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The map label for this gene is bcc [H]

Identifier: 239617742

GI number: 239617742

Start: 1452089

End: 1452499

Strand: Reverse

Name: bcc [H]

Synonym: Kole_1366

Alternate gene names: 239617742

Gene position: 1452499-1452089 (Counterclockwise)

Preceding gene: 239617743

Following gene: 239617734

Centisome position: 63.09

GC content: 44.04

Gene sequence:

>411_bases
ATGCTGAGAAAATTCAGGGTAAAAGTTAACGGGAAAGAATACATCGTTGAAGTCGAAGAACTGTCTTCAGAAGCCACAAA
GGTTCAAACTTCTGCGCCGTCACCAGCACCATCTAAGGTTGTATCTCAGCCTCTCAGAAAAGAAGAAACTAAGCCCAAAC
CTCAAAAAGAAACCAAACCACAACCGGCTCAATCCGAAGGCCATAGCATAATCGCCCCAATGTCCGGAGTAATACTCGAA
ATACTCGTATCACCGGGAACCCATGTTAAAGCTGGAGACACTGTGGTCGTAATGGAAGCTATGAAAATGGAGAATAACAT
CCTGTCTGAATTCGATGGCGTCGTTAAAGAGGTAAAAGTAAACAAAGGTGACAACGTAGAAGCGGGACAGGTGATGGTAG
TACTCGAATAA

Upstream 100 bases:

>100_bases
ACAGATTCATTATTAGATCCATTAAACCATCAAGGAAACTCCGGTCCAGCTGGAAAAGCAGAAAACCAATGACACAATGG
AAACCAAGGAGGAGCAAGAA

Downstream 100 bases:

>100_bases
TTTCCCTCAAAAATAAGAAAGGGAGTTATCTGTCATTCACGATAGCTCCCTTTTTTATTCAAGGATCAATGACTATCAGT
CTGCTTTGCCCAACAGCCTT

Product: biotin/lipoyl attachment domain-containing protein

Products: propanoyl-CoA; CO2

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 136; Mature: 136

Protein sequence:

>136_residues
MLRKFRVKVNGKEYIVEVEELSSEATKVQTSAPSPAPSKVVSQPLRKEETKPKPQKETKPQPAQSEGHSIIAPMSGVILE
ILVSPGTHVKAGDTVVVMEAMKMENNILSEFDGVVKEVKVNKGDNVEAGQVMVVLE

Sequences:

>Translated_136_residues
MLRKFRVKVNGKEYIVEVEELSSEATKVQTSAPSPAPSKVVSQPLRKEETKPKPQKETKPQPAQSEGHSIIAPMSGVILE
ILVSPGTHVKAGDTVVVMEAMKMENNILSEFDGVVKEVKVNKGDNVEAGQVMVVLE
>Mature_136_residues
MLRKFRVKVNGKEYIVEVEELSSEATKVQTSAPSPAPSKVVSQPLRKEETKPKPQKETKPQPAQSEGHSIIAPMSGVILE
ILVSPGTHVKAGDTVVVMEAMKMENNILSEFDGVVKEVKVNKGDNVEAGQVMVVLE

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319695, Length=82, Percent_Identity=43.9024390243902, Blast_Score=67, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6321376, Length=95, Percent_Identity=41.0526315789474, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: 4.1.1.41

Molecular weight: Translated: 14792; Mature: 14792

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRKFRVKVNGKEYIVEVEELSSEATKVQTSAPSPAPSKVVSQPLRKEETKPKPQKETKP
CCCEEEEEECCCEEEEEHHHHCCHHHEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
QPAQSEGHSIIAPMSGVILEILVSPGTHVKAGDTVVVMEAMKMENNILSEFDGVVKEVKV
CCCCCCCCEEECCHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHEEC
NKGDNVEAGQVMVVLE
CCCCCCCCCEEEEEEC
>Mature Secondary Structure
MLRKFRVKVNGKEYIVEVEELSSEATKVQTSAPSPAPSKVVSQPLRKEETKPKPQKETKP
CCCEEEEEECCCEEEEEHHHHCCHHHEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
QPAQSEGHSIIAPMSGVILEILVSPGTHVKAGDTVVVMEAMKMENNILSEFDGVVKEVKV
CCCCCCCCEEECCHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHEEC
NKGDNVEAGQVMVVLE
CCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-methylmalonyl-CoA

Specific reaction: (S)-methylmalonyl-CoA = propanoyl-CoA + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8431283; 12397186 [H]