7838616714697, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI1786382, Length=199, Percent_Identity=30.6532663316583, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147362, Length=509, Percent_Identity=56.385068762279, Blast_Score=582, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI25147359, Length=509, Percent_Identity=56.385068762279, Blast_Score=581, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI17552936, Length=510, Percent_Identity=34.9019607843137, Blast_Score=282, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI71997163, Length=389, Percent_Identity=22.879177377892, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI133931226, Length=395, Percent_Identity=23.2911392405063, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24586065, Length=525, Percent_Identity=33.5238095238095, Blast_Score=265, Evalue=8e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 56372; Mature: 56241

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGDELNEKLEKFKKLDEKITLGGGKERIEKQHAQGKLTARERIELLCDPGSFEEIDKFV
CCHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHCCCCCHHHHHHEEECCCCHHHHHHHH
KHRSTFFGLDKKDFPADGVVTGIGEINGRKVAVFSQDFTVQGGSLGEMHAKKIMKIQDLA
HHHHHHCCCCCCCCCCCCEEECCCCCCCCEEEEEECCEEECCCCCHHHHHHHHHHHHHHH
IKLGIPIIGINDSGGARIQEGVDSLYGYGGIFYRNTLASGVIPQITVIAGPCAGGAVYSP
HEECCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCH
AITDFIIMVNQISQMFITGPQVIKAVTGEDIDKNGLGGAMIHNSKSGVAHFITETDSDAM
HHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCEEEECCCCCCEEEEECCCHHHH
QLVRKLISYIPQNNSEEPEITEPMSVSQVPELREIVPENPKQAYDVKKVIELVVDNGEFL
HHHHHHHHHCCCCCCCCCCCCCCCCHHCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCHH
EVHKHYAKNIVIGFARIAGRSVGIIANQPSVYAGVLDIDSSDKAARFIRFLDAFNIPIIT
HHHHHHHHHHHEEHHHHCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEE
FVDTPGFLPGISQEHGGIIRHGAKLLYAYSEATVPKITTIIRKAYGGAYIAMGSQHLGAD
EECCCCCCCCCCCCCCCHHHCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCCC
MVFAWPGAEIAVMGPEGAANIIFRKEIQAAEDSEKVRKERIEEYKEMFANPYTAAARGYI
EEEECCCCEEEEECCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
EEVIDPADTRLKIARALEILDSKVEGRPTKKHGNIPL
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
GGDELNEKLEKFKKLDEKITLGGGKERIEKQHAQGKLTARERIELLCDPGSFEEIDKFV
CHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHCCCCCHHHHHHEEECCCCHHHHHHHH
KHRSTFFGLDKKDFPADGVVTGIGEINGRKVAVFSQDFTVQGGSLGEMHAKKIMKIQDLA
HHHHHHCCCCCCCCCCCCEEECCCCCCCCEEEEEECCEEECCCCCHHHHHHHHHHHHHHH
IKLGIPIIGINDSGGARIQEGVDSLYGYGGIFYRNTLASGVIPQITVIAGPCAGGAVYSP
HEECCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCH
AITDFIIMVNQISQMFITGPQVIKAVTGEDIDKNGLGGAMIHNSKSGVAHFITETDSDAM
HHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCEEEECCCCCCEEEEECCCHHHH
QLVRKLISYIPQNNSEEPEITEPMSVSQVPELREIVPENPKQAYDVKKVIELVVDNGEFL
HHHHHHHHHCCCCCCCCCCCCCCCCHHCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCHH
EVHKHYAKNIVIGFARIAGRSVGIIANQPSVYAGVLDIDSSDKAARFIRFLDAFNIPIIT
HHHHHHHHHHHEEHHHHCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEE
FVDTPGFLPGISQEHGGIIRHGAKLLYAYSEATVPKITTIIRKAYGGAYIAMGSQHLGAD
EECCCCCCCCCCCCCCCHHHCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCCC
MVFAWPGAEIAVMGPEGAANIIFRKEIQAAEDSEKVRKERIEEYKEMFANPYTAAARGYI
EEEECCCCEEEEECCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
EEVIDPADTRLKIARALEILDSKVEGRPTKKHGNIPL
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]