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The map label for this gene is icd [H]

Identifier: 239617606

GI number: 239617606

Start: 1303493

End: 1304695

Strand: Reverse

Name: icd [H]

Synonym: Kole_1227

Alternate gene names: 239617606

Gene position: 1304695-1303493 (Counterclockwise)

Preceding gene: 239617607

Following gene: 239617605

Centisome position: 56.67

GC content: 40.48

Gene sequence:

>1203_bases
TTGGAAGGACAGAAAATAAAGGTAGAAAACAACAGTATTTTGGTTCCAAATAATCCCATAATCCCATATATAGCAGGTGA
TGGAATAGGGCCCGAAATAATGAGGGCTGCGATGTTGGTGTGGAATTCAGCAATTTCTCGTGTTTATGCAGGGAAAAGAA
AAGTCGTATGGAAGGAAATATATGCAGGTGAAAAGGCTATAGAAATCTTTGGTGATCCACTTCCTGAAGAAACAATAGAA
GCTATTAAGAGTCATGTTGTTTCTATAAAATCACCTTTGACCACCCCGGTCGGAAGGGGATACAGGAGCCTTAATGTGAA
GCTCAGGCAGGTTCTGGATCTGTATGCATGTATAAGGCCTGTCAAATGGATAAAAGGAGTTCCAGCTCCAGTTAAGCACC
CGGAACTTTTAGATGTGGTAATTTTCCGTGAGAACACGGAAGACGTGTACGCTGGAATAGAATGGAAAAAAGGCTCACAA
GAAGCGAAAAAGGTTATCGACTTTTTAAGAGATACGTTTAATCTGGAAATTAGAGGCGATTCAGGACTTGGATTGAAGCC
CATAAGTGAATTCGCTACGAAGAGAATTACGAGAAAAGCTATTCAATACGCCCTGGAAAATGGCAGAAAGAGTGTCACCA
TAGTCCATAAGGGAAATATAATGAAATACACAGAGGGCGCTTTTGTAGAATGGGCTTATGAAGTGGCTTTGAATGAATTT
GAAGGCAAAGTGGTTTCGGAGAGAGAGTTAAATGAGCCCGTATCTGAAAAATTGATCGTAAAAGATAGAATAGCGGATAA
CATGTTCCAGCAGATACTCTTAGAACCTTCGGAGTACGATATAATGCTCCTCCCTAACCTGAATGGAGATTATCTGTCTG
ATGCTGTTGCAGCTCAGGTTGGTGGTATAGGGTTAGTTCCTGGTGCAAACATAGGAGATTTTGTGGCTTTGTTTGAACCA
ACACACGGTACAGCACCGCAACTTGCTGGAAAGGAAATAGCAAACCCAACATCCTTGATATTATCCGGTGCTATGATGTT
CGATTATATTGGATGGAAAGAAGTTGGAAGTATTATAAGAAAAGCTGTTGAGAAAACTATAATGGACGGGAAGATGACCA
TAGATCTCGCAAGAAAGAAAGGTGTAGAGCCTCTTAAAACCACGGAATTTGCAGAAGAAATCATTAAAAACATTGAAGAA
TAG

Upstream 100 bases:

>100_bases
ATTTAACCCCATGCCAGATTTTATATTGAAGATCGTAGAAAAAGGTGGAATAAGAAATTACATAAAAGAGTTTGGAGACT
ACTTTGTGGAGTGATTCGCC

Downstream 100 bases:

>100_bases
GGATTCGAGAGTGCCGCTTCGCTGAGAAAGTGCTGAGCTGCGCTCAGGAGGCTCACGACGTTGAGGCTTGCAGCGCTGAC
AATCGATAATACGACGCTTG

Product: Isocitrate dehydrogenase (NADP(+))

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MEGQKIKVENNSILVPNNPIIPYIAGDGIGPEIMRAAMLVWNSAISRVYAGKRKVVWKEIYAGEKAIEIFGDPLPEETIE
AIKSHVVSIKSPLTTPVGRGYRSLNVKLRQVLDLYACIRPVKWIKGVPAPVKHPELLDVVIFRENTEDVYAGIEWKKGSQ
EAKKVIDFLRDTFNLEIRGDSGLGLKPISEFATKRITRKAIQYALENGRKSVTIVHKGNIMKYTEGAFVEWAYEVALNEF
EGKVVSERELNEPVSEKLIVKDRIADNMFQQILLEPSEYDIMLLPNLNGDYLSDAVAAQVGGIGLVPGANIGDFVALFEP
THGTAPQLAGKEIANPTSLILSGAMMFDYIGWKEVGSIIRKAVEKTIMDGKMTIDLARKKGVEPLKTTEFAEEIIKNIEE

Sequences:

>Translated_400_residues
MEGQKIKVENNSILVPNNPIIPYIAGDGIGPEIMRAAMLVWNSAISRVYAGKRKVVWKEIYAGEKAIEIFGDPLPEETIE
AIKSHVVSIKSPLTTPVGRGYRSLNVKLRQVLDLYACIRPVKWIKGVPAPVKHPELLDVVIFRENTEDVYAGIEWKKGSQ
EAKKVIDFLRDTFNLEIRGDSGLGLKPISEFATKRITRKAIQYALENGRKSVTIVHKGNIMKYTEGAFVEWAYEVALNEF
EGKVVSERELNEPVSEKLIVKDRIADNMFQQILLEPSEYDIMLLPNLNGDYLSDAVAAQVGGIGLVPGANIGDFVALFEP
THGTAPQLAGKEIANPTSLILSGAMMFDYIGWKEVGSIIRKAVEKTIMDGKMTIDLARKKGVEPLKTTEFAEEIIKNIEE
>Mature_400_residues
MEGQKIKVENNSILVPNNPIIPYIAGDGIGPEIMRAAMLVWNSAISRVYAGKRKVVWKEIYAGEKAIEIFGDPLPEETIE
AIKSHVVSIKSPLTTPVGRGYRSLNVKLRQVLDLYACIRPVKWIKGVPAPVKHPELLDVVIFRENTEDVYAGIEWKKGSQ
EAKKVIDFLRDTFNLEIRGDSGLGLKPISEFATKRITRKAIQYALENGRKSVTIVHKGNIMKYTEGAFVEWAYEVALNEF
EGKVVSERELNEPVSEKLIVKDRIADNMFQQILLEPSEYDIMLLPNLNGDYLSDAVAAQVGGIGLVPGANIGDFVALFEP
THGTAPQLAGKEIANPTSLILSGAMMFDYIGWKEVGSIIRKAVEKTIMDGKMTIDLARKKGVEPLKTTEFAEEIIKNIEE

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=382, Percent_Identity=35.6020942408377, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4758582, Length=382, Percent_Identity=30.8900523560209, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI28178838, Length=346, Percent_Identity=32.3699421965318, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI28178821, Length=348, Percent_Identity=29.5977011494253, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI28178816, Length=346, Percent_Identity=29.7687861271676, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI28178819, Length=180, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1787381, Length=407, Percent_Identity=52.8255528255528, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI87081683, Length=398, Percent_Identity=28.1407035175879, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1788101, Length=368, Percent_Identity=26.9021739130435, Blast_Score=118, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71986051, Length=357, Percent_Identity=35.5742296918768, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI25144293, Length=383, Percent_Identity=30.5483028720627, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17505779, Length=352, Percent_Identity=32.6704545454545, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17550882, Length=400, Percent_Identity=29.25, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6324709, Length=386, Percent_Identity=32.3834196891192, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322097, Length=373, Percent_Identity=34.5844504021448, Blast_Score=182, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6324291, Length=324, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6319830, Length=404, Percent_Identity=26.7326732673267, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24643270, Length=388, Percent_Identity=35.0515463917526, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24643268, Length=388, Percent_Identity=35.0515463917526, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24661184, Length=381, Percent_Identity=34.3832020997375, Blast_Score=204, Evalue=6e-53,
Organism=Drosophila melanogaster, GI161078635, Length=381, Percent_Identity=30.7086614173228, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI161078637, Length=381, Percent_Identity=30.7086614173228, Blast_Score=141, Evalue=7e-34,
Organism=Drosophila melanogaster, GI161078639, Length=378, Percent_Identity=30.952380952381, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI161078633, Length=381, Percent_Identity=30.7086614173228, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24650122, Length=381, Percent_Identity=30.7086614173228, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI281362242, Length=391, Percent_Identity=31.9693094629156, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24648872, Length=391, Percent_Identity=31.9693094629156, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI20130355, Length=376, Percent_Identity=25.7978723404255, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 44451; Mature: 44451

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGQKIKVENNSILVPNNPIIPYIAGDGIGPEIMRAAMLVWNSAISRVYAGKRKVVWKEI
CCCCEEEECCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
YAGEKAIEIFGDPLPEETIEAIKSHVVSIKSPLTTPVGRGYRSLNVKLRQVLDLYACIRP
HCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHH
VKWIKGVPAPVKHPELLDVVIFRENTEDVYAGIEWKKGSQEAKKVIDFLRDTFNLEIRGD
HHHHCCCCCCCCCCCEEEEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHHEEEEEECC
SGLGLKPISEFATKRITRKAIQYALENGRKSVTIVHKGNIMKYTEGAFVEWAYEVALNEF
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHH
EGKVVSERELNEPVSEKLIVKDRIADNMFQQILLEPSEYDIMLLPNLNGDYLSDAVAAQV
CCCEECHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHH
GGIGLVPGANIGDFVALFEPTHGTAPQLAGKEIANPTSLILSGAMMFDYIGWKEVGSIIR
CCEECCCCCCCCCEEEEECCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHCCHHHHHHHHH
KAVEKTIMDGKMTIDLARKKGVEPLKTTEFAEEIIKNIEE
HHHHHHHHCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEGQKIKVENNSILVPNNPIIPYIAGDGIGPEIMRAAMLVWNSAISRVYAGKRKVVWKEI
CCCCEEEECCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
YAGEKAIEIFGDPLPEETIEAIKSHVVSIKSPLTTPVGRGYRSLNVKLRQVLDLYACIRP
HCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHH
VKWIKGVPAPVKHPELLDVVIFRENTEDVYAGIEWKKGSQEAKKVIDFLRDTFNLEIRGD
HHHHCCCCCCCCCCCEEEEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHHEEEEEECC
SGLGLKPISEFATKRITRKAIQYALENGRKSVTIVHKGNIMKYTEGAFVEWAYEVALNEF
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHH
EGKVVSERELNEPVSEKLIVKDRIADNMFQQILLEPSEYDIMLLPNLNGDYLSDAVAAQV
CCCEECHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHH
GGIGLVPGANIGDFVALFEPTHGTAPQLAGKEIANPTSLILSGAMMFDYIGWKEVGSIIR
CCEECCCCCCCCCEEEEECCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHCCHHHHHHHHH
KAVEKTIMDGKMTIDLARKKGVEPLKTTEFAEEIIKNIEE
HHHHHHHHCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9325430; 9389475 [H]